Putative hydrolase, alpha/beta fold family

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase - alpha/beta fold family - putative

Species:

Leishmania infantum

UniProt:

A4I3N6_LEIIN

TriTrypDb:

LINF_280021800

Length:

346

Annotations

Annotations by Jardim et al.

Hydrolase, hydrolase, alpha/beta fold family

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Phosphorylation

Amastigote: 22, 25, 4

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I3N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3N6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	32
GO:0016787	hydrolase activity	2	32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.695
CLV_NRD_NRD_1	279	281	PF00675	0.413
CLV_PCSK_KEX2_1	54	56	PF00082	0.485
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.510
CLV_PCSK_SKI1_1	245	249	PF00082	0.371
CLV_PCSK_SKI1_1	280	284	PF00082	0.317
CLV_PCSK_SKI1_1	33	37	PF00082	0.543
CLV_PCSK_SKI1_1	54	58	PF00082	0.493
DOC_MAPK_gen_1	20	28	PF00069	0.746
DOC_MAPK_MEF2A_6	181	189	PF00069	0.417
DOC_MAPK_MEF2A_6	280	289	PF00069	0.315
DOC_MAPK_MEF2A_6	319	328	PF00069	0.448
DOC_PP1_RVXF_1	311	318	PF00149	0.414
DOC_PP2B_LxvP_1	124	127	PF13499	0.353
DOC_PP4_FxxP_1	116	119	PF00568	0.457
DOC_PP4_FxxP_1	63	66	PF00568	0.398
DOC_SPAK_OSR1_1	207	211	PF12202	0.257
DOC_USP7_MATH_1	12	16	PF00917	0.703
DOC_USP7_MATH_1	27	31	PF00917	0.638
DOC_USP7_MATH_1	6	10	PF00917	0.691
DOC_USP7_UBL2_3	277	281	PF12436	0.266
LIG_14-3-3_CanoR_1	123	127	PF00244	0.475
LIG_14-3-3_CanoR_1	181	186	PF00244	0.354
LIG_14-3-3_CanoR_1	20	28	PF00244	0.464
LIG_14-3-3_CanoR_1	280	285	PF00244	0.392
LIG_Actin_WH2_2	74	89	PF00022	0.239
LIG_AP2alpha_1	39	43	PF02296	0.493
LIG_APCC_ABBA_1	89	94	PF00400	0.248
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	109	113	PF00533	0.421
LIG_BRCT_BRCA1_1	84	88	PF00533	0.455
LIG_DLG_GKlike_1	181	188	PF00625	0.457
LIG_eIF4E_1	303	309	PF01652	0.449
LIG_FHA_1	2	8	PF00498	0.521
LIG_FHA_1	284	290	PF00498	0.310
LIG_FHA_2	109	115	PF00498	0.395
LIG_FHA_2	60	66	PF00498	0.409
LIG_FXI_DFP_1	113	117	PF00024	0.409
LIG_GBD_Chelix_1	73	81	PF00786	0.493
LIG_LIR_Apic_2	114	119	PF02991	0.456
LIG_LIR_Apic_2	62	66	PF02991	0.426
LIG_LIR_Gen_1	110	121	PF02991	0.266
LIG_LIR_Gen_1	40	50	PF02991	0.513
LIG_LIR_Gen_1	57	66	PF02991	0.295
LIG_LIR_Gen_1	85	93	PF02991	0.413
LIG_LIR_Nem_3	110	116	PF02991	0.455
LIG_LIR_Nem_3	40	46	PF02991	0.483
LIG_LIR_Nem_3	57	63	PF02991	0.312
LIG_LIR_Nem_3	85	91	PF02991	0.385
LIG_LIR_Nem_3	94	100	PF02991	0.350
LIG_MYND_2	118	122	PF01753	0.248
LIG_Pex14_1	226	230	PF04695	0.449
LIG_Pex14_2	39	43	PF04695	0.399
LIG_Pex14_2	88	92	PF04695	0.387
LIG_SH2_GRB2like	102	105	PF00017	0.358
LIG_SH2_STAP1	205	209	PF00017	0.465
LIG_SH2_STAP1	84	88	PF00017	0.239
LIG_SH2_STAT3	230	233	PF00017	0.449
LIG_SH2_STAT5	138	141	PF00017	0.379
LIG_SH2_STAT5	230	233	PF00017	0.447
LIG_SH2_STAT5	246	249	PF00017	0.325
LIG_SH2_STAT5	98	101	PF00017	0.321
LIG_SH3_3	194	200	PF00018	0.456
LIG_SH3_3	279	285	PF00018	0.344
LIG_SH3_3	292	298	PF00018	0.357
LIG_SH3_3	312	318	PF00018	0.385
LIG_SH3_3	63	69	PF00018	0.468
LIG_UBA3_1	337	344	PF00899	0.333
LIG_WRC_WIRS_1	60	65	PF05994	0.395
MOD_CK1_1	22	28	PF00069	0.499
MOD_CK2_1	128	134	PF00069	0.409
MOD_CK2_1	246	252	PF00069	0.502
MOD_Cter_Amidation	52	55	PF01082	0.502
MOD_GlcNHglycan	1	4	PF01048	0.493
MOD_GlcNHglycan	215	218	PF01048	0.390
MOD_GSK3_1	1	8	PF00069	0.751
MOD_GSK3_1	104	111	PF00069	0.408
MOD_GSK3_1	12	19	PF00069	0.757
MOD_GSK3_1	22	29	PF00069	0.638
MOD_GSK3_1	45	52	PF00069	0.549
MOD_N-GLC_1	22	27	PF02516	0.638
MOD_N-GLC_1	338	343	PF02516	0.459
MOD_NEK2_1	1	6	PF00069	0.552
MOD_NEK2_1	162	167	PF00069	0.405
MOD_NEK2_1	26	31	PF00069	0.549
MOD_NEK2_1	338	343	PF00069	0.479
MOD_NEK2_1	77	82	PF00069	0.434
MOD_PIKK_1	108	114	PF00454	0.248
MOD_PIKK_1	229	235	PF00454	0.449
MOD_PIKK_1	27	33	PF00454	0.346
MOD_PKA_1	280	286	PF00069	0.432
MOD_PKA_1	54	60	PF00069	0.502
MOD_PKA_2	104	110	PF00069	0.444
MOD_PKA_2	122	128	PF00069	0.249
MOD_PKA_2	19	25	PF00069	0.791
MOD_PKA_2	54	60	PF00069	0.455
MOD_Plk_1	22	28	PF00069	0.636
MOD_Plk_1	338	344	PF00069	0.535
MOD_Plk_4	198	204	PF00069	0.401
MOD_Plk_4	283	289	PF00069	0.326
MOD_Plk_4	338	344	PF00069	0.602
MOD_Plk_4	77	83	PF00069	0.492
MOD_SUMO_rev_2	34	44	PF00179	0.542
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.453
TRG_ENDOCYTIC_2	205	208	PF00928	0.449
TRG_ENDOCYTIC_2	60	63	PF00928	0.399
TRG_ENDOCYTIC_2	97	100	PF00928	0.380
TRG_NES_CRM1_1	146	158	PF08389	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	29%	80%
A0A0N0P3S4	Leptomonas seymouri	37%	95%
A0A0N1PA10	Leptomonas seymouri	70%	100%
A0A0N1PCQ2	Leptomonas seymouri	47%	100%
A0A0S4JQB3	Bodo saltans	40%	100%
A0A1X0NSR3	Trypanosomatidae	37%	77%
A0A1X0NSS6	Trypanosomatidae	44%	100%
A0A3Q8IAY1	Leishmania donovani	36%	89%
A0A3R7KKJ0	Trypanosoma rangeli	43%	100%
A0A3S5IRR1	Trypanosoma rangeli	33%	85%
A0A3S7WUJ3	Leishmania donovani	41%	100%
A0A3S7WUK0	Leishmania donovani	32%	80%
A0A3S7X1K2	Leishmania donovani	100%	100%
A0A422NS41	Trypanosoma rangeli	37%	80%
A4H956	Leishmania braziliensis	45%	100%
A4H959	Leishmania braziliensis	31%	100%
A4H960	Leishmania braziliensis	40%	100%
A4HGL0	Leishmania braziliensis	81%	100%
A4HXH8	Leishmania infantum	41%	100%
A4HXI1	Leishmania infantum	32%	100%
A4HXI2	Leishmania infantum	36%	100%
A4JPX5	Burkholderia vietnamiensis (strain G4 / LMG 22486)	26%	100%
B2JQW2	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	27%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O05235	Bacillus subtilis (strain 168)	23%	100%
P00632	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	27%	100%
P47229	Paraburkholderia xenovorans (strain LB400)	24%	100%
Q4Q8A8	Leishmania major	94%	100%
Q4QE86	Leishmania major	38%	100%
Q4QE87	Leishmania major	32%	100%
Q4QE90	Leishmania major	42%	100%
Q52011	Pseudomonas furukawaii	24%	100%
Q52532	Pseudomonas sp.	25%	100%
Q54528	Streptomyces purpurascens	31%	100%
Q54809	Streptomyces peucetius	29%	100%
Q55217	Streptomyces sp. (strain C5)	29%	100%
Q59695	Pseudomonas putida	27%	94%
Q83WC8	Acinetobacter calcoaceticus	23%	100%
V5AZB9	Trypanosoma cruzi	39%	81%
V5BER0	Trypanosoma cruzi	45%	100%
V5BNU9	Trypanosoma cruzi	30%	85%