Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3M4_LEIIN

TriTrypDb:

LINF_280020400

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.623
CLV_C14_Caspase3-7	159	163	PF00656	0.609
CLV_C14_Caspase3-7	723	727	PF00656	0.584
CLV_C14_Caspase3-7	732	736	PF00656	0.495
CLV_C14_Caspase3-7	79	83	PF00656	0.634
CLV_NRD_NRD_1	106	108	PF00675	0.562
CLV_NRD_NRD_1	211	213	PF00675	0.606
CLV_NRD_NRD_1	484	486	PF00675	0.498
CLV_NRD_NRD_1	495	497	PF00675	0.616
CLV_NRD_NRD_1	562	564	PF00675	0.548
CLV_NRD_NRD_1	73	75	PF00675	0.778
CLV_NRD_NRD_1	91	93	PF00675	0.531
CLV_PCSK_FUR_1	491	495	PF00082	0.572
CLV_PCSK_KEX2_1	106	108	PF00082	0.562
CLV_PCSK_KEX2_1	211	213	PF00082	0.606
CLV_PCSK_KEX2_1	484	486	PF00082	0.610
CLV_PCSK_KEX2_1	493	495	PF00082	0.550
CLV_PCSK_KEX2_1	564	566	PF00082	0.799
CLV_PCSK_KEX2_1	72	74	PF00082	0.777
CLV_PCSK_KEX2_1	91	93	PF00082	0.525
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.682
CLV_PCSK_PC7_1	207	213	PF00082	0.631
CLV_PCSK_PC7_1	491	497	PF00082	0.685
CLV_PCSK_SKI1_1	207	211	PF00082	0.713
CLV_PCSK_SKI1_1	519	523	PF00082	0.683
CLV_PCSK_SKI1_1	542	546	PF00082	0.502
CLV_PCSK_SKI1_1	651	655	PF00082	0.580
CLV_PCSK_SKI1_1	667	671	PF00082	0.641
DEG_APCC_DBOX_1	301	309	PF00400	0.599
DEG_APCC_DBOX_1	532	540	PF00400	0.621
DEG_APCC_DBOX_1	541	549	PF00400	0.507
DEG_COP1_1	568	577	PF00400	0.628
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DOC_CKS1_1	640	645	PF01111	0.638
DOC_MAPK_DCC_7	220	229	PF00069	0.613
DOC_MAPK_gen_1	289	298	PF00069	0.527
DOC_MAPK_gen_1	91	98	PF00069	0.654
DOC_MAPK_MEF2A_6	220	229	PF00069	0.685
DOC_MAPK_RevD_3	481	496	PF00069	0.567
DOC_PP1_RVXF_1	398	405	PF00149	0.422
DOC_PP2B_LxvP_1	588	591	PF13499	0.698
DOC_PP2B_LxvP_1	7	10	PF13499	0.598
DOC_PP2B_LxvP_1	739	742	PF13499	0.613
DOC_PP2B_PxIxI_1	717	723	PF00149	0.592
DOC_PP4_FxxP_1	640	643	PF00568	0.687
DOC_PP4_FxxP_1	690	693	PF00568	0.618
DOC_SPAK_OSR1_1	144	148	PF12202	0.581
DOC_USP7_MATH_1	17	21	PF00917	0.565
DOC_USP7_MATH_1	219	223	PF00917	0.691
DOC_USP7_MATH_1	329	333	PF00917	0.689
DOC_USP7_MATH_1	36	40	PF00917	0.542
DOC_USP7_MATH_1	408	412	PF00917	0.592
DOC_USP7_MATH_1	434	438	PF00917	0.479
DOC_USP7_MATH_1	448	452	PF00917	0.525
DOC_USP7_MATH_1	606	610	PF00917	0.576
DOC_USP7_MATH_1	665	669	PF00917	0.540
DOC_WW_Pin1_4	109	114	PF00397	0.606
DOC_WW_Pin1_4	11	16	PF00397	0.588
DOC_WW_Pin1_4	149	154	PF00397	0.641
DOC_WW_Pin1_4	190	195	PF00397	0.607
DOC_WW_Pin1_4	318	323	PF00397	0.640
DOC_WW_Pin1_4	512	517	PF00397	0.669
DOC_WW_Pin1_4	590	595	PF00397	0.695
DOC_WW_Pin1_4	602	607	PF00397	0.616
DOC_WW_Pin1_4	639	644	PF00397	0.685
DOC_WW_Pin1_4	689	694	PF00397	0.742
DOC_WW_Pin1_4	712	717	PF00397	0.646
LIG_14-3-3_CanoR_1	169	177	PF00244	0.613
LIG_14-3-3_CanoR_1	220	227	PF00244	0.606
LIG_14-3-3_CanoR_1	267	274	PF00244	0.560
LIG_14-3-3_CanoR_1	276	281	PF00244	0.535
LIG_14-3-3_CanoR_1	409	414	PF00244	0.622
LIG_14-3-3_CanoR_1	444	452	PF00244	0.546
LIG_14-3-3_CanoR_1	519	528	PF00244	0.701
LIG_14-3-3_CanoR_1	542	551	PF00244	0.591
LIG_14-3-3_CanoR_1	55	65	PF00244	0.654
LIG_14-3-3_CanoR_1	571	575	PF00244	0.582
LIG_14-3-3_CanoR_1	651	661	PF00244	0.632
LIG_14-3-3_CanoR_1	72	77	PF00244	0.623
LIG_14-3-3_CanoR_1	91	96	PF00244	0.606
LIG_Actin_WH2_2	399	416	PF00022	0.462
LIG_AP2alpha_1	461	465	PF02296	0.522
LIG_BIR_III_4	473	477	PF00653	0.481
LIG_BRCT_BRCA1_1	93	97	PF00533	0.654
LIG_Clathr_ClatBox_1	728	732	PF01394	0.475
LIG_EVH1_1	588	592	PF00568	0.616
LIG_FHA_1	150	156	PF00498	0.685
LIG_FHA_1	219	225	PF00498	0.716
LIG_FHA_1	396	402	PF00498	0.485
LIG_FHA_1	613	619	PF00498	0.611
LIG_FHA_1	85	91	PF00498	0.582
LIG_FHA_2	132	138	PF00498	0.602
LIG_FHA_2	495	501	PF00498	0.643
LIG_FHA_2	77	83	PF00498	0.810
LIG_GSK3_LRP6_1	590	596	PF00069	0.611
LIG_Integrin_RGD_1	622	624	PF01839	0.552
LIG_LIR_Apic_2	403	407	PF02991	0.482
LIG_LIR_Apic_2	576	580	PF02991	0.580
LIG_LIR_Apic_2	639	643	PF02991	0.683
LIG_LIR_Apic_2	689	693	PF02991	0.612
LIG_LIR_Gen_1	342	351	PF02991	0.433
LIG_LIR_Gen_1	593	601	PF02991	0.663
LIG_LIR_Nem_3	342	346	PF02991	0.430
LIG_LIR_Nem_3	462	468	PF02991	0.457
LIG_LIR_Nem_3	529	534	PF02991	0.549
LIG_LIR_Nem_3	593	598	PF02991	0.681
LIG_MYND_1	586	590	PF01753	0.646
LIG_Pex14_2	461	465	PF04695	0.522
LIG_Pex14_2	640	644	PF04695	0.639
LIG_SH2_STAP1	631	635	PF00017	0.610
LIG_SH2_STAT5	175	178	PF00017	0.608
LIG_SH2_STAT5	577	580	PF00017	0.647
LIG_SH2_STAT5	631	634	PF00017	0.679
LIG_SH3_1	622	628	PF00018	0.532
LIG_SH3_3	188	194	PF00018	0.713
LIG_SH3_3	316	322	PF00018	0.624
LIG_SH3_3	430	436	PF00018	0.476
LIG_SH3_3	583	589	PF00018	0.774
LIG_SH3_3	622	628	PF00018	0.592
LIG_SH3_3	7	13	PF00018	0.593
LIG_SUMO_SIM_anti_2	350	356	PF11976	0.436
LIG_SUMO_SIM_par_1	124	130	PF11976	0.632
LIG_SUMO_SIM_par_1	196	206	PF11976	0.634
LIG_SUMO_SIM_par_1	535	540	PF11976	0.528
LIG_SUMO_SIM_par_1	717	723	PF11976	0.520
LIG_SxIP_EBH_1	276	287	PF03271	0.549
LIG_TRAF2_1	44	47	PF00917	0.595
LIG_WRC_WIRS_1	128	133	PF05994	0.595
LIG_WW_1	9	12	PF00397	0.585
MOD_CDK_SPK_2	149	154	PF00069	0.641
MOD_CDK_SPxxK_3	512	519	PF00069	0.676
MOD_CK1_1	100	106	PF00069	0.654
MOD_CK1_1	133	139	PF00069	0.702
MOD_CK1_1	200	206	PF00069	0.624
MOD_CK1_1	213	219	PF00069	0.559
MOD_CK1_1	246	252	PF00069	0.607
MOD_CK1_1	347	353	PF00069	0.591
MOD_CK1_1	395	401	PF00069	0.434
MOD_CK1_1	554	560	PF00069	0.619
MOD_CK1_1	573	579	PF00069	0.588
MOD_CK1_1	593	599	PF00069	0.553
MOD_CK1_1	639	645	PF00069	0.678
MOD_CK1_1	689	695	PF00069	0.609
MOD_CK1_1	706	712	PF00069	0.579
MOD_CK1_1	83	89	PF00069	0.611
MOD_CK2_1	133	139	PF00069	0.551
MOD_CK2_1	29	35	PF00069	0.600
MOD_CK2_1	494	500	PF00069	0.655
MOD_CK2_1	593	599	PF00069	0.730
MOD_CK2_1	83	89	PF00069	0.616
MOD_GlcNHglycan	212	215	PF01048	0.690
MOD_GlcNHglycan	286	289	PF01048	0.584
MOD_GlcNHglycan	31	34	PF01048	0.600
MOD_GlcNHglycan	315	318	PF01048	0.655
MOD_GlcNHglycan	374	378	PF01048	0.480
MOD_GlcNHglycan	38	41	PF01048	0.567
MOD_GlcNHglycan	473	477	PF01048	0.481
MOD_GlcNHglycan	487	490	PF01048	0.657
MOD_GlcNHglycan	557	560	PF01048	0.650
MOD_GlcNHglycan	610	613	PF01048	0.566
MOD_GlcNHglycan	667	670	PF01048	0.553
MOD_GlcNHglycan	680	683	PF01048	0.553
MOD_GlcNHglycan	696	699	PF01048	0.502
MOD_GlcNHglycan	708	711	PF01048	0.574
MOD_GSK3_1	11	18	PF00069	0.592
MOD_GSK3_1	127	134	PF00069	0.656
MOD_GSK3_1	178	185	PF00069	0.687
MOD_GSK3_1	210	217	PF00069	0.699
MOD_GSK3_1	243	250	PF00069	0.655
MOD_GSK3_1	276	283	PF00069	0.638
MOD_GSK3_1	311	318	PF00069	0.615
MOD_GSK3_1	349	356	PF00069	0.428
MOD_GSK3_1	551	558	PF00069	0.557
MOD_GSK3_1	602	609	PF00069	0.572
MOD_GSK3_1	613	620	PF00069	0.571
MOD_GSK3_1	72	79	PF00069	0.682
MOD_GSK3_1	80	87	PF00069	0.611
MOD_LATS_1	309	315	PF00433	0.486
MOD_N-GLC_1	131	136	PF02516	0.560
MOD_N-GLC_1	56	61	PF02516	0.660
MOD_N-GLC_1	602	607	PF02516	0.519
MOD_N-GLC_2	334	336	PF02516	0.559
MOD_NEK2_1	21	26	PF00069	0.603
MOD_NEK2_1	210	215	PF00069	0.649
MOD_NEK2_1	315	320	PF00069	0.634
MOD_NEK2_1	330	335	PF00069	0.624
MOD_NEK2_1	461	466	PF00069	0.460
MOD_NEK2_1	551	556	PF00069	0.597
MOD_NEK2_1	63	68	PF00069	0.751
MOD_NEK2_1	670	675	PF00069	0.597
MOD_NEK2_1	76	81	PF00069	0.597
MOD_NEK2_2	156	161	PF00069	0.675
MOD_NEK2_2	301	306	PF00069	0.561
MOD_PIKK_1	76	82	PF00454	0.589
MOD_PK_1	276	282	PF00069	0.539
MOD_PK_1	91	97	PF00069	0.656
MOD_PKA_1	494	500	PF00069	0.587
MOD_PKA_1	72	78	PF00069	0.621
MOD_PKA_1	91	97	PF00069	0.555
MOD_PKA_2	210	216	PF00069	0.685
MOD_PKA_2	219	225	PF00069	0.656
MOD_PKA_2	246	252	PF00069	0.614
MOD_PKA_2	275	281	PF00069	0.588
MOD_PKA_2	29	35	PF00069	0.600
MOD_PKA_2	301	307	PF00069	0.606
MOD_PKA_2	408	414	PF00069	0.636
MOD_PKA_2	443	449	PF00069	0.525
MOD_PKA_2	494	500	PF00069	0.736
MOD_PKA_2	570	576	PF00069	0.578
MOD_PKA_2	63	69	PF00069	0.719
MOD_PKA_2	72	78	PF00069	0.659
MOD_PKA_2	91	97	PF00069	0.626
MOD_PKB_1	563	571	PF00069	0.554
MOD_Plk_1	203	209	PF00069	0.550
MOD_Plk_1	292	298	PF00069	0.548
MOD_Plk_1	422	428	PF00069	0.520
MOD_Plk_1	461	467	PF00069	0.436
MOD_Plk_1	551	557	PF00069	0.498
MOD_Plk_4	17	23	PF00069	0.565
MOD_Plk_4	276	282	PF00069	0.598
MOD_Plk_4	292	298	PF00069	0.565
MOD_Plk_4	349	355	PF00069	0.427
MOD_Plk_4	387	393	PF00069	0.432
MOD_Plk_4	434	440	PF00069	0.463
MOD_Plk_4	573	579	PF00069	0.635
MOD_Plk_4	613	619	PF00069	0.611
MOD_Plk_4	91	97	PF00069	0.656
MOD_ProDKin_1	109	115	PF00069	0.606
MOD_ProDKin_1	11	17	PF00069	0.588
MOD_ProDKin_1	149	155	PF00069	0.639
MOD_ProDKin_1	190	196	PF00069	0.607
MOD_ProDKin_1	318	324	PF00069	0.641
MOD_ProDKin_1	512	518	PF00069	0.670
MOD_ProDKin_1	590	596	PF00069	0.685
MOD_ProDKin_1	602	608	PF00069	0.614
MOD_ProDKin_1	639	645	PF00069	0.685
MOD_ProDKin_1	689	695	PF00069	0.742
MOD_ProDKin_1	712	718	PF00069	0.641
TRG_DiLeu_BaEn_1	293	298	PF01217	0.541
TRG_DiLeu_BaLyEn_6	715	720	PF01217	0.548
TRG_ER_diArg_1	210	212	PF00400	0.599
TRG_ER_diArg_1	483	485	PF00400	0.553
TRG_ER_diArg_1	491	494	PF00400	0.562
TRG_ER_diArg_1	495	498	PF00400	0.472
TRG_ER_diArg_1	562	565	PF00400	0.549
TRG_ER_diArg_1	585	588	PF00400	0.647
TRG_ER_diArg_1	648	651	PF00400	0.674
TRG_ER_diArg_1	72	74	PF00400	0.626
TRG_ER_diArg_1	90	92	PF00400	0.575
TRG_NLS_MonoExtC_3	562	567	PF00514	0.548
TRG_NLS_MonoExtN_4	563	568	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I813	Leptomonas seymouri	41%	100%
A0A3Q8ID48	Leishmania donovani	99%	100%
A4HGJ7	Leishmania braziliensis	74%	99%
E9AZW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8C1	Leishmania major	91%	100%