LeishMANIAdb
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Haloacid dehalogenase-like hydrolase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Haloacid dehalogenase-like hydrolase-like protein
Gene product:
haloacid dehalogenase-like hydrolase-like protein
Species:
Leishmania infantum
UniProt:
A4I3L4_LEIIN
TriTrypDb:
LINF_280019300
Length:
333

Annotations

Annotations by Jardim et al.

Hydrolase, Haloacid dehalogenase-like hydrolase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3L4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3L4

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 9
GO:0016787 hydrolase activity 2 9
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 10 14 PF00656 0.460
CLV_C14_Caspase3-7 49 53 PF00656 0.417
CLV_PCSK_SKI1_1 197 201 PF00082 0.291
CLV_PCSK_SKI1_1 251 255 PF00082 0.318
CLV_PCSK_SKI1_1 326 330 PF00082 0.440
DEG_APCC_DBOX_1 27 35 PF00400 0.481
DOC_MAPK_gen_1 323 333 PF00069 0.569
DOC_PP1_RVXF_1 140 146 PF00149 0.523
DOC_PP1_RVXF_1 195 201 PF00149 0.491
DOC_PP4_FxxP_1 329 332 PF00568 0.456
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P7I9 Leptomonas seymouri 38% 100%
A0A0N0P7W9 Leptomonas seymouri 32% 100%
A0A0N1I1D8 Leptomonas seymouri 65% 100%
A0A0N1I836 Leptomonas seymouri 26% 100%
A0A0N1I9R7 Leptomonas seymouri 28% 100%
A0A0N1ILU0 Leptomonas seymouri 31% 88%
A0A0N1IM34 Leptomonas seymouri 29% 100%
A0A0N1PEM6 Leptomonas seymouri 29% 85%
A0A1X0NRL0 Trypanosomatidae 30% 100%
A0A1X0NYN3 Trypanosomatidae 36% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS