AMP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AMP-binding enzyme/AMP-binding enzyme C-terminal domain/Ankyrin repeats (3 copies)/Ankyrin repeat/Ankyrin repeats (many copies) - putative

Species:

Leishmania infantum

UniProt:

A4I3T3_LEIIN

TriTrypDb:

LINF_280027100

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3T3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019748	secondary metabolic process	2	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043038	amino acid activation	4	1
GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0044550	secondary metabolite biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0019842	vitamin binding	3	1
GO:0031177	phosphopantetheine binding	3	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0072341	modified amino acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.476
CLV_C14_Caspase3-7	478	482	PF00656	0.494
CLV_C14_Caspase3-7	486	490	PF00656	0.528
CLV_NRD_NRD_1	24	26	PF00675	0.371
CLV_NRD_NRD_1	357	359	PF00675	0.352
CLV_NRD_NRD_1	444	446	PF00675	0.446
CLV_NRD_NRD_1	650	652	PF00675	0.590
CLV_NRD_NRD_1	712	714	PF00675	0.461
CLV_NRD_NRD_1	811	813	PF00675	0.617
CLV_NRD_NRD_1	825	827	PF00675	0.510
CLV_NRD_NRD_1	841	843	PF00675	0.464
CLV_PCSK_FUR_1	355	359	PF00082	0.478
CLV_PCSK_FUR_1	849	853	PF00082	0.500
CLV_PCSK_KEX2_1	23	25	PF00082	0.370
CLV_PCSK_KEX2_1	357	359	PF00082	0.352
CLV_PCSK_KEX2_1	444	446	PF00082	0.446
CLV_PCSK_KEX2_1	650	652	PF00082	0.590
CLV_PCSK_KEX2_1	712	714	PF00082	0.461
CLV_PCSK_KEX2_1	809	811	PF00082	0.681
CLV_PCSK_KEX2_1	841	843	PF00082	0.590
CLV_PCSK_KEX2_1	851	853	PF00082	0.458
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.795
CLV_PCSK_PC1ET2_1	851	853	PF00082	0.584
CLV_PCSK_PC7_1	19	25	PF00082	0.525
CLV_PCSK_SKI1_1	107	111	PF00082	0.478
CLV_PCSK_SKI1_1	203	207	PF00082	0.352
CLV_PCSK_SKI1_1	368	372	PF00082	0.496
CLV_PCSK_SKI1_1	445	449	PF00082	0.450
CLV_PCSK_SKI1_1	712	716	PF00082	0.399
DEG_APCC_DBOX_1	221	229	PF00400	0.387
DEG_APCC_DBOX_1	367	375	PF00400	0.492
DEG_APCC_DBOX_1	638	646	PF00400	0.405
DOC_CKS1_1	143	148	PF01111	0.406
DOC_CKS1_1	176	181	PF01111	0.352
DOC_CKS1_1	456	461	PF01111	0.657
DOC_CKS1_1	762	767	PF01111	0.471
DOC_CYCLIN_RxL_1	442	450	PF00134	0.391
DOC_CYCLIN_RxL_1	706	718	PF00134	0.407
DOC_CYCLIN_yClb5_NLxxxL_5	98	105	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	555	561	PF00134	0.502
DOC_MAPK_gen_1	355	364	PF00069	0.361
DOC_MAPK_gen_1	462	470	PF00069	0.521
DOC_MAPK_gen_1	532	541	PF00069	0.394
DOC_MAPK_gen_1	650	661	PF00069	0.604
DOC_MAPK_gen_1	725	735	PF00069	0.352
DOC_MAPK_MEF2A_6	532	541	PF00069	0.417
DOC_MAPK_MEF2A_6	654	663	PF00069	0.555
DOC_MAPK_MEF2A_6	9	17	PF00069	0.487
DOC_PP1_RVXF_1	443	450	PF00149	0.464
DOC_PP2B_LxvP_1	435	438	PF13499	0.396
DOC_PP2B_LxvP_1	510	513	PF13499	0.490
DOC_PP2B_LxvP_1	555	558	PF13499	0.589
DOC_PP2B_LxvP_1	605	608	PF13499	0.556
DOC_PP4_FxxP_1	131	134	PF00568	0.406
DOC_PP4_FxxP_1	440	443	PF00568	0.447
DOC_USP7_MATH_1	314	318	PF00917	0.400
DOC_USP7_MATH_1	617	621	PF00917	0.567
DOC_USP7_MATH_1	662	666	PF00917	0.407
DOC_USP7_MATH_1	704	708	PF00917	0.387
DOC_USP7_MATH_1	736	740	PF00917	0.406
DOC_WW_Pin1_4	126	131	PF00397	0.376
DOC_WW_Pin1_4	142	147	PF00397	0.147
DOC_WW_Pin1_4	175	180	PF00397	0.352
DOC_WW_Pin1_4	317	322	PF00397	0.437
DOC_WW_Pin1_4	397	402	PF00397	0.593
DOC_WW_Pin1_4	455	460	PF00397	0.636
DOC_WW_Pin1_4	61	66	PF00397	0.371
DOC_WW_Pin1_4	654	659	PF00397	0.487
DOC_WW_Pin1_4	761	766	PF00397	0.478
LIG_14-3-3_CanoR_1	210	216	PF00244	0.331
LIG_14-3-3_CanoR_1	340	349	PF00244	0.400
LIG_14-3-3_CanoR_1	500	506	PF00244	0.513
LIG_14-3-3_CanoR_1	654	658	PF00244	0.586
LIG_14-3-3_CanoR_1	688	694	PF00244	0.380
LIG_14-3-3_CanoR_1	728	733	PF00244	0.354
LIG_14-3-3_CanoR_1	826	831	PF00244	0.530
LIG_BRCT_BRCA1_1	127	131	PF00533	0.354
LIG_BRCT_BRCA1_1	277	281	PF00533	0.450
LIG_BRCT_BRCA1_1	318	322	PF00533	0.433
LIG_deltaCOP1_diTrp_1	759	768	PF00928	0.428
LIG_FHA_1	171	177	PF00498	0.352
LIG_FHA_1	2	8	PF00498	0.549
LIG_FHA_1	333	339	PF00498	0.352
LIG_FHA_1	398	404	PF00498	0.566
LIG_FHA_1	408	414	PF00498	0.562
LIG_FHA_1	458	464	PF00498	0.576
LIG_FHA_1	516	522	PF00498	0.498
LIG_FHA_1	654	660	PF00498	0.478
LIG_FHA_1	673	679	PF00498	0.529
LIG_FHA_1	742	748	PF00498	0.400
LIG_FHA_1	773	779	PF00498	0.497
LIG_FHA_2	152	158	PF00498	0.478
LIG_FHA_2	216	222	PF00498	0.478
LIG_FHA_2	245	251	PF00498	0.478
LIG_FHA_2	833	839	PF00498	0.480
LIG_GBD_Chelix_1	425	433	PF00786	0.438
LIG_LIR_Apic_2	128	134	PF02991	0.406
LIG_LIR_Apic_2	439	443	PF02991	0.532
LIG_LIR_Gen_1	235	245	PF02991	0.330
LIG_LIR_Gen_1	4	13	PF02991	0.540
LIG_LIR_Gen_1	504	514	PF02991	0.463
LIG_LIR_Gen_1	818	825	PF02991	0.533
LIG_LIR_Nem_3	224	229	PF02991	0.340
LIG_LIR_Nem_3	235	240	PF02991	0.281
LIG_LIR_Nem_3	297	302	PF02991	0.405
LIG_LIR_Nem_3	4	8	PF02991	0.531
LIG_LIR_Nem_3	496	502	PF02991	0.453
LIG_LIR_Nem_3	619	625	PF02991	0.478
LIG_LIR_Nem_3	818	824	PF02991	0.540
LIG_LIR_Nem_3	829	833	PF02991	0.533
LIG_MLH1_MIPbox_1	128	132	PF16413	0.406
LIG_NRBOX	428	434	PF00104	0.530
LIG_NRBOX	710	716	PF00104	0.406
LIG_PCNA_PIPBox_1	379	388	PF02747	0.477
LIG_Pex3_1	429	440	PF04882	0.534
LIG_REV1ctd_RIR_1	330	338	PF16727	0.387
LIG_RPA_C_Fungi	417	429	PF08784	0.486
LIG_RPA_C_Fungi	701	713	PF08784	0.303
LIG_SH2_CRK	499	503	PF00017	0.470
LIG_SH2_SRC	520	523	PF00017	0.495
LIG_SH2_STAT5	104	107	PF00017	0.352
LIG_SH2_STAT5	151	154	PF00017	0.379
LIG_SH2_STAT5	520	523	PF00017	0.488
LIG_SH2_STAT5	538	541	PF00017	0.290
LIG_SH2_STAT5	573	576	PF00017	0.414
LIG_SH2_STAT5	784	787	PF00017	0.485
LIG_SH2_STAT5	81	84	PF00017	0.405
LIG_SH2_STAT5	830	833	PF00017	0.574
LIG_SH3_3	173	179	PF00018	0.352
LIG_SH3_3	453	459	PF00018	0.615
LIG_SH3_3	555	561	PF00018	0.464
LIG_SH3_3	7	13	PF00018	0.519
LIG_TRAF2_1	282	285	PF00917	0.361
LIG_TRAF2_1	370	373	PF00917	0.485
LIG_TRAF2_1	428	431	PF00917	0.457
LIG_TRAF2_1	44	47	PF00917	0.400
LIG_TRAF2_1	475	478	PF00917	0.501
LIG_TYR_ITIM	831	836	PF00017	0.454
LIG_TYR_ITSM	233	240	PF00017	0.406
LIG_WRC_WIRS_1	437	442	PF05994	0.530
MOD_CDK_SPxK_1	61	67	PF00069	0.303
MOD_CDK_SPxxK_3	455	462	PF00069	0.644
MOD_CK1_1	183	189	PF00069	0.459
MOD_CK1_1	317	323	PF00069	0.416
MOD_CK1_1	665	671	PF00069	0.503
MOD_CK1_1	787	793	PF00069	0.619
MOD_CK1_1	85	91	PF00069	0.352
MOD_CK2_1	244	250	PF00069	0.416
MOD_CK2_1	340	346	PF00069	0.415
MOD_CK2_1	41	47	PF00069	0.468
MOD_CK2_1	587	593	PF00069	0.665
MOD_CK2_1	609	615	PF00069	0.596
MOD_CK2_1	832	838	PF00069	0.586
MOD_CK2_1	857	863	PF00069	0.572
MOD_Cter_Amidation	355	358	PF01082	0.352
MOD_GlcNHglycan	293	296	PF01048	0.390
MOD_GlcNHglycan	395	398	PF01048	0.607
MOD_GlcNHglycan	43	46	PF01048	0.341
MOD_GlcNHglycan	706	709	PF01048	0.406
MOD_GlcNHglycan	738	741	PF01048	0.356
MOD_GlcNHglycan	787	790	PF01048	0.614
MOD_GlcNHglycan	792	795	PF01048	0.612
MOD_GlcNHglycan	84	87	PF01048	0.352
MOD_GlcNHglycan	863	867	PF01048	0.535
MOD_GSK3_1	145	152	PF00069	0.360
MOD_GSK3_1	170	177	PF00069	0.384
MOD_GSK3_1	180	187	PF00069	0.352
MOD_GSK3_1	190	197	PF00069	0.147
MOD_GSK3_1	232	239	PF00069	0.399
MOD_GSK3_1	29	36	PF00069	0.400
MOD_GSK3_1	393	400	PF00069	0.534
MOD_GSK3_1	447	454	PF00069	0.510
MOD_GSK3_1	457	464	PF00069	0.573
MOD_GSK3_1	59	66	PF00069	0.426
MOD_GSK3_1	783	790	PF00069	0.546
MOD_GSK3_1	81	88	PF00069	0.354
MOD_GSK3_1	815	822	PF00069	0.548
MOD_N-GLC_1	47	52	PF02516	0.395
MOD_N-GLC_1	815	820	PF02516	0.599
MOD_NEK2_1	1	6	PF00069	0.499
MOD_NEK2_1	125	130	PF00069	0.352
MOD_NEK2_1	215	220	PF00069	0.406
MOD_NEK2_1	291	296	PF00069	0.400
MOD_NEK2_1	447	452	PF00069	0.357
MOD_NEK2_1	531	536	PF00069	0.419
MOD_NEK2_1	702	707	PF00069	0.478
MOD_NEK2_1	783	788	PF00069	0.534
MOD_NEK2_2	617	622	PF00069	0.460
MOD_NEK2_2	832	837	PF00069	0.433
MOD_PIKK_1	151	157	PF00454	0.406
MOD_PIKK_1	209	215	PF00454	0.399
MOD_PIKK_1	384	390	PF00454	0.469
MOD_PIKK_1	463	469	PF00454	0.596
MOD_PKA_1	826	832	PF00069	0.544
MOD_PKA_2	209	215	PF00069	0.331
MOD_PKA_2	653	659	PF00069	0.590
MOD_PKA_2	687	693	PF00069	0.380
MOD_PKA_2	819	825	PF00069	0.556
MOD_Plk_1	232	238	PF00069	0.352
MOD_Plk_1	33	39	PF00069	0.489
MOD_Plk_1	73	79	PF00069	0.420
MOD_Plk_4	145	151	PF00069	0.474
MOD_Plk_4	190	196	PF00069	0.420
MOD_Plk_4	232	238	PF00069	0.352
MOD_Plk_4	34	40	PF00069	0.478
MOD_Plk_4	436	442	PF00069	0.491
MOD_Plk_4	617	623	PF00069	0.451
MOD_Plk_4	728	734	PF00069	0.379
MOD_Plk_4	826	832	PF00069	0.622
MOD_ProDKin_1	126	132	PF00069	0.376
MOD_ProDKin_1	142	148	PF00069	0.147
MOD_ProDKin_1	175	181	PF00069	0.352
MOD_ProDKin_1	317	323	PF00069	0.437
MOD_ProDKin_1	397	403	PF00069	0.583
MOD_ProDKin_1	455	461	PF00069	0.642
MOD_ProDKin_1	61	67	PF00069	0.371
MOD_ProDKin_1	654	660	PF00069	0.480
MOD_ProDKin_1	761	767	PF00069	0.476
MOD_SUMO_rev_2	359	364	PF00179	0.478
MOD_SUMO_rev_2	583	592	PF00179	0.655
MOD_SUMO_rev_2	85	94	PF00179	0.352
TRG_DiLeu_BaEn_1	743	748	PF01217	0.406
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.474
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.666
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.516
TRG_DiLeu_BaLyEn_6	710	715	PF01217	0.428
TRG_DiLeu_LyEn_5	743	748	PF01217	0.478
TRG_ENDOCYTIC_2	237	240	PF00928	0.330
TRG_ENDOCYTIC_2	299	302	PF00928	0.456
TRG_ENDOCYTIC_2	499	502	PF00928	0.471
TRG_ENDOCYTIC_2	538	541	PF00928	0.423
TRG_ENDOCYTIC_2	833	836	PF00928	0.461
TRG_ER_diArg_1	23	25	PF00400	0.373
TRG_ER_diArg_1	261	264	PF00400	0.478
TRG_ER_diArg_1	354	357	PF00400	0.428
TRG_ER_diArg_1	443	445	PF00400	0.455
TRG_ER_diArg_1	711	713	PF00400	0.400
TRG_ER_diArg_1	810	812	PF00400	0.704
TRG_ER_diArg_1	841	843	PF00400	0.521
TRG_NES_CRM1_1	672	684	PF08389	0.406
TRG_NLS_Bipartite_1	809	830	PF00514	0.600
TRG_NLS_MonoCore_2	808	813	PF00514	0.698
TRG_NLS_MonoExtN_4	823	830	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	746	750	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5E5	Leptomonas seymouri	54%	85%
A0A0S4JM65	Bodo saltans	30%	73%
A0A3Q8IEY8	Leishmania donovani	99%	87%
A4HGQ9	Leishmania braziliensis	80%	100%
E9B025	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
M1W600	Claviceps purpurea (strain 20.1)	24%	67%
Q4Q861	Leishmania major	95%	100%
Q8J0L6	Claviceps purpurea	24%	66%