LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I3L2_LEIIN
TriTrypDb:
LINF_280019100
Length:
350

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005929 cilium 4 6
GO:0042995 cell projection 2 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0110165 cellular anatomical entity 1 6
GO:0120025 plasma membrane bounded cell projection 3 6

Expansion

Sequence features

A4I3L2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3L2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 183 185 PF00675 0.460
CLV_NRD_NRD_1 289 291 PF00675 0.429
CLV_NRD_NRD_1 324 326 PF00675 0.470
CLV_NRD_NRD_1 50 52 PF00675 0.679
CLV_NRD_NRD_1 91 93 PF00675 0.691
CLV_PCSK_KEX2_1 183 185 PF00082 0.460
CLV_PCSK_KEX2_1 289 291 PF00082 0.429
CLV_PCSK_KEX2_1 324 326 PF00082 0.413
CLV_PCSK_KEX2_1 50 52 PF00082 0.679
CLV_PCSK_KEX2_1 91 93 PF00082 0.661
CLV_PCSK_SKI1_1 289 293 PF00082 0.355
CLV_PCSK_SKI1_1 35 39 PF00082 0.621
DEG_APCC_DBOX_1 165 173 PF00400 0.463
DOC_MAPK_gen_1 286 294 PF00069 0.421
DOC_MAPK_gen_1 328 336 PF00069 0.530
DOC_MAPK_MEF2A_6 218 227 PF00069 0.419
DOC_MAPK_MEF2A_6 328 336 PF00069 0.520
DOC_USP7_MATH_1 129 133 PF00917 0.698
DOC_USP7_MATH_1 154 158 PF00917 0.659
DOC_USP7_MATH_1 264 268 PF00917 0.498
DOC_USP7_MATH_1 42 46 PF00917 0.709
DOC_WW_Pin1_4 11 16 PF00397 0.674
DOC_WW_Pin1_4 119 124 PF00397 0.752
DOC_WW_Pin1_4 150 155 PF00397 0.626
DOC_WW_Pin1_4 18 23 PF00397 0.682
DOC_WW_Pin1_4 260 265 PF00397 0.380
DOC_WW_Pin1_4 328 333 PF00397 0.506
DOC_WW_Pin1_4 58 63 PF00397 0.696
LIG_14-3-3_CanoR_1 128 134 PF00244 0.604
LIG_14-3-3_CanoR_1 166 170 PF00244 0.424
LIG_14-3-3_CanoR_1 176 181 PF00244 0.367
LIG_14-3-3_CanoR_1 43 47 PF00244 0.623
LIG_Actin_WH2_2 287 304 PF00022 0.498
LIG_BIR_II_1 1 5 PF00653 0.637
LIG_deltaCOP1_diTrp_1 72 77 PF00928 0.602
LIG_FHA_1 222 228 PF00498 0.420
LIG_FHA_1 273 279 PF00498 0.436
LIG_FHA_1 329 335 PF00498 0.520
LIG_FHA_1 77 83 PF00498 0.660
LIG_FHA_2 229 235 PF00498 0.422
LIG_FHA_2 36 42 PF00498 0.619
LIG_LIR_Gen_1 234 243 PF02991 0.422
LIG_LIR_Nem_3 234 238 PF02991 0.411
LIG_PDZ_Class_1 345 350 PF00595 0.567
LIG_SH2_GRB2like 235 238 PF00017 0.342
LIG_SH2_PTP2 235 238 PF00017 0.408
LIG_SH2_SRC 214 217 PF00017 0.453
LIG_SH2_STAT5 173 176 PF00017 0.451
LIG_SH2_STAT5 214 217 PF00017 0.595
LIG_SH2_STAT5 229 232 PF00017 0.427
LIG_SH2_STAT5 235 238 PF00017 0.352
LIG_SH3_3 117 123 PF00018 0.820
LIG_SH3_3 12 18 PF00018 0.641
LIG_SH3_3 131 137 PF00018 0.533
LIG_SH3_3 222 228 PF00018 0.420
LIG_SH3_3 77 83 PF00018 0.511
LIG_SUMO_SIM_par_1 274 279 PF11976 0.437
LIG_SUMO_SIM_par_1 331 338 PF11976 0.544
LIG_SUMO_SIM_par_1 78 84 PF11976 0.492
LIG_TRAF2_1 339 342 PF00917 0.646
LIG_TYR_ITIM 233 238 PF00017 0.410
LIG_WW_3 66 70 PF00397 0.641
MOD_CDC14_SPxK_1 155 158 PF00782 0.594
MOD_CDK_SPK_2 119 124 PF00069 0.624
MOD_CDK_SPK_2 18 23 PF00069 0.620
MOD_CDK_SPxK_1 152 158 PF00069 0.587
MOD_CDK_SPxxK_3 62 69 PF00069 0.573
MOD_CK1_1 122 128 PF00069 0.625
MOD_CK1_1 159 165 PF00069 0.511
MOD_CK1_1 168 174 PF00069 0.403
MOD_CK1_1 21 27 PF00069 0.700
MOD_CK1_1 28 34 PF00069 0.678
MOD_CK1_1 61 67 PF00069 0.700
MOD_CK1_1 84 90 PF00069 0.549
MOD_CK2_1 228 234 PF00069 0.428
MOD_CK2_1 35 41 PF00069 0.599
MOD_Cter_Amidation 287 290 PF01082 0.416
MOD_GlcNHglycan 131 134 PF01048 0.651
MOD_GlcNHglycan 158 161 PF01048 0.565
MOD_GlcNHglycan 246 249 PF01048 0.569
MOD_GlcNHglycan 266 269 PF01048 0.527
MOD_GlcNHglycan 30 33 PF01048 0.711
MOD_GlcNHglycan 52 55 PF01048 0.816
MOD_GSK3_1 115 122 PF00069 0.636
MOD_GSK3_1 123 130 PF00069 0.618
MOD_GSK3_1 150 157 PF00069 0.633
MOD_GSK3_1 161 168 PF00069 0.398
MOD_GSK3_1 172 179 PF00069 0.400
MOD_GSK3_1 21 28 PF00069 0.673
MOD_GSK3_1 244 251 PF00069 0.639
MOD_GSK3_1 260 267 PF00069 0.574
MOD_GSK3_1 272 279 PF00069 0.442
MOD_GSK3_1 324 331 PF00069 0.443
MOD_GSK3_1 341 348 PF00069 0.570
MOD_GSK3_1 58 65 PF00069 0.656
MOD_GSK3_1 81 88 PF00069 0.517
MOD_N-GLC_2 237 239 PF02516 0.343
MOD_NEK2_1 172 177 PF00069 0.435
MOD_NEK2_1 76 81 PF00069 0.595
MOD_PIKK_1 93 99 PF00454 0.590
MOD_PKA_1 324 330 PF00069 0.442
MOD_PKA_1 50 56 PF00069 0.678
MOD_PKA_2 127 133 PF00069 0.604
MOD_PKA_2 165 171 PF00069 0.477
MOD_PKA_2 210 216 PF00069 0.457
MOD_PKA_2 324 330 PF00069 0.437
MOD_PKA_2 42 48 PF00069 0.659
MOD_PKA_2 50 56 PF00069 0.667
MOD_PKA_2 85 91 PF00069 0.668
MOD_PKB_1 312 320 PF00069 0.377
MOD_Plk_1 115 121 PF00069 0.631
MOD_Plk_1 276 282 PF00069 0.448
MOD_Plk_4 107 113 PF00069 0.567
MOD_Plk_4 137 143 PF00069 0.611
MOD_Plk_4 210 216 PF00069 0.457
MOD_Plk_4 221 227 PF00069 0.415
MOD_Plk_4 4 10 PF00069 0.631
MOD_Plk_4 76 82 PF00069 0.547
MOD_ProDKin_1 11 17 PF00069 0.674
MOD_ProDKin_1 119 125 PF00069 0.751
MOD_ProDKin_1 150 156 PF00069 0.630
MOD_ProDKin_1 18 24 PF00069 0.683
MOD_ProDKin_1 260 266 PF00069 0.390
MOD_ProDKin_1 328 334 PF00069 0.511
MOD_ProDKin_1 58 64 PF00069 0.692
TRG_DiLeu_BaLyEn_6 185 190 PF01217 0.412
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.336
TRG_ENDOCYTIC_2 235 238 PF00928 0.408
TRG_ER_diArg_1 182 184 PF00400 0.456
TRG_ER_diArg_1 289 291 PF00400 0.429
TRG_ER_diArg_1 323 325 PF00400 0.414
TRG_ER_diArg_1 90 92 PF00400 0.660
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.468

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IDS7 Leishmania donovani 100% 100%
A4HGI0 Leishmania braziliensis 64% 96%
E9AZV2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q8D3 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS