Putative DNA polymerase kappa

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase kappa - putative

Species:

Leishmania infantum

UniProt:

A4I3M2_LEIIN

TriTrypDb:

LINF_280020200

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4I3M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006259	DNA metabolic process	4	13
GO:0006281	DNA repair	5	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0006950	response to stress	2	13
GO:0006974	DNA damage response	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0033554	cellular response to stress	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0050896	response to stimulus	1	13
GO:0051716	cellular response to stimulus	2	13
GO:0071704	organic substance metabolic process	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13
GO:0000731	DNA synthesis involved in DNA repair	6	2
GO:0006301	postreplication repair	6	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019985	translesion synthesis	7	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0042276	error-prone translesion synthesis	8	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071897	DNA biosynthetic process	5	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:0006260	DNA replication	5	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0003887	DNA-directed DNA polymerase activity	5	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0034061	DNA polymerase activity	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.238
CLV_NRD_NRD_1	276	278	PF00675	0.459
CLV_NRD_NRD_1	60	62	PF00675	0.326
CLV_PCSK_FUR_1	58	62	PF00082	0.161
CLV_PCSK_KEX2_1	109	111	PF00082	0.238
CLV_PCSK_KEX2_1	60	62	PF00082	0.348
CLV_PCSK_SKI1_1	186	190	PF00082	0.487
CLV_PCSK_SKI1_1	297	301	PF00082	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.429
DOC_MAPK_gen_1	359	368	PF00069	0.460
DOC_MAPK_MEF2A_6	164	171	PF00069	0.460
DOC_MAPK_MEF2A_6	361	370	PF00069	0.414
DOC_PP1_RVXF_1	313	320	PF00149	0.386
DOC_USP7_MATH_1	118	122	PF00917	0.371
DOC_USP7_MATH_1	20	24	PF00917	0.410
DOC_USP7_MATH_1	258	262	PF00917	0.451
DOC_USP7_MATH_1	272	276	PF00917	0.451
DOC_USP7_MATH_1	325	329	PF00917	0.306
DOC_USP7_MATH_1	338	342	PF00917	0.235
DOC_USP7_UBL2_3	274	278	PF12436	0.614
DOC_WW_Pin1_4	124	129	PF00397	0.371
DOC_WW_Pin1_4	254	259	PF00397	0.437
DOC_WW_Pin1_4	34	39	PF00397	0.371
DOC_WW_Pin1_4	398	403	PF00397	0.479
LIG_14-3-3_CanoR_1	277	283	PF00244	0.413
LIG_14-3-3_CanoR_1	297	306	PF00244	0.283
LIG_Actin_WH2_2	248	266	PF00022	0.418
LIG_BRCT_BRCA1_1	322	326	PF00533	0.306
LIG_FHA_1	312	318	PF00498	0.434
LIG_FHA_1	84	90	PF00498	0.462
LIG_FHA_2	148	154	PF00498	0.426
LIG_FHA_2	182	188	PF00498	0.400
LIG_FHA_2	93	99	PF00498	0.393
LIG_LIR_Apic_2	48	53	PF02991	0.429
LIG_LIR_Gen_1	127	137	PF02991	0.438
LIG_LIR_Gen_1	339	349	PF02991	0.307
LIG_LIR_Gen_1	74	85	PF02991	0.460
LIG_LIR_Nem_3	127	133	PF02991	0.438
LIG_LIR_Nem_3	201	207	PF02991	0.306
LIG_LIR_Nem_3	290	296	PF02991	0.465
LIG_LIR_Nem_3	339	345	PF02991	0.288
LIG_LIR_Nem_3	362	366	PF02991	0.373
LIG_LIR_Nem_3	74	80	PF02991	0.577
LIG_NRP_CendR_1	406	409	PF00754	0.494
LIG_OCRL_FandH_1	355	367	PF00620	0.270
LIG_Rb_pABgroove_1	67	75	PF01858	0.410
LIG_SH2_NCK_1	24	28	PF00017	0.361
LIG_SH2_NCK_1	3	7	PF00017	0.502
LIG_SH2_PTP2	77	80	PF00017	0.429
LIG_SH2_SRC	73	76	PF00017	0.445
LIG_SH2_STAT5	197	200	PF00017	0.408
LIG_SH2_STAT5	207	210	PF00017	0.289
LIG_SH2_STAT5	320	323	PF00017	0.511
LIG_SH2_STAT5	77	80	PF00017	0.541
LIG_SH2_STAT5	92	95	PF00017	0.481
LIG_SH3_3	134	140	PF00018	0.653
LIG_SH3_3	226	232	PF00018	0.377
LIG_SH3_3	349	355	PF00018	0.298
LIG_SH3_4	139	146	PF00018	0.416
LIG_SUMO_SIM_par_1	144	150	PF11976	0.389
LIG_TRAF2_1	150	153	PF00917	0.490
LIG_TRAF2_1	5	8	PF00917	0.563
MOD_CK1_1	23	29	PF00069	0.401
MOD_CK1_1	249	255	PF00069	0.388
MOD_CK1_1	336	342	PF00069	0.320
MOD_CK1_1	398	404	PF00069	0.617
MOD_CK1_1	48	54	PF00069	0.361
MOD_CK2_1	10	16	PF00069	0.438
MOD_CK2_1	147	153	PF00069	0.494
MOD_CK2_1	219	225	PF00069	0.572
MOD_Cter_Amidation	380	383	PF01082	0.490
MOD_GlcNHglycan	120	123	PF01048	0.262
MOD_GlcNHglycan	233	236	PF01048	0.593
MOD_GlcNHglycan	242	245	PF01048	0.414
MOD_GlcNHglycan	260	263	PF01048	0.440
MOD_GlcNHglycan	34	37	PF01048	0.296
MOD_GlcNHglycan	391	394	PF01048	0.610
MOD_GlcNHglycan	98	102	PF01048	0.350
MOD_GSK3_1	227	234	PF00069	0.556
MOD_GSK3_1	254	261	PF00069	0.468
MOD_GSK3_1	273	280	PF00069	0.393
MOD_GSK3_1	398	405	PF00069	0.620
MOD_GSK3_1	83	90	PF00069	0.462
MOD_LATS_1	295	301	PF00433	0.237
MOD_N-GLC_1	219	224	PF02516	0.405
MOD_NEK2_1	206	211	PF00069	0.299
MOD_NEK2_1	319	324	PF00069	0.518
MOD_NEK2_1	32	37	PF00069	0.451
MOD_NEK2_2	181	186	PF00069	0.531
MOD_PIKK_1	113	119	PF00454	0.462
MOD_PIKK_1	297	303	PF00454	0.248
MOD_PIKK_1	395	401	PF00454	0.479
MOD_PKA_1	277	283	PF00069	0.385
MOD_PKA_2	249	255	PF00069	0.418
MOD_Plk_1	200	206	PF00069	0.447
MOD_Plk_1	83	89	PF00069	0.474
MOD_Plk_2-3	83	89	PF00069	0.460
MOD_Plk_4	45	51	PF00069	0.445
MOD_ProDKin_1	124	130	PF00069	0.371
MOD_ProDKin_1	254	260	PF00069	0.442
MOD_ProDKin_1	34	40	PF00069	0.371
MOD_ProDKin_1	398	404	PF00069	0.480
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.451
TRG_ENDOCYTIC_2	207	210	PF00928	0.459
TRG_ENDOCYTIC_2	3	6	PF00928	0.517
TRG_ENDOCYTIC_2	346	349	PF00928	0.380
TRG_ENDOCYTIC_2	77	80	PF00928	0.429
TRG_ER_diArg_1	108	111	PF00400	0.407
TRG_ER_diArg_1	148	151	PF00400	0.387
TRG_ER_diArg_1	58	61	PF00400	0.524
TRG_NES_CRM1_1	153	165	PF08389	0.372
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYM2	Trypanosomatidae	36%	67%
A0A1X0NZ35	Trypanosomatidae	38%	80%
A0A3R7KKS0	Trypanosoma rangeli	37%	98%
A0A3S7X1H5	Leishmania donovani	94%	76%
A0A3S7X1J7	Leishmania donovani	39%	68%
A0A422MU96	Trypanosoma rangeli	39%	100%
A0AK80	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	24%	100%
A1KUQ3	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	30%	100%
A4I3M1	Leishmania infantum	39%	68%
A5IH02	Legionella pneumophila (strain Corby)	33%	100%
A5VZT3	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	31%	100%
A9MY13	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	32%	100%
B2UKN1	Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)	26%	100%
B8DBV7	Listeria monocytogenes serotype 4a (strain HCC23)	24%	100%
C1KWR9	Listeria monocytogenes serotype 4b (strain CLIP80459)	25%	100%
D0A846	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	72%
D0A851	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	72%
D0A852	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	72%
E9AZW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	68%
E9AZW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P34409	Caenorhabditis elegans	29%	69%
P63989	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P63990	Salmonella typhi	32%	100%
Q4Q8C3	Leishmania major	82%	100%
Q4Q8C4	Leishmania major	39%	68%
Q57SU1	Salmonella choleraesuis (strain SC-B67)	32%	100%
Q5PF76	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	32%	100%
Q5WYY8	Legionella pneumophila (strain Lens)	33%	100%
Q5X7J1	Legionella pneumophila (strain Paris)	33%	100%
Q5ZY20	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	33%	100%
Q71Y46	Listeria monocytogenes serotype 4b (strain F2365)	25%	100%
Q88NK4	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	30%	100%
Q8Y5T0	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	25%	100%
Q92A40	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	24%	100%
Q98LV1	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	24%	93%
Q9JRG1	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	30%	100%
Q9JYS8	Neisseria meningitidis serogroup B (strain MC58)	30%	100%