Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf - putative

Species:

Leishmania infantum

UniProt:

A4I3Q4_LEIIN

TriTrypDb:

LINF_280024000

Length:

296

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, GTPase activating for Arf, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Q4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	8
GO:0008047	enzyme activator activity	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0030695	GTPase regulator activity	4	8
GO:0060589	nucleoside-triphosphatase regulator activity	3	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	64	66	PF00675	0.469
DEG_SCF_TRCP1_1	201	207	PF00400	0.561
DEG_SPOP_SBC_1	87	91	PF00917	0.543
DOC_CKS1_1	81	86	PF01111	0.519
DOC_USP7_MATH_1	189	193	PF00917	0.625
DOC_USP7_MATH_1	258	262	PF00917	0.585
DOC_USP7_MATH_1	87	91	PF00917	0.554
DOC_USP7_MATH_2	84	90	PF00917	0.528
DOC_USP7_UBL2_3	62	66	PF12436	0.313
DOC_WW_Pin1_4	129	134	PF00397	0.607
DOC_WW_Pin1_4	175	180	PF00397	0.576
DOC_WW_Pin1_4	236	241	PF00397	0.703
DOC_WW_Pin1_4	80	85	PF00397	0.493
DOC_WW_Pin1_4	96	101	PF00397	0.721
LIG_14-3-3_CanoR_1	45	55	PF00244	0.301
LIG_BRCT_BRCA1_1	201	205	PF00533	0.556
LIG_deltaCOP1_diTrp_1	201	209	PF00928	0.602
LIG_FHA_1	245	251	PF00498	0.593
LIG_FHA_1	269	275	PF00498	0.537
LIG_FHA_1	50	56	PF00498	0.301
LIG_FHA_1	91	97	PF00498	0.671
LIG_FHA_2	240	246	PF00498	0.775
LIG_FHA_2	81	87	PF00498	0.486
LIG_LIR_Apic_2	123	129	PF02991	0.637
LIG_LIR_Apic_2	37	41	PF02991	0.302
LIG_LIR_LC3C_4	19	24	PF02991	0.278
LIG_LIR_Nem_3	155	160	PF02991	0.604
LIG_Pex14_2	205	209	PF04695	0.564
LIG_SH2_CRK	38	42	PF00017	0.282
LIG_SH2_NCK_1	169	173	PF00017	0.619
LIG_SH2_NCK_1	38	42	PF00017	0.302
LIG_SH2_STAP1	36	40	PF00017	0.359
LIG_SH2_STAP1	63	67	PF00017	0.357
LIG_SH3_3	127	133	PF00018	0.640
LIG_SH3_3	213	219	PF00018	0.686
LIG_SUMO_SIM_par_1	18	25	PF11976	0.334
LIG_TRAF2_1	138	141	PF00917	0.621
MOD_CK1_1	132	138	PF00069	0.625
MOD_CK1_1	178	184	PF00069	0.665
MOD_CK1_1	236	242	PF00069	0.667
MOD_CK1_1	282	288	PF00069	0.633
MOD_CK1_1	90	96	PF00069	0.598
MOD_CK1_1	99	105	PF00069	0.673
MOD_CK2_1	258	264	PF00069	0.479
MOD_CK2_1	58	64	PF00069	0.354
MOD_CK2_1	80	86	PF00069	0.441
MOD_GlcNHglycan	157	160	PF01048	0.638
MOD_GlcNHglycan	196	199	PF01048	0.650
MOD_GlcNHglycan	201	204	PF01048	0.603
MOD_GlcNHglycan	220	223	PF01048	0.656
MOD_GlcNHglycan	225	228	PF01048	0.623
MOD_GlcNHglycan	235	238	PF01048	0.611
MOD_GlcNHglycan	256	259	PF01048	0.562
MOD_GlcNHglycan	282	285	PF01048	0.682
MOD_GlcNHglycan	42	45	PF01048	0.434
MOD_GlcNHglycan	90	93	PF01048	0.608
MOD_GSK3_1	128	135	PF00069	0.669
MOD_GSK3_1	136	143	PF00069	0.608
MOD_GSK3_1	144	151	PF00069	0.519
MOD_GSK3_1	155	162	PF00069	0.508
MOD_GSK3_1	235	242	PF00069	0.833
MOD_GSK3_1	254	261	PF00069	0.658
MOD_GSK3_1	264	271	PF00069	0.467
MOD_GSK3_1	278	285	PF00069	0.650
MOD_GSK3_1	3	10	PF00069	0.359
MOD_GSK3_1	40	47	PF00069	0.338
MOD_GSK3_1	86	93	PF00069	0.581
MOD_GSK3_1	95	102	PF00069	0.742
MOD_N-GLC_1	199	204	PF02516	0.593
MOD_N-GLC_1	254	259	PF02516	0.608
MOD_N-GLC_1	47	52	PF02516	0.308
MOD_NEK2_1	268	273	PF00069	0.503
MOD_NMyristoyl	1	7	PF02799	0.357
MOD_PIKK_1	112	118	PF00454	0.616
MOD_PIKK_1	136	142	PF00454	0.675
MOD_PIKK_1	204	210	PF00454	0.573
MOD_PK_1	7	13	PF00069	0.323
MOD_PKA_2	44	50	PF00069	0.366
MOD_Plk_4	16	22	PF00069	0.338
MOD_Plk_4	211	217	PF00069	0.654
MOD_Plk_4	264	270	PF00069	0.487
MOD_ProDKin_1	129	135	PF00069	0.609
MOD_ProDKin_1	175	181	PF00069	0.577
MOD_ProDKin_1	236	242	PF00069	0.702
MOD_ProDKin_1	80	86	PF00069	0.507
MOD_ProDKin_1	96	102	PF00069	0.719
MOD_SUMO_rev_2	61	67	PF00179	0.357
TRG_DiLeu_BaEn_1	18	23	PF01217	0.301
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.313
TRG_ER_diArg_1	31	34	PF00400	0.330
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT1	Leptomonas seymouri	43%	74%
A0A3S7X1K9	Leishmania donovani	99%	100%
A4HGN0	Leishmania braziliensis	62%	100%
E9ADN4	Leishmania major	28%	76%
E9AZZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q889	Leishmania major	89%	100%