Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3K8_LEIIN

TriTrypDb:

LINF_280018700

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3K8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.393
CLV_C14_Caspase3-7	286	290	PF00656	0.567
CLV_C14_Caspase3-7	86	90	PF00656	0.446
CLV_NRD_NRD_1	18	20	PF00675	0.439
CLV_NRD_NRD_1	404	406	PF00675	0.450
CLV_NRD_NRD_1	423	425	PF00675	0.557
CLV_NRD_NRD_1	8	10	PF00675	0.524
CLV_NRD_NRD_1	83	85	PF00675	0.388
CLV_PCSK_KEX2_1	114	116	PF00082	0.511
CLV_PCSK_KEX2_1	306	308	PF00082	0.656
CLV_PCSK_KEX2_1	423	425	PF00082	0.515
CLV_PCSK_KEX2_1	8	10	PF00082	0.539
CLV_PCSK_KEX2_1	83	85	PF00082	0.388
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.431
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.523
CLV_PCSK_PC7_1	4	10	PF00082	0.666
CLV_PCSK_SKI1_1	114	118	PF00082	0.500
CLV_PCSK_SKI1_1	147	151	PF00082	0.445
DEG_APCC_KENBOX_2	214	218	PF00400	0.417
DEG_SPOP_SBC_1	190	194	PF00917	0.439
DOC_MAPK_gen_1	114	124	PF00069	0.452
DOC_MAPK_MEF2A_6	118	126	PF00069	0.449
DOC_USP7_MATH_1	103	107	PF00917	0.319
DOC_USP7_MATH_1	185	189	PF00917	0.503
DOC_USP7_MATH_1	190	194	PF00917	0.578
DOC_USP7_MATH_1	273	277	PF00917	0.680
DOC_USP7_MATH_1	31	35	PF00917	0.468
DOC_USP7_MATH_1	361	365	PF00917	0.698
DOC_USP7_UBL2_3	114	118	PF12436	0.430
DOC_WW_Pin1_4	231	236	PF00397	0.392
DOC_WW_Pin1_4	348	353	PF00397	0.463
DOC_WW_Pin1_4	430	435	PF00397	0.510
LIG_14-3-3_CanoR_1	147	153	PF00244	0.413
LIG_14-3-3_CanoR_1	19	23	PF00244	0.527
LIG_CSL_BTD_1	431	434	PF09270	0.507
LIG_FHA_1	251	257	PF00498	0.367
LIG_FHA_1	41	47	PF00498	0.465
LIG_FHA_1	5	11	PF00498	0.541
LIG_FHA_2	153	159	PF00498	0.479
LIG_FHA_2	174	180	PF00498	0.478
LIG_FHA_2	345	351	PF00498	0.546
LIG_Integrin_RGD_1	295	297	PF01839	0.531
LIG_Integrin_RGD_1	328	330	PF01839	0.527
LIG_LIR_Gen_1	156	167	PF02991	0.395
LIG_LIR_Gen_1	67	77	PF02991	0.314
LIG_LIR_Gen_1	89	99	PF02991	0.451
LIG_LIR_Nem_3	108	113	PF02991	0.409
LIG_LIR_Nem_3	156	162	PF02991	0.378
LIG_LIR_Nem_3	216	222	PF02991	0.511
LIG_LIR_Nem_3	330	336	PF02991	0.468
LIG_LIR_Nem_3	67	72	PF02991	0.316
LIG_LIR_Nem_3	89	94	PF02991	0.465
LIG_LYPXL_S_1	109	113	PF13949	0.428
LIG_LYPXL_yS_3	110	113	PF13949	0.438
LIG_PCNA_yPIPBox_3	93	107	PF02747	0.463
LIG_PDZ_Class_3	434	439	PF00595	0.531
LIG_Pex14_2	333	337	PF04695	0.408
LIG_SH2_CRK	159	163	PF00017	0.318
LIG_SH2_CRK	75	79	PF00017	0.328
LIG_SH2_CRK	91	95	PF00017	0.324
LIG_SH2_GRB2like	91	94	PF00017	0.537
LIG_SH2_STAP1	148	152	PF00017	0.411
LIG_SH2_STAP1	159	163	PF00017	0.271
LIG_SH3_1	269	275	PF00018	0.430
LIG_SH3_1	75	81	PF00018	0.330
LIG_SH3_2	78	83	PF14604	0.345
LIG_SH3_3	113	119	PF00018	0.522
LIG_SH3_3	269	275	PF00018	0.430
LIG_SH3_3	71	77	PF00018	0.348
LIG_Sin3_3	203	210	PF02671	0.435
LIG_SUMO_SIM_par_1	135	141	PF11976	0.294
LIG_TRAF2_1	396	399	PF00917	0.458
LIG_TRAF2_1	61	64	PF00917	0.515
LIG_WRC_WIRS_1	130	135	PF05994	0.441
LIG_WRC_WIRS_1	96	101	PF05994	0.334
MOD_CK1_1	132	138	PF00069	0.522
MOD_CK1_1	151	157	PF00069	0.281
MOD_CK1_1	18	24	PF00069	0.473
MOD_CK1_1	234	240	PF00069	0.494
MOD_CK1_1	277	283	PF00069	0.716
MOD_CK1_1	287	293	PF00069	0.684
MOD_CK1_1	348	354	PF00069	0.562
MOD_CK1_1	378	384	PF00069	0.602
MOD_CK1_1	419	425	PF00069	0.628
MOD_CK1_1	95	101	PF00069	0.331
MOD_CK2_1	152	158	PF00069	0.530
MOD_CK2_1	280	286	PF00069	0.719
MOD_CK2_1	344	350	PF00069	0.532
MOD_CK2_1	351	357	PF00069	0.650
MOD_CK2_1	58	64	PF00069	0.428
MOD_CK2_1	95	101	PF00069	0.365
MOD_GlcNHglycan	101	104	PF01048	0.414
MOD_GlcNHglycan	134	137	PF01048	0.293
MOD_GlcNHglycan	193	196	PF01048	0.669
MOD_GlcNHglycan	203	206	PF01048	0.546
MOD_GlcNHglycan	279	282	PF01048	0.646
MOD_GlcNHglycan	289	292	PF01048	0.762
MOD_GlcNHglycan	302	305	PF01048	0.663
MOD_GlcNHglycan	346	350	PF01048	0.473
MOD_GlcNHglycan	369	372	PF01048	0.713
MOD_GlcNHglycan	380	383	PF01048	0.620
MOD_GSK3_1	147	154	PF00069	0.411
MOD_GSK3_1	169	176	PF00069	0.497
MOD_GSK3_1	185	192	PF00069	0.536
MOD_GSK3_1	231	238	PF00069	0.385
MOD_GSK3_1	273	280	PF00069	0.630
MOD_GSK3_1	281	288	PF00069	0.630
MOD_GSK3_1	344	351	PF00069	0.488
MOD_GSK3_1	363	370	PF00069	0.678
MOD_GSK3_1	378	385	PF00069	0.610
MOD_GSK3_1	95	102	PF00069	0.463
MOD_N-GLC_1	173	178	PF02516	0.526
MOD_N-GLC_1	416	421	PF02516	0.495
MOD_N-GLC_1	92	97	PF02516	0.491
MOD_NEK2_1	152	157	PF00069	0.382
MOD_NEK2_1	191	196	PF00069	0.678
MOD_NEK2_1	367	372	PF00069	0.516
MOD_NEK2_1	375	380	PF00069	0.575
MOD_NEK2_1	416	421	PF00069	0.576
MOD_NEK2_1	428	433	PF00069	0.519
MOD_NEK2_1	99	104	PF00069	0.469
MOD_NEK2_2	218	223	PF00069	0.393
MOD_PIKK_1	235	241	PF00454	0.511
MOD_PIKK_1	394	400	PF00454	0.604
MOD_PKA_2	18	24	PF00069	0.517
MOD_PKA_2	277	283	PF00069	0.679
MOD_Plk_1	173	179	PF00069	0.477
MOD_Plk_1	416	422	PF00069	0.551
MOD_Plk_1	92	98	PF00069	0.489
MOD_Plk_4	173	179	PF00069	0.402
MOD_Plk_4	223	229	PF00069	0.328
MOD_Plk_4	363	369	PF00069	0.532
MOD_Plk_4	95	101	PF00069	0.334
MOD_ProDKin_1	231	237	PF00069	0.396
MOD_ProDKin_1	348	354	PF00069	0.476
MOD_ProDKin_1	430	436	PF00069	0.515
TRG_DiLeu_BaEn_1	158	163	PF01217	0.464
TRG_ENDOCYTIC_2	110	113	PF00928	0.438
TRG_ENDOCYTIC_2	159	162	PF00928	0.363
TRG_ENDOCYTIC_2	219	222	PF00928	0.376
TRG_ENDOCYTIC_2	91	94	PF00928	0.419
TRG_ER_diArg_1	122	125	PF00400	0.542
TRG_ER_diArg_1	423	425	PF00400	0.524
TRG_ER_diArg_1	8	10	PF00400	0.570
TRG_ER_diArg_1	82	84	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK1	Leptomonas seymouri	63%	100%
A0A0S4JAC2	Bodo saltans	28%	100%
A0A1X0P2Q2	Trypanosomatidae	41%	100%
A0A3Q8ID39	Leishmania donovani	100%	100%
A0A422NY97	Trypanosoma rangeli	40%	100%
A4HGH6	Leishmania braziliensis	82%	97%
C9ZPW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8D7	Leishmania major	95%	100%
V5BAD6	Trypanosoma cruzi	41%	100%