Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family - putative

Species:

Leishmania infantum

UniProt:

A4I3Q1_LEIIN

TriTrypDb:

LINF_280023700

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 141

Expansion

Sequence features

A4I3Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3Q1

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0070475	rRNA base methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.555
CLV_NRD_NRD_1	109	111	PF00675	0.531
CLV_NRD_NRD_1	139	141	PF00675	0.739
CLV_NRD_NRD_1	174	176	PF00675	0.473
CLV_NRD_NRD_1	179	181	PF00675	0.531
CLV_NRD_NRD_1	210	212	PF00675	0.688
CLV_NRD_NRD_1	26	28	PF00675	0.436
CLV_NRD_NRD_1	309	311	PF00675	0.604
CLV_NRD_NRD_1	428	430	PF00675	0.791
CLV_NRD_NRD_1	493	495	PF00675	0.253
CLV_PCSK_FUR_1	136	140	PF00082	0.718
CLV_PCSK_FUR_1	172	176	PF00082	0.455
CLV_PCSK_KEX2_1	138	140	PF00082	0.746
CLV_PCSK_KEX2_1	174	176	PF00082	0.461
CLV_PCSK_KEX2_1	181	183	PF00082	0.530
CLV_PCSK_KEX2_1	206	208	PF00082	0.717
CLV_PCSK_KEX2_1	210	212	PF00082	0.695
CLV_PCSK_KEX2_1	355	357	PF00082	0.254
CLV_PCSK_KEX2_1	428	430	PF00082	0.792
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.722
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.544
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.773
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.274
CLV_PCSK_SKI1_1	206	210	PF00082	0.730
CLV_PCSK_SKI1_1	284	288	PF00082	0.684
CLV_PCSK_SKI1_1	381	385	PF00082	0.278
CLV_PCSK_SKI1_1	494	498	PF00082	0.254
CLV_PCSK_SKI1_1	527	531	PF00082	0.253
CLV_PCSK_SKI1_1	93	97	PF00082	0.503
CLV_Separin_Metazoa	524	528	PF03568	0.539
DEG_APCC_DBOX_1	309	317	PF00400	0.426
DEG_Nend_UBRbox_2	1	3	PF02207	0.408
DOC_ANK_TNKS_1	138	145	PF00023	0.727
DOC_CYCLIN_RxL_1	19	29	PF00134	0.387
DOC_CYCLIN_RxL_1	488	500	PF00134	0.496
DOC_MAPK_gen_1	155	164	PF00069	0.373
DOC_MAPK_MEF2A_6	158	166	PF00069	0.406
DOC_PP2B_LxvP_1	151	154	PF13499	0.488
DOC_PP2B_LxvP_1	333	336	PF13499	0.453
DOC_PP2B_PxIxI_1	335	341	PF00149	0.530
DOC_USP7_MATH_1	193	197	PF00917	0.765
DOC_USP7_MATH_1	246	250	PF00917	0.417
DOC_USP7_MATH_1	280	284	PF00917	0.733
DOC_USP7_MATH_1	391	395	PF00917	0.453
DOC_USP7_UBL2_3	28	32	PF12436	0.435
DOC_USP7_UBL2_3	284	288	PF12436	0.774
LIG_14-3-3_CanoR_1	158	163	PF00244	0.373
LIG_14-3-3_CanoR_1	210	215	PF00244	0.727
LIG_14-3-3_CanoR_1	257	265	PF00244	0.363
LIG_14-3-3_CanoR_1	356	361	PF00244	0.465
LIG_14-3-3_CanoR_1	381	389	PF00244	0.539
LIG_14-3-3_CanoR_1	428	434	PF00244	0.662
LIG_14-3-3_CanoR_1	93	102	PF00244	0.511
LIG_Actin_WH2_2	159	176	PF00022	0.436
LIG_BIR_III_2	268	272	PF00653	0.536
LIG_BRCT_BRCA1_1	369	373	PF00533	0.475
LIG_Clathr_ClatBox_1	501	505	PF01394	0.464
LIG_FHA_1	159	165	PF00498	0.403
LIG_FHA_1	325	331	PF00498	0.453
LIG_FHA_1	34	40	PF00498	0.383
LIG_FHA_1	382	388	PF00498	0.475
LIG_FHA_1	512	518	PF00498	0.462
LIG_FHA_2	341	347	PF00498	0.533
LIG_FHA_2	398	404	PF00498	0.454
LIG_FHA_2	84	90	PF00498	0.473
LIG_IRF3_LxIS_1	159	165	PF10401	0.496
LIG_LIR_Gen_1	36	44	PF02991	0.370
LIG_LIR_Gen_1	364	373	PF02991	0.465
LIG_LIR_Nem_3	104	109	PF02991	0.405
LIG_LIR_Nem_3	36	40	PF02991	0.379
LIG_LIR_Nem_3	364	368	PF02991	0.465
LIG_LIR_Nem_3	370	376	PF02991	0.460
LIG_LIR_Nem_3	58	63	PF02991	0.367
LIG_REV1ctd_RIR_1	57	63	PF16727	0.422
LIG_SH2_CRK	156	160	PF00017	0.355
LIG_SH2_CRK	37	41	PF00017	0.383
LIG_SH2_CRK	76	80	PF00017	0.374
LIG_SH2_GRB2like	365	368	PF00017	0.464
LIG_SH2_NCK_1	156	160	PF00017	0.355
LIG_SH2_PTP2	365	368	PF00017	0.478
LIG_SH2_SRC	365	368	PF00017	0.478
LIG_SH2_STAP1	76	80	PF00017	0.374
LIG_SH2_STAT3	62	65	PF00017	0.523
LIG_SH2_STAT5	101	104	PF00017	0.388
LIG_SH2_STAT5	315	318	PF00017	0.453
LIG_SH2_STAT5	365	368	PF00017	0.464
LIG_SH2_STAT5	581	584	PF00017	0.471
LIG_SH3_3	111	117	PF00018	0.517
LIG_SH3_3	213	219	PF00018	0.652
LIG_SH3_3	224	230	PF00018	0.421
LIG_SH3_3	231	237	PF00018	0.368
LIG_SUMO_SIM_par_1	270	276	PF11976	0.600
LIG_SUMO_SIM_par_1	51	58	PF11976	0.513
LIG_TRAF2_1	165	168	PF00917	0.523
LIG_TRAF2_1	449	452	PF00917	0.756
LIG_WRC_WIRS_1	501	506	PF05994	0.464
LIG_WW_3	115	119	PF00397	0.541
MOD_CK1_1	500	506	PF00069	0.487
MOD_CK1_1	513	519	PF00069	0.404
MOD_CK2_1	162	168	PF00069	0.411
MOD_CK2_1	477	483	PF00069	0.343
MOD_CK2_1	513	519	PF00069	0.478
MOD_Cter_Amidation	136	139	PF01082	0.718
MOD_GlcNHglycan	140	143	PF01048	0.706
MOD_GlcNHglycan	175	178	PF01048	0.578
MOD_GlcNHglycan	189	192	PF01048	0.633
MOD_GlcNHglycan	202	205	PF01048	0.639
MOD_GlcNHglycan	248	251	PF01048	0.435
MOD_GlcNHglycan	393	396	PF01048	0.271
MOD_GlcNHglycan	466	469	PF01048	0.765
MOD_GlcNHglycan	97	100	PF01048	0.429
MOD_GSK3_1	143	150	PF00069	0.656
MOD_GSK3_1	158	165	PF00069	0.446
MOD_GSK3_1	183	190	PF00069	0.612
MOD_GSK3_1	206	213	PF00069	0.748
MOD_GSK3_1	286	293	PF00069	0.790
MOD_GSK3_1	389	396	PF00069	0.446
MOD_GSK3_1	506	513	PF00069	0.464
MOD_GSK3_1	83	90	PF00069	0.474
MOD_GSK3_1	93	100	PF00069	0.411
MOD_N-GLC_1	17	22	PF02516	0.454
MOD_N-GLC_1	302	307	PF02516	0.707
MOD_N-GLC_1	324	329	PF02516	0.253
MOD_N-GLC_1	87	92	PF02516	0.570
MOD_NEK2_1	147	152	PF00069	0.381
MOD_NEK2_1	497	502	PF00069	0.494
MOD_NEK2_1	564	569	PF00069	0.453
MOD_PIKK_1	221	227	PF00454	0.571
MOD_PIKK_1	325	331	PF00454	0.478
MOD_PIKK_1	420	426	PF00454	0.559
MOD_PIKK_1	93	99	PF00454	0.504
MOD_PKA_1	138	144	PF00069	0.768
MOD_PKA_1	206	212	PF00069	0.768
MOD_PKA_1	33	39	PF00069	0.403
MOD_PKA_1	428	434	PF00069	0.683
MOD_PKA_2	138	144	PF00069	0.724
MOD_PKA_2	173	179	PF00069	0.583
MOD_PKA_2	183	189	PF00069	0.674
MOD_PKA_2	206	212	PF00069	0.753
MOD_PKA_2	256	262	PF00069	0.369
MOD_PKA_2	428	434	PF00069	0.683
MOD_PKA_2	540	546	PF00069	0.558
MOD_PKB_1	459	467	PF00069	0.580
MOD_Plk_1	477	483	PF00069	0.382
MOD_Plk_4	497	503	PF00069	0.506
MOD_Plk_4	97	103	PF00069	0.446
MOD_SUMO_for_1	129	132	PF00179	0.563
MOD_SUMO_for_1	481	484	PF00179	0.530
TRG_DiLeu_BaEn_4	451	457	PF01217	0.543
TRG_ENDOCYTIC_2	106	109	PF00928	0.408
TRG_ENDOCYTIC_2	156	159	PF00928	0.356
TRG_ENDOCYTIC_2	365	368	PF00928	0.471
TRG_ENDOCYTIC_2	37	40	PF00928	0.385
TRG_ENDOCYTIC_2	47	50	PF00928	0.355
TRG_ENDOCYTIC_2	76	79	PF00928	0.366
TRG_ER_diArg_1	172	175	PF00400	0.451
TRG_ER_diArg_1	428	430	PF00400	0.660
TRG_NLS_MonoExtC_3	137	143	PF00514	0.710
TRG_NLS_MonoExtC_3	179	184	PF00514	0.619
TRG_NLS_MonoExtN_4	136	142	PF00514	0.712
TRG_NLS_MonoExtN_4	284	291	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I291	Leptomonas seymouri	71%	100%
A0A0S4JC42	Bodo saltans	53%	100%
A0A1X0NQY2	Trypanosomatidae	58%	100%
A0A3S7X1L9	Leishmania donovani	98%	100%
A0A422NZ09	Trypanosoma rangeli	57%	100%
A4HGM7	Leishmania braziliensis	83%	98%
D0A8B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AZZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O14039	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4Q892	Leishmania major	91%	100%
Q8GYE8	Arabidopsis thaliana	28%	100%
Q9NAA7	Caenorhabditis elegans	23%	100%
V5BAN7	Trypanosoma cruzi	58%	100%