Conserved plasma membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF423) - putative

Species:

Leishmania infantum

UniProt:

A4I3M7_LEIIN

TriTrypDb:

LINF_280020800

Length:

138

Annotations

LeishMANIAdb annotations

Similar to Prokaryotic YgdD inner membrane proteins.. Topology is somewhat unclear but likely to start / end in cytoplasm. Might have been acquired by horizontal gene transfer.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4I3M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.270
CLV_PCSK_KEX2_1	82	84	PF00082	0.294
CLV_PCSK_SKI1_1	6	10	PF00082	0.387
DOC_USP7_MATH_1	31	35	PF00917	0.328
LIG_14-3-3_CanoR_1	99	108	PF00244	0.249
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_BRCT_BRCA1_1	33	37	PF00533	0.311
LIG_EH1_1	58	66	PF00400	0.286
LIG_LIR_Gen_1	34	41	PF02991	0.254
LIG_LIR_Nem_3	34	40	PF02991	0.254
LIG_LIR_Nem_3	43	49	PF02991	0.254
LIG_SH2_CRK	102	106	PF00017	0.279
LIG_SH2_CRK	55	59	PF00017	0.297
LIG_SH2_NCK_1	49	53	PF00017	0.254
LIG_SH2_SRC	100	103	PF00017	0.274
LIG_SH2_STAP1	85	89	PF00017	0.247
LIG_SH2_STAT5	100	103	PF00017	0.300
LIG_SH3_3	102	108	PF00018	0.224
LIG_SH3_3	70	76	PF00018	0.246
MOD_GlcNHglycan	1	4	PF01048	0.378
MOD_GlcNHglycan	21	24	PF01048	0.312
MOD_GlcNHglycan	9	12	PF01048	0.377
MOD_GSK3_1	109	116	PF00069	0.365
MOD_NEK2_1	131	136	PF00069	0.362
MOD_NEK2_1	40	45	PF00069	0.255
MOD_NEK2_1	57	62	PF00069	0.342
MOD_NEK2_1	9	14	PF00069	0.581
MOD_NEK2_1	95	100	PF00069	0.380
MOD_Plk_4	89	95	PF00069	0.291
TRG_ENDOCYTIC_2	102	105	PF00928	0.279
TRG_ENDOCYTIC_2	55	58	PF00928	0.349
TRG_ENDOCYTIC_2	85	88	PF00928	0.297
TRG_ER_diArg_1	81	83	PF00400	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH3	Leptomonas seymouri	82%	100%
A0A0N1I149	Leptomonas seymouri	27%	100%
A0A0N1I2H5	Leptomonas seymouri	31%	100%
A0A0S4JA03	Bodo saltans	33%	100%
A0A1X0NW75	Trypanosomatidae	32%	100%
A0A1X0NYR3	Trypanosomatidae	36%	100%
A0A3Q8IGS2	Leishmania donovani	30%	100%
A0A3R7NJS9	Trypanosoma rangeli	32%	100%
A0A3S7X1H0	Leishmania donovani	35%	100%
A0A3S7X1J0	Leishmania donovani	100%	100%
A4HGK1	Leishmania braziliensis	83%	100%
A4HGK2	Leishmania braziliensis	31%	100%
A4HGK3	Leishmania braziliensis	29%	100%
A4I3M8	Leishmania infantum	30%	100%
A4I3M9	Leishmania infantum	35%	100%
A4K526	Bufo gargarizans	31%	100%
D0A7U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A857	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AZW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AZW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AZX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q8B5	Leishmania major	34%	100%
Q4Q8B6	Leishmania major	30%	100%
Q4Q8B7	Leishmania major	96%	100%
Q568J8	Danio rerio	34%	100%