Putative zinc transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc transporter 3 - putative

Species:

Leishmania infantum

UniProt:

A4I3R9_LEIIN

TriTrypDb:

LINF_280025800

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	34
GO:0110165	cellular anatomical entity	1	34
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	4

Expansion

Sequence features

A4I3R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3R9

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	4
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	4
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	4
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098662	inorganic cation transmembrane transport	5	4
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	34
GO:0008324	monoatomic cation transmembrane transporter activity	4	34
GO:0015075	monoatomic ion transmembrane transporter activity	3	34
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	34
GO:0022857	transmembrane transporter activity	2	34
GO:0022890	inorganic cation transmembrane transporter activity	4	34
GO:0046873	metal ion transmembrane transporter activity	5	34
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0046915	transition metal ion transmembrane transporter activity	6	4
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.590
CLV_C14_Caspase3-7	79	83	PF00656	0.636
CLV_C14_Caspase3-7	91	95	PF00656	0.607
CLV_NRD_NRD_1	243	245	PF00675	0.397
CLV_PCSK_KEX2_1	137	139	PF00082	0.345
CLV_PCSK_KEX2_1	440	442	PF00082	0.276
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.345
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.310
CLV_PCSK_SKI1_1	387	391	PF00082	0.606
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.383
DOC_MAPK_gen_1	137	144	PF00069	0.620
DOC_MAPK_gen_1	24	31	PF00069	0.361
DOC_MAPK_MEF2A_6	137	144	PF00069	0.471
DOC_MAPK_MEF2A_6	330	338	PF00069	0.322
DOC_MAPK_MEF2A_6	357	366	PF00069	0.600
DOC_MAPK_NFAT4_5	357	365	PF00069	0.540
DOC_PP2B_LxvP_1	370	373	PF13499	0.463
DOC_USP7_MATH_1	34	38	PF00917	0.358
DOC_USP7_MATH_1	352	356	PF00917	0.558
DOC_USP7_MATH_1	396	400	PF00917	0.326
DOC_USP7_MATH_2	28	34	PF00917	0.381
LIG_14-3-3_CanoR_1	61	67	PF00244	0.484
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_1	1	5	PF00653	0.430
LIG_BIR_III_3	1	5	PF00653	0.430
LIG_BRCT_BRCA1_1	172	176	PF00533	0.256
LIG_Clathr_ClatBox_1	417	421	PF01394	0.489
LIG_deltaCOP1_diTrp_1	190	196	PF00928	0.268
LIG_eIF4E_1	412	418	PF01652	0.386
LIG_FHA_1	155	161	PF00498	0.428
LIG_FHA_1	378	384	PF00498	0.319
LIG_FHA_1	392	398	PF00498	0.307
LIG_FHA_2	53	59	PF00498	0.455
LIG_GBD_Chelix_1	300	308	PF00786	0.406
LIG_GBD_Chelix_1	362	370	PF00786	0.372
LIG_LIR_Gen_1	190	200	PF02991	0.264
LIG_LIR_Gen_1	393	402	PF02991	0.378
LIG_LIR_Nem_3	190	195	PF02991	0.322
LIG_LIR_Nem_3	314	319	PF02991	0.418
LIG_LIR_Nem_3	393	398	PF02991	0.403
LIG_PDZ_Wminus1_1	460	462	PF00595	0.405
LIG_Pex14_1	192	196	PF04695	0.516
LIG_Pex14_2	31	35	PF04695	0.343
LIG_Pex14_2	338	342	PF04695	0.444
LIG_Pex14_2	415	419	PF04695	0.432
LIG_PTB_Apo_2	235	242	PF02174	0.437
LIG_SH2_CRK	395	399	PF00017	0.268
LIG_SH2_NCK_1	395	399	PF00017	0.268
LIG_SH2_SRC	147	150	PF00017	0.575
LIG_SH2_SRC	66	69	PF00017	0.463
LIG_SH2_STAT5	147	150	PF00017	0.548
LIG_SH2_STAT5	412	415	PF00017	0.362
LIG_SH3_1	225	231	PF00018	0.464
LIG_SH3_3	225	231	PF00018	0.573
LIG_SH3_3	268	274	PF00018	0.443
LIG_SH3_3	285	291	PF00018	0.614
LIG_SUMO_SIM_anti_2	361	366	PF11976	0.501
LIG_SxIP_EBH_1	125	138	PF03271	0.402
LIG_TYR_ITSM	391	398	PF00017	0.268
LIG_UBA3_1	131	137	PF00899	0.298
MOD_CK1_1	391	397	PF00069	0.367
MOD_CK1_1	76	82	PF00069	0.479
MOD_CK1_1	88	94	PF00069	0.592
MOD_CK2_1	181	187	PF00069	0.288
MOD_CK2_1	62	68	PF00069	0.476
MOD_Cter_Amidation	135	138	PF01082	0.399
MOD_GlcNHglycan	32	35	PF01048	0.698
MOD_GlcNHglycan	36	39	PF01048	0.675
MOD_GlcNHglycan	370	373	PF01048	0.425
MOD_GlcNHglycan	390	393	PF01048	0.410
MOD_GlcNHglycan	398	401	PF01048	0.378
MOD_GlcNHglycan	68	71	PF01048	0.657
MOD_GlcNHglycan	78	81	PF01048	0.661
MOD_GlcNHglycan	90	93	PF01048	0.844
MOD_GSK3_1	123	130	PF00069	0.362
MOD_GSK3_1	30	37	PF00069	0.407
MOD_GSK3_1	352	359	PF00069	0.555
MOD_GSK3_1	379	386	PF00069	0.382
MOD_GSK3_1	38	45	PF00069	0.454
MOD_GSK3_1	62	69	PF00069	0.647
MOD_N-GLC_2	238	240	PF02516	0.264
MOD_NEK2_1	123	128	PF00069	0.378
MOD_NEK2_1	308	313	PF00069	0.404
MOD_NEK2_1	321	326	PF00069	0.348
MOD_NEK2_1	366	371	PF00069	0.392
MOD_NEK2_1	390	395	PF00069	0.347
MOD_NEK2_1	42	47	PF00069	0.401
MOD_NEK2_2	352	357	PF00069	0.502
MOD_PIKK_1	42	48	PF00454	0.549
MOD_PKA_2	216	222	PF00069	0.575
MOD_PKA_2	62	68	PF00069	0.484
MOD_Plk_1	352	358	PF00069	0.468
MOD_Plk_4	123	129	PF00069	0.385
MOD_Plk_4	170	176	PF00069	0.285
MOD_Plk_4	311	317	PF00069	0.391
MOD_Plk_4	379	385	PF00069	0.407
TRG_DiLeu_BaEn_2	189	195	PF01217	0.313
TRG_ENDOCYTIC_2	395	398	PF00928	0.368
TRG_ENDOCYTIC_2	412	415	PF00928	0.371
TRG_ENDOCYTIC_2	445	448	PF00928	0.434
TRG_ER_diArg_1	61	64	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	40%	100%
A0A1X0NR51	Trypanosomatidae	34%	100%
A0A1X0NSB9	Trypanosomatidae	37%	100%
A0A1X0NSI7	Trypanosomatidae	38%	100%
A0A3R7LZX6	Trypanosoma rangeli	41%	100%
A0A3S7X1N7	Leishmania donovani	99%	100%
A0A3S7X501	Leishmania donovani	40%	100%
A0A3S7X7B0	Leishmania donovani	35%	100%
A0A422MUI2	Trypanosoma rangeli	37%	100%
A4HGP7	Leishmania braziliensis	80%	100%
A4HJU9	Leishmania braziliensis	41%	100%
A4HJV0	Leishmania braziliensis	41%	100%
A4HJV1	Leishmania braziliensis	36%	99%
A4HM27	Leishmania braziliensis	33%	94%
A4I7B1	Leishmania infantum	40%	100%
A4I9G1	Leishmania infantum	35%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	93%
O04089	Arabidopsis thaliana	27%	100%
O23039	Arabidopsis thaliana	29%	100%
O64738	Arabidopsis thaliana	26%	100%
O81123	Arabidopsis thaliana	24%	100%
O81850	Arabidopsis thaliana	25%	100%
O82643	Arabidopsis thaliana	27%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q38856	Arabidopsis thaliana	24%	100%
Q4Q3L6	Leishmania major	33%	92%
Q4Q5V0	Leishmania major	39%	100%
Q4Q5V1	Leishmania major	39%	100%
Q4Q873	Leishmania major	86%	96%
Q6L8G0	Oryza sativa subsp. japonica	28%	100%
Q6L8G1	Oryza sativa subsp. japonica	28%	100%
Q75HB1	Oryza sativa subsp. japonica	29%	100%
Q7XLD4	Oryza sativa subsp. japonica	26%	100%
Q8S3W4	Arabidopsis thaliana	22%	100%
Q8W245	Arabidopsis thaliana	22%	100%
Q8W246	Arabidopsis thaliana	28%	100%
Q9FIS2	Arabidopsis thaliana	26%	100%
Q9SLG3	Arabidopsis thaliana	28%	100%
V5AWN3	Trypanosoma cruzi	38%	100%
V5BC34	Trypanosoma cruzi	36%	100%
V5DCU2	Trypanosoma cruzi	45%	100%