Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I3K6_LEIIN

TriTrypDb:

LINF_280018500

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.565
CLV_MEL_PAP_1	194	200	PF00089	0.496
CLV_NRD_NRD_1	109	111	PF00675	0.592
CLV_NRD_NRD_1	429	431	PF00675	0.627
CLV_NRD_NRD_1	73	75	PF00675	0.320
CLV_PCSK_KEX2_1	427	429	PF00082	0.557
CLV_PCSK_KEX2_1	72	74	PF00082	0.328
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.557
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.328
CLV_PCSK_SKI1_1	162	166	PF00082	0.645
CLV_PCSK_SKI1_1	407	411	PF00082	0.387
DEG_Nend_UBRbox_2	1	3	PF02207	0.627
DEG_SPOP_SBC_1	116	120	PF00917	0.740
DEG_SPOP_SBC_1	459	463	PF00917	0.596
DOC_CDC14_PxL_1	439	447	PF14671	0.446
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.470
DOC_MAPK_gen_1	205	212	PF00069	0.534
DOC_MAPK_gen_1	27	36	PF00069	0.315
DOC_MAPK_gen_1	322	329	PF00069	0.544
DOC_MAPK_gen_1	427	437	PF00069	0.471
DOC_MAPK_MEF2A_6	190	198	PF00069	0.465
DOC_MAPK_MEF2A_6	27	36	PF00069	0.315
DOC_MAPK_MEF2A_6	430	439	PF00069	0.507
DOC_PP2B_LxvP_1	158	161	PF13499	0.619
DOC_PP2B_LxvP_1	385	388	PF13499	0.534
DOC_PP2B_LxvP_1	456	459	PF13499	0.599
DOC_USP7_MATH_1	116	120	PF00917	0.763
DOC_USP7_MATH_1	168	172	PF00917	0.584
DOC_USP7_MATH_1	230	234	PF00917	0.497
DOC_USP7_MATH_1	265	269	PF00917	0.460
DOC_USP7_MATH_1	332	336	PF00917	0.652
DOC_USP7_MATH_1	429	433	PF00917	0.594
DOC_USP7_MATH_1	460	464	PF00917	0.549
DOC_USP7_UBL2_3	427	431	PF12436	0.547
DOC_WW_Pin1_4	117	122	PF00397	0.743
DOC_WW_Pin1_4	223	228	PF00397	0.590
DOC_WW_Pin1_4	300	305	PF00397	0.635
DOC_WW_Pin1_4	336	341	PF00397	0.592
LIG_14-3-3_CanoR_1	190	195	PF00244	0.611
LIG_14-3-3_CanoR_1	222	227	PF00244	0.501
LIG_14-3-3_CanoR_1	298	305	PF00244	0.562
LIG_14-3-3_CanoR_1	59	67	PF00244	0.344
LIG_Actin_WH2_2	184	199	PF00022	0.528
LIG_APCC_ABBA_1	34	39	PF00400	0.315
LIG_APCC_ABBA_1	7	12	PF00400	0.368
LIG_BIR_III_4	180	184	PF00653	0.558
LIG_BRCT_BRCA1_1	169	173	PF00533	0.615
LIG_Clathr_ClatBox_1	244	248	PF01394	0.483
LIG_FHA_1	219	225	PF00498	0.427
LIG_FHA_1	232	238	PF00498	0.594
LIG_FHA_1	274	280	PF00498	0.631
LIG_FHA_1	339	345	PF00498	0.532
LIG_FHA_1	352	358	PF00498	0.327
LIG_FHA_2	120	126	PF00498	0.773
LIG_FHA_2	141	147	PF00498	0.666
LIG_FHA_2	310	316	PF00498	0.735
LIG_GBD_Chelix_1	269	277	PF00786	0.430
LIG_LIR_Gen_1	352	363	PF02991	0.367
LIG_LIR_Gen_1	438	445	PF02991	0.471
LIG_LIR_Gen_1	55	65	PF02991	0.327
LIG_LIR_Nem_3	233	238	PF02991	0.441
LIG_LIR_Nem_3	352	358	PF02991	0.349
LIG_LIR_Nem_3	438	442	PF02991	0.443
LIG_LIR_Nem_3	55	60	PF02991	0.327
LIG_LIR_Nem_3	61	67	PF02991	0.306
LIG_LYPXL_SIV_4	349	357	PF13949	0.449
LIG_PDZ_Class_2	465	470	PF00595	0.640
LIG_Pex14_1	235	239	PF04695	0.441
LIG_SH2_CRK	215	219	PF00017	0.424
LIG_SH2_CRK	29	33	PF00017	0.315
LIG_SH2_CRK	350	354	PF00017	0.432
LIG_SH2_CRK	355	359	PF00017	0.397
LIG_SH2_CRK	57	61	PF00017	0.315
LIG_SH2_CRK	64	68	PF00017	0.315
LIG_SH2_NCK_1	350	354	PF00017	0.447
LIG_SH2_NCK_1	355	359	PF00017	0.413
LIG_SH2_STAP1	231	235	PF00017	0.541
LIG_SH2_STAT5	187	190	PF00017	0.473
LIG_SH2_STAT5	251	254	PF00017	0.418
LIG_SH3_3	154	160	PF00018	0.690
LIG_SH3_3	224	230	PF00018	0.558
LIG_SH3_3	261	267	PF00018	0.520
LIG_SH3_3	326	332	PF00018	0.680
LIG_TYR_ITIM	348	353	PF00017	0.450
LIG_WW_1	8	11	PF00397	0.418
LIG_WW_3	159	163	PF00397	0.647
MOD_CK1_1	115	121	PF00069	0.695
MOD_CK1_1	175	181	PF00069	0.669
MOD_CK1_1	19	25	PF00069	0.390
MOD_CK1_1	226	232	PF00069	0.548
MOD_CK1_1	296	302	PF00069	0.588
MOD_CK1_1	3	9	PF00069	0.588
MOD_CK1_1	303	309	PF00069	0.709
MOD_CK1_1	318	324	PF00069	0.508
MOD_CK1_1	335	341	PF00069	0.573
MOD_CK1_1	351	357	PF00069	0.289
MOD_CK1_1	447	453	PF00069	0.576
MOD_CK2_1	119	125	PF00069	0.800
MOD_CK2_1	336	342	PF00069	0.503
MOD_CK2_1	399	405	PF00069	0.423
MOD_CK2_1	446	452	PF00069	0.538
MOD_CK2_1	65	71	PF00069	0.305
MOD_Cter_Amidation	108	111	PF01082	0.589
MOD_GlcNHglycan	105	108	PF01048	0.559
MOD_GlcNHglycan	114	117	PF01048	0.569
MOD_GlcNHglycan	138	141	PF01048	0.775
MOD_GlcNHglycan	170	173	PF01048	0.533
MOD_GlcNHglycan	174	177	PF01048	0.574
MOD_GlcNHglycan	299	302	PF01048	0.707
MOD_GlcNHglycan	317	320	PF01048	0.557
MOD_GlcNHglycan	401	404	PF01048	0.423
MOD_GSK3_1	110	117	PF00069	0.716
MOD_GSK3_1	136	143	PF00069	0.640
MOD_GSK3_1	168	175	PF00069	0.674
MOD_GSK3_1	218	225	PF00069	0.484
MOD_GSK3_1	226	233	PF00069	0.586
MOD_GSK3_1	293	300	PF00069	0.593
MOD_GSK3_1	332	339	PF00069	0.615
MOD_GSK3_1	391	398	PF00069	0.409
MOD_GSK3_1	454	461	PF00069	0.595
MOD_N-GLC_1	273	278	PF02516	0.467
MOD_N-GLC_1	395	400	PF02516	0.512
MOD_N-GLC_1	452	457	PF02516	0.582
MOD_NEK2_1	103	108	PF00069	0.584
MOD_NEK2_1	348	353	PF00069	0.518
MOD_NEK2_1	444	449	PF00069	0.577
MOD_PKA_1	110	116	PF00069	0.577
MOD_PKA_1	30	36	PF00069	0.315
MOD_PKA_2	109	115	PF00069	0.663
MOD_PKA_2	297	303	PF00069	0.656
MOD_PKA_2	429	435	PF00069	0.479
MOD_PKA_2	58	64	PF00069	0.334
MOD_Plk_1	140	146	PF00069	0.657
MOD_Plk_1	273	279	PF00069	0.474
MOD_Plk_1	333	339	PF00069	0.520
MOD_Plk_1	388	394	PF00069	0.482
MOD_Plk_1	395	401	PF00069	0.451
MOD_Plk_1	452	458	PF00069	0.586
MOD_Plk_4	265	271	PF00069	0.373
MOD_Plk_4	273	279	PF00069	0.455
MOD_Plk_4	381	387	PF00069	0.455
MOD_Plk_4	388	394	PF00069	0.445
MOD_ProDKin_1	117	123	PF00069	0.744
MOD_ProDKin_1	223	229	PF00069	0.586
MOD_ProDKin_1	300	306	PF00069	0.639
MOD_ProDKin_1	336	342	PF00069	0.576
TRG_DiLeu_BaEn_1	240	245	PF01217	0.430
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.506
TRG_ENDOCYTIC_2	11	14	PF00928	0.315
TRG_ENDOCYTIC_2	215	218	PF00928	0.422
TRG_ENDOCYTIC_2	29	32	PF00928	0.315
TRG_ENDOCYTIC_2	350	353	PF00928	0.434
TRG_ENDOCYTIC_2	355	358	PF00928	0.390
TRG_ENDOCYTIC_2	57	60	PF00928	0.315
TRG_ENDOCYTIC_2	64	67	PF00928	0.315
TRG_ER_diArg_1	465	468	PF00400	0.554
TRG_NES_CRM1_1	186	201	PF08389	0.459
TRG_NLS_MonoExtC_3	426	431	PF00514	0.541
TRG_NLS_MonoExtN_4	427	434	PF00514	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU4	Leptomonas seymouri	43%	100%
A0A3Q8IEL1	Leishmania donovani	100%	100%
A4HGH4	Leishmania braziliensis	71%	100%
E9AZU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q8D9	Leishmania major	87%	100%