Haloacid dehalogenase-like hydrolase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase-like protein

Species:

Leishmania infantum

UniProt:

A4I3L7_LEIIN

TriTrypDb:

LINF_280019600

Length:

402

Annotations

Annotations by Jardim et al.

Hydrolase, Haloacid dehalogenase-like hydrolase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3L7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	31
GO:0016787	hydrolase activity	2	31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.461
CLV_NRD_NRD_1	15	17	PF00675	0.599
CLV_NRD_NRD_1	378	380	PF00675	0.313
CLV_NRD_NRD_1	81	83	PF00675	0.303
CLV_PCSK_FUR_1	78	82	PF00082	0.372
CLV_PCSK_KEX2_1	15	17	PF00082	0.445
CLV_PCSK_KEX2_1	278	280	PF00082	0.286
CLV_PCSK_KEX2_1	80	82	PF00082	0.290
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.330
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.311
CLV_PCSK_SKI1_1	278	282	PF00082	0.317
CLV_PCSK_SKI1_1	52	56	PF00082	0.335
CLV_PCSK_SKI1_1	71	75	PF00082	0.217
DEG_APCC_DBOX_1	51	59	PF00400	0.552
DEG_SCF_FBW7_1	124	131	PF00400	0.504
DEG_SPOP_SBC_1	116	120	PF00917	0.515
DEG_SPOP_SBC_1	397	401	PF00917	0.497
DOC_CKS1_1	125	130	PF01111	0.502
DOC_CKS1_1	92	97	PF01111	0.636
DOC_CKS1_1	99	104	PF01111	0.677
DOC_MAPK_DCC_7	358	368	PF00069	0.443
DOC_MAPK_gen_1	15	22	PF00069	0.606
DOC_MAPK_gen_1	358	368	PF00069	0.512
DOC_MAPK_gen_1	78	85	PF00069	0.565
DOC_MAPK_MEF2A_6	360	368	PF00069	0.469
DOC_MAPK_MEF2A_6	90	99	PF00069	0.636
DOC_USP7_MATH_1	116	120	PF00917	0.718
DOC_USP7_MATH_1	126	130	PF00917	0.702
DOC_USP7_MATH_1	149	153	PF00917	0.577
DOC_USP7_MATH_1	266	270	PF00917	0.590
DOC_USP7_MATH_1	397	401	PF00917	0.774
DOC_WW_Pin1_4	112	117	PF00397	0.693
DOC_WW_Pin1_4	124	129	PF00397	0.636
DOC_WW_Pin1_4	91	96	PF00397	0.619
DOC_WW_Pin1_4	98	103	PF00397	0.650
LIG_14-3-3_CanoR_1	238	242	PF00244	0.511
LIG_14-3-3_CanoR_1	255	262	PF00244	0.589
LIG_14-3-3_CanoR_1	379	387	PF00244	0.615
LIG_14-3-3_CanoR_1	71	79	PF00244	0.526
LIG_BRCT_BRCA1_1	256	260	PF00533	0.572
LIG_BRCT_BRCA1_1	381	385	PF00533	0.311
LIG_EVH1_1	124	128	PF00568	0.500
LIG_FHA_1	138	144	PF00498	0.622
LIG_FHA_1	238	244	PF00498	0.571
LIG_FHA_1	248	254	PF00498	0.470
LIG_FHA_1	282	288	PF00498	0.405
LIG_FHA_1	298	304	PF00498	0.550
LIG_FHA_1	49	55	PF00498	0.500
LIG_FHA_1	87	93	PF00498	0.590
LIG_FHA_2	324	330	PF00498	0.510
LIG_FHA_2	99	105	PF00498	0.675
LIG_IBAR_NPY_1	27	29	PF08397	0.339
LIG_LIR_Gen_1	177	186	PF02991	0.525
LIG_LIR_Nem_3	177	182	PF02991	0.525
LIG_LIR_Nem_3	240	244	PF02991	0.543
LIG_LIR_Nem_3	258	264	PF02991	0.513
LIG_MYND_3	363	367	PF01753	0.455
LIG_NRBOX	54	60	PF00104	0.567
LIG_Pex14_1	221	225	PF04695	0.530
LIG_SH2_CRK	206	210	PF00017	0.564
LIG_SH2_CRK	29	33	PF00017	0.365
LIG_SH2_GRB2like	206	209	PF00017	0.584
LIG_SH2_NCK_1	158	162	PF00017	0.567
LIG_SH2_NCK_1	206	210	PF00017	0.611
LIG_SH2_STAP1	166	170	PF00017	0.552
LIG_SH2_STAP1	179	183	PF00017	0.490
LIG_SH2_STAP1	50	54	PF00017	0.574
LIG_SH2_STAT5	206	209	PF00017	0.531
LIG_SH2_STAT5	301	304	PF00017	0.605
LIG_SH2_STAT5	50	53	PF00017	0.495
LIG_SH3_3	120	126	PF00018	0.510
LIG_SH3_3	17	23	PF00018	0.604
LIG_SH3_3	96	102	PF00018	0.641
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.536
LIG_TRAF2_1	217	220	PF00917	0.518
MOD_CDK_SPxxK_3	103	110	PF00069	0.521
MOD_CK1_1	106	112	PF00069	0.748
MOD_CK1_1	115	121	PF00069	0.729
MOD_CK1_1	130	136	PF00069	0.584
MOD_CK1_1	237	243	PF00069	0.562
MOD_CK1_1	274	280	PF00069	0.562
MOD_CK1_1	3	9	PF00069	0.428
MOD_CK1_1	308	314	PF00069	0.507
MOD_CK1_1	43	49	PF00069	0.506
MOD_CK2_1	224	230	PF00069	0.548
MOD_CK2_1	242	248	PF00069	0.485
MOD_CK2_1	267	273	PF00069	0.520
MOD_CK2_1	98	104	PF00069	0.665
MOD_GlcNHglycan	112	115	PF01048	0.755
MOD_GlcNHglycan	132	135	PF01048	0.625
MOD_GlcNHglycan	297	300	PF01048	0.330
MOD_GlcNHglycan	313	316	PF01048	0.267
MOD_GSK3_1	106	113	PF00069	0.717
MOD_GSK3_1	115	122	PF00069	0.738
MOD_GSK3_1	124	131	PF00069	0.683
MOD_GSK3_1	267	274	PF00069	0.566
MOD_GSK3_1	36	43	PF00069	0.529
MOD_N-GLC_1	116	121	PF02516	0.535
MOD_N-GLC_1	137	142	PF02516	0.434
MOD_N-GLC_2	328	330	PF02516	0.216
MOD_NEK2_1	148	153	PF00069	0.520
MOD_NEK2_1	247	252	PF00069	0.577
MOD_NEK2_1	289	294	PF00069	0.558
MOD_NEK2_1	323	328	PF00069	0.505
MOD_NEK2_1	342	347	PF00069	0.565
MOD_NEK2_1	36	41	PF00069	0.496
MOD_NEK2_1	86	91	PF00069	0.419
MOD_PIKK_1	53	59	PF00454	0.493
MOD_PKA_1	379	385	PF00069	0.472
MOD_PKA_2	237	243	PF00069	0.518
MOD_PKA_2	254	260	PF00069	0.569
MOD_Plk_1	166	172	PF00069	0.578
MOD_Plk_1	247	253	PF00069	0.409
MOD_Plk_1	266	272	PF00069	0.445
MOD_Plk_1	289	295	PF00069	0.535
MOD_Plk_1	323	329	PF00069	0.518
MOD_Plk_2-3	215	221	PF00069	0.567
MOD_Plk_2-3	267	273	PF00069	0.421
MOD_Plk_4	119	125	PF00069	0.530
MOD_Plk_4	177	183	PF00069	0.506
MOD_Plk_4	267	273	PF00069	0.601
MOD_Plk_4	3	9	PF00069	0.680
MOD_Plk_4	36	42	PF00069	0.504
MOD_ProDKin_1	112	118	PF00069	0.691
MOD_ProDKin_1	124	130	PF00069	0.635
MOD_ProDKin_1	91	97	PF00069	0.612
MOD_ProDKin_1	98	104	PF00069	0.655
MOD_SUMO_for_1	287	290	PF00179	0.405
MOD_SUMO_rev_2	210	218	PF00179	0.582
MOD_SUMO_rev_2	282	289	PF00179	0.585
TRG_ENDOCYTIC_2	179	182	PF00928	0.478
TRG_ENDOCYTIC_2	29	32	PF00928	0.351
TRG_ER_diArg_1	15	17	PF00400	0.449
TRG_ER_diArg_1	81	83	PF00400	0.443
TRG_NLS_MonoExtC_3	359	364	PF00514	0.416
TRG_NLS_MonoExtN_4	357	364	PF00514	0.416
TRG_NLS_MonoExtN_4	78	84	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	29%	100%
A0A0N0P7W9	Leptomonas seymouri	24%	100%
A0A0N1I1D8	Leptomonas seymouri	30%	100%
A0A0N1ILU0	Leptomonas seymouri	28%	100%
A0A0N1PEM6	Leptomonas seymouri	65%	100%
A0A1X0NRL0	Trypanosomatidae	26%	100%
A0A1X0NYN3	Trypanosomatidae	30%	100%
A0A1X0NYY3	Trypanosomatidae	29%	100%
A0A1X0P2Q4	Trypanosomatidae	39%	100%
A0A3Q8IDX0	Leishmania donovani	28%	100%
A0A3Q8IEU6	Leishmania donovani	100%	100%
A0A3Q8IGR3	Leishmania donovani	28%	100%
A0A3R7M7Z1	Trypanosoma rangeli	27%	100%
A0A3S7X1G8	Leishmania donovani	32%	100%
A0A422MX56	Trypanosoma rangeli	26%	100%
A0A422N4F0	Trypanosoma rangeli	30%	100%
A4HGI1	Leishmania braziliensis	27%	90%
A4HGI6	Leishmania braziliensis	30%	83%
A4HGI9	Leishmania braziliensis	27%	100%
A4HGJ0	Leishmania braziliensis	31%	91%
A4I3L4	Leishmania infantum	29%	85%
A4I3L6	Leishmania infantum	32%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	83%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8C8	Leishmania major	95%	100%
Q4Q8C9	Leishmania major	29%	100%
Q4Q8D1	Leishmania major	29%	83%
V5BGL5	Trypanosoma cruzi	33%	100%
V5D8D2	Trypanosoma cruzi	27%	100%