Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3M3_LEIIN

TriTrypDb:

LINF_280020300

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.487
CLV_C14_Caspase3-7	209	213	PF00656	0.554
CLV_C14_Caspase3-7	640	644	PF00656	0.553
CLV_NRD_NRD_1	18	20	PF00675	0.643
CLV_NRD_NRD_1	244	246	PF00675	0.388
CLV_NRD_NRD_1	26	28	PF00675	0.582
CLV_NRD_NRD_1	276	278	PF00675	0.412
CLV_NRD_NRD_1	326	328	PF00675	0.505
CLV_NRD_NRD_1	37	39	PF00675	0.538
CLV_NRD_NRD_1	545	547	PF00675	0.624
CLV_NRD_NRD_1	695	697	PF00675	0.606
CLV_NRD_NRD_1	713	715	PF00675	0.678
CLV_NRD_NRD_1	95	97	PF00675	0.668
CLV_PCSK_KEX2_1	18	20	PF00082	0.643
CLV_PCSK_KEX2_1	181	183	PF00082	0.455
CLV_PCSK_KEX2_1	244	246	PF00082	0.457
CLV_PCSK_KEX2_1	26	28	PF00082	0.582
CLV_PCSK_KEX2_1	276	278	PF00082	0.412
CLV_PCSK_KEX2_1	292	294	PF00082	0.484
CLV_PCSK_KEX2_1	326	328	PF00082	0.505
CLV_PCSK_KEX2_1	42	44	PF00082	0.662
CLV_PCSK_KEX2_1	468	470	PF00082	0.388
CLV_PCSK_KEX2_1	683	685	PF00082	0.429
CLV_PCSK_KEX2_1	695	697	PF00082	0.558
CLV_PCSK_KEX2_1	713	715	PF00082	0.660
CLV_PCSK_KEX2_1	95	97	PF00082	0.668
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.486
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.509
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.662
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.388
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.412
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.668
CLV_PCSK_PC7_1	38	44	PF00082	0.637
CLV_PCSK_SKI1_1	19	23	PF00082	0.641
CLV_PCSK_SKI1_1	327	331	PF00082	0.498
CLV_PCSK_SKI1_1	39	43	PF00082	0.637
CLV_PCSK_SKI1_1	425	429	PF00082	0.457
CLV_PCSK_SKI1_1	469	473	PF00082	0.479
CLV_PCSK_SKI1_1	588	592	PF00082	0.462
CLV_PCSK_SKI1_1	649	653	PF00082	0.433
CLV_PCSK_SKI1_1	683	687	PF00082	0.586
CLV_PCSK_SKI1_1	697	701	PF00082	0.489
CLV_PCSK_SKI1_1	96	100	PF00082	0.644
DEG_APCC_DBOX_1	600	608	PF00400	0.464
DEG_COP1_1	135	143	PF00400	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.666
DEG_ODPH_VHL_1	512	525	PF01847	0.485
DEG_SPOP_SBC_1	216	220	PF00917	0.611
DEG_SPOP_SBC_1	353	357	PF00917	0.627
DOC_CKS1_1	311	316	PF01111	0.512
DOC_CKS1_1	444	449	PF01111	0.426
DOC_CYCLIN_RxL_1	160	173	PF00134	0.391
DOC_MAPK_DCC_7	409	417	PF00069	0.412
DOC_MAPK_DCC_7	509	517	PF00069	0.431
DOC_MAPK_gen_1	3	13	PF00069	0.619
DOC_MAPK_gen_1	646	655	PF00069	0.419
DOC_MAPK_MEF2A_6	409	417	PF00069	0.450
DOC_MAPK_MEF2A_6	6	15	PF00069	0.625
DOC_MAPK_MEF2A_6	646	655	PF00069	0.419
DOC_PP1_RVXF_1	163	170	PF00149	0.394
DOC_PP1_RVXF_1	675	681	PF00149	0.482
DOC_PP2B_LxvP_1	13	16	PF13499	0.613
DOC_PP2B_LxvP_1	138	141	PF13499	0.487
DOC_PP2B_LxvP_1	502	505	PF13499	0.508
DOC_PP4_MxPP_1	663	666	PF00568	0.387
DOC_USP7_MATH_1	132	136	PF00917	0.439
DOC_USP7_MATH_1	196	200	PF00917	0.445
DOC_USP7_MATH_1	216	220	PF00917	0.660
DOC_USP7_MATH_1	304	308	PF00917	0.529
DOC_USP7_MATH_1	335	339	PF00917	0.549
DOC_USP7_MATH_1	413	417	PF00917	0.464
DOC_USP7_MATH_1	536	540	PF00917	0.471
DOC_USP7_MATH_1	57	61	PF00917	0.637
DOC_USP7_MATH_1	577	581	PF00917	0.462
DOC_WW_Pin1_4	310	315	PF00397	0.450
DOC_WW_Pin1_4	371	376	PF00397	0.401
DOC_WW_Pin1_4	443	448	PF00397	0.362
DOC_WW_Pin1_4	707	712	PF00397	0.637
LIG_14-3-3_CanoR_1	192	196	PF00244	0.527
LIG_14-3-3_CanoR_1	276	286	PF00244	0.404
LIG_14-3-3_CanoR_1	422	428	PF00244	0.423
LIG_14-3-3_CanoR_1	563	570	PF00244	0.435
LIG_14-3-3_CanoR_1	596	600	PF00244	0.450
LIG_14-3-3_CanoR_1	6	12	PF00244	0.626
LIG_14-3-3_CanoR_1	649	654	PF00244	0.430
LIG_Actin_WH2_2	495	511	PF00022	0.423
LIG_BIR_III_4	212	216	PF00653	0.647
LIG_BRCT_BRCA1_1	105	109	PF00533	0.634
LIG_BRCT_BRCA1_1	198	202	PF00533	0.420
LIG_BRCT_BRCA1_1	429	433	PF00533	0.520
LIG_BRCT_BRCA1_1	79	83	PF00533	0.595
LIG_CtBP_PxDLS_1	505	509	PF00389	0.513
LIG_eIF4E_1	466	472	PF01652	0.482
LIG_FHA_1	143	149	PF00498	0.468
LIG_FHA_1	360	366	PF00498	0.483
LIG_FHA_1	371	377	PF00498	0.397
LIG_FHA_1	454	460	PF00498	0.388
LIG_FHA_1	585	591	PF00498	0.449
LIG_FHA_1	650	656	PF00498	0.362
LIG_FHA_1	72	78	PF00498	0.536
LIG_FHA_1	8	14	PF00498	0.618
LIG_FHA_2	151	157	PF00498	0.506
LIG_FHA_2	184	190	PF00498	0.487
LIG_FHA_2	311	317	PF00498	0.455
LIG_FHA_2	459	465	PF00498	0.303
LIG_FHA_2	613	619	PF00498	0.614
LIG_FHA_2	97	103	PF00498	0.628
LIG_LIR_Apic_2	142	147	PF02991	0.485
LIG_LIR_Gen_1	199	210	PF02991	0.424
LIG_LIR_Gen_1	446	457	PF02991	0.352
LIG_LIR_Gen_1	647	658	PF02991	0.391
LIG_LIR_Nem_3	106	112	PF02991	0.625
LIG_LIR_Nem_3	199	205	PF02991	0.377
LIG_LIR_Nem_3	263	268	PF02991	0.381
LIG_LIR_Nem_3	446	452	PF02991	0.351
LIG_LIR_Nem_3	456	460	PF02991	0.352
LIG_LIR_Nem_3	467	473	PF02991	0.345
LIG_LIR_Nem_3	591	595	PF02991	0.505
LIG_LIR_Nem_3	647	653	PF02991	0.402
LIG_MLH1_MIPbox_1	198	202	PF16413	0.420
LIG_PCNA_PIPBox_1	578	587	PF02747	0.366
LIG_PDZ_Class_2	720	725	PF00595	0.572
LIG_Pex14_2	433	437	PF04695	0.461
LIG_Pex14_2	445	449	PF04695	0.291
LIG_SH2_CRK	144	148	PF00017	0.479
LIG_SH2_CRK	592	596	PF00017	0.445
LIG_SH2_NCK_1	485	489	PF00017	0.405
LIG_SH2_PTP2	650	653	PF00017	0.404
LIG_SH2_STAP1	265	269	PF00017	0.450
LIG_SH2_STAP1	466	470	PF00017	0.442
LIG_SH2_STAP1	485	489	PF00017	0.217
LIG_SH2_STAP1	84	88	PF00017	0.619
LIG_SH2_STAT3	64	67	PF00017	0.656
LIG_SH2_STAT5	125	128	PF00017	0.510
LIG_SH2_STAT5	144	147	PF00017	0.303
LIG_SH2_STAT5	178	181	PF00017	0.567
LIG_SH2_STAT5	201	204	PF00017	0.356
LIG_SH2_STAT5	246	249	PF00017	0.554
LIG_SH2_STAT5	268	271	PF00017	0.557
LIG_SH2_STAT5	470	473	PF00017	0.395
LIG_SH2_STAT5	474	477	PF00017	0.403
LIG_SH2_STAT5	493	496	PF00017	0.293
LIG_SH2_STAT5	586	589	PF00017	0.429
LIG_SH2_STAT5	650	653	PF00017	0.427
LIG_SH2_STAT5	679	682	PF00017	0.478
LIG_SH3_3	308	314	PF00018	0.642
LIG_SH3_3	441	447	PF00018	0.380
LIG_SH3_3	594	600	PF00018	0.395
LIG_SH3_3	60	66	PF00018	0.661
LIG_SH3_3	659	665	PF00018	0.581
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.452
LIG_SUMO_SIM_par_1	135	142	PF11976	0.487
LIG_SUMO_SIM_par_1	413	419	PF11976	0.391
LIG_SUMO_SIM_par_1	665	671	PF11976	0.551
LIG_SUMO_SIM_par_1	9	14	PF11976	0.622
LIG_TRAF2_1	615	618	PF00917	0.485
LIG_TYR_ITIM	590	595	PF00017	0.488
LIG_UBA3_1	541	548	PF00899	0.578
LIG_WRC_WIRS_1	417	422	PF05994	0.468
LIG_WW_3	333	337	PF00397	0.524
MOD_CDC14_SPxK_1	710	713	PF00782	0.634
MOD_CDK_SPxK_1	707	713	PF00069	0.636
MOD_CDK_SPxxK_3	707	714	PF00069	0.635
MOD_CK1_1	218	224	PF00069	0.565
MOD_CK1_1	361	367	PF00069	0.452
MOD_CK1_1	37	43	PF00069	0.628
MOD_CK1_1	416	422	PF00069	0.374
MOD_CK1_1	477	483	PF00069	0.357
MOD_CK2_1	150	156	PF00069	0.464
MOD_CK2_1	302	308	PF00069	0.559
MOD_CK2_1	310	316	PF00069	0.466
MOD_CK2_1	612	618	PF00069	0.502
MOD_Cter_Amidation	711	714	PF01082	0.685
MOD_GlcNHglycan	206	209	PF01048	0.585
MOD_GlcNHglycan	337	340	PF01048	0.817
MOD_GlcNHglycan	39	42	PF01048	0.754
MOD_GlcNHglycan	409	412	PF01048	0.517
MOD_GlcNHglycan	592	595	PF01048	0.368
MOD_GlcNHglycan	646	649	PF01048	0.535
MOD_GSK3_1	260	267	PF00069	0.402
MOD_GSK3_1	354	361	PF00069	0.613
MOD_GSK3_1	423	430	PF00069	0.466
MOD_GSK3_1	433	440	PF00069	0.327
MOD_GSK3_1	517	524	PF00069	0.411
MOD_GSK3_1	584	591	PF00069	0.436
MOD_GSK3_1	7	14	PF00069	0.721
MOD_N-GLC_1	272	277	PF02516	0.399
MOD_N-GLC_2	552	554	PF02516	0.499
MOD_NEK2_1	191	196	PF00069	0.470
MOD_NEK2_1	204	209	PF00069	0.387
MOD_NEK2_1	22	27	PF00069	0.630
MOD_NEK2_1	272	277	PF00069	0.418
MOD_NEK2_1	31	36	PF00069	0.631
MOD_NEK2_1	433	438	PF00069	0.460
MOD_NEK2_1	453	458	PF00069	0.231
MOD_NEK2_1	508	513	PF00069	0.404
MOD_NEK2_1	517	522	PF00069	0.389
MOD_NEK2_1	590	595	PF00069	0.385
MOD_NEK2_1	656	661	PF00069	0.456
MOD_NEK2_1	678	683	PF00069	0.478
MOD_NEK2_1	83	88	PF00069	0.733
MOD_NEK2_2	196	201	PF00069	0.439
MOD_NEK2_2	413	418	PF00069	0.394
MOD_NEK2_2	577	582	PF00069	0.458
MOD_PIKK_1	277	283	PF00454	0.399
MOD_PIKK_1	55	61	PF00454	0.748
MOD_PIKK_1	554	560	PF00454	0.497
MOD_PKA_1	96	102	PF00069	0.634
MOD_PKA_2	191	197	PF00069	0.552
MOD_PKA_2	335	341	PF00069	0.663
MOD_PKA_2	37	43	PF00069	0.709
MOD_PKA_2	477	483	PF00069	0.429
MOD_PKA_2	508	514	PF00069	0.453
MOD_PKA_2	521	527	PF00069	0.417
MOD_PKA_2	562	568	PF00069	0.449
MOD_PKA_2	595	601	PF00069	0.387
MOD_PKA_2	7	13	PF00069	0.576
MOD_Plk_1	260	266	PF00069	0.399
MOD_Plk_1	277	283	PF00069	0.409
MOD_Plk_1	77	83	PF00069	0.582
MOD_Plk_1	84	90	PF00069	0.553
MOD_Plk_4	103	109	PF00069	0.607
MOD_Plk_4	196	202	PF00069	0.364
MOD_Plk_4	264	270	PF00069	0.445
MOD_Plk_4	498	504	PF00069	0.488
MOD_Plk_4	718	724	PF00069	0.648
MOD_Plk_4	78	84	PF00069	0.605
MOD_ProDKin_1	310	316	PF00069	0.450
MOD_ProDKin_1	371	377	PF00069	0.399
MOD_ProDKin_1	443	449	PF00069	0.356
MOD_ProDKin_1	707	713	PF00069	0.636
MOD_SUMO_for_1	117	120	PF00179	0.501
MOD_SUMO_for_1	41	44	PF00179	0.688
MOD_SUMO_rev_2	225	235	PF00179	0.472
MOD_SUMO_rev_2	702	710	PF00179	0.548
TRG_DiLeu_BaEn_1	467	472	PF01217	0.494
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.447
TRG_ENDOCYTIC_2	125	128	PF00928	0.521
TRG_ENDOCYTIC_2	171	174	PF00928	0.411
TRG_ENDOCYTIC_2	201	204	PF00928	0.356
TRG_ENDOCYTIC_2	268	271	PF00928	0.389
TRG_ENDOCYTIC_2	473	476	PF00928	0.462
TRG_ENDOCYTIC_2	592	595	PF00928	0.468
TRG_ENDOCYTIC_2	650	653	PF00928	0.427
TRG_ER_diArg_1	243	245	PF00400	0.382
TRG_ER_diArg_1	325	327	PF00400	0.490
TRG_ER_diArg_1	635	638	PF00400	0.466
TRG_ER_diArg_1	694	696	PF00400	0.518
TRG_NLS_MonoExtC_3	545	550	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D3	Leptomonas seymouri	34%	86%
A0A3S5H7J3	Leishmania donovani	100%	100%
A4HGJ6	Leishmania braziliensis	78%	99%
E9AZW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8C2	Leishmania major	92%	100%