Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3U7_LEIIN

TriTrypDb:

LINF_280028500

Length:

245

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3U7

PDB structure(s): 7ane_ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.505
CLV_C14_Caspase3-7	27	31	PF00656	0.526
CLV_NRD_NRD_1	138	140	PF00675	0.348
CLV_NRD_NRD_1	8	10	PF00675	0.372
CLV_PCSK_KEX2_1	138	140	PF00082	0.348
CLV_PCSK_KEX2_1	8	10	PF00082	0.372
CLV_PCSK_SKI1_1	206	210	PF00082	0.452
CLV_PCSK_SKI1_1	81	85	PF00082	0.316
DEG_APCC_DBOX_1	80	88	PF00400	0.298
DEG_Nend_UBRbox_2	1	3	PF02207	0.466
DEG_SCF_FBW7_2	29	36	PF00400	0.488
DEG_SCF_FBW7_2	63	69	PF00400	0.554
DEG_SPOP_SBC_1	122	126	PF00917	0.327
DOC_CKS1_1	63	68	PF01111	0.438
DOC_MAPK_HePTP_8	89	101	PF00069	0.380
DOC_MAPK_MEF2A_6	81	89	PF00069	0.300
DOC_MAPK_MEF2A_6	92	101	PF00069	0.348
DOC_PP1_RVXF_1	204	210	PF00149	0.434
DOC_PP2B_LxvP_1	85	88	PF13499	0.301
DOC_USP7_MATH_1	122	126	PF00917	0.327
DOC_USP7_MATH_1	88	92	PF00917	0.465
DOC_WW_Pin1_4	25	30	PF00397	0.517
DOC_WW_Pin1_4	62	67	PF00397	0.464
LIG_14-3-3_CanoR_1	110	115	PF00244	0.498
LIG_14-3-3_CanoR_1	123	128	PF00244	0.434
LIG_14-3-3_CanoR_1	220	224	PF00244	0.491
LIG_14-3-3_CanoR_1	48	56	PF00244	0.439
LIG_deltaCOP1_diTrp_1	160	168	PF00928	0.353
LIG_DLG_GKlike_1	123	131	PF00625	0.327
LIG_FHA_2	32	38	PF00498	0.683
LIG_FHA_2	63	69	PF00498	0.422
LIG_LIR_Gen_1	147	156	PF02991	0.323
LIG_LIR_Gen_1	225	234	PF02991	0.372
LIG_NRBOX	78	84	PF00104	0.439
LIG_PCNA_PIPBox_1	114	123	PF02747	0.469
LIG_Pex14_1	164	168	PF04695	0.356
LIG_Pex14_1	233	237	PF04695	0.395
LIG_Pex14_2	168	172	PF04695	0.419
LIG_SH2_SRC	127	130	PF00017	0.422
LIG_SH2_STAP1	127	131	PF00017	0.421
LIG_SH2_STAT3	154	157	PF00017	0.309
LIG_SH3_1	60	66	PF00018	0.436
LIG_SH3_3	60	66	PF00018	0.462
LIG_Sin3_3	95	102	PF02671	0.317
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.294
LIG_TRAF2_1	20	23	PF00917	0.544
LIG_TRAF2_1	34	37	PF00917	0.511
LIG_TRAF2_1	44	47	PF00917	0.557
LIG_TRAF2_1	66	69	PF00917	0.523
LIG_TRFH_1	59	63	PF08558	0.335
LIG_WRC_WIRS_1	223	228	PF05994	0.414
MOD_CDK_SPK_2	62	67	PF00069	0.426
MOD_CK1_1	113	119	PF00069	0.355
MOD_CK1_1	222	228	PF00069	0.510
MOD_CK1_1	28	34	PF00069	0.688
MOD_CK2_1	123	129	PF00069	0.332
MOD_CK2_1	172	178	PF00069	0.536
MOD_CK2_1	222	228	PF00069	0.512
MOD_CK2_1	239	245	PF00069	0.396
MOD_CK2_1	31	37	PF00069	0.692
MOD_CK2_1	62	68	PF00069	0.416
MOD_GlcNHglycan	104	107	PF01048	0.480
MOD_GSK3_1	215	222	PF00069	0.498
MOD_GSK3_1	24	31	PF00069	0.659
MOD_NEK2_1	102	107	PF00069	0.476
MOD_NEK2_1	121	126	PF00069	0.463
MOD_NEK2_1	137	142	PF00069	0.330
MOD_NEK2_1	152	157	PF00069	0.244
MOD_NEK2_1	172	177	PF00069	0.263
MOD_PIKK_1	215	221	PF00454	0.555
MOD_PKA_2	122	128	PF00069	0.537
MOD_PKA_2	137	143	PF00069	0.502
MOD_PKA_2	219	225	PF00069	0.493
MOD_PKA_2	47	53	PF00069	0.327
MOD_ProDKin_1	25	31	PF00069	0.516
MOD_ProDKin_1	62	68	PF00069	0.473
MOD_SUMO_rev_2	193	202	PF00179	0.471
MOD_SUMO_rev_2	211	218	PF00179	0.527
MOD_SUMO_rev_2	36	45	PF00179	0.499
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.299
TRG_ENDOCYTIC_2	149	152	PF00928	0.327
TRG_ER_diArg_1	137	139	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE2	Leptomonas seymouri	76%	74%
A0A0S4IX75	Bodo saltans	45%	80%
A0A1X0NQT5	Trypanosomatidae	54%	83%
A0A3R7N764	Trypanosoma rangeli	54%	88%
A0A3S7X1T5	Leishmania donovani	100%	100%
A4HGS2	Leishmania braziliensis	90%	100%
D0A916	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	87%
E9B039	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q847	Leishmania major	96%	100%
V5B8A1	Trypanosoma cruzi	52%	88%