LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative phenylalanine-4-hydroxylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phenylalanine-4-hydroxylase
Gene product:
phenylalanine-4-hydroxylase
Species:
Leishmania infantum
UniProt:
A4I3K7_LEIIN
TriTrypDb:
LINF_280018600
Length:
452

Annotations

Annotations by Jardim et al.

Amino acid metabolism, phenylalanine-4-hydroxylase PAH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3K7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3K7

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 4
GO:0006520 amino acid metabolic process 3 4
GO:0006558 L-phenylalanine metabolic process 5 1
GO:0006725 cellular aromatic compound metabolic process 3 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009072 aromatic amino acid metabolic process 4 4
GO:0009987 cellular process 1 4
GO:0019752 carboxylic acid metabolic process 5 4
GO:0043436 oxoacid metabolic process 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044281 small molecule metabolic process 2 4
GO:0071704 organic substance metabolic process 2 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901605 alpha-amino acid metabolic process 4 1
GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004497 monooxygenase activity 3 9
GO:0004505 phenylalanine 4-monooxygenase activity 5 6
GO:0005488 binding 1 9
GO:0005506 iron ion binding 6 9
GO:0016491 oxidoreductase activity 2 9
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 9
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen 4 9
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0046914 transition metal ion binding 5 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 400 404 PF00656 0.439
CLV_NRD_NRD_1 167 169 PF00675 0.241
CLV_NRD_NRD_1 348 350 PF00675 0.290
CLV_NRD_NRD_1 405 407 PF00675 0.290
CLV_NRD_NRD_1 428 430 PF00675 0.280
CLV_PCSK_FUR_1 164 168 PF00082 0.306
CLV_PCSK_KEX2_1 166 168 PF00082 0.241
CLV_PCSK_KEX2_1 348 350 PF00082 0.290
CLV_PCSK_KEX2_1 428 430 PF00082 0.283
CLV_PCSK_KEX2_1 446 448 PF00082 0.638
CLV_PCSK_PC1ET2_1 446 448 PF00082 0.553
CLV_PCSK_SKI1_1 103 107 PF00082 0.300
CLV_PCSK_SKI1_1 252 256 PF00082 0.260
CLV_PCSK_SKI1_1 261 265 PF00082 0.215
CLV_PCSK_SKI1_1 329 333 PF00082 0.306
CLV_PCSK_SKI1_1 6 10 PF00082 0.559
CLV_PCSK_SKI1_1 86 90 PF00082 0.342
DEG_APCC_DBOX_1 260 268 PF00400 0.506
DEG_Nend_Nbox_1 1 3 PF02207 0.532
DOC_CDC14_PxL_1 297 305 PF14671 0.506
DOC_CKS1_1 285 290 PF01111 0.439
DOC_CYCLIN_RxL_1 3 10 PF00134 0.427
DOC_MAPK_gen_1 164 173 PF00069 0.493
DOC_MAPK_gen_1 175 185 PF00069 0.528
DOC_MAPK_gen_1 35 45 PF00069 0.418
DOC_MAPK_MEF2A_6 38 47 PF00069 0.399
DOC_PP1_RVXF_1 330 336 PF00149 0.439
DOC_USP7_UBL2_3 31 35 PF12436 0.539
DOC_WW_Pin1_4 230 235 PF00397 0.446
DOC_WW_Pin1_4 284 289 PF00397 0.454
DOC_WW_Pin1_4 381 386 PF00397 0.506
LIG_14-3-3_CanoR_1 194 199 PF00244 0.514
LIG_14-3-3_CanoR_1 270 278 PF00244 0.439
LIG_14-3-3_CanoR_1 38 44 PF00244 0.365
LIG_14-3-3_CanoR_1 428 434 PF00244 0.502
LIG_14-3-3_CterR_2 447 452 PF00244 0.599
LIG_BRCT_BRCA1_1 259 263 PF00533 0.439
LIG_BRCT_BRCA1_1 336 340 PF00533 0.463
LIG_eIF4E_1 217 223 PF01652 0.506
LIG_FHA_1 231 237 PF00498 0.533
LIG_FHA_1 253 259 PF00498 0.469
LIG_FHA_1 273 279 PF00498 0.371
LIG_FHA_1 310 316 PF00498 0.507
LIG_FHA_1 85 91 PF00498 0.415
LIG_FHA_2 16 22 PF00498 0.490
LIG_FHA_2 187 193 PF00498 0.439
LIG_FHA_2 257 263 PF00498 0.519
LIG_LIR_Apic_2 120 124 PF02991 0.346
LIG_LIR_Gen_1 197 208 PF02991 0.447
LIG_LIR_Gen_1 305 315 PF02991 0.448
LIG_LIR_Gen_1 437 445 PF02991 0.511
LIG_LIR_Gen_1 87 96 PF02991 0.357
LIG_LIR_Nem_3 197 203 PF02991 0.473
LIG_LIR_Nem_3 305 311 PF02991 0.452
LIG_LIR_Nem_3 421 426 PF02991 0.441
LIG_LIR_Nem_3 437 441 PF02991 0.396
LIG_LIR_Nem_3 60 65 PF02991 0.473
LIG_LIR_Nem_3 87 92 PF02991 0.349
LIG_NRBOX 54 60 PF00104 0.356
LIG_PCNA_yPIPBox_3 405 417 PF02747 0.474
LIG_PDZ_Class_2 447 452 PF00595 0.630
LIG_Pex14_1 196 200 PF04695 0.531
LIG_SH2_CRK 215 219 PF00017 0.506
LIG_SH2_GRB2like 79 82 PF00017 0.543
LIG_SH2_PTP2 217 220 PF00017 0.506
LIG_SH2_STAP1 273 277 PF00017 0.463
LIG_SH2_STAP1 336 340 PF00017 0.439
LIG_SH2_STAP1 426 430 PF00017 0.439
LIG_SH2_STAP1 65 69 PF00017 0.535
LIG_SH2_STAP1 79 83 PF00017 0.450
LIG_SH2_STAT3 273 276 PF00017 0.463
LIG_SH2_STAT5 188 191 PF00017 0.439
LIG_SH2_STAT5 217 220 PF00017 0.508
LIG_SH2_STAT5 277 280 PF00017 0.439
LIG_SH2_STAT5 286 289 PF00017 0.439
LIG_SH2_STAT5 395 398 PF00017 0.439
LIG_SH2_STAT5 420 423 PF00017 0.486
LIG_SH2_STAT5 95 98 PF00017 0.390
LIG_SH3_3 121 127 PF00018 0.276
LIG_SH3_3 148 154 PF00018 0.461
LIG_SH3_3 372 378 PF00018 0.439
LIG_SH3_3 58 64 PF00018 0.391
LIG_SUMO_SIM_par_1 219 224 PF11976 0.493
LIG_TRAF2_1 143 146 PF00917 0.506
LIG_TRAF2_1 189 192 PF00917 0.439
LIG_TRAF2_1 413 416 PF00917 0.493
LIG_TYR_ITIM 198 203 PF00017 0.493
LIG_UBA3_1 326 332 PF00899 0.506
LIG_WRPW_2 62 65 PF00400 0.354
MOD_CDK_SPxxK_3 230 237 PF00069 0.441
MOD_CK1_1 25 31 PF00069 0.424
MOD_CK1_1 46 52 PF00069 0.518
MOD_CK2_1 186 192 PF00069 0.446
MOD_CK2_1 356 362 PF00069 0.467
MOD_CK2_1 410 416 PF00069 0.528
MOD_Cter_Amidation 346 349 PF01082 0.290
MOD_GlcNHglycan 25 28 PF01048 0.375
MOD_GSK3_1 226 233 PF00069 0.484
MOD_GSK3_1 252 259 PF00069 0.521
MOD_GSK3_1 316 323 PF00069 0.463
MOD_GSK3_1 34 41 PF00069 0.395
MOD_GSK3_1 407 414 PF00069 0.530
MOD_GSK3_1 418 425 PF00069 0.462
MOD_GSK3_1 63 70 PF00069 0.476
MOD_N-GLC_1 186 191 PF02516 0.263
MOD_N-GLC_1 309 314 PF02516 0.241
MOD_N-GLC_1 67 72 PF02516 0.381
MOD_NEK2_1 136 141 PF00069 0.439
MOD_NEK2_1 2 7 PF00069 0.515
MOD_NEK2_1 228 233 PF00069 0.477
MOD_NEK2_1 272 277 PF00069 0.449
MOD_NEK2_1 311 316 PF00069 0.506
MOD_NEK2_1 43 48 PF00069 0.366
MOD_NEK2_1 445 450 PF00069 0.592
MOD_NEK2_2 15 20 PF00069 0.523
MOD_NEK2_2 418 423 PF00069 0.506
MOD_NEK2_2 84 89 PF00069 0.461
MOD_PIKK_1 228 234 PF00454 0.450
MOD_PIKK_1 272 278 PF00454 0.439
MOD_PIKK_1 309 315 PF00454 0.506
MOD_PIKK_1 411 417 PF00454 0.493
MOD_PIKK_1 67 73 PF00454 0.458
MOD_PK_1 63 69 PF00069 0.425
MOD_PKA_2 39 45 PF00069 0.552
MOD_Plk_1 136 142 PF00069 0.457
MOD_Plk_1 67 73 PF00069 0.391
MOD_Plk_1 97 103 PF00069 0.368
MOD_Plk_4 117 123 PF00069 0.359
MOD_Plk_4 407 413 PF00069 0.536
MOD_Plk_4 418 424 PF00069 0.563
MOD_Plk_4 57 63 PF00069 0.542
MOD_ProDKin_1 230 236 PF00069 0.446
MOD_ProDKin_1 284 290 PF00069 0.454
MOD_ProDKin_1 381 387 PF00069 0.506
MOD_SUMO_rev_2 28 37 PF00179 0.515
TRG_DiLeu_BaEn_1 54 59 PF01217 0.431
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.514
TRG_DiLeu_BaLyEn_6 298 303 PF01217 0.506
TRG_DiLeu_BaLyEn_6 3 8 PF01217 0.536
TRG_ENDOCYTIC_2 200 203 PF00928 0.506
TRG_ENDOCYTIC_2 215 218 PF00928 0.439
TRG_ER_diArg_1 163 166 PF00400 0.506
TRG_ER_diArg_1 3 6 PF00400 0.535
TRG_ER_diArg_1 428 430 PF00400 0.485
TRG_NES_CRM1_1 291 305 PF08389 0.506
TRG_Pf-PMV_PEXEL_1 131 135 PF00026 0.293
TRG_Pf-PMV_PEXEL_1 6 10 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A060X6Z0 Oncorhynchus mykiss 42% 92%
A0A0N1HZV2 Leptomonas seymouri 82% 100%
A0A0S4JDM5 Bodo saltans 56% 100%
A0A3S5H7J2 Leishmania donovani 100% 100%
A4HGH5 Leishmania braziliensis 92% 100%
A8X3V8 Caenorhabditis briggsae 44% 87%
B6DT73 Bodo saltans 56% 100%
E9AZU7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O17446 Schistosoma mansoni 42% 97%
O42091 Anguilla anguilla 43% 93%
P00439 Homo sapiens 42% 100%
P04176 Rattus norvegicus 44% 100%
P04177 Rattus norvegicus 43% 91%
P07101 Homo sapiens 42% 86%
P09810 Rattus norvegicus 43% 100%
P11982 Phasianidae sp. 42% 92%
P16331 Mus musculus 44% 100%
P17276 Drosophila melanogaster 43% 100%
P17289 Bos taurus 42% 92%
P17290 Oryctolagus cuniculus 42% 100%
P17532 Mus musculus 44% 100%
P17752 Homo sapiens 44% 100%
P18459 Drosophila melanogaster 48% 78%
P24529 Mus musculus 43% 91%
P70080 Gallus gallus 44% 100%
P90925 Caenorhabditis elegans 45% 99%
P90986 Caenorhabditis elegans 46% 87%
Q0EAB8 Equus caballus 51% 92%
Q2HZ26 Macaca mulatta 50% 92%
Q2KIH7 Bos taurus 42% 100%
Q54XS1 Dictyostelium discoideum 47% 100%
Q6WRI4 Leishmania major 98% 100%
Q76IQ3 Canis lupus familiaris 42% 91%
Q8CGU9 Rattus norvegicus 42% 93%
Q8CGV2 Mus musculus 40% 93%
Q8IWU9 Homo sapiens 42% 92%
Q92142 Xenopus laevis 41% 94%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS