DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3P5_LEIIN

TriTrypDb:

LINF_280023000

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.525
CLV_C14_Caspase3-7	481	485	PF00656	0.462
CLV_NRD_NRD_1	375	377	PF00675	0.415
CLV_NRD_NRD_1	402	404	PF00675	0.555
CLV_PCSK_KEX2_1	348	350	PF00082	0.397
CLV_PCSK_KEX2_1	375	377	PF00082	0.349
CLV_PCSK_KEX2_1	402	404	PF00082	0.555
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.390
CLV_PCSK_PC7_1	344	350	PF00082	0.454
CLV_PCSK_SKI1_1	255	259	PF00082	0.558
CLV_PCSK_SKI1_1	639	643	PF00082	0.403
CLV_PCSK_SKI1_1	691	695	PF00082	0.438
CLV_PCSK_SKI1_1	85	89	PF00082	0.452
DEG_APCC_DBOX_1	302	310	PF00400	0.481
DEG_APCC_DBOX_1	690	698	PF00400	0.556
DEG_Nend_UBRbox_3	1	3	PF02207	0.527
DEG_ODPH_VHL_1	312	323	PF01847	0.292
DEG_SCF_FBW7_1	155	162	PF00400	0.529
DEG_SIAH_1	140	148	PF03145	0.498
DOC_CKS1_1	105	110	PF01111	0.618
DOC_CYCLIN_yCln2_LP_2	633	636	PF00134	0.477
DOC_MAPK_gen_1	708	715	PF00069	0.440
DOC_MAPK_MEF2A_6	590	598	PF00069	0.553
DOC_MAPK_MEF2A_6	708	715	PF00069	0.398
DOC_PP2B_LxvP_1	138	141	PF13499	0.431
DOC_PP2B_LxvP_1	264	267	PF13499	0.667
DOC_PP2B_LxvP_1	415	418	PF13499	0.472
DOC_PP2B_LxvP_1	596	599	PF13499	0.556
DOC_PP2B_LxvP_1	633	636	PF13499	0.419
DOC_PP4_FxxP_1	319	322	PF00568	0.324
DOC_PP4_FxxP_1	371	374	PF00568	0.444
DOC_SPAK_OSR1_1	382	386	PF12202	0.523
DOC_USP7_MATH_1	150	154	PF00917	0.650
DOC_USP7_MATH_1	165	169	PF00917	0.606
DOC_USP7_MATH_1	172	176	PF00917	0.666
DOC_USP7_MATH_1	200	204	PF00917	0.620
DOC_USP7_MATH_1	210	214	PF00917	0.580
DOC_USP7_MATH_1	22	26	PF00917	0.674
DOC_USP7_MATH_1	221	225	PF00917	0.558
DOC_USP7_MATH_1	274	278	PF00917	0.696
DOC_USP7_MATH_1	289	293	PF00917	0.690
DOC_USP7_MATH_1	301	305	PF00917	0.453
DOC_USP7_MATH_1	405	409	PF00917	0.476
DOC_USP7_MATH_1	489	493	PF00917	0.467
DOC_USP7_MATH_1	519	523	PF00917	0.488
DOC_USP7_MATH_2	50	56	PF00917	0.444
DOC_USP7_UBL2_3	535	539	PF12436	0.410
DOC_WW_Pin1_4	104	109	PF00397	0.708
DOC_WW_Pin1_4	155	160	PF00397	0.679
DOC_WW_Pin1_4	178	183	PF00397	0.789
DOC_WW_Pin1_4	295	300	PF00397	0.703
DOC_WW_Pin1_4	485	490	PF00397	0.460
LIG_14-3-3_CanoR_1	303	307	PF00244	0.507
LIG_14-3-3_CanoR_1	382	386	PF00244	0.489
LIG_14-3-3_CanoR_1	406	413	PF00244	0.511
LIG_14-3-3_CanoR_1	525	530	PF00244	0.485
LIG_14-3-3_CanoR_1	585	590	PF00244	0.569
LIG_14-3-3_CanoR_1	6	13	PF00244	0.573
LIG_BIR_III_2	285	289	PF00653	0.617
LIG_BIR_III_2	617	621	PF00653	0.440
LIG_BIR_III_2	640	644	PF00653	0.497
LIG_BRCT_BRCA1_1	276	280	PF00533	0.512
LIG_eIF4E_1	616	622	PF01652	0.444
LIG_FHA_1	150	156	PF00498	0.675
LIG_FHA_1	303	309	PF00498	0.490
LIG_FHA_1	316	322	PF00498	0.410
LIG_FHA_1	449	455	PF00498	0.479
LIG_FHA_1	485	491	PF00498	0.540
LIG_FHA_1	49	55	PF00498	0.498
LIG_FHA_1	493	499	PF00498	0.493
LIG_FHA_1	521	527	PF00498	0.400
LIG_FHA_1	64	70	PF00498	0.597
LIG_FHA_1	730	736	PF00498	0.319
LIG_FHA_2	179	185	PF00498	0.639
LIG_FHA_2	228	234	PF00498	0.650
LIG_FHA_2	25	31	PF00498	0.496
LIG_FHA_2	282	288	PF00498	0.625
LIG_FHA_2	529	535	PF00498	0.482
LIG_FHA_2	576	582	PF00498	0.441
LIG_LIR_Apic_2	318	322	PF02991	0.323
LIG_LIR_Apic_2	370	374	PF02991	0.521
LIG_LIR_Apic_2	661	666	PF02991	0.400
LIG_LIR_Gen_1	423	431	PF02991	0.499
LIG_LIR_Gen_1	492	501	PF02991	0.402
LIG_LIR_Gen_1	547	556	PF02991	0.436
LIG_LIR_Gen_1	614	622	PF02991	0.413
LIG_LIR_Gen_1	68	76	PF02991	0.495
LIG_LIR_Nem_3	277	283	PF02991	0.712
LIG_LIR_Nem_3	318	323	PF02991	0.449
LIG_LIR_Nem_3	340	346	PF02991	0.482
LIG_LIR_Nem_3	423	427	PF02991	0.459
LIG_LIR_Nem_3	492	497	PF02991	0.409
LIG_LIR_Nem_3	544	548	PF02991	0.418
LIG_LIR_Nem_3	614	619	PF02991	0.414
LIG_LIR_Nem_3	654	659	PF02991	0.443
LIG_LIR_Nem_3	68	73	PF02991	0.518
LIG_NRBOX	525	531	PF00104	0.409
LIG_Rb_pABgroove_1	610	618	PF01858	0.408
LIG_SH2_CRK	424	428	PF00017	0.462
LIG_SH2_CRK	527	531	PF00017	0.414
LIG_SH2_CRK	566	570	PF00017	0.415
LIG_SH2_CRK	616	620	PF00017	0.456
LIG_SH2_SRC	378	381	PF00017	0.411
LIG_SH2_STAP1	424	428	PF00017	0.363
LIG_SH2_STAP1	572	576	PF00017	0.455
LIG_SH2_STAT3	75	78	PF00017	0.391
LIG_SH2_STAT5	315	318	PF00017	0.443
LIG_SH2_STAT5	346	349	PF00017	0.393
LIG_SH2_STAT5	353	356	PF00017	0.348
LIG_SH2_STAT5	424	427	PF00017	0.453
LIG_SH2_STAT5	460	463	PF00017	0.396
LIG_SH2_STAT5	659	662	PF00017	0.427
LIG_SH2_STAT5	718	721	PF00017	0.353
LIG_SH2_STAT5	75	78	PF00017	0.567
LIG_SH3_1	234	240	PF00018	0.713
LIG_SH3_3	102	108	PF00018	0.629
LIG_SH3_3	126	132	PF00018	0.450
LIG_SH3_3	138	144	PF00018	0.450
LIG_SH3_3	168	174	PF00018	0.482
LIG_SH3_3	190	196	PF00018	0.684
LIG_SH3_3	204	210	PF00018	0.690
LIG_SH3_3	234	240	PF00018	0.623
LIG_SH3_3	311	317	PF00018	0.518
LIG_SH3_3	325	331	PF00018	0.370
LIG_SH3_3	415	421	PF00018	0.405
LIG_SH3_3	44	50	PF00018	0.436
LIG_SH3_3	588	594	PF00018	0.558
LIG_SH3_3	663	669	PF00018	0.440
LIG_SH3_3	676	682	PF00018	0.419
LIG_SH3_3	692	698	PF00018	0.456
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.498
LIG_SUMO_SIM_anti_2	628	635	PF11976	0.429
LIG_SUMO_SIM_anti_2	670	675	PF11976	0.413
LIG_SUMO_SIM_par_1	126	133	PF11976	0.492
LIG_SUMO_SIM_par_1	495	503	PF11976	0.366
LIG_SUMO_SIM_par_1	732	738	PF11976	0.321
LIG_WRC_WIRS_1	316	321	PF05994	0.384
LIG_WRC_WIRS_1	545	550	PF05994	0.429
LIG_WW_2	207	210	PF00397	0.517
LIG_WW_3	403	407	PF00397	0.529
MOD_CK1_1	104	110	PF00069	0.622
MOD_CK1_1	114	120	PF00069	0.435
MOD_CK1_1	175	181	PF00069	0.740
MOD_CK1_1	213	219	PF00069	0.705
MOD_CK1_1	224	230	PF00069	0.711
MOD_CK1_1	24	30	PF00069	0.552
MOD_CK1_1	359	365	PF00069	0.441
MOD_CK1_1	492	498	PF00069	0.337
MOD_CK1_1	528	534	PF00069	0.480
MOD_CK1_1	544	550	PF00069	0.411
MOD_CK1_1	706	712	PF00069	0.482
MOD_CK1_1	729	735	PF00069	0.403
MOD_CK2_1	281	287	PF00069	0.591
MOD_CK2_1	289	295	PF00069	0.717
MOD_CK2_1	528	534	PF00069	0.400
MOD_CK2_1	652	658	PF00069	0.476
MOD_GlcNHglycan	112	116	PF01048	0.530
MOD_GlcNHglycan	132	135	PF01048	0.465
MOD_GlcNHglycan	14	17	PF01048	0.556
MOD_GlcNHglycan	152	155	PF01048	0.567
MOD_GlcNHglycan	200	203	PF01048	0.742
MOD_GlcNHglycan	216	219	PF01048	0.502
MOD_GlcNHglycan	24	27	PF01048	0.595
MOD_GlcNHglycan	250	253	PF01048	0.644
MOD_GlcNHglycan	388	391	PF01048	0.596
MOD_GlcNHglycan	395	398	PF01048	0.581
MOD_GlcNHglycan	517	520	PF01048	0.552
MOD_GlcNHglycan	54	57	PF01048	0.504
MOD_GlcNHglycan	728	731	PF01048	0.409
MOD_GlcNHglycan	737	740	PF01048	0.389
MOD_GSK3_1	155	162	PF00069	0.685
MOD_GSK3_1	172	179	PF00069	0.731
MOD_GSK3_1	198	205	PF00069	0.721
MOD_GSK3_1	20	27	PF00069	0.588
MOD_GSK3_1	210	217	PF00069	0.812
MOD_GSK3_1	244	251	PF00069	0.689
MOD_GSK3_1	48	55	PF00069	0.525
MOD_GSK3_1	485	492	PF00069	0.565
MOD_GSK3_1	515	522	PF00069	0.422
MOD_GSK3_1	537	544	PF00069	0.540
MOD_GSK3_1	59	66	PF00069	0.641
MOD_GSK3_1	699	706	PF00069	0.535
MOD_GSK3_1	7	14	PF00069	0.635
MOD_GSK3_1	717	724	PF00069	0.487
MOD_NEK2_1	183	188	PF00069	0.646
MOD_NEK2_1	214	219	PF00069	0.609
MOD_NEK2_1	302	307	PF00069	0.689
MOD_NEK2_1	448	453	PF00069	0.421
MOD_NEK2_1	461	466	PF00069	0.416
MOD_NEK2_2	339	344	PF00069	0.355
MOD_PIKK_1	114	120	PF00454	0.435
MOD_PIKK_1	461	467	PF00454	0.398
MOD_PIKK_1	528	534	PF00454	0.453
MOD_PIKK_1	537	543	PF00454	0.409
MOD_PKA_2	224	230	PF00069	0.595
MOD_PKA_2	248	254	PF00069	0.666
MOD_PKA_2	302	308	PF00069	0.538
MOD_PKA_2	356	362	PF00069	0.492
MOD_PKA_2	381	387	PF00069	0.543
MOD_PKA_2	405	411	PF00069	0.489
MOD_PKB_1	583	591	PF00069	0.579
MOD_Plk_1	111	117	PF00069	0.445
MOD_Plk_1	339	345	PF00069	0.420
MOD_Plk_1	422	428	PF00069	0.507
MOD_Plk_4	315	321	PF00069	0.384
MOD_Plk_4	489	495	PF00069	0.421
MOD_Plk_4	525	531	PF00069	0.425
MOD_Plk_4	544	550	PF00069	0.240
MOD_Plk_4	575	581	PF00069	0.438
MOD_Plk_4	629	635	PF00069	0.427
MOD_Plk_4	667	673	PF00069	0.424
MOD_ProDKin_1	104	110	PF00069	0.701
MOD_ProDKin_1	155	161	PF00069	0.677
MOD_ProDKin_1	178	184	PF00069	0.796
MOD_ProDKin_1	295	301	PF00069	0.693
MOD_ProDKin_1	485	491	PF00069	0.460
MOD_SUMO_for_1	677	680	PF00179	0.483
MOD_SUMO_rev_2	509	518	PF00179	0.442
TRG_DiLeu_BaEn_1	126	131	PF01217	0.416
TRG_DiLeu_BaEn_1	629	634	PF01217	0.389
TRG_DiLeu_BaEn_4	126	132	PF01217	0.431
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.409
TRG_DiLeu_BaLyEn_6	692	697	PF01217	0.452
TRG_ENDOCYTIC_2	353	356	PF00928	0.336
TRG_ENDOCYTIC_2	424	427	PF00928	0.453
TRG_ENDOCYTIC_2	460	463	PF00928	0.384
TRG_ENDOCYTIC_2	527	530	PF00928	0.469
TRG_ENDOCYTIC_2	566	569	PF00928	0.440
TRG_ENDOCYTIC_2	616	619	PF00928	0.474
TRG_ER_diArg_1	374	376	PF00400	0.458
TRG_ER_diArg_1	401	403	PF00400	0.612
TRG_ER_diArg_1	468	471	PF00400	0.394
TRG_ER_diArg_1	583	586	PF00400	0.565
TRG_ER_diArg_1	707	710	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE00	Leptomonas seymouri	54%	100%
A0A3S7X1J9	Leishmania donovani	99%	100%
A4HGM0	Leishmania braziliensis	81%	100%
A4HHZ8	Leishmania braziliensis	26%	100%
D0A8B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AZY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B0H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q899	Leishmania major	91%	100%
V5B7S2	Trypanosoma cruzi	26%	100%