Kelch repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I3U4_LEIIN

TriTrypDb:

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.454
CLV_NRD_NRD_1	319	321	PF00675	0.395
CLV_NRD_NRD_1	373	375	PF00675	0.423
CLV_NRD_NRD_1	47	49	PF00675	0.292
CLV_NRD_NRD_1	84	86	PF00675	0.383
CLV_PCSK_KEX2_1	309	311	PF00082	0.403
CLV_PCSK_KEX2_1	375	377	PF00082	0.442
CLV_PCSK_KEX2_1	47	49	PF00082	0.292
CLV_PCSK_KEX2_1	84	86	PF00082	0.383
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.403
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.442
CLV_PCSK_PC7_1	371	377	PF00082	0.429
CLV_PCSK_SKI1_1	138	142	PF00082	0.333
CLV_PCSK_SKI1_1	151	155	PF00082	0.375
CLV_PCSK_SKI1_1	261	265	PF00082	0.398
CLV_PCSK_SKI1_1	35	39	PF00082	0.337
CLV_PCSK_SKI1_1	47	51	PF00082	0.301
CLV_PCSK_SKI1_1	71	75	PF00082	0.481
CLV_PCSK_SKI1_1	92	96	PF00082	0.438
DEG_APCC_DBOX_1	137	145	PF00400	0.336
DEG_APCC_DBOX_1	17	25	PF00400	0.311
DOC_CKS1_1	59	64	PF01111	0.448
DOC_CKS1_1	93	98	PF01111	0.461
DOC_MAPK_gen_1	136	144	PF00069	0.345
DOC_MAPK_gen_1	30	39	PF00069	0.336
DOC_MAPK_gen_1	309	316	PF00069	0.386
DOC_MAPK_HePTP_8	29	41	PF00069	0.347
DOC_MAPK_MEF2A_6	309	318	PF00069	0.391
DOC_MAPK_MEF2A_6	32	41	PF00069	0.350
DOC_PP1_RVXF_1	165	172	PF00149	0.363
DOC_PP2B_LxvP_1	56	59	PF13499	0.362
DOC_USP7_MATH_1	134	138	PF00917	0.385
DOC_USP7_MATH_1	152	156	PF00917	0.359
DOC_USP7_MATH_1	217	221	PF00917	0.494
DOC_USP7_MATH_1	224	228	PF00917	0.520
DOC_USP7_MATH_1	328	332	PF00917	0.383
DOC_WW_Pin1_4	102	107	PF00397	0.529
DOC_WW_Pin1_4	58	63	PF00397	0.425
DOC_WW_Pin1_4	92	97	PF00397	0.449
LIG_14-3-3_CanoR_1	195	201	PF00244	0.471
LIG_14-3-3_CanoR_1	298	304	PF00244	0.458
LIG_14-3-3_CanoR_1	327	333	PF00244	0.387
LIG_14-3-3_CanoR_1	48	58	PF00244	0.332
LIG_FHA_1	50	56	PF00498	0.338
LIG_FHA_2	187	193	PF00498	0.464
LIG_FHA_2	221	227	PF00498	0.513
LIG_FHA_2	55	61	PF00498	0.385
LIG_FXI_DFP_1	74	78	PF00024	0.445
LIG_GBD_Chelix_1	86	94	PF00786	0.391
LIG_LIR_Gen_1	154	161	PF02991	0.321
LIG_LIR_Gen_1	223	233	PF02991	0.508
LIG_LIR_Gen_1	236	246	PF02991	0.453
LIG_LIR_Gen_1	350	361	PF02991	0.351
LIG_LIR_Gen_1	367	377	PF02991	0.419
LIG_LIR_Nem_3	154	160	PF02991	0.325
LIG_LIR_Nem_3	165	169	PF02991	0.324
LIG_LIR_Nem_3	223	228	PF02991	0.519
LIG_LIR_Nem_3	236	241	PF02991	0.472
LIG_LIR_Nem_3	31	37	PF02991	0.328
LIG_LIR_Nem_3	350	356	PF02991	0.352
LIG_LIR_Nem_3	367	372	PF02991	0.408
LIG_Pex14_1	34	38	PF04695	0.336
LIG_PTAP_UEV_1	218	223	PF05743	0.499
LIG_REV1ctd_RIR_1	316	325	PF16727	0.378
LIG_SH2_CRK	238	242	PF00017	0.462
LIG_SH2_GRB2like	20	23	PF00017	0.295
LIG_SH2_STAT5	20	23	PF00017	0.295
LIG_SH3_2	59	64	PF14604	0.448
LIG_SH3_3	103	109	PF00018	0.532
LIG_SH3_3	213	219	PF00018	0.484
LIG_SH3_3	247	253	PF00018	0.399
LIG_SH3_3	34	40	PF00018	0.342
LIG_SH3_3	56	62	PF00018	0.398
LIG_SUMO_SIM_par_1	25	31	PF11976	0.314
LIG_SUMO_SIM_par_1	271	278	PF11976	0.448
LIG_SUMO_SIM_par_1	54	61	PF11976	0.380
MOD_CDK_SPxK_1	58	64	PF00069	0.436
MOD_CDK_SPxxK_3	92	99	PF00069	0.464
MOD_CK1_1	198	204	PF00069	0.465
MOD_CK1_1	220	226	PF00069	0.513
MOD_CK1_1	231	237	PF00069	0.487
MOD_CK1_1	274	280	PF00069	0.440
MOD_CK1_1	301	307	PF00069	0.436
MOD_CK2_1	112	118	PF00069	0.541
MOD_GlcNHglycan	154	157	PF01048	0.343
MOD_GlcNHglycan	219	222	PF01048	0.499
MOD_GlcNHglycan	304	307	PF01048	0.428
MOD_GlcNHglycan	346	349	PF01048	0.383
MOD_GlcNHglycan	67	70	PF01048	0.483
MOD_GlcNHglycan	99	102	PF01048	0.519
MOD_GSK3_1	130	137	PF00069	0.387
MOD_GSK3_1	194	201	PF00069	0.473
MOD_GSK3_1	220	227	PF00069	0.512
MOD_GSK3_1	277	284	PF00069	0.440
MOD_GSK3_1	294	301	PF00069	0.474
MOD_GSK3_1	54	61	PF00069	0.380
MOD_N-GLC_1	162	167	PF02516	0.319
MOD_N-GLC_1	231	236	PF02516	0.487
MOD_NEK2_1	228	233	PF00069	0.501
MOD_NEK2_1	281	286	PF00069	0.451
MOD_NEK2_1	294	299	PF00069	0.478
MOD_NEK2_1	97	102	PF00069	0.513
MOD_PIKK_1	172	178	PF00454	0.460
MOD_PIKK_1	265	271	PF00454	0.416
MOD_PKA_2	130	136	PF00069	0.395
MOD_PKA_2	194	200	PF00069	0.478
MOD_PKA_2	65	71	PF00069	0.490
MOD_Plk_1	277	283	PF00069	0.436
MOD_Plk_1	288	294	PF00069	0.478
MOD_Plk_1	367	373	PF00069	0.407
MOD_Plk_1	78	84	PF00069	0.397
MOD_Plk_4	271	277	PF00069	0.448
MOD_Plk_4	288	294	PF00069	0.478
MOD_Plk_4	328	334	PF00069	0.393
MOD_ProDKin_1	102	108	PF00069	0.529
MOD_ProDKin_1	58	64	PF00069	0.436
MOD_ProDKin_1	92	98	PF00069	0.456
MOD_SUMO_rev_2	147	153	PF00179	0.362
TRG_DiLeu_BaEn_1	4	9	PF01217	0.344
TRG_ENDOCYTIC_2	238	241	PF00928	0.467
TRG_ER_diArg_1	29	32	PF00400	0.339
TRG_ER_diArg_1	374	377	PF00400	0.439
TRG_ER_diArg_1	46	48	PF00400	0.299
TRG_ER_diArg_1	84	86	PF00400	0.383
TRG_NLS_MonoExtC_3	373	378	PF00514	0.434
TRG_NLS_MonoExtN_4	371	378	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.443