Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3S9_LEIIN

TriTrypDb:

LINF_280026700

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.689
CLV_NRD_NRD_1	16	18	PF00675	0.587
CLV_NRD_NRD_1	204	206	PF00675	0.619
CLV_NRD_NRD_1	290	292	PF00675	0.514
CLV_PCSK_FUR_1	510	514	PF00082	0.442
CLV_PCSK_KEX2_1	16	18	PF00082	0.587
CLV_PCSK_KEX2_1	204	206	PF00082	0.636
CLV_PCSK_KEX2_1	244	246	PF00082	0.358
CLV_PCSK_KEX2_1	290	292	PF00082	0.514
CLV_PCSK_KEX2_1	318	320	PF00082	0.487
CLV_PCSK_KEX2_1	512	514	PF00082	0.484
CLV_PCSK_KEX2_1	544	546	PF00082	0.556
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.358
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.527
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.484
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.556
CLV_PCSK_PC7_1	200	206	PF00082	0.381
CLV_PCSK_PC7_1	286	292	PF00082	0.513
CLV_PCSK_PC7_1	314	320	PF00082	0.369
CLV_PCSK_SKI1_1	176	180	PF00082	0.340
CLV_PCSK_SKI1_1	231	235	PF00082	0.399
DEG_APCC_DBOX_1	3	11	PF00400	0.355
DEG_COP1_1	119	129	PF00400	0.556
DOC_CKS1_1	387	392	PF01111	0.590
DOC_CKS1_1	421	426	PF01111	0.612
DOC_CYCLIN_RxL_1	510	518	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.673
DOC_MAPK_DCC_7	231	240	PF00069	0.498
DOC_MAPK_gen_1	510	519	PF00069	0.501
DOC_MAPK_HePTP_8	329	341	PF00069	0.425
DOC_MAPK_MEF2A_6	332	341	PF00069	0.569
DOC_MAPK_MEF2A_6	4	11	PF00069	0.484
DOC_MAPK_MEF2A_6	510	519	PF00069	0.501
DOC_MAPK_NFAT4_5	512	520	PF00069	0.512
DOC_PP4_FxxP_1	349	352	PF00568	0.390
DOC_USP7_MATH_1	125	129	PF00917	0.523
DOC_USP7_MATH_1	32	36	PF00917	0.696
DOC_USP7_MATH_1	370	374	PF00917	0.537
DOC_USP7_MATH_1	480	484	PF00917	0.646
DOC_USP7_MATH_1	497	501	PF00917	0.694
DOC_WW_Pin1_4	166	171	PF00397	0.391
DOC_WW_Pin1_4	238	243	PF00397	0.516
DOC_WW_Pin1_4	348	353	PF00397	0.418
DOC_WW_Pin1_4	386	391	PF00397	0.565
DOC_WW_Pin1_4	420	425	PF00397	0.641
LIG_14-3-3_CanoR_1	183	189	PF00244	0.360
LIG_14-3-3_CanoR_1	264	271	PF00244	0.402
LIG_14-3-3_CanoR_1	332	337	PF00244	0.591
LIG_14-3-3_CanoR_1	371	375	PF00244	0.697
LIG_14-3-3_CanoR_1	469	478	PF00244	0.535
LIG_APCC_ABBA_1	450	455	PF00400	0.405
LIG_BIR_III_2	122	126	PF00653	0.464
LIG_BIR_III_4	396	400	PF00653	0.583
LIG_BRCT_BRCA1_1	184	188	PF00533	0.346
LIG_BRCT_BRCA1_1	210	214	PF00533	0.431
LIG_BRCT_BRCA1_1	254	258	PF00533	0.561
LIG_BRCT_BRCA1_1	445	449	PF00533	0.474
LIG_BRCT_BRCA1_1	7	11	PF00533	0.477
LIG_Clathr_ClatBox_1	342	346	PF01394	0.334
LIG_CSL_BTD_1	387	390	PF09270	0.579
LIG_deltaCOP1_diTrp_1	134	140	PF00928	0.471
LIG_FHA_1	173	179	PF00498	0.369
LIG_FHA_1	22	28	PF00498	0.406
LIG_FHA_1	387	393	PF00498	0.608
LIG_FHA_1	442	448	PF00498	0.571
LIG_FHA_2	117	123	PF00498	0.572
LIG_FHA_2	172	178	PF00498	0.466
LIG_FHA_2	275	281	PF00498	0.446
LIG_FHA_2	396	402	PF00498	0.605
LIG_FHA_2	406	412	PF00498	0.594
LIG_FHA_2	432	438	PF00498	0.748
LIG_GBD_Chelix_1	339	347	PF00786	0.413
LIG_LIR_Apic_2	160	166	PF02991	0.452
LIG_LIR_Apic_2	346	352	PF02991	0.403
LIG_LIR_Gen_1	373	382	PF02991	0.510
LIG_LIR_Nem_3	128	132	PF02991	0.457
LIG_LIR_Nem_3	255	261	PF02991	0.441
LIG_LIR_Nem_3	267	273	PF02991	0.392
LIG_LIR_Nem_3	373	379	PF02991	0.635
LIG_LIR_Nem_3	448	453	PF02991	0.433
LIG_LIR_Nem_3	76	81	PF02991	0.484
LIG_NRBOX	338	344	PF00104	0.486
LIG_Pex14_2	140	144	PF04695	0.438
LIG_Pex14_2	449	453	PF04695	0.411
LIG_REV1ctd_RIR_1	447	455	PF16727	0.408
LIG_SH2_CRK	493	497	PF00017	0.609
LIG_SH2_NCK_1	71	75	PF00017	0.491
LIG_SH2_SRC	54	57	PF00017	0.383
LIG_SH2_SRC	71	74	PF00017	0.489
LIG_SH2_STAP1	78	82	PF00017	0.508
LIG_SH2_STAT5	155	158	PF00017	0.415
LIG_SH2_STAT5	173	176	PF00017	0.427
LIG_SH2_STAT5	357	360	PF00017	0.359
LIG_SH2_STAT5	41	44	PF00017	0.533
LIG_SH2_STAT5	462	465	PF00017	0.515
LIG_SH2_STAT5	493	496	PF00017	0.538
LIG_SH2_STAT5	54	57	PF00017	0.324
LIG_SH2_STAT5	81	84	PF00017	0.517
LIG_SH3_3	265	271	PF00018	0.459
LIG_SH3_3	300	306	PF00018	0.312
LIG_SH3_3	349	355	PF00018	0.375
LIG_SH3_3	60	66	PF00018	0.420
LIG_SUMO_SIM_anti_2	338	343	PF11976	0.359
LIG_SUMO_SIM_par_1	341	346	PF11976	0.382
LIG_SUMO_SIM_par_1	389	394	PF11976	0.540
LIG_TRAF2_1	44	47	PF00917	0.420
LIG_TRAF2_1	74	77	PF00917	0.592
LIG_WRC_WIRS_1	126	131	PF05994	0.479
MOD_CDC14_SPxK_1	241	244	PF00782	0.355
MOD_CDK_SPxK_1	238	244	PF00069	0.341
MOD_CDK_SPxxK_3	238	245	PF00069	0.479
MOD_CK1_1	128	134	PF00069	0.446
MOD_CK1_1	225	231	PF00069	0.524
MOD_CK1_1	335	341	PF00069	0.456
MOD_CK1_1	39	45	PF00069	0.606
MOD_CK1_1	431	437	PF00069	0.715
MOD_CK1_1	57	63	PF00069	0.312
MOD_CK2_1	128	134	PF00069	0.444
MOD_CK2_1	135	141	PF00069	0.368
MOD_CK2_1	171	177	PF00069	0.415
MOD_CK2_1	274	280	PF00069	0.433
MOD_CK2_1	395	401	PF00069	0.582
MOD_CMANNOS	385	388	PF00535	0.526
MOD_Cter_Amidation	14	17	PF01082	0.606
MOD_GlcNHglycan	11	14	PF01048	0.522
MOD_GlcNHglycan	110	113	PF01048	0.604
MOD_GlcNHglycan	201	204	PF01048	0.409
MOD_GlcNHglycan	224	227	PF01048	0.508
MOD_GlcNHglycan	323	326	PF01048	0.649
MOD_GlcNHglycan	33	37	PF01048	0.632
MOD_GlcNHglycan	359	362	PF01048	0.330
MOD_GlcNHglycan	372	375	PF01048	0.532
MOD_GlcNHglycan	499	502	PF01048	0.698
MOD_GlcNHglycan	95	98	PF01048	0.735
MOD_GSK3_1	108	115	PF00069	0.713
MOD_GSK3_1	210	217	PF00069	0.573
MOD_GSK3_1	218	225	PF00069	0.451
MOD_GSK3_1	252	259	PF00069	0.453
MOD_GSK3_1	32	39	PF00069	0.713
MOD_GSK3_1	370	377	PF00069	0.568
MOD_GSK3_1	401	408	PF00069	0.638
MOD_GSK3_1	480	487	PF00069	0.672
MOD_GSK3_1	5	12	PF00069	0.399
MOD_N-GLC_1	183	188	PF02516	0.386
MOD_N-GLC_1	57	62	PF02516	0.472
MOD_N-GLC_1	87	92	PF02516	0.758
MOD_NEK2_1	182	187	PF00069	0.360
MOD_NEK2_1	214	219	PF00069	0.469
MOD_NEK2_1	222	227	PF00069	0.537
MOD_NEK2_1	256	261	PF00069	0.531
MOD_NEK2_1	298	303	PF00069	0.466
MOD_NEK2_1	470	475	PF00069	0.595
MOD_NEK2_2	135	140	PF00069	0.361
MOD_NEK2_2	21	26	PF00069	0.396
MOD_PIKK_1	380	386	PF00454	0.577
MOD_PIKK_1	417	423	PF00454	0.603
MOD_PKA_2	182	188	PF00069	0.355
MOD_PKA_2	199	205	PF00069	0.442
MOD_PKA_2	263	269	PF00069	0.393
MOD_PKA_2	370	376	PF00069	0.691
MOD_Plk_1	214	220	PF00069	0.335
MOD_Plk_1	298	304	PF00069	0.350
MOD_Plk_1	36	42	PF00069	0.487
MOD_Plk_1	380	386	PF00069	0.553
MOD_Plk_1	57	63	PF00069	0.404
MOD_Plk_4	135	141	PF00069	0.430
MOD_Plk_4	269	275	PF00069	0.474
MOD_Plk_4	5	11	PF00069	0.392
MOD_Plk_4	77	83	PF00069	0.508
MOD_ProDKin_1	166	172	PF00069	0.380
MOD_ProDKin_1	238	244	PF00069	0.522
MOD_ProDKin_1	348	354	PF00069	0.421
MOD_ProDKin_1	386	392	PF00069	0.570
MOD_ProDKin_1	420	426	PF00069	0.641
TRG_DiLeu_BaEn_1	177	182	PF01217	0.446
TRG_DiLeu_BaEn_1	293	298	PF01217	0.403
TRG_DiLeu_BaEn_1	499	504	PF01217	0.527
TRG_DiLeu_BaEn_3	529	535	PF01217	0.568
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.590
TRG_ENDOCYTIC_2	493	496	PF00928	0.558
TRG_ER_diArg_1	290	292	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	513	518	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL93	Leptomonas seymouri	60%	100%
A0A1X0NQS9	Trypanosomatidae	35%	100%
A0A3S7X1P6	Leishmania donovani	99%	100%
A0A422NBH7	Trypanosoma rangeli	39%	100%
A4HGQ5	Leishmania braziliensis	77%	100%
D0A878	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B021	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q865	Leishmania major	89%	100%
V5DCT5	Trypanosoma cruzi	37%	100%