Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania infantum

UniProt:

A4I3L9_LEIIN

TriTrypDb:

LINF_280019800

Length:

540

Annotations

Annotations by Jardim et al.

Plasma membrane, Amastin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I3L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.557
CLV_NRD_NRD_1	200	202	PF00675	0.519
CLV_NRD_NRD_1	256	258	PF00675	0.486
CLV_NRD_NRD_1	424	426	PF00675	0.540
CLV_PCSK_FUR_1	254	258	PF00082	0.480
CLV_PCSK_KEX2_1	199	201	PF00082	0.527
CLV_PCSK_KEX2_1	253	255	PF00082	0.475
CLV_PCSK_KEX2_1	256	258	PF00082	0.473
CLV_PCSK_KEX2_1	424	426	PF00082	0.540
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.475
CLV_PCSK_PC7_1	196	202	PF00082	0.493
CLV_PCSK_PC7_1	249	255	PF00082	0.466
CLV_PCSK_SKI1_1	154	158	PF00082	0.602
CLV_PCSK_SKI1_1	467	471	PF00082	0.363
CLV_PCSK_SKI1_1	8	12	PF00082	0.509
DEG_APCC_DBOX_1	466	474	PF00400	0.563
DEG_SCF_FBW7_1	105	112	PF00400	0.822
DOC_CKS1_1	202	207	PF01111	0.681
DOC_CKS1_1	269	274	PF01111	0.812
DOC_CKS1_1	418	423	PF01111	0.336
DOC_MAPK_MEF2A_6	365	374	PF00069	0.389
DOC_MAPK_NFAT4_5	365	373	PF00069	0.323
DOC_PP4_FxxP_1	526	529	PF00568	0.424
DOC_USP7_MATH_1	101	105	PF00917	0.824
DOC_USP7_MATH_1	118	122	PF00917	0.625
DOC_USP7_MATH_1	167	171	PF00917	0.759
DOC_USP7_MATH_1	259	263	PF00917	0.793
DOC_USP7_MATH_1	273	277	PF00917	0.628
DOC_USP7_MATH_1	315	319	PF00917	0.709
DOC_USP7_MATH_1	527	531	PF00917	0.375
DOC_WW_Pin1_4	105	110	PF00397	0.822
DOC_WW_Pin1_4	114	119	PF00397	0.780
DOC_WW_Pin1_4	181	186	PF00397	0.819
DOC_WW_Pin1_4	201	206	PF00397	0.691
DOC_WW_Pin1_4	225	230	PF00397	0.752
DOC_WW_Pin1_4	255	260	PF00397	0.829
DOC_WW_Pin1_4	268	273	PF00397	0.683
DOC_WW_Pin1_4	32	37	PF00397	0.745
DOC_WW_Pin1_4	417	422	PF00397	0.336
LIG_14-3-3_CanoR_1	102	108	PF00244	0.823
LIG_14-3-3_CanoR_1	172	176	PF00244	0.761
LIG_14-3-3_CanoR_1	192	196	PF00244	0.630
LIG_14-3-3_CanoR_1	277	283	PF00244	0.715
LIG_14-3-3_CanoR_1	323	331	PF00244	0.583
LIG_Actin_WH2_2	442	458	PF00022	0.412
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BIR_III_2	345	349	PF00653	0.584
LIG_BRCT_BRCA1_1	317	321	PF00533	0.644
LIG_EH1_1	432	440	PF00400	0.513
LIG_FHA_1	202	208	PF00498	0.752
LIG_FHA_1	384	390	PF00498	0.346
LIG_FHA_1	408	414	PF00498	0.359
LIG_FHA_1	418	424	PF00498	0.316
LIG_FHA_1	435	441	PF00498	0.297
LIG_FHA_1	478	484	PF00498	0.327
LIG_FHA_2	106	112	PF00498	0.758
LIG_FHA_2	220	226	PF00498	0.752
LIG_LIR_Apic_2	161	166	PF02991	0.734
LIG_LIR_Apic_2	318	322	PF02991	0.664
LIG_LIR_Apic_2	409	414	PF02991	0.362
LIG_LIR_Apic_2	523	529	PF02991	0.325
LIG_LIR_Gen_1	484	492	PF02991	0.411
LIG_LIR_Gen_1	78	86	PF02991	0.791
LIG_LIR_Nem_3	264	270	PF02991	0.785
LIG_LIR_Nem_3	313	319	PF02991	0.673
LIG_LIR_Nem_3	398	402	PF02991	0.304
LIG_LIR_Nem_3	484	488	PF02991	0.404
LIG_LIR_Nem_3	78	83	PF02991	0.790
LIG_LYPXL_yS_3	131	134	PF13949	0.648
LIG_NRBOX	437	443	PF00104	0.436
LIG_SH2_CRK	163	167	PF00017	0.738
LIG_SH2_CRK	411	415	PF00017	0.330
LIG_SH2_NCK_1	163	167	PF00017	0.738
LIG_SH2_NCK_1	270	274	PF00017	0.811
LIG_SH2_PTP2	319	322	PF00017	0.665
LIG_SH2_STAP1	290	294	PF00017	0.693
LIG_SH2_STAT5	203	206	PF00017	0.750
LIG_SH2_STAT5	270	273	PF00017	0.812
LIG_SH2_STAT5	319	322	PF00017	0.665
LIG_SH2_STAT5	358	361	PF00017	0.604
LIG_SH2_STAT5	369	372	PF00017	0.405
LIG_SH2_STAT5	411	414	PF00017	0.372
LIG_SH2_STAT5	422	425	PF00017	0.346
LIG_SH3_1	199	205	PF00018	0.683
LIG_SH3_3	112	118	PF00018	0.780
LIG_SH3_3	126	132	PF00018	0.662
LIG_SH3_3	199	205	PF00018	0.665
LIG_SH3_3	30	36	PF00018	0.748
LIG_SH3_3	379	385	PF00018	0.389
LIG_SH3_3	413	419	PF00018	0.336
LIG_SH3_3	80	86	PF00018	0.759
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.456
LIG_SUMO_SIM_anti_2	386	393	PF11976	0.323
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.424
LIG_SUMO_SIM_par_1	378	383	PF11976	0.416
LIG_TRAF2_1	286	289	PF00917	0.704
LIG_TYR_ITIM	129	134	PF00017	0.677
LIG_WRC_WIRS_1	14	19	PF05994	0.793
MOD_CDK_SPK_2	105	110	PF00069	0.822
MOD_CDK_SPxxK_3	417	424	PF00069	0.336
MOD_CK1_1	15	21	PF00069	0.735
MOD_CK1_1	161	167	PF00069	0.770
MOD_CK1_1	276	282	PF00069	0.797
MOD_CK1_1	306	312	PF00069	0.721
MOD_CK1_1	383	389	PF00069	0.411
MOD_CK1_1	409	415	PF00069	0.352
MOD_CK1_1	434	440	PF00069	0.353
MOD_CK1_1	463	469	PF00069	0.530
MOD_CK1_1	76	82	PF00069	0.802
MOD_CK2_1	114	120	PF00069	0.807
MOD_CK2_1	13	19	PF00069	0.722
MOD_CK2_1	171	177	PF00069	0.737
MOD_CK2_1	219	225	PF00069	0.752
MOD_CK2_1	255	261	PF00069	0.750
MOD_CK2_1	283	289	PF00069	0.787
MOD_Cter_Amidation	197	200	PF01082	0.528
MOD_Cter_Amidation	6	9	PF01082	0.426
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.765
MOD_DYRK1A_RPxSP_1	201	205	PF00069	0.748
MOD_GlcNHglycan	120	124	PF01048	0.589
MOD_GlcNHglycan	143	146	PF01048	0.558
MOD_GlcNHglycan	158	161	PF01048	0.501
MOD_GlcNHglycan	163	166	PF01048	0.493
MOD_GlcNHglycan	284	288	PF01048	0.478
MOD_GlcNHglycan	325	328	PF01048	0.397
MOD_GlcNHglycan	40	43	PF01048	0.607
MOD_GlcNHglycan	493	496	PF01048	0.561
MOD_GlcNHglycan	55	58	PF01048	0.434
MOD_GlcNHglycan	75	78	PF01048	0.507
MOD_GSK3_1	101	108	PF00069	0.756
MOD_GSK3_1	114	121	PF00069	0.769
MOD_GSK3_1	167	174	PF00069	0.773
MOD_GSK3_1	255	262	PF00069	0.777
MOD_GSK3_1	32	39	PF00069	0.819
MOD_GSK3_1	380	387	PF00069	0.411
MOD_GSK3_1	477	484	PF00069	0.341
MOD_N-GLC_1	407	412	PF02516	0.547
MOD_N-GLC_1	510	515	PF02516	0.546
MOD_N-GLC_2	404	406	PF02516	0.494
MOD_NEK2_1	373	378	PF00069	0.369
MOD_NEK2_1	38	43	PF00069	0.682
MOD_NEK2_1	50	55	PF00069	0.721
MOD_NEK2_1	510	515	PF00069	0.333
MOD_NEK2_1	520	525	PF00069	0.353
MOD_NEK2_2	206	211	PF00069	0.670
MOD_PIKK_1	167	173	PF00454	0.737
MOD_PIKK_1	384	390	PF00454	0.304
MOD_PIKK_1	477	483	PF00454	0.375
MOD_PKA_2	101	107	PF00069	0.823
MOD_PKA_2	171	177	PF00069	0.765
MOD_PKA_2	191	197	PF00069	0.637
MOD_PKA_2	276	282	PF00069	0.719
MOD_Plk_1	12	18	PF00069	0.788
MOD_Plk_1	406	412	PF00069	0.355
MOD_Plk_1	510	516	PF00069	0.382
MOD_Plk_2-3	13	19	PF00069	0.719
MOD_Plk_4	315	321	PF00069	0.663
MOD_Plk_4	395	401	PF00069	0.253
MOD_Plk_4	511	517	PF00069	0.495
MOD_Plk_4	520	526	PF00069	0.401
MOD_Plk_4	95	101	PF00069	0.814
MOD_ProDKin_1	105	111	PF00069	0.821
MOD_ProDKin_1	114	120	PF00069	0.781
MOD_ProDKin_1	181	187	PF00069	0.819
MOD_ProDKin_1	201	207	PF00069	0.691
MOD_ProDKin_1	225	231	PF00069	0.754
MOD_ProDKin_1	255	261	PF00069	0.827
MOD_ProDKin_1	268	274	PF00069	0.681
MOD_ProDKin_1	32	38	PF00069	0.745
MOD_ProDKin_1	417	423	PF00069	0.336
MOD_SUMO_rev_2	247	255	PF00179	0.756
TRG_ENDOCYTIC_2	131	134	PF00928	0.676
TRG_ENDOCYTIC_2	358	361	PF00928	0.606
TRG_ENDOCYTIC_2	369	372	PF00928	0.411
TRG_ER_diArg_1	199	201	PF00400	0.813
TRG_ER_diArg_1	254	257	PF00400	0.681
TRG_ER_diArg_1	423	425	PF00400	0.341
TRG_NLS_MonoExtC_3	195	200	PF00514	0.699
TRG_NLS_MonoExtC_3	252	257	PF00514	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU6	Leptomonas seymouri	38%	100%
A0A3S7X1I0	Leishmania donovani	99%	100%
E9AIT0	Leishmania braziliensis	60%	100%
E9AZV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q8C6	Leishmania major	85%	100%