Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3T0_LEIIN

TriTrypDb:

LINF_280026800

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3T0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007098	centrosome cycle	3	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010824	regulation of centrosome duplication	6	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0031023	microtubule organizing center organization	3	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0044089	positive regulation of cellular component biogenesis	5	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0046599	regulation of centriole replication	6	1
GO:0046601	positive regulation of centriole replication	7	1
GO:0046605	regulation of centrosome cycle	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051495	positive regulation of cytoskeleton organization	7	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1902115	regulation of organelle assembly	5	1
GO:1902117	positive regulation of organelle assembly	6	1
GO:1903722	regulation of centriole elongation	6	1
GO:1903724	positive regulation of centriole elongation	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.731
CLV_MEL_PAP_1	152	158	PF00089	0.589
CLV_NRD_NRD_1	125	127	PF00675	0.582
CLV_NRD_NRD_1	168	170	PF00675	0.546
CLV_NRD_NRD_1	238	240	PF00675	0.506
CLV_NRD_NRD_1	256	258	PF00675	0.411
CLV_NRD_NRD_1	268	270	PF00675	0.610
CLV_NRD_NRD_1	412	414	PF00675	0.720
CLV_NRD_NRD_1	421	423	PF00675	0.753
CLV_NRD_NRD_1	50	52	PF00675	0.509
CLV_NRD_NRD_1	529	531	PF00675	0.560
CLV_PCSK_KEX2_1	105	107	PF00082	0.463
CLV_PCSK_KEX2_1	125	127	PF00082	0.285
CLV_PCSK_KEX2_1	167	169	PF00082	0.550
CLV_PCSK_KEX2_1	231	233	PF00082	0.539
CLV_PCSK_KEX2_1	267	269	PF00082	0.644
CLV_PCSK_KEX2_1	421	423	PF00082	0.781
CLV_PCSK_KEX2_1	50	52	PF00082	0.523
CLV_PCSK_KEX2_1	529	531	PF00082	0.560
CLV_PCSK_KEX2_1	90	92	PF00082	0.528
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.506
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.589
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.592
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.511
CLV_PCSK_SKI1_1	105	109	PF00082	0.484
CLV_PCSK_SKI1_1	147	151	PF00082	0.516
CLV_PCSK_SKI1_1	168	172	PF00082	0.509
CLV_PCSK_SKI1_1	42	46	PF00082	0.542
DEG_APCC_DBOX_1	70	78	PF00400	0.493
DEG_SCF_TRCP1_1	427	433	PF00400	0.706
DEG_SPOP_SBC_1	454	458	PF00917	0.663
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.643
DOC_MAPK_DCC_7	335	344	PF00069	0.590
DOC_MAPK_gen_1	145	152	PF00069	0.515
DOC_MAPK_gen_1	335	344	PF00069	0.702
DOC_MAPK_MEF2A_6	145	152	PF00069	0.476
DOC_MAPK_MEF2A_6	231	238	PF00069	0.388
DOC_MAPK_NFAT4_5	145	153	PF00069	0.477
DOC_PP2B_LxvP_1	284	287	PF13499	0.676
DOC_USP7_MATH_1	134	138	PF00917	0.534
DOC_USP7_MATH_1	380	384	PF00917	0.753
DOC_USP7_MATH_1	430	434	PF00917	0.750
DOC_USP7_MATH_1	522	526	PF00917	0.684
DOC_USP7_MATH_1	56	60	PF00917	0.622
DOC_WW_Pin1_4	2	7	PF00397	0.754
DOC_WW_Pin1_4	261	266	PF00397	0.729
DOC_WW_Pin1_4	365	370	PF00397	0.769
DOC_WW_Pin1_4	412	417	PF00397	0.636
DOC_WW_Pin1_4	499	504	PF00397	0.548
LIG_14-3-3_CanoR_1	155	163	PF00244	0.521
LIG_14-3-3_CanoR_1	268	273	PF00244	0.696
LIG_14-3-3_CanoR_1	474	479	PF00244	0.718
LIG_BIR_II_1	1	5	PF00653	0.735
LIG_BRCT_BRCA1_1	284	288	PF00533	0.684
LIG_FHA_1	169	175	PF00498	0.574
LIG_FHA_1	386	392	PF00498	0.712
LIG_FHA_1	399	405	PF00498	0.624
LIG_FHA_1	430	436	PF00498	0.753
LIG_FHA_1	455	461	PF00498	0.706
LIG_FHA_1	90	96	PF00498	0.609
LIG_FHA_2	125	131	PF00498	0.540
LIG_FHA_2	343	349	PF00498	0.761
LIG_FHA_2	355	361	PF00498	0.577
LIG_FHA_2	377	383	PF00498	0.783
LIG_FHA_2	395	401	PF00498	0.709
LIG_FHA_2	439	445	PF00498	0.682
LIG_FHA_2	502	508	PF00498	0.673
LIG_LIR_Gen_1	162	170	PF02991	0.506
LIG_LIR_Gen_1	252	259	PF02991	0.618
LIG_LIR_Gen_1	313	322	PF02991	0.642
LIG_LIR_Nem_3	162	166	PF02991	0.503
LIG_LIR_Nem_3	252	256	PF02991	0.551
LIG_LIR_Nem_3	313	319	PF02991	0.573
LIG_LIR_Nem_3	444	450	PF02991	0.541
LIG_LYPXL_yS_3	447	450	PF13949	0.662
LIG_MYND_1	479	483	PF01753	0.646
LIG_SH2_CRK	163	167	PF00017	0.527
LIG_SH2_CRK	241	245	PF00017	0.577
LIG_SH2_CRK	316	320	PF00017	0.557
LIG_SH2_NCK_1	20	24	PF00017	0.473
LIG_SH2_STAP1	20	24	PF00017	0.473
LIG_SH2_STAP1	569	573	PF00017	0.454
LIG_SH2_STAT3	37	40	PF00017	0.572
LIG_SH2_STAT3	572	575	PF00017	0.574
LIG_SH2_STAT5	116	119	PF00017	0.575
LIG_SH2_STAT5	173	176	PF00017	0.555
LIG_SH2_STAT5	572	575	PF00017	0.574
LIG_SH3_3	277	283	PF00018	0.651
LIG_SH3_3	284	290	PF00018	0.514
LIG_SH3_3	344	350	PF00018	0.727
LIG_SH3_3	477	483	PF00018	0.623
LIG_TRAF2_1	127	130	PF00917	0.589
LIG_TRAF2_1	159	162	PF00917	0.600
LIG_TRAF2_1	461	464	PF00917	0.687
LIG_TRAF2_1	504	507	PF00917	0.703
LIG_UBA3_1	318	323	PF00899	0.530
LIG_WRC_WIRS_1	532	537	PF05994	0.522
MOD_CDC14_SPxK_1	264	267	PF00782	0.654
MOD_CDK_SPxK_1	261	267	PF00069	0.640
MOD_CDK_SPxxK_3	2	9	PF00069	0.711
MOD_CDK_SPxxK_3	261	268	PF00069	0.646
MOD_CDK_SPxxK_3	365	372	PF00069	0.758
MOD_CK1_1	219	225	PF00069	0.560
MOD_CK1_1	362	368	PF00069	0.732
MOD_CK1_1	402	408	PF00069	0.631
MOD_CK1_1	442	448	PF00069	0.638
MOD_CK1_1	469	475	PF00069	0.766
MOD_CK2_1	124	130	PF00069	0.585
MOD_CK2_1	342	348	PF00069	0.760
MOD_CK2_1	376	382	PF00069	0.740
MOD_CK2_1	394	400	PF00069	0.702
MOD_CK2_1	425	431	PF00069	0.714
MOD_CK2_1	501	507	PF00069	0.713
MOD_GlcNHglycan	11	14	PF01048	0.610
MOD_GlcNHglycan	157	160	PF01048	0.512
MOD_GlcNHglycan	208	212	PF01048	0.590
MOD_GlcNHglycan	284	287	PF01048	0.722
MOD_GlcNHglycan	290	293	PF01048	0.729
MOD_GlcNHglycan	306	309	PF01048	0.561
MOD_GlcNHglycan	382	385	PF01048	0.775
MOD_GlcNHglycan	404	407	PF01048	0.735
MOD_GlcNHglycan	427	430	PF01048	0.763
MOD_GlcNHglycan	444	447	PF01048	0.625
MOD_GlcNHglycan	520	523	PF01048	0.596
MOD_GlcNHglycan	524	527	PF01048	0.654
MOD_GSK3_1	168	175	PF00069	0.447
MOD_GSK3_1	190	197	PF00069	0.570
MOD_GSK3_1	350	357	PF00069	0.718
MOD_GSK3_1	358	365	PF00069	0.675
MOD_GSK3_1	370	377	PF00069	0.524
MOD_GSK3_1	386	393	PF00069	0.612
MOD_GSK3_1	394	401	PF00069	0.638
MOD_GSK3_1	425	432	PF00069	0.752
MOD_GSK3_1	438	445	PF00069	0.632
MOD_GSK3_1	469	476	PF00069	0.707
MOD_GSK3_1	518	525	PF00069	0.591
MOD_GSK3_1	546	553	PF00069	0.495
MOD_N-GLC_1	177	182	PF02516	0.588
MOD_N-GLC_1	333	338	PF02516	0.694
MOD_NEK2_1	1	6	PF00069	0.725
MOD_NEK2_1	133	138	PF00069	0.569
MOD_NEK2_1	192	197	PF00069	0.581
MOD_NEK2_1	216	221	PF00069	0.513
MOD_NEK2_1	354	359	PF00069	0.770
MOD_NEK2_1	399	404	PF00069	0.724
MOD_NEK2_1	438	443	PF00069	0.693
MOD_NEK2_1	492	497	PF00069	0.491
MOD_NEK2_1	516	521	PF00069	0.676
MOD_NEK2_1	546	551	PF00069	0.479
MOD_NEK2_2	350	355	PF00069	0.584
MOD_PIKK_1	192	198	PF00454	0.598
MOD_PIKK_1	216	222	PF00454	0.535
MOD_PK_1	232	238	PF00069	0.387
MOD_PKA_1	168	174	PF00069	0.400
MOD_PKA_1	268	274	PF00069	0.663
MOD_PKA_2	124	130	PF00069	0.585
MOD_PKA_2	14	20	PF00069	0.518
MOD_PKA_2	154	160	PF00069	0.516
MOD_PKA_2	168	174	PF00069	0.508
MOD_PKA_2	268	274	PF00069	0.663
MOD_PKA_2	334	340	PF00069	0.732
MOD_PKA_2	473	479	PF00069	0.725
MOD_PKA_2	56	62	PF00069	0.607
MOD_Plk_1	395	401	PF00069	0.687
MOD_Plk_1	430	436	PF00069	0.724
MOD_Plk_1	439	445	PF00069	0.679
MOD_Plk_4	232	238	PF00069	0.530
MOD_Plk_4	430	436	PF00069	0.713
MOD_Plk_4	455	461	PF00069	0.658
MOD_Plk_4	531	537	PF00069	0.528
MOD_ProDKin_1	2	8	PF00069	0.750
MOD_ProDKin_1	261	267	PF00069	0.733
MOD_ProDKin_1	365	371	PF00069	0.769
MOD_ProDKin_1	412	418	PF00069	0.638
MOD_ProDKin_1	499	505	PF00069	0.545
MOD_SUMO_for_1	322	325	PF00179	0.579
MOD_SUMO_rev_2	55	64	PF00179	0.575
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.500
TRG_ENDOCYTIC_2	163	166	PF00928	0.495
TRG_ENDOCYTIC_2	241	244	PF00928	0.466
TRG_ENDOCYTIC_2	316	319	PF00928	0.560
TRG_ENDOCYTIC_2	447	450	PF00928	0.545
TRG_ER_diArg_1	125	128	PF00400	0.585
TRG_ER_diArg_1	166	169	PF00400	0.556
TRG_ER_diArg_1	421	423	PF00400	0.804
TRG_ER_diArg_1	50	52	PF00400	0.563
TRG_NES_CRM1_1	531	544	PF08389	0.531
TRG_NES_CRM1_1	72	86	PF08389	0.483
TRG_NLS_Bipartite_1	257	271	PF00514	0.654
TRG_NLS_Bipartite_1	90	109	PF00514	0.572
TRG_NLS_MonoExtN_4	265	271	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.749
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF9	Leptomonas seymouri	54%	93%
A0A1X0NR42	Trypanosomatidae	32%	98%
A0A3S5IQW4	Trypanosoma rangeli	32%	94%
A0A3S7X1P3	Leishmania donovani	100%	100%
A4HGQ6	Leishmania braziliensis	81%	100%
D0A877	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B022	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q864	Leishmania major	95%	100%
V5AWM8	Trypanosoma cruzi	31%	100%