Putative ATP-dependent RNA helicase

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase - putative

Species:

Leishmania infantum

UniProt:

A4I3L0_LEIIN

TriTrypDb:

LINF_280018900

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 671

Expansion

Sequence features

A4I3L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3L0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003724	RNA helicase activity	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008186	ATP-dependent activity, acting on RNA	2	11
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	581	585	PF00656	0.707
CLV_C14_Caspase3-7	723	727	PF00656	0.639
CLV_C14_Caspase3-7	810	814	PF00656	0.691
CLV_C14_Caspase3-7	878	882	PF00656	0.704
CLV_NRD_NRD_1	184	186	PF00675	0.247
CLV_NRD_NRD_1	355	357	PF00675	0.236
CLV_NRD_NRD_1	48	50	PF00675	0.447
CLV_NRD_NRD_1	547	549	PF00675	0.547
CLV_NRD_NRD_1	643	645	PF00675	0.544
CLV_NRD_NRD_1	724	726	PF00675	0.599
CLV_NRD_NRD_1	762	764	PF00675	0.466
CLV_NRD_NRD_1	765	767	PF00675	0.464
CLV_NRD_NRD_1	774	776	PF00675	0.516
CLV_NRD_NRD_1	857	859	PF00675	0.658
CLV_NRD_NRD_1	894	896	PF00675	0.744
CLV_PCSK_FUR_1	763	767	PF00082	0.492
CLV_PCSK_KEX2_1	186	188	PF00082	0.236
CLV_PCSK_KEX2_1	309	311	PF00082	0.226
CLV_PCSK_KEX2_1	355	357	PF00082	0.236
CLV_PCSK_KEX2_1	48	50	PF00082	0.478
CLV_PCSK_KEX2_1	642	644	PF00082	0.540
CLV_PCSK_KEX2_1	724	726	PF00082	0.541
CLV_PCSK_KEX2_1	762	764	PF00082	0.472
CLV_PCSK_KEX2_1	765	767	PF00082	0.472
CLV_PCSK_KEX2_1	859	861	PF00082	0.631
CLV_PCSK_KEX2_1	894	896	PF00082	0.727
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.236
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.236
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.540
CLV_PCSK_PC1ET2_1	859	861	PF00082	0.653
CLV_PCSK_PC7_1	720	726	PF00082	0.524
CLV_PCSK_SKI1_1	167	171	PF00082	0.311
CLV_PCSK_SKI1_1	335	339	PF00082	0.236
CLV_PCSK_SKI1_1	453	457	PF00082	0.289
CLV_PCSK_SKI1_1	485	489	PF00082	0.288
CLV_PCSK_SKI1_1	518	522	PF00082	0.517
CLV_PCSK_SKI1_1	662	666	PF00082	0.690
CLV_PCSK_SKI1_1	825	829	PF00082	0.512
CLV_PCSK_SKI1_1	848	852	PF00082	0.760
DEG_APCC_DBOX_1	184	192	PF00400	0.448
DEG_APCC_DBOX_1	47	55	PF00400	0.414
DEG_Nend_UBRbox_1	1	4	PF02207	0.629
DEG_SCF_FBW7_1	419	426	PF00400	0.350
DEG_SPOP_SBC_1	60	64	PF00917	0.693
DOC_CKS1_1	195	200	PF01111	0.436
DOC_CKS1_1	420	425	PF01111	0.342
DOC_CKS1_1	91	96	PF01111	0.397
DOC_CYCLIN_yCln2_LP_2	381	387	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	502	508	PF00134	0.358
DOC_MAPK_gen_1	185	193	PF00069	0.436
DOC_MAPK_gen_1	299	307	PF00069	0.288
DOC_MAPK_gen_1	338	347	PF00069	0.444
DOC_MAPK_gen_1	352	361	PF00069	0.415
DOC_MAPK_gen_1	365	372	PF00069	0.436
DOC_MAPK_MEF2A_6	186	195	PF00069	0.436
DOC_MAPK_MEF2A_6	355	363	PF00069	0.447
DOC_MAPK_MEF2A_6	453	461	PF00069	0.276
DOC_MAPK_MEF2A_6	97	104	PF00069	0.522
DOC_MAPK_NFAT4_5	97	105	PF00069	0.522
DOC_PP1_RVXF_1	117	124	PF00149	0.436
DOC_PP1_RVXF_1	313	320	PF00149	0.436
DOC_PP1_RVXF_1	377	384	PF00149	0.436
DOC_PP1_RVXF_1	475	482	PF00149	0.288
DOC_PP1_RVXF_1	660	666	PF00149	0.656
DOC_PP2B_LxvP_1	502	505	PF13499	0.315
DOC_PP4_FxxP_1	123	126	PF00568	0.436
DOC_PP4_FxxP_1	420	423	PF00568	0.333
DOC_USP7_MATH_1	235	239	PF00917	0.541
DOC_USP7_MATH_1	264	268	PF00917	0.400
DOC_USP7_MATH_1	508	512	PF00917	0.345
DOC_USP7_MATH_1	60	64	PF00917	0.666
DOC_USP7_MATH_1	604	608	PF00917	0.708
DOC_USP7_MATH_1	611	615	PF00917	0.752
DOC_USP7_MATH_1	690	694	PF00917	0.773
DOC_USP7_MATH_1	727	731	PF00917	0.532
DOC_USP7_MATH_1	793	797	PF00917	0.676
DOC_USP7_UBL2_3	15	19	PF12436	0.592
DOC_USP7_UBL2_3	335	339	PF12436	0.447
DOC_WW_Pin1_4	145	150	PF00397	0.436
DOC_WW_Pin1_4	194	199	PF00397	0.436
DOC_WW_Pin1_4	281	286	PF00397	0.410
DOC_WW_Pin1_4	419	424	PF00397	0.342
DOC_WW_Pin1_4	691	696	PF00397	0.786
DOC_WW_Pin1_4	884	889	PF00397	0.681
DOC_WW_Pin1_4	90	95	PF00397	0.396
LIG_14-3-3_CanoR_1	247	251	PF00244	0.436
LIG_14-3-3_CanoR_1	272	279	PF00244	0.519
LIG_14-3-3_CanoR_1	365	372	PF00244	0.497
LIG_14-3-3_CanoR_1	414	419	PF00244	0.365
LIG_14-3-3_CanoR_1	775	780	PF00244	0.582
LIG_14-3-3_CanoR_1	792	801	PF00244	0.438
LIG_APCC_ABBAyCdc20_2	831	837	PF00400	0.598
LIG_BIR_III_4	605	609	PF00653	0.447
LIG_BRCT_BRCA1_1	248	252	PF00533	0.541
LIG_BRCT_BRCA1_1	416	420	PF00533	0.342
LIG_BRCT_BRCA1_1	477	481	PF00533	0.288
LIG_Clathr_ClatBox_1	218	222	PF01394	0.477
LIG_DLG_GKlike_1	414	421	PF00625	0.355
LIG_EH1_1	157	165	PF00400	0.447
LIG_EH1_1	188	196	PF00400	0.497
LIG_FAT_LD_1	301	309	PF03623	0.436
LIG_FHA_1	148	154	PF00498	0.436
LIG_FHA_1	235	241	PF00498	0.497
LIG_FHA_1	255	261	PF00498	0.305
LIG_FHA_1	274	280	PF00498	0.504
LIG_FHA_1	424	430	PF00498	0.356
LIG_FHA_1	738	744	PF00498	0.604
LIG_FHA_1	818	824	PF00498	0.616
LIG_FHA_1	97	103	PF00498	0.478
LIG_FHA_2	420	426	PF00498	0.342
LIG_FHA_2	545	551	PF00498	0.543
LIG_FHA_2	60	66	PF00498	0.679
LIG_FHA_2	628	634	PF00498	0.545
LIG_FHA_2	776	782	PF00498	0.584
LIG_GBD_Chelix_1	153	161	PF00786	0.236
LIG_GBD_Chelix_1	293	301	PF00786	0.345
LIG_HCF-1_HBM_1	65	68	PF13415	0.621
LIG_Integrin_RGD_1	576	578	PF01839	0.470
LIG_IRF3_LxIS_1	71	77	PF10401	0.496
LIG_LIR_Apic_2	120	126	PF02991	0.436
LIG_LIR_Apic_2	417	423	PF02991	0.344
LIG_LIR_Gen_1	454	464	PF02991	0.346
LIG_LIR_Gen_1	65	76	PF02991	0.432
LIG_LIR_Nem_3	357	363	PF02991	0.430
LIG_LIR_Nem_3	382	386	PF02991	0.436
LIG_LIR_Nem_3	454	459	PF02991	0.327
LIG_LIR_Nem_3	65	71	PF02991	0.459
LIG_LIR_Nem_3	866	870	PF02991	0.711
LIG_MAD2	335	343	PF02301	0.447
LIG_MLH1_MIPbox_1	477	481	PF16413	0.304
LIG_NRBOX	300	306	PF00104	0.436
LIG_NRP_CendR_1	897	900	PF00754	0.762
LIG_Pex14_1	388	392	PF04695	0.436
LIG_PTB_Apo_2	267	274	PF02174	0.419
LIG_PTB_Phospho_1	267	273	PF10480	0.422
LIG_SH2_CRK	89	93	PF00017	0.454
LIG_SH2_NCK_1	392	396	PF00017	0.461
LIG_SH2_SRC	242	245	PF00017	0.522
LIG_SH2_SRC	431	434	PF00017	0.505
LIG_SH2_STAP1	808	812	PF00017	0.643
LIG_SH2_STAT3	466	469	PF00017	0.288
LIG_SH2_STAT5	242	245	PF00017	0.504
LIG_SH2_STAT5	273	276	PF00017	0.400
LIG_SH2_STAT5	401	404	PF00017	0.436
LIG_SH2_STAT5	431	434	PF00017	0.505
LIG_SH2_STAT5	475	478	PF00017	0.288
LIG_SH2_STAT5	480	483	PF00017	0.288
LIG_SH2_STAT5	89	92	PF00017	0.529
LIG_SH3_2	889	894	PF14604	0.678
LIG_SH3_3	192	198	PF00018	0.447
LIG_SH3_3	502	508	PF00018	0.358
LIG_SH3_3	882	888	PF00018	0.694
LIG_Sin3_3	209	216	PF02671	0.511
LIG_TRAF2_1	33	36	PF00917	0.543
LIG_TRAF2_1	630	633	PF00917	0.627
LIG_TRAF2_1	671	674	PF00917	0.714
LIG_TRAF2_1	700	703	PF00917	0.733
LIG_TYR_ITIM	164	169	PF00017	0.345
LIG_UBA3_1	262	269	PF00899	0.507
LIG_UBA3_1	304	309	PF00899	0.288
LIG_UBA3_1	428	435	PF00899	0.365
LIG_UBA3_1	91	97	PF00899	0.406
LIG_WRC_WIRS_1	360	365	PF05994	0.304
MOD_CDC14_SPxK_1	148	151	PF00782	0.288
MOD_CDK_SPK_2	419	424	PF00069	0.399
MOD_CDK_SPxK_1	145	151	PF00069	0.288
MOD_CDK_SPxK_1	194	200	PF00069	0.288
MOD_CDK_SPxxK_3	90	97	PF00069	0.409
MOD_CK1_1	117	123	PF00069	0.277
MOD_CK1_1	30	36	PF00069	0.477
MOD_CK1_1	397	403	PF00069	0.288
MOD_CK1_1	544	550	PF00069	0.694
MOD_CK1_1	609	615	PF00069	0.752
MOD_CK1_1	69	75	PF00069	0.440
MOD_CK1_1	693	699	PF00069	0.747
MOD_CK1_1	77	83	PF00069	0.329
MOD_CK1_1	774	780	PF00069	0.580
MOD_CK1_1	819	825	PF00069	0.554
MOD_CK2_1	30	36	PF00069	0.450
MOD_CK2_1	419	425	PF00069	0.337
MOD_CK2_1	448	454	PF00069	0.476
MOD_CK2_1	544	550	PF00069	0.547
MOD_CK2_1	59	65	PF00069	0.690
MOD_CK2_1	627	633	PF00069	0.538
MOD_CK2_1	668	674	PF00069	0.686
MOD_CK2_1	775	781	PF00069	0.556
MOD_CK2_1	812	818	PF00069	0.736
MOD_GlcNHglycan	116	119	PF01048	0.288
MOD_GlcNHglycan	170	173	PF01048	0.288
MOD_GlcNHglycan	252	255	PF01048	0.301
MOD_GlcNHglycan	367	370	PF01048	0.373
MOD_GlcNHglycan	396	399	PF01048	0.288
MOD_GlcNHglycan	518	521	PF01048	0.633
MOD_GlcNHglycan	578	583	PF01048	0.582
MOD_GlcNHglycan	586	589	PF01048	0.769
MOD_GlcNHglycan	605	609	PF01048	0.408
MOD_GlcNHglycan	683	686	PF01048	0.737
MOD_GlcNHglycan	708	711	PF01048	0.703
MOD_GlcNHglycan	780	784	PF01048	0.635
MOD_GlcNHglycan	802	806	PF01048	0.713
MOD_GlcNHglycan	853	856	PF01048	0.737
MOD_GSK3_1	246	253	PF00069	0.304
MOD_GSK3_1	273	280	PF00069	0.465
MOD_GSK3_1	341	348	PF00069	0.323
MOD_GSK3_1	371	378	PF00069	0.409
MOD_GSK3_1	419	426	PF00069	0.350
MOD_GSK3_1	771	778	PF00069	0.544
MOD_GSK3_1	779	786	PF00069	0.624
MOD_GSK3_1	812	819	PF00069	0.661
MOD_N-GLC_1	60	65	PF02516	0.660
MOD_N-GLC_1	703	708	PF02516	0.652
MOD_N-GLC_1	875	880	PF02516	0.698
MOD_NEK2_1	250	255	PF00069	0.288
MOD_NEK2_1	319	324	PF00069	0.288
MOD_NEK2_1	331	336	PF00069	0.255
MOD_NEK2_1	345	350	PF00069	0.252
MOD_NEK2_1	448	453	PF00069	0.491
MOD_NEK2_1	498	503	PF00069	0.296
MOD_NEK2_1	516	521	PF00069	0.499
MOD_NEK2_1	851	856	PF00069	0.616
MOD_NEK2_2	264	269	PF00069	0.404
MOD_NEK2_2	475	480	PF00069	0.304
MOD_NEK2_2	611	616	PF00069	0.751
MOD_PIKK_1	252	258	PF00454	0.296
MOD_PIKK_1	273	279	PF00454	0.558
MOD_PIKK_1	74	80	PF00454	0.366
MOD_PKA_1	571	577	PF00069	0.462
MOD_PKA_1	775	781	PF00069	0.594
MOD_PKA_1	858	864	PF00069	0.747
MOD_PKA_2	246	252	PF00069	0.299
MOD_PKA_2	771	777	PF00069	0.562
MOD_Plk_1	703	709	PF00069	0.694
MOD_Plk_1	846	852	PF00069	0.747
MOD_Plk_2-3	668	674	PF00069	0.716
MOD_Plk_2-3	833	839	PF00069	0.617
MOD_Plk_2-3	875	881	PF00069	0.713
MOD_Plk_4	235	241	PF00069	0.353
MOD_Plk_4	246	252	PF00069	0.221
MOD_Plk_4	397	403	PF00069	0.285
MOD_Plk_4	414	420	PF00069	0.285
MOD_Plk_4	427	433	PF00069	0.319
MOD_Plk_4	616	622	PF00069	0.743
MOD_Plk_4	846	852	PF00069	0.553
MOD_Plk_4	87	93	PF00069	0.557
MOD_ProDKin_1	145	151	PF00069	0.288
MOD_ProDKin_1	194	200	PF00069	0.288
MOD_ProDKin_1	281	287	PF00069	0.406
MOD_ProDKin_1	419	425	PF00069	0.337
MOD_ProDKin_1	691	697	PF00069	0.786
MOD_ProDKin_1	884	890	PF00069	0.680
MOD_ProDKin_1	90	96	PF00069	0.288
MOD_SUMO_for_1	464	467	PF00179	0.304
MOD_SUMO_for_1	599	602	PF00179	0.624
MOD_SUMO_rev_2	180	188	PF00179	0.288
MOD_SUMO_rev_2	840	850	PF00179	0.537
TRG_DiLeu_BaEn_1	223	228	PF01217	0.288
TRG_DiLeu_BaEn_4	183	189	PF01217	0.304
TRG_DiLeu_BaEn_4	35	41	PF01217	0.526
TRG_DiLeu_BaLyEn_6	822	827	PF01217	0.552
TRG_DiLeu_LyEn_5	223	228	PF01217	0.288
TRG_ENDOCYTIC_2	166	169	PF00928	0.345
TRG_ENDOCYTIC_2	68	71	PF00928	0.429
TRG_ENDOCYTIC_2	867	870	PF00928	0.716
TRG_ENDOCYTIC_2	89	92	PF00928	0.408
TRG_ER_diArg_1	185	188	PF00400	0.304
TRG_ER_diArg_1	354	356	PF00400	0.288
TRG_ER_diArg_1	47	49	PF00400	0.538
TRG_ER_diArg_1	652	655	PF00400	0.528
TRG_ER_diArg_1	717	720	PF00400	0.712
TRG_ER_diArg_1	743	746	PF00400	0.471
TRG_ER_diArg_1	761	763	PF00400	0.509
TRG_ER_diArg_1	764	766	PF00400	0.462
TRG_ER_diArg_1	893	895	PF00400	0.768
TRG_ER_diArg_1	896	899	PF00400	0.773
TRG_NLS_MonoCore_2	641	646	PF00514	0.604
TRG_NLS_MonoExtC_3	758	763	PF00514	0.497
TRG_NLS_MonoExtC_3	857	862	PF00514	0.722
TRG_NLS_MonoExtN_4	335	342	PF00514	0.304
TRG_NLS_MonoExtN_4	640	646	PF00514	0.521
TRG_NLS_MonoExtN_4	757	763	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	765	770	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J1	Leptomonas seymouri	73%	100%
A0A0S4JDX4	Bodo saltans	55%	100%
A0A1X0P3K1	Trypanosomatidae	54%	96%
A0A3S7X1H1	Leishmania donovani	99%	100%
A0A422NYB4	Trypanosoma rangeli	60%	100%
A4HGH8	Leishmania braziliensis	86%	100%
A4HP48	Leishmania braziliensis	38%	100%
C9ZPV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AKB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0UMB9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	40%	100%
Q4Q8D5	Leishmania major	94%	100%
V5DAZ9	Trypanosoma cruzi	60%	95%