LeishMANIAdb
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Putative DNA polymerase kappa

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative DNA polymerase kappa
Gene product:
DNA polymerase kappa - putative
Species:
Leishmania infantum
UniProt:
A4I3M0_LEIIN
TriTrypDb:
LINF_280020000
Length:
753

Annotations

Annotations by Jardim et al.

Polymerase, DNA polymerase kappa

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4I3M0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3M0

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 13
GO:0006259 DNA metabolic process 4 13
GO:0006281 DNA repair 5 13
GO:0006725 cellular aromatic compound metabolic process 3 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0006950 response to stress 2 13
GO:0006974 DNA damage response 4 13
GO:0008152 metabolic process 1 13
GO:0009987 cellular process 1 13
GO:0033554 cellular response to stress 3 13
GO:0034641 cellular nitrogen compound metabolic process 3 13
GO:0043170 macromolecule metabolic process 3 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044260 obsolete cellular macromolecule metabolic process 3 13
GO:0046483 heterocycle metabolic process 3 13
GO:0050896 response to stimulus 1 13
GO:0051716 cellular response to stimulus 2 13
GO:0071704 organic substance metabolic process 2 13
GO:0090304 nucleic acid metabolic process 4 13
GO:1901360 organic cyclic compound metabolic process 3 13
GO:0000731 DNA synthesis involved in DNA repair 6 2
GO:0006301 postreplication repair 6 2
GO:0009058 biosynthetic process 2 2
GO:0009059 macromolecule biosynthetic process 4 2
GO:0018130 heterocycle biosynthetic process 4 2
GO:0019438 aromatic compound biosynthetic process 4 2
GO:0019985 translesion synthesis 7 2
GO:0034654 nucleobase-containing compound biosynthetic process 4 2
GO:0042276 error-prone translesion synthesis 8 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044271 cellular nitrogen compound biosynthetic process 4 2
GO:0071897 DNA biosynthetic process 5 2
GO:1901362 organic cyclic compound biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
GO:0006260 DNA replication 5 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 13
GO:0003677 DNA binding 4 13
GO:0003684 damaged DNA binding 5 13
GO:0003824 catalytic activity 1 13
GO:0003887 DNA-directed DNA polymerase activity 5 13
GO:0005488 binding 1 13
GO:0016740 transferase activity 2 13
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 13
GO:0016779 nucleotidyltransferase activity 4 13
GO:0034061 DNA polymerase activity 4 13
GO:0097159 organic cyclic compound binding 2 13
GO:0140097 catalytic activity, acting on DNA 3 13
GO:0140640 catalytic activity, acting on a nucleic acid 2 13
GO:1901363 heterocyclic compound binding 2 13
GO:0043167 ion binding 2 2
GO:0043169 cation binding 3 2
GO:0046872 metal ion binding 4 2
GO:0016491 oxidoreductase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 676 680 PF00656 0.656
CLV_MEL_PAP_1 272 278 PF00089 0.154
CLV_NRD_NRD_1 147 149 PF00675 0.386
CLV_NRD_NRD_1 178 180 PF00675 0.439
CLV_NRD_NRD_1 274 276 PF00675 0.215
CLV_NRD_NRD_1 31 33 PF00675 0.558
CLV_NRD_NRD_1 364 366 PF00675 0.373
CLV_NRD_NRD_1 454 456 PF00675 0.385
CLV_NRD_NRD_1 504 506 PF00675 0.265
CLV_NRD_NRD_1 532 534 PF00675 0.326
CLV_NRD_NRD_1 577 579 PF00675 0.278
CLV_NRD_NRD_1 606 608 PF00675 0.242
CLV_NRD_NRD_1 651 653 PF00675 0.664
CLV_NRD_NRD_1 662 664 PF00675 0.661
CLV_PCSK_KEX2_1 274 276 PF00082 0.154
CLV_PCSK_KEX2_1 31 33 PF00082 0.559
CLV_PCSK_KEX2_1 363 365 PF00082 0.365
CLV_PCSK_KEX2_1 532 534 PF00082 0.342
CLV_PCSK_KEX2_1 577 579 PF00082 0.278
CLV_PCSK_KEX2_1 605 607 PF00082 0.242
CLV_PCSK_KEX2_1 650 652 PF00082 0.562
CLV_PCSK_KEX2_1 664 666 PF00082 0.638
CLV_PCSK_PC1ET2_1 664 666 PF00082 0.744
CLV_PCSK_SKI1_1 23 27 PF00082 0.532
CLV_PCSK_SKI1_1 32 36 PF00082 0.527
CLV_PCSK_SKI1_1 520 524 PF00082 0.250
CLV_PCSK_SKI1_1 577 581 PF00082 0.242
CLV_Separin_Metazoa 574 578 PF03568 0.442
DEG_APCC_DBOX_1 22 30 PF00400 0.498
DEG_APCC_DBOX_1 445 453 PF00400 0.317
DEG_APCC_DBOX_1 519 527 PF00400 0.471
DEG_APCC_DBOX_1 576 584 PF00400 0.442
DEG_SCF_FBW7_1 54 61 PF00400 0.563
DEG_SCF_FBW7_1 62 69 PF00400 0.525
DEG_SPOP_SBC_1 478 482 PF00917 0.544
DEG_SPOP_SBC_1 711 715 PF00917 0.558
DOC_ANK_TNKS_1 664 671 PF00023 0.555
DOC_CKS1_1 55 60 PF01111 0.574
DOC_CKS1_1 63 68 PF01111 0.549
DOC_MAPK_gen_1 184 193 PF00069 0.434
DOC_MAPK_MEF2A_6 227 236 PF00069 0.354
DOC_MAPK_MEF2A_6 289 296 PF00069 0.441
DOC_MIT_MIM_1 594 606 PF04212 0.436
DOC_PP1_RVXF_1 139 146 PF00149 0.512
DOC_PP2B_LxvP_1 583 586 PF13499 0.436
DOC_PP4_FxxP_1 126 129 PF00568 0.491
DOC_SPAK_OSR1_1 275 279 PF12202 0.354
DOC_SPAK_OSR1_1 351 355 PF12202 0.442
DOC_USP7_MATH_1 102 106 PF00917 0.703
DOC_USP7_MATH_1 119 123 PF00917 0.637
DOC_USP7_MATH_1 477 481 PF00917 0.624
DOC_USP7_MATH_1 710 714 PF00917 0.740
DOC_USP7_UBL2_3 165 169 PF12436 0.425
DOC_USP7_UBL2_3 560 564 PF12436 0.442
DOC_WW_Pin1_4 10 15 PF00397 0.700
DOC_WW_Pin1_4 378 383 PF00397 0.436
DOC_WW_Pin1_4 38 43 PF00397 0.641
DOC_WW_Pin1_4 46 51 PF00397 0.649
DOC_WW_Pin1_4 54 59 PF00397 0.523
DOC_WW_Pin1_4 62 67 PF00397 0.568
DOC_WW_Pin1_4 70 75 PF00397 0.680
DOC_WW_Pin1_4 715 720 PF00397 0.636
LIG_14-3-3_CanoR_1 110 119 PF00244 0.571
LIG_14-3-3_CanoR_1 23 29 PF00244 0.652
LIG_14-3-3_CanoR_1 455 459 PF00244 0.384
LIG_14-3-3_CanoR_1 505 509 PF00244 0.413
LIG_14-3-3_CanoR_1 532 538 PF00244 0.551
LIG_14-3-3_CanoR_1 640 649 PF00244 0.456
LIG_14-3-3_CanoR_1 76 83 PF00244 0.527
LIG_Actin_WH2_2 519 534 PF00022 0.519
LIG_APCC_ABBA_1 232 237 PF00400 0.281
LIG_APCC_ABBA_1 566 571 PF00400 0.478
LIG_BIR_II_1 1 5 PF00653 0.638
LIG_BRCT_BRCA1_1 307 311 PF00533 0.478
LIG_BRCT_BRCA1_1 634 638 PF00533 0.402
LIG_Clathr_ClatBox_1 324 328 PF01394 0.418
LIG_FHA_1 158 164 PF00498 0.415
LIG_FHA_1 267 273 PF00498 0.430
LIG_FHA_1 379 385 PF00498 0.457
LIG_FHA_1 616 622 PF00498 0.540
LIG_FHA_1 62 68 PF00498 0.543
LIG_FHA_1 637 643 PF00498 0.493
LIG_FHA_1 78 84 PF00498 0.495
LIG_FHA_2 436 442 PF00498 0.319
LIG_FHA_2 535 541 PF00498 0.456
LIG_FHA_2 700 706 PF00498 0.564
LIG_GSK3_LRP6_1 62 67 PF00069 0.525
LIG_LIR_Apic_2 125 129 PF02991 0.486
LIG_LIR_Apic_2 389 394 PF02991 0.560
LIG_LIR_Gen_1 228 236 PF02991 0.352
LIG_LIR_Gen_1 239 247 PF02991 0.434
LIG_LIR_Gen_1 457 466 PF02991 0.358
LIG_LIR_Gen_1 589 599 PF02991 0.462
LIG_LIR_Nem_3 207 212 PF02991 0.392
LIG_LIR_Nem_3 220 226 PF02991 0.416
LIG_LIR_Nem_3 228 232 PF02991 0.362
LIG_LIR_Nem_3 239 245 PF02991 0.446
LIG_LIR_Nem_3 308 314 PF02991 0.470
LIG_LIR_Nem_3 457 461 PF02991 0.342
LIG_LIR_Nem_3 511 517 PF02991 0.498
LIG_LIR_Nem_3 589 594 PF02991 0.445
LIG_MLH1_MIPbox_1 634 638 PF16413 0.402
LIG_NRBOX 579 585 PF00104 0.478
LIG_PCNA_PIPBox_1 331 340 PF02747 0.478
LIG_PCNA_PIPBox_1 631 640 PF02747 0.485
LIG_PCNA_yPIPBox_3 179 192 PF02747 0.365
LIG_PCNA_yPIPBox_3 631 640 PF02747 0.454
LIG_PTB_Apo_2 247 254 PF02174 0.478
LIG_PTB_Phospho_1 247 253 PF10480 0.478
LIG_Rb_pABgroove_1 466 474 PF01858 0.443
LIG_REV1ctd_RIR_1 635 644 PF16727 0.524
LIG_SH2_CRK 391 395 PF00017 0.450
LIG_SH2_CRK 528 532 PF00017 0.462
LIG_SH2_GRB2like 174 177 PF00017 0.378
LIG_SH2_NCK_1 253 257 PF00017 0.534
LIG_SH2_SRC 253 256 PF00017 0.418
LIG_SH2_STAP1 198 202 PF00017 0.406
LIG_SH2_STAP1 318 322 PF00017 0.488
LIG_SH2_STAP1 458 462 PF00017 0.343
LIG_SH2_STAT5 144 147 PF00017 0.353
LIG_SH2_STAT5 174 177 PF00017 0.454
LIG_SH2_STAT5 233 236 PF00017 0.323
LIG_SH2_STAT5 271 274 PF00017 0.470
LIG_SH2_STAT5 337 340 PF00017 0.481
LIG_SH2_STAT5 411 414 PF00017 0.424
LIG_SH2_STAT5 451 454 PF00017 0.338
LIG_SH2_STAT5 569 572 PF00017 0.439
LIG_SH2_STAT5 681 684 PF00017 0.572
LIG_SH3_1 60 66 PF00018 0.509
LIG_SH3_2 55 60 PF14604 0.569
LIG_SH3_3 292 298 PF00018 0.478
LIG_SH3_3 39 45 PF00018 0.654
LIG_SH3_3 47 53 PF00018 0.696
LIG_SH3_3 56 62 PF00018 0.660
LIG_SH3_3 704 710 PF00018 0.627
LIG_SH3_4 393 400 PF00018 0.348
LIG_SUMO_SIM_par_1 293 300 PF11976 0.478
LIG_SUMO_SIM_par_1 617 623 PF11976 0.493
LIG_SUMO_SIM_par_1 691 699 PF11976 0.594
LIG_TYR_ITIM 526 531 PF00017 0.309
LIG_UBA3_1 163 169 PF00899 0.440
LIG_UBA3_1 449 456 PF00899 0.448
LIG_WRC_WIRS_1 123 128 PF05994 0.468
LIG_WRC_WIRS_1 226 231 PF05994 0.289
MOD_CDK_SPK_2 41 46 PF00069 0.571
MOD_CDK_SPxK_1 54 60 PF00069 0.525
MOD_CDK_SPxK_1 70 76 PF00069 0.560
MOD_CK1_1 101 107 PF00069 0.537
MOD_CK1_1 109 115 PF00069 0.675
MOD_CK1_1 122 128 PF00069 0.561
MOD_CK1_1 168 174 PF00069 0.461
MOD_CK1_1 201 207 PF00069 0.464
MOD_CK1_1 228 234 PF00069 0.394
MOD_CK1_1 264 270 PF00069 0.249
MOD_CK1_1 41 47 PF00069 0.749
MOD_CK1_1 426 432 PF00069 0.437
MOD_CK1_1 482 488 PF00069 0.534
MOD_CK1_1 534 540 PF00069 0.281
MOD_CK1_1 610 616 PF00069 0.601
MOD_CK1_1 696 702 PF00069 0.561
MOD_CK1_1 718 724 PF00069 0.635
MOD_CK1_1 8 14 PF00069 0.589
MOD_CK1_1 88 94 PF00069 0.651
MOD_CK2_1 435 441 PF00069 0.338
MOD_CK2_1 534 540 PF00069 0.301
MOD_CK2_1 620 626 PF00069 0.533
MOD_CK2_1 682 688 PF00069 0.573
MOD_CK2_1 699 705 PF00069 0.760
MOD_Cter_Amidation 503 506 PF01082 0.416
MOD_GlcNHglycan 104 107 PF01048 0.500
MOD_GlcNHglycan 153 156 PF01048 0.432
MOD_GlcNHglycan 279 282 PF01048 0.419
MOD_GlcNHglycan 307 310 PF01048 0.345
MOD_GlcNHglycan 374 377 PF01048 0.324
MOD_GlcNHglycan 481 484 PF01048 0.756
MOD_GlcNHglycan 622 625 PF01048 0.533
MOD_GlcNHglycan 7 10 PF01048 0.699
MOD_GlcNHglycan 726 729 PF01048 0.572
MOD_GlcNHglycan 742 746 PF01048 0.775
MOD_GlcNHglycan 80 83 PF01048 0.661
MOD_GlcNHglycan 91 94 PF01048 0.611
MOD_GlcNHglycan 99 103 PF01048 0.543
MOD_GSK3_1 106 113 PF00069 0.637
MOD_GSK3_1 130 137 PF00069 0.601
MOD_GSK3_1 165 172 PF00069 0.409
MOD_GSK3_1 261 268 PF00069 0.309
MOD_GSK3_1 4 11 PF00069 0.618
MOD_GSK3_1 478 485 PF00069 0.613
MOD_GSK3_1 54 61 PF00069 0.707
MOD_GSK3_1 610 617 PF00069 0.664
MOD_GSK3_1 62 69 PF00069 0.631
MOD_GSK3_1 626 633 PF00069 0.563
MOD_GSK3_1 641 648 PF00069 0.374
MOD_GSK3_1 711 718 PF00069 0.607
MOD_GSK3_1 85 92 PF00069 0.682
MOD_GSK3_1 98 105 PF00069 0.665
MOD_LATS_1 558 564 PF00433 0.333
MOD_N-GLC_1 134 139 PF02516 0.520
MOD_N-GLC_1 169 174 PF02516 0.371
MOD_N-GLC_1 89 94 PF02516 0.588
MOD_NEK2_1 192 197 PF00069 0.443
MOD_NEK2_1 265 270 PF00069 0.324
MOD_NEK2_1 343 348 PF00069 0.393
MOD_NEK2_1 35 40 PF00069 0.600
MOD_NEK2_1 372 377 PF00069 0.318
MOD_NEK2_1 461 466 PF00069 0.332
MOD_NEK2_1 543 548 PF00069 0.290
MOD_NEK2_1 632 637 PF00069 0.436
MOD_NEK2_1 642 647 PF00069 0.544
MOD_NEK2_1 712 717 PF00069 0.574
MOD_NEK2_2 119 124 PF00069 0.506
MOD_NEK2_2 198 203 PF00069 0.382
MOD_PIKK_1 543 549 PF00454 0.316
MOD_PIKK_1 696 702 PF00454 0.620
MOD_PKA_2 109 115 PF00069 0.580
MOD_PKA_2 426 432 PF00069 0.353
MOD_PKA_2 454 460 PF00069 0.390
MOD_PKA_2 504 510 PF00069 0.273
MOD_PKA_2 531 537 PF00069 0.369
MOD_PKA_2 75 81 PF00069 0.668
MOD_PKB_1 605 613 PF00069 0.456
MOD_Plk_1 169 175 PF00069 0.374
MOD_Plk_1 198 204 PF00069 0.357
MOD_Plk_1 510 516 PF00069 0.299
MOD_Plk_4 122 128 PF00069 0.573
MOD_Plk_4 169 175 PF00069 0.374
MOD_Plk_4 228 234 PF00069 0.380
MOD_Plk_4 24 30 PF00069 0.636
MOD_Plk_4 261 267 PF00069 0.249
MOD_Plk_4 426 432 PF00069 0.416
MOD_ProDKin_1 10 16 PF00069 0.701
MOD_ProDKin_1 378 384 PF00069 0.273
MOD_ProDKin_1 38 44 PF00069 0.640
MOD_ProDKin_1 46 52 PF00069 0.645
MOD_ProDKin_1 54 60 PF00069 0.526
MOD_ProDKin_1 62 68 PF00069 0.570
MOD_ProDKin_1 70 76 PF00069 0.682
MOD_ProDKin_1 715 721 PF00069 0.634
MOD_SUMO_rev_2 146 150 PF00179 0.372
MOD_SUMO_rev_2 172 181 PF00179 0.461
MOD_SUMO_rev_2 703 710 PF00179 0.538
TRG_DiLeu_BaEn_1 21 26 PF01217 0.560
TRG_DiLeu_BaLyEn_6 592 597 PF01217 0.319
TRG_ENDOCYTIC_2 226 229 PF00928 0.364
TRG_ENDOCYTIC_2 233 236 PF00928 0.295
TRG_ENDOCYTIC_2 253 256 PF00928 0.143
TRG_ENDOCYTIC_2 458 461 PF00928 0.401
TRG_ENDOCYTIC_2 472 475 PF00928 0.596
TRG_ENDOCYTIC_2 528 531 PF00928 0.243
TRG_ER_diArg_1 274 276 PF00400 0.225
TRG_ER_diArg_1 363 365 PF00400 0.269
TRG_ER_diArg_1 446 449 PF00400 0.313
TRG_ER_diArg_1 531 533 PF00400 0.417
TRG_ER_diArg_1 576 578 PF00400 0.333
TRG_ER_diArg_1 604 607 PF00400 0.281
TRG_ER_diArg_1 649 652 PF00400 0.475
TRG_ER_diArg_1 663 666 PF00400 0.648
TRG_NES_CRM1_1 323 336 PF08389 0.334
TRG_NES_CRM1_1 574 589 PF08389 0.322
TRG_NLS_Bipartite_1 650 668 PF00514 0.504
TRG_NLS_MonoCore_2 663 668 PF00514 0.555
TRG_NLS_MonoExtC_3 662 667 PF00514 0.690
TRG_NLS_MonoExtN_4 663 668 PF00514 0.563
TRG_Pf-PMV_PEXEL_1 210 215 PF00026 0.376
TRG_Pf-PMV_PEXEL_1 357 361 PF00026 0.281
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.232
TRG_Pf-PMV_PEXEL_1 578 582 PF00026 0.333
TRG_Pf-PMV_PEXEL_1 667 671 PF00026 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7I6 Leptomonas seymouri 56% 100%
A0A0S4JDU0 Bodo saltans 37% 85%
A0A3Q8IEM0 Leishmania donovani 99% 100%
A0A3S7X1J7 Leishmania donovani 37% 100%
A4HGJ3 Leishmania braziliensis 72% 99%
A4I3M1 Leishmania infantum 37% 100%
D0A852 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AZW1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AZW2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
P34409 Caenorhabditis elegans 32% 100%
Q4Q8C4 Leishmania major 36% 100%
Q4Q8C5 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS