LeishMANIAdb
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Putative ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase
Gene product:
Cell division control protein 48 - putative
Species:
Leishmania infantum
UniProt:
A4I3M5_LEIIN
TriTrypDb:
LINF_280020500 *
Length:
696

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3M5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M5

Function

Biological processes
TermNameLevelCount
GO:0009987 cellular process 1 1
GO:0051301 cell division 2 1
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 227 229 PF00675 0.489
CLV_NRD_NRD_1 326 328 PF00675 0.442
CLV_NRD_NRD_1 367 369 PF00675 0.441
CLV_NRD_NRD_1 39 41 PF00675 0.520
CLV_NRD_NRD_1 420 422 PF00675 0.303
CLV_NRD_NRD_1 459 461 PF00675 0.673
CLV_NRD_NRD_1 542 544 PF00675 0.409
CLV_NRD_NRD_1 548 550 PF00675 0.397
CLV_NRD_NRD_1 600 602 PF00675 0.494
CLV_NRD_NRD_1 662 664 PF00675 0.473
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I9Q8 Leptomonas seymouri 56% 98%
A0A1X0NZ99 Trypanosomatidae 43% 100%
A0A3Q8II41 Leishmania donovani 100% 90%
A0A422MTD5 Trypanosoma rangeli 42% 100%
A4HGJ8 Leishmania braziliensis 77% 100%
D0A856 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AZW6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q8C0 Leishmania major 93% 100%
V5BCT3 Trypanosoma cruzi 41% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS