Arrestin_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3P9_LEIIN

TriTrypDb:

LINF_280023500

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3P9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0008289	lipid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.691
CLV_MEL_PAP_1	323	329	PF00089	0.516
CLV_PCSK_SKI1_1	162	166	PF00082	0.608
CLV_PCSK_SKI1_1	426	430	PF00082	0.447
DEG_APCC_DBOX_1	325	333	PF00400	0.531
DEG_SCF_FBW7_1	80	87	PF00400	0.556
DEG_SPOP_SBC_1	267	271	PF00917	0.636
DOC_CKS1_1	81	86	PF01111	0.570
DOC_MAPK_MEF2A_6	114	123	PF00069	0.536
DOC_MAPK_MEF2A_6	319	327	PF00069	0.489
DOC_PP1_RVXF_1	123	129	PF00149	0.521
DOC_PP2B_LxvP_1	433	436	PF13499	0.485
DOC_PP4_MxPP_1	1	4	PF00568	0.536
DOC_SPAK_OSR1_1	297	301	PF12202	0.428
DOC_USP7_MATH_1	108	112	PF00917	0.747
DOC_USP7_MATH_1	21	25	PF00917	0.556
DOC_USP7_MATH_1	259	263	PF00917	0.665
DOC_USP7_MATH_1	267	271	PF00917	0.643
DOC_USP7_MATH_1	281	285	PF00917	0.581
DOC_USP7_MATH_1	62	66	PF00917	0.736
DOC_USP7_MATH_1	7	11	PF00917	0.650
DOC_USP7_MATH_1	84	88	PF00917	0.573
DOC_USP7_MATH_1	99	103	PF00917	0.724
DOC_USP7_MATH_2	62	68	PF00917	0.686
DOC_WW_Pin1_4	100	105	PF00397	0.705
DOC_WW_Pin1_4	128	133	PF00397	0.512
DOC_WW_Pin1_4	231	236	PF00397	0.637
DOC_WW_Pin1_4	268	273	PF00397	0.648
DOC_WW_Pin1_4	31	36	PF00397	0.586
DOC_WW_Pin1_4	360	365	PF00397	0.520
DOC_WW_Pin1_4	80	85	PF00397	0.618
LIG_14-3-3_CanoR_1	297	303	PF00244	0.398
LIG_14-3-3_CanoR_1	326	330	PF00244	0.512
LIG_14-3-3_CanoR_1	440	446	PF00244	0.558
LIG_Actin_WH2_2	311	328	PF00022	0.513
LIG_Actin_WH2_2	414	432	PF00022	0.506
LIG_BRCT_BRCA1_1	220	224	PF00533	0.572
LIG_BRCT_BRCA1_1	385	389	PF00533	0.615
LIG_BRCT_BRCA1_1	64	68	PF00533	0.690
LIG_FHA_1	191	197	PF00498	0.671
LIG_FHA_1	199	205	PF00498	0.532
LIG_FHA_1	284	290	PF00498	0.441
LIG_FHA_1	371	377	PF00498	0.574
LIG_FHA_2	173	179	PF00498	0.771
LIG_LIR_Apic_2	354	359	PF02991	0.466
LIG_LIR_Gen_1	131	140	PF02991	0.492
LIG_LIR_Gen_1	341	348	PF02991	0.434
LIG_LIR_Gen_1	387	398	PF02991	0.595
LIG_LIR_Nem_3	131	137	PF02991	0.443
LIG_LIR_Nem_3	341	346	PF02991	0.429
LIG_LIR_Nem_3	387	393	PF02991	0.552
LIG_LIR_Nem_3	87	92	PF02991	0.578
LIG_PCNA_yPIPBox_3	337	349	PF02747	0.447
LIG_Pex14_2	389	393	PF04695	0.591
LIG_PTB_Apo_2	35	42	PF02174	0.567
LIG_PTB_Phospho_1	35	41	PF10480	0.565
LIG_SH2_CRK	81	85	PF00017	0.572
LIG_SH2_GRB2like	411	414	PF00017	0.574
LIG_SH2_PTP2	343	346	PF00017	0.383
LIG_SH2_SRC	120	123	PF00017	0.534
LIG_SH2_STAT5	120	123	PF00017	0.534
LIG_SH2_STAT5	185	188	PF00017	0.684
LIG_SH2_STAT5	295	298	PF00017	0.429
LIG_SH2_STAT5	343	346	PF00017	0.412
LIG_SH2_STAT5	411	414	PF00017	0.574
LIG_SH3_3	273	279	PF00018	0.669
LIG_SH3_3	285	291	PF00018	0.534
LIG_SH3_3	324	330	PF00018	0.471
LIG_SH3_3	358	364	PF00018	0.496
LIG_SH3_3	436	442	PF00018	0.464
LIG_TYR_ITIM	118	123	PF00017	0.542
MOD_CK1_1	102	108	PF00069	0.685
MOD_CK1_1	14	20	PF00069	0.637
MOD_CK1_1	192	198	PF00069	0.597
MOD_CK1_1	218	224	PF00069	0.591
MOD_CK1_1	268	274	PF00069	0.684
MOD_CK1_1	28	34	PF00069	0.607
MOD_CK1_1	284	290	PF00069	0.537
MOD_CK1_1	396	402	PF00069	0.628
MOD_CK1_1	94	100	PF00069	0.637
MOD_CK2_1	172	178	PF00069	0.648
MOD_CK2_1	274	280	PF00069	0.681
MOD_GlcNHglycan	110	113	PF01048	0.665
MOD_GlcNHglycan	13	16	PF01048	0.588
MOD_GlcNHglycan	25	28	PF01048	0.749
MOD_GlcNHglycan	257	260	PF01048	0.679
MOD_GlcNHglycan	38	41	PF01048	0.709
MOD_GlcNHglycan	405	410	PF01048	0.730
MOD_GlcNHglycan	5	8	PF01048	0.634
MOD_GlcNHglycan	64	67	PF01048	0.828
MOD_GlcNHglycan	71	75	PF01048	0.585
MOD_GlcNHglycan	93	96	PF01048	0.611
MOD_GSK3_1	172	179	PF00069	0.747
MOD_GSK3_1	185	192	PF00069	0.537
MOD_GSK3_1	21	28	PF00069	0.619
MOD_GSK3_1	223	230	PF00069	0.650
MOD_GSK3_1	255	262	PF00069	0.639
MOD_GSK3_1	266	273	PF00069	0.642
MOD_GSK3_1	3	10	PF00069	0.761
MOD_GSK3_1	384	391	PF00069	0.726
MOD_GSK3_1	392	399	PF00069	0.535
MOD_GSK3_1	441	448	PF00069	0.531
MOD_GSK3_1	60	67	PF00069	0.741
MOD_GSK3_1	80	87	PF00069	0.692
MOD_GSK3_1	91	98	PF00069	0.576
MOD_N-GLC_1	215	220	PF02516	0.581
MOD_N-GLC_2	351	353	PF02516	0.388
MOD_NEK2_1	196	201	PF00069	0.694
MOD_NEK2_1	298	303	PF00069	0.374
MOD_NEK2_1	306	311	PF00069	0.406
MOD_NEK2_1	325	330	PF00069	0.503
MOD_NEK2_1	36	41	PF00069	0.600
MOD_NEK2_1	370	375	PF00069	0.558
MOD_NEK2_1	393	398	PF00069	0.619
MOD_NEK2_1	429	434	PF00069	0.488
MOD_NEK2_2	259	264	PF00069	0.586
MOD_PIKK_1	270	276	PF00454	0.741
MOD_PIKK_1	415	421	PF00454	0.434
MOD_PKA_2	179	185	PF00069	0.744
MOD_PKA_2	325	331	PF00069	0.509
MOD_PKA_2	368	374	PF00069	0.467
MOD_PKA_2	429	435	PF00069	0.509
MOD_Plk_1	259	265	PF00069	0.586
MOD_Plk_1	415	421	PF00069	0.514
MOD_Plk_4	192	198	PF00069	0.718
MOD_Plk_4	284	290	PF00069	0.539
MOD_Plk_4	362	368	PF00069	0.447
MOD_Plk_4	429	435	PF00069	0.452
MOD_Plk_4	44	50	PF00069	0.626
MOD_ProDKin_1	100	106	PF00069	0.707
MOD_ProDKin_1	128	134	PF00069	0.511
MOD_ProDKin_1	231	237	PF00069	0.635
MOD_ProDKin_1	268	274	PF00069	0.649
MOD_ProDKin_1	31	37	PF00069	0.586
MOD_ProDKin_1	360	366	PF00069	0.515
MOD_ProDKin_1	80	86	PF00069	0.616
TRG_DiLeu_BaEn_2	415	421	PF01217	0.514
TRG_ENDOCYTIC_2	120	123	PF00928	0.534
TRG_ENDOCYTIC_2	295	298	PF00928	0.429
TRG_ENDOCYTIC_2	343	346	PF00928	0.523
TRG_ENDOCYTIC_2	390	393	PF00928	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P822	Leptomonas seymouri	56%	72%
A0A3S7X1N8	Leishmania donovani	99%	72%
A4HGM5	Leishmania braziliensis	69%	100%
D0A8B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q894	Leishmania major	92%	99%