Putative glycerophosphoryl diester phosphodiesterase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerophosphoryl diester phosphodiesterase - putative

Species:

Leishmania infantum

UniProt:

A4I3T9_LEIIN

TriTrypDb:

LINF_280027700

Length:

349

Annotations

Annotations by Jardim et al.

Lipid Metabolism, glycerophosphoryl diester phosphodiesterase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4I3T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3T9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009056	catabolic process	2	1
GO:0009395	phospholipid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046475	glycerophospholipid catabolic process	6	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046503	glycerolipid catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	5
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.435
CLV_C14_Caspase3-7	81	85	PF00656	0.472
CLV_NRD_NRD_1	221	223	PF00675	0.295
CLV_PCSK_KEX2_1	125	127	PF00082	0.273
CLV_PCSK_KEX2_1	223	225	PF00082	0.286
CLV_PCSK_KEX2_1	339	341	PF00082	0.529
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.310
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.302
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.529
CLV_PCSK_SKI1_1	135	139	PF00082	0.297
CLV_PCSK_SKI1_1	232	236	PF00082	0.281
CLV_PCSK_SKI1_1	32	36	PF00082	0.336
DEG_Nend_UBRbox_1	1	4	PF02207	0.316
DEG_SPOP_SBC_1	260	264	PF00917	0.329
DOC_CYCLIN_RxL_1	27	36	PF00134	0.436
DOC_MAPK_FxFP_2	39	42	PF00069	0.545
DOC_MAPK_gen_1	125	132	PF00069	0.443
DOC_MAPK_gen_1	162	169	PF00069	0.418
DOC_MAPK_gen_1	339	348	PF00069	0.282
DOC_MAPK_gen_1	80	89	PF00069	0.504
DOC_MAPK_MEF2A_6	125	132	PF00069	0.510
DOC_MAPK_MEF2A_6	162	171	PF00069	0.468
DOC_MAPK_MEF2A_6	178	187	PF00069	0.384
DOC_MAPK_MEF2A_6	339	348	PF00069	0.356
DOC_MAPK_NFAT4_5	125	133	PF00069	0.510
DOC_MAPK_RevD_3	15	30	PF00069	0.388
DOC_PP4_FxxP_1	228	231	PF00568	0.473
DOC_PP4_FxxP_1	256	259	PF00568	0.251
DOC_PP4_FxxP_1	285	288	PF00568	0.335
DOC_PP4_FxxP_1	39	42	PF00568	0.545
DOC_USP7_MATH_1	142	146	PF00917	0.430
DOC_USP7_MATH_1	25	29	PF00917	0.511
DOC_USP7_UBL2_3	115	119	PF12436	0.565
DOC_USP7_UBL2_3	174	178	PF12436	0.507
DOC_WW_Pin1_4	284	289	PF00397	0.282
LIG_APCC_ABBA_1	167	172	PF00400	0.429
LIG_BRCT_BRCA1_1	176	180	PF00533	0.477
LIG_BRCT_BRCA1_1	194	198	PF00533	0.422
LIG_CaM_IQ_9	19	34	PF13499	0.471
LIG_FHA_1	125	131	PF00498	0.501
LIG_FHA_1	132	138	PF00498	0.439
LIG_FHA_1	149	155	PF00498	0.451
LIG_FHA_1	235	241	PF00498	0.414
LIG_FHA_2	105	111	PF00498	0.450
LIG_LIR_Apic_2	254	259	PF02991	0.246
LIG_LIR_Apic_2	36	42	PF02991	0.400
LIG_LIR_Gen_1	177	188	PF02991	0.570
LIG_LIR_Gen_1	237	246	PF02991	0.294
LIG_LIR_Gen_1	250	261	PF02991	0.235
LIG_LIR_Gen_1	59	69	PF02991	0.453
LIG_LIR_LC3C_4	109	113	PF02991	0.468
LIG_LIR_Nem_3	177	183	PF02991	0.552
LIG_LIR_Nem_3	233	238	PF02991	0.280
LIG_LIR_Nem_3	250	256	PF02991	0.194
LIG_LIR_Nem_3	272	276	PF02991	0.372
LIG_LYPXL_SIV_4	13	21	PF13949	0.171
LIG_PCNA_yPIPBox_3	317	330	PF02747	0.290
LIG_PTB_Apo_2	208	215	PF02174	0.489
LIG_SH2_CRK	103	107	PF00017	0.499
LIG_SH2_CRK	242	246	PF00017	0.376
LIG_SH2_CRK	273	277	PF00017	0.308
LIG_SH2_PTP2	14	17	PF00017	0.285
LIG_SH2_STAT5	14	17	PF00017	0.249
LIG_SH2_STAT5	213	216	PF00017	0.496
LIG_SH2_STAT5	238	241	PF00017	0.266
LIG_SH2_STAT5	242	245	PF00017	0.256
LIG_SH2_STAT5	248	251	PF00017	0.371
LIG_SH2_STAT5	293	296	PF00017	0.318
LIG_SH2_STAT5	61	64	PF00017	0.464
LIG_SH3_1	162	168	PF00018	0.435
LIG_SH3_3	162	168	PF00018	0.416
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.426
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.372
LIG_SUMO_SIM_par_1	126	131	PF11976	0.470
LIG_SUMO_SIM_par_1	5	10	PF11976	0.345
LIG_SUMO_SIM_par_1	73	78	PF11976	0.429
LIG_TYR_ITIM	240	245	PF00017	0.352
LIG_TYR_ITIM	246	251	PF00017	0.434
LIG_UBA3_1	21	29	PF00899	0.333
LIG_WRC_WIRS_1	60	65	PF05994	0.464
MOD_CK2_1	104	110	PF00069	0.472
MOD_CK2_1	30	36	PF00069	0.457
MOD_GlcNHglycan	9	12	PF01048	0.277
MOD_GSK3_1	194	201	PF00069	0.481
MOD_GSK3_1	37	44	PF00069	0.613
MOD_GSK3_1	91	98	PF00069	0.482
MOD_NEK2_1	198	203	PF00069	0.472
MOD_NEK2_1	234	239	PF00069	0.414
MOD_NEK2_1	240	245	PF00069	0.388
MOD_NEK2_1	261	266	PF00069	0.365
MOD_NEK2_1	283	288	PF00069	0.355
MOD_NEK2_1	95	100	PF00069	0.450
MOD_NEK2_2	56	61	PF00069	0.408
MOD_PK_1	2	8	PF00069	0.166
MOD_PKA_1	37	43	PF00069	0.562
MOD_PKA_2	192	198	PF00069	0.520
MOD_PKA_2	79	85	PF00069	0.464
MOD_Plk_1	149	155	PF00069	0.445
MOD_Plk_1	56	62	PF00069	0.408
MOD_Plk_1	91	97	PF00069	0.445
MOD_Plk_4	2	8	PF00069	0.290
MOD_Plk_4	234	240	PF00069	0.411
MOD_Plk_4	30	36	PF00069	0.584
MOD_Plk_4	49	55	PF00069	0.389
MOD_Plk_4	56	62	PF00069	0.399
MOD_ProDKin_1	284	290	PF00069	0.278
MOD_SUMO_for_1	173	176	PF00179	0.455
MOD_SUMO_rev_2	172	180	PF00179	0.510
MOD_SUMO_rev_2	33	40	PF00179	0.451
TRG_DiLeu_BaEn_2	175	181	PF01217	0.544
TRG_DiLeu_BaEn_2	193	199	PF01217	0.372
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.301
TRG_ENDOCYTIC_2	103	106	PF00928	0.505
TRG_ENDOCYTIC_2	14	17	PF00928	0.352
TRG_ENDOCYTIC_2	225	228	PF00928	0.481
TRG_ENDOCYTIC_2	238	241	PF00928	0.266
TRG_ENDOCYTIC_2	242	245	PF00928	0.254
TRG_ENDOCYTIC_2	248	251	PF00928	0.388
TRG_ENDOCYTIC_2	253	256	PF00928	0.266
TRG_ENDOCYTIC_2	273	276	PF00928	0.197
TRG_ENDOCYTIC_2	61	64	PF00928	0.470
TRG_ER_diArg_1	221	224	PF00400	0.503
TRG_NLS_MonoExtC_3	221	226	PF00514	0.516
TRG_NLS_MonoExtN_4	219	226	PF00514	0.557
TRG_NLS_MonoExtN_4	27	33	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.227
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.217
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E4	Leptomonas seymouri	56%	99%
A0A0S4IJ80	Bodo saltans	35%	85%
A0A1X0NRF0	Trypanosomatidae	46%	98%
A0A3R7NHN9	Trypanosoma rangeli	44%	99%
A0A3S7X1Q6	Leishmania donovani	99%	100%
A4HGR4	Leishmania braziliensis	79%	100%
D0A869	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B031	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q0VGK4	Rattus norvegicus	28%	100%
Q4Q855	Leishmania major	91%	100%
Q7L5L3	Homo sapiens	27%	100%
Q8N9F7	Homo sapiens	29%	100%
Q99LY2	Mus musculus	26%	100%
Q9CRY7	Mus musculus	28%	100%