LeishMANIAdb
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Putative glycosomal membrane protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glycosomal membrane protein
Gene product:
glycosomal membrane protein - putative
Species:
Leishmania infantum
UniProt:
A4I3V7_LEIIN
TriTrypDb:
LINF_280029400
Length:
222

Annotations

Annotations by Jardim et al.

Glycosome membrane, Peroxin 11 glycosomal membrane

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0005778 peroxisomal membrane 6 1
GO:0016020 membrane 2 1
GO:0020015 glycosome 7 1
GO:0031090 organelle membrane 3 1
GO:0031903 microbody membrane 5 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I3V7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3V7

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 14
GO:0009987 cellular process 1 14
GO:0016043 cellular component organization 3 14
GO:0016559 peroxisome fission 6 14
GO:0048285 organelle fission 5 14
GO:0071840 cellular component organization or biogenesis 2 14
GO:0032535 regulation of cellular component size 4 1
GO:0044375 regulation of peroxisome size 5 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0090066 regulation of anatomical structure size 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 37 41 PF00656 0.450
CLV_MEL_PAP_1 153 159 PF00089 0.378
CLV_PCSK_KEX2_1 155 157 PF00082 0.411
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.443
CLV_PCSK_SKI1_1 128 132 PF00082 0.266
CLV_PCSK_SKI1_1 150 154 PF00082 0.284
CLV_PCSK_SKI1_1 165 169 PF00082 0.416
CLV_PCSK_SKI1_1 6 10 PF00082 0.234
DOC_MAPK_gen_1 164 174 PF00069 0.236
DOC_MAPK_gen_1 42 49 PF00069 0.534
DOC_MAPK_gen_1 71 81 PF00069 0.509
DOC_MAPK_MEF2A_6 176 185 PF00069 0.234
DOC_PP1_RVXF_1 89 96 PF00149 0.471
DOC_USP7_MATH_1 35 39 PF00917 0.424
DOC_USP7_UBL2_3 124 128 PF12436 0.459
DOC_USP7_UBL2_3 164 168 PF12436 0.277
DOC_WW_Pin1_4 193 198 PF00397 0.323
LIG_Actin_WH2_2 136 152 PF00022 0.256
LIG_BIR_II_1 1 5 PF00653 0.505
LIG_CSL_BTD_1 194 197 PF09270 0.192
LIG_LIR_Gen_1 2 11 PF02991 0.398
LIG_LIR_Nem_3 132 138 PF02991 0.334
LIG_LIR_Nem_3 18 24 PF02991 0.393
LIG_LIR_Nem_3 2 7 PF02991 0.459
LIG_LIR_Nem_3 94 99 PF02991 0.455
LIG_NRBOX 6 12 PF00104 0.499
LIG_Pex14_2 135 139 PF04695 0.254
LIG_Pex14_2 23 27 PF04695 0.439
LIG_Pex14_2 92 96 PF04695 0.510
LIG_PTB_Apo_2 98 105 PF02174 0.438
LIG_PTB_Phospho_1 98 104 PF10480 0.416
LIG_REV1ctd_RIR_1 25 33 PF16727 0.515
LIG_REV1ctd_RIR_1 93 101 PF16727 0.482
LIG_SH2_CRK 21 25 PF00017 0.425
LIG_SH2_GRB2like 215 218 PF00017 0.423
LIG_SH2_PTP2 46 49 PF00017 0.408
LIG_SH2_STAP1 129 133 PF00017 0.432
LIG_SH2_STAT5 104 107 PF00017 0.398
LIG_SH2_STAT5 190 193 PF00017 0.217
LIG_SH2_STAT5 215 218 PF00017 0.445
LIG_SH2_STAT5 46 49 PF00017 0.408
LIG_SUMO_SIM_par_1 170 175 PF11976 0.282
LIG_UBA3_1 59 64 PF00899 0.449
MOD_CK1_1 193 199 PF00069 0.215
MOD_CK1_1 38 44 PF00069 0.447
MOD_CK1_1 52 58 PF00069 0.426
MOD_CK2_1 160 166 PF00069 0.208
MOD_GlcNHglycan 208 211 PF01048 0.275
MOD_GlcNHglycan 54 57 PF01048 0.270
MOD_GSK3_1 155 162 PF00069 0.212
MOD_GSK3_1 172 179 PF00069 0.329
MOD_GSK3_1 34 41 PF00069 0.454
MOD_N-GLC_1 216 221 PF02516 0.230
MOD_NEK2_1 216 221 PF00069 0.515
MOD_PIKK_1 35 41 PF00454 0.484
MOD_PKA_1 155 161 PF00069 0.209
MOD_PKA_2 155 161 PF00069 0.211
MOD_Plk_4 190 196 PF00069 0.225
MOD_Plk_4 211 217 PF00069 0.282
MOD_Plk_4 99 105 PF00069 0.488
MOD_ProDKin_1 193 199 PF00069 0.323
MOD_SUMO_rev_2 163 170 PF00179 0.207
TRG_DiLeu_BaEn_2 87 93 PF01217 0.503
TRG_ENDOCYTIC_2 21 24 PF00928 0.416
TRG_ENDOCYTIC_2 46 49 PF00928 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJG1 Leptomonas seymouri 34% 100%
A0A0N1PCA1 Leptomonas seymouri 83% 100%
A0A0S4IU25 Bodo saltans 50% 100%
A0A1X0NR15 Trypanosomatidae 54% 100%
A0A3S5H7J8 Leishmania donovani 33% 100%
A0A3S7X1W3 Leishmania donovani 100% 100%
A0A422N9F6 Trypanosoma rangeli 56% 100%
A4HD72 Leishmania braziliensis 25% 100%
A4HGS9 Leishmania braziliensis 32% 100%
A4HGT0 Leishmania braziliensis 86% 100%
A4I3V6 Leishmania infantum 34% 100%
D0A924 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9B046 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B047 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q838 Leishmania major 95% 100%
Q4Q839 Leishmania major 33% 100%
V5BEE7 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS