LeishMANIAdb
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Putative ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase
Gene product:
Cell division control protein 48 - putative
Species:
Leishmania infantum
UniProt:
A4I3M5_LEIIN
TriTrypDb:
LINF_280020500 *
Length:
696

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3M5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M5

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 1
GO:0051301 cell division 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 227 229 PF00675 0.489
CLV_NRD_NRD_1 326 328 PF00675 0.442
CLV_NRD_NRD_1 367 369 PF00675 0.441
CLV_NRD_NRD_1 39 41 PF00675 0.520
CLV_NRD_NRD_1 420 422 PF00675 0.303
CLV_NRD_NRD_1 459 461 PF00675 0.673
CLV_NRD_NRD_1 542 544 PF00675 0.409
CLV_NRD_NRD_1 548 550 PF00675 0.397
CLV_NRD_NRD_1 600 602 PF00675 0.494
CLV_NRD_NRD_1 662 664 PF00675 0.473
CLV_NRD_NRD_1 67 69 PF00675 0.484
CLV_NRD_NRD_1 71 73 PF00675 0.493
CLV_NRD_NRD_1 82 84 PF00675 0.503
CLV_PCSK_KEX2_1 227 229 PF00082 0.489
CLV_PCSK_KEX2_1 326 328 PF00082 0.442
CLV_PCSK_KEX2_1 353 355 PF00082 0.456
CLV_PCSK_KEX2_1 367 369 PF00082 0.363
CLV_PCSK_KEX2_1 39 41 PF00082 0.518
CLV_PCSK_KEX2_1 420 422 PF00082 0.322
CLV_PCSK_KEX2_1 458 460 PF00082 0.664
CLV_PCSK_KEX2_1 548 550 PF00082 0.390
CLV_PCSK_KEX2_1 600 602 PF00082 0.494
CLV_PCSK_KEX2_1 662 664 PF00082 0.498
CLV_PCSK_KEX2_1 67 69 PF00082 0.484
CLV_PCSK_KEX2_1 71 73 PF00082 0.493
CLV_PCSK_KEX2_1 82 84 PF00082 0.499
CLV_PCSK_PC1ET2_1 353 355 PF00082 0.522
CLV_PCSK_PC7_1 363 369 PF00082 0.547
CLV_PCSK_PC7_1 67 73 PF00082 0.438
CLV_PCSK_SKI1_1 227 231 PF00082 0.390
CLV_PCSK_SKI1_1 354 358 PF00082 0.392
CLV_PCSK_SKI1_1 387 391 PF00082 0.279
CLV_PCSK_SKI1_1 591 595 PF00082 0.466
CLV_PCSK_SKI1_1 611 615 PF00082 0.424
CLV_PCSK_SKI1_1 623 627 PF00082 0.401
CLV_PCSK_SKI1_1 663 667 PF00082 0.418
CLV_PCSK_SKI1_1 67 71 PF00082 0.506
CLV_Separin_Metazoa 3 7 PF03568 0.537
DEG_COP1_1 21 30 PF00400 0.504
DEG_Nend_UBRbox_2 1 3 PF02207 0.471
DEG_SPOP_SBC_1 133 137 PF00917 0.742
DEG_SPOP_SBC_1 96 100 PF00917 0.567
DOC_CDC14_PxL_1 404 412 PF14671 0.279
DOC_CKS1_1 219 224 PF01111 0.382
DOC_CYCLIN_yCln2_LP_2 518 524 PF00134 0.410
DOC_MAPK_gen_1 326 334 PF00069 0.436
DOC_MAPK_gen_1 370 379 PF00069 0.424
DOC_MAPK_gen_1 39 46 PF00069 0.452
DOC_MAPK_gen_1 430 438 PF00069 0.279
DOC_MAPK_gen_1 525 535 PF00069 0.279
DOC_MAPK_MEF2A_6 430 438 PF00069 0.279
DOC_PP2B_LxvP_1 247 250 PF13499 0.515
DOC_PP2B_LxvP_1 533 536 PF13499 0.422
DOC_PP4_FxxP_1 230 233 PF00568 0.467
DOC_SPAK_OSR1_1 368 372 PF12202 0.468
DOC_USP7_MATH_1 280 284 PF00917 0.497
DOC_USP7_MATH_1 313 317 PF00917 0.448
DOC_USP7_MATH_1 461 465 PF00917 0.744
DOC_USP7_MATH_1 542 546 PF00917 0.383
DOC_USP7_MATH_1 635 639 PF00917 0.574
DOC_USP7_UBL2_3 349 353 PF12436 0.486
DOC_WW_Pin1_4 171 176 PF00397 0.416
DOC_WW_Pin1_4 218 223 PF00397 0.425
DOC_WW_Pin1_4 278 283 PF00397 0.500
DOC_WW_Pin1_4 285 290 PF00397 0.599
DOC_WW_Pin1_4 430 435 PF00397 0.318
DOC_WW_Pin1_4 98 103 PF00397 0.609
LIG_14-3-3_CanoR_1 138 146 PF00244 0.788
LIG_14-3-3_CanoR_1 190 195 PF00244 0.445
LIG_14-3-3_CanoR_1 284 288 PF00244 0.711
LIG_14-3-3_CanoR_1 326 334 PF00244 0.407
LIG_14-3-3_CanoR_1 354 359 PF00244 0.462
LIG_14-3-3_CanoR_1 39 47 PF00244 0.437
LIG_14-3-3_CanoR_1 487 496 PF00244 0.305
LIG_14-3-3_CanoR_1 543 547 PF00244 0.382
LIG_14-3-3_CanoR_1 611 617 PF00244 0.404
LIG_14-3-3_CanoR_1 71 75 PF00244 0.475
LIG_Actin_WH2_2 435 451 PF00022 0.410
LIG_Actin_WH2_2 511 527 PF00022 0.280
LIG_APCC_ABBAyCdc20_2 548 554 PF00400 0.438
LIG_BRCT_BRCA1_1 327 331 PF00533 0.454
LIG_BRCT_BRCA1_1 434 438 PF00533 0.279
LIG_BRCT_BRCA1_1 601 605 PF00533 0.465
LIG_Clathr_ClatBox_1 108 112 PF01394 0.418
LIG_Clathr_ClatBox_1 436 440 PF01394 0.410
LIG_deltaCOP1_diTrp_1 554 558 PF00928 0.372
LIG_FHA_1 183 189 PF00498 0.497
LIG_FHA_1 196 202 PF00498 0.271
LIG_FHA_1 221 227 PF00498 0.491
LIG_FHA_1 257 263 PF00498 0.372
LIG_FHA_1 29 35 PF00498 0.684
LIG_FHA_1 355 361 PF00498 0.498
LIG_FHA_1 373 379 PF00498 0.268
LIG_FHA_1 39 45 PF00498 0.447
LIG_FHA_1 451 457 PF00498 0.357
LIG_FHA_1 511 517 PF00498 0.302
LIG_FHA_1 61 67 PF00498 0.548
LIG_FHA_1 624 630 PF00498 0.463
LIG_FHA_1 664 670 PF00498 0.429
LIG_FHA_2 219 225 PF00498 0.383
LIG_FHA_2 319 325 PF00498 0.475
LIG_FHA_2 335 341 PF00498 0.382
LIG_FHA_2 480 486 PF00498 0.355
LIG_FHA_2 529 535 PF00498 0.279
LIG_FHA_2 583 589 PF00498 0.429
LIG_FHA_2 71 77 PF00498 0.470
LIG_FHA_2 99 105 PF00498 0.557
LIG_GBD_Chelix_1 488 496 PF00786 0.322
LIG_LIR_Gen_1 166 176 PF02991 0.387
LIG_LIR_Gen_1 328 336 PF02991 0.402
LIG_LIR_Gen_1 337 346 PF02991 0.365
LIG_LIR_Gen_1 401 411 PF02991 0.279
LIG_LIR_Gen_1 503 512 PF02991 0.314
LIG_LIR_LC3C_4 203 208 PF02991 0.263
LIG_LIR_Nem_3 158 163 PF02991 0.418
LIG_LIR_Nem_3 166 171 PF02991 0.327
LIG_LIR_Nem_3 263 267 PF02991 0.404
LIG_LIR_Nem_3 328 334 PF02991 0.383
LIG_LIR_Nem_3 337 342 PF02991 0.377
LIG_LIR_Nem_3 364 369 PF02991 0.518
LIG_LIR_Nem_3 401 407 PF02991 0.279
LIG_LIR_Nem_3 424 428 PF02991 0.410
LIG_LIR_Nem_3 503 509 PF02991 0.314
LIG_LYPXL_S_1 159 163 PF13949 0.462
LIG_LYPXL_yS_3 160 163 PF13949 0.488
LIG_NRBOX 491 497 PF00104 0.322
LIG_NRBOX 528 534 PF00104 0.355
LIG_NRBOX 65 71 PF00104 0.508
LIG_Pex14_2 613 617 PF04695 0.379
LIG_RPA_C_Fungi 482 494 PF08784 0.306
LIG_SH2_CRK 168 172 PF00017 0.372
LIG_SH2_CRK 264 268 PF00017 0.336
LIG_SH2_GRB2like 450 453 PF00017 0.355
LIG_SH2_SRC 215 218 PF00017 0.344
LIG_SH2_STAP1 215 219 PF00017 0.538
LIG_SH2_STAP1 450 454 PF00017 0.391
LIG_SH2_STAP1 75 79 PF00017 0.423
LIG_SH2_STAT5 117 120 PF00017 0.546
LIG_SH2_STAT5 168 171 PF00017 0.500
LIG_SH2_STAT5 212 215 PF00017 0.437
LIG_SH2_STAT5 277 280 PF00017 0.521
LIG_SH2_STAT5 314 317 PF00017 0.416
LIG_SH2_STAT5 425 428 PF00017 0.410
LIG_SH3_3 140 146 PF00018 0.761
LIG_SH3_3 242 248 PF00018 0.551
LIG_SH3_3 353 359 PF00018 0.364
LIG_SH3_3 43 49 PF00018 0.471
LIG_SH3_3 532 538 PF00018 0.308
LIG_Sin3_3 683 690 PF02671 0.419
LIG_SUMO_SIM_anti_2 103 109 PF11976 0.446
LIG_SUMO_SIM_anti_2 682 689 PF11976 0.432
LIG_SUMO_SIM_par_1 106 112 PF11976 0.379
LIG_SxIP_EBH_1 39 53 PF03271 0.486
LIG_TYR_ITIM 262 267 PF00017 0.330
LIG_WW_2 245 248 PF00397 0.337
MOD_CDC14_SPxK_1 281 284 PF00782 0.470
MOD_CDK_SPxK_1 278 284 PF00069 0.439
MOD_CK1_1 129 135 PF00069 0.741
MOD_CK1_1 152 158 PF00069 0.540
MOD_CK1_1 283 289 PF00069 0.641
MOD_CK1_1 290 296 PF00069 0.654
MOD_CK1_1 316 322 PF00069 0.444
MOD_CK1_1 476 482 PF00069 0.327
MOD_CK1_1 564 570 PF00069 0.600
MOD_CK1_1 672 678 PF00069 0.597
MOD_CK2_1 176 182 PF00069 0.518
MOD_CK2_1 218 224 PF00069 0.387
MOD_CK2_1 318 324 PF00069 0.499
MOD_CK2_1 5 11 PF00069 0.613
MOD_CK2_1 528 534 PF00069 0.279
MOD_CK2_1 582 588 PF00069 0.429
MOD_CK2_1 603 609 PF00069 0.443
MOD_CK2_1 98 104 PF00069 0.657
MOD_CMANNOS 555 558 PF00535 0.369
MOD_GlcNHglycan 129 132 PF01048 0.746
MOD_GlcNHglycan 151 154 PF01048 0.609
MOD_GlcNHglycan 19 23 PF01048 0.582
MOD_GlcNHglycan 290 293 PF01048 0.631
MOD_GlcNHglycan 31 34 PF01048 0.488
MOD_GlcNHglycan 316 319 PF01048 0.363
MOD_GlcNHglycan 327 330 PF01048 0.385
MOD_GlcNHglycan 463 466 PF01048 0.620
MOD_GlcNHglycan 569 572 PF01048 0.740
MOD_GlcNHglycan 605 608 PF01048 0.410
MOD_GlcNHglycan 671 674 PF01048 0.592
MOD_GlcNHglycan 90 93 PF01048 0.624
MOD_GSK3_1 125 132 PF00069 0.675
MOD_GSK3_1 133 140 PF00069 0.682
MOD_GSK3_1 144 151 PF00069 0.491
MOD_GSK3_1 166 173 PF00069 0.525
MOD_GSK3_1 18 25 PF00069 0.587
MOD_GSK3_1 256 263 PF00069 0.441
MOD_GSK3_1 283 290 PF00069 0.714
MOD_GSK3_1 314 321 PF00069 0.439
MOD_GSK3_1 38 45 PF00069 0.575
MOD_GSK3_1 473 480 PF00069 0.689
MOD_GSK3_1 599 606 PF00069 0.380
MOD_GSK3_1 625 632 PF00069 0.362
MOD_GSK3_1 668 675 PF00069 0.507
MOD_GSK3_1 82 89 PF00069 0.568
MOD_GSK3_1 94 101 PF00069 0.639
MOD_N-GLC_1 398 403 PF02516 0.279
MOD_N-GLC_1 611 616 PF02516 0.423
MOD_NEK2_1 398 403 PF00069 0.279
MOD_NEK2_1 668 673 PF00069 0.553
MOD_NEK2_1 70 75 PF00069 0.577
MOD_PIKK_1 144 150 PF00454 0.533
MOD_PIKK_1 176 182 PF00454 0.463
MOD_PIKK_1 582 588 PF00454 0.608
MOD_PIKK_1 629 635 PF00454 0.446
MOD_PK_1 190 196 PF00069 0.501
MOD_PK_1 82 88 PF00069 0.384
MOD_PKA_1 82 88 PF00069 0.469
MOD_PKA_2 137 143 PF00069 0.742
MOD_PKA_2 283 289 PF00069 0.582
MOD_PKA_2 325 331 PF00069 0.374
MOD_PKA_2 362 368 PF00069 0.489
MOD_PKA_2 371 377 PF00069 0.378
MOD_PKA_2 38 44 PF00069 0.517
MOD_PKA_2 461 467 PF00069 0.705
MOD_PKA_2 5 11 PF00069 0.587
MOD_PKA_2 542 548 PF00069 0.380
MOD_PKA_2 599 605 PF00069 0.483
MOD_PKA_2 70 76 PF00069 0.474
MOD_PKA_2 82 88 PF00069 0.581
MOD_PKB_1 370 378 PF00069 0.428
MOD_PKB_1 430 438 PF00069 0.279
MOD_PKB_1 458 466 PF00069 0.755
MOD_Plk_1 398 404 PF00069 0.279
MOD_Plk_1 582 588 PF00069 0.408
MOD_Plk_1 611 617 PF00069 0.417
MOD_Plk_4 155 161 PF00069 0.552
MOD_Plk_4 166 172 PF00069 0.389
MOD_Plk_4 22 28 PF00069 0.506
MOD_Plk_4 385 391 PF00069 0.279
MOD_Plk_4 398 404 PF00069 0.279
MOD_Plk_4 42 48 PF00069 0.609
MOD_Plk_4 432 438 PF00069 0.279
MOD_Plk_4 528 534 PF00069 0.279
MOD_Plk_4 542 548 PF00069 0.361
MOD_Plk_4 564 570 PF00069 0.668
MOD_Plk_4 612 618 PF00069 0.462
MOD_ProDKin_1 171 177 PF00069 0.407
MOD_ProDKin_1 218 224 PF00069 0.424
MOD_ProDKin_1 278 284 PF00069 0.512
MOD_ProDKin_1 285 291 PF00069 0.601
MOD_ProDKin_1 430 436 PF00069 0.318
MOD_ProDKin_1 98 104 PF00069 0.594
TRG_DiLeu_BaEn_1 104 109 PF01217 0.487
TRG_DiLeu_BaLyEn_6 491 496 PF01217 0.391
TRG_DiLeu_BaLyEn_6 518 523 PF01217 0.410
TRG_DiLeu_BaLyEn_6 65 70 PF01217 0.506
TRG_ENDOCYTIC_2 160 163 PF00928 0.507
TRG_ENDOCYTIC_2 168 171 PF00928 0.368
TRG_ENDOCYTIC_2 264 267 PF00928 0.367
TRG_ENDOCYTIC_2 366 369 PF00928 0.454
TRG_ENDOCYTIC_2 404 407 PF00928 0.279
TRG_ENDOCYTIC_2 425 428 PF00928 0.410
TRG_ER_diArg_1 208 211 PF00400 0.517
TRG_ER_diArg_1 226 228 PF00400 0.482
TRG_ER_diArg_1 325 327 PF00400 0.429
TRG_ER_diArg_1 360 363 PF00400 0.478
TRG_ER_diArg_1 366 368 PF00400 0.423
TRG_ER_diArg_1 369 372 PF00400 0.427
TRG_ER_diArg_1 420 422 PF00400 0.320
TRG_ER_diArg_1 458 460 PF00400 0.727
TRG_ER_diArg_1 547 549 PF00400 0.525
TRG_ER_diArg_1 599 601 PF00400 0.495
TRG_ER_diArg_1 66 68 PF00400 0.481
TRG_ER_diArg_1 661 663 PF00400 0.537
TRG_ER_diArg_1 70 72 PF00400 0.454
TRG_ER_diArg_1 81 83 PF00400 0.475
TRG_ER_diLys_1 692 696 PF00400 0.475
TRG_Pf-PMV_PEXEL_1 420 424 PF00026 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9Q8 Leptomonas seymouri 56% 98%
A0A1X0NZ99 Trypanosomatidae 43% 100%
A0A3Q8II41 Leishmania donovani 100% 90%
A0A422MTD5 Trypanosoma rangeli 42% 100%
A4HGJ8 Leishmania braziliensis 77% 100%
D0A856 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AZW6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q8C0 Leishmania major 93% 100%
V5BCT3 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS