Putative target SNARE

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qa-SNARE protein

Species:

Leishmania infantum

UniProt:

A4I3M6_LEIIN

TriTrypDb:

LINF_280020600

Length:

169

Annotations

LeishMANIAdb annotations

Homologous to animal syntaxin proteins, involved in vesulcular fusion to membranes. Although most proteins appear to be membrane-embedded, some Lesihmaniid members are likely not.. For some reason, multiple copies are seen in Leptomonas

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I3M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0016192	vesicle-mediated transport	4	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.512
CLV_C14_Caspase3-7	43	47	PF00656	0.365
CLV_C14_Caspase3-7	57	61	PF00656	0.199
CLV_PCSK_SKI1_1	107	111	PF00082	0.461
CLV_PCSK_SKI1_1	147	151	PF00082	0.512
CLV_PCSK_SKI1_1	39	43	PF00082	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.420
DOC_USP7_MATH_1	116	120	PF00917	0.384
DOC_USP7_UBL2_3	50	54	PF12436	0.384
DOC_WW_Pin1_4	162	167	PF00397	0.540
LIG_14-3-3_CanoR_1	157	166	PF00244	0.458
LIG_14-3-3_CanoR_1	92	101	PF00244	0.424
LIG_Actin_WH2_2	41	58	PF00022	0.494
LIG_BRCT_BRCA1_1	139	143	PF00533	0.512
LIG_FHA_1	50	56	PF00498	0.512
LIG_FHA_1	75	81	PF00498	0.384
LIG_FHA_2	112	118	PF00498	0.512
LIG_FHA_2	12	18	PF00498	0.374
LIG_GBD_Chelix_1	79	87	PF00786	0.512
LIG_LIR_Gen_1	73	84	PF02991	0.363
LIG_LIR_Nem_3	73	79	PF02991	0.363
LIG_SH2_GRB2like	113	116	PF00017	0.512
LIG_SH2_NCK_1	113	117	PF00017	0.384
LIG_SH2_STAP1	76	80	PF00017	0.384
LIG_SH2_STAT3	101	104	PF00017	0.411
LIG_SH2_STAT3	141	144	PF00017	0.512
LIG_SH2_STAT3	90	93	PF00017	0.442
LIG_SH2_STAT5	113	116	PF00017	0.512
LIG_SH2_STAT5	141	144	PF00017	0.374
LIG_SH2_STAT5	76	79	PF00017	0.377
MOD_CK1_1	160	166	PF00069	0.471
MOD_CK1_1	31	37	PF00069	0.397
MOD_CK1_1	49	55	PF00069	0.347
MOD_CK2_1	11	17	PF00069	0.499
MOD_CK2_1	149	155	PF00069	0.512
MOD_CK2_1	92	98	PF00069	0.512
MOD_GlcNHglycan	117	121	PF01048	0.512
MOD_GlcNHglycan	65	68	PF01048	0.441
MOD_GlcNHglycan	94	97	PF01048	0.416
MOD_GSK3_1	149	156	PF00069	0.680
MOD_GSK3_1	157	164	PF00069	0.617
MOD_GSK3_1	54	61	PF00069	0.384
MOD_N-GLC_1	135	140	PF02516	0.374
MOD_PIKK_1	102	108	PF00454	0.512
MOD_PK_1	54	60	PF00069	0.365
MOD_PKA_2	156	162	PF00069	0.438
MOD_PKA_2	31	37	PF00069	0.397
MOD_Plk_1	136	142	PF00069	0.337
MOD_Plk_4	137	143	PF00069	0.514
MOD_Plk_4	149	155	PF00069	0.365
MOD_ProDKin_1	162	168	PF00069	0.541
TRG_ENDOCYTIC_2	76	79	PF00928	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGJ9	Leishmania braziliensis	85%	68%
A4HGK0	Leishmania braziliensis	83%	100%