LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I3K4_LEIIN
TriTrypDb:
LINF_280018300
Length:
438

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3K4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3K4

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0030030 cell projection organization 4 1
GO:0044782 cilium organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0005509 calcium ion binding 5 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 274 278 PF00656 0.507
CLV_NRD_NRD_1 332 334 PF00675 0.475
CLV_NRD_NRD_1 345 347 PF00675 0.283
CLV_NRD_NRD_1 409 411 PF00675 0.471
CLV_NRD_NRD_1 41 43 PF00675 0.401
CLV_NRD_NRD_1 95 97 PF00675 0.396
CLV_PCSK_FUR_1 409 413 PF00082 0.477
CLV_PCSK_KEX2_1 332 334 PF00082 0.496
CLV_PCSK_KEX2_1 409 411 PF00082 0.466
CLV_PCSK_KEX2_1 41 43 PF00082 0.380
CLV_PCSK_PC1ET2_1 411 413 PF00082 0.503
CLV_PCSK_SKI1_1 326 330 PF00082 0.516
DEG_APCC_DBOX_1 32 40 PF00400 0.482
DEG_APCC_DBOX_1 331 339 PF00400 0.395
DEG_SCF_FBW7_1 127 134 PF00400 0.469
DEG_SCF_FBW7_1 208 214 PF00400 0.485
DEG_SPOP_SBC_1 212 216 PF00917 0.503
DOC_CKS1_1 128 133 PF01111 0.486
DOC_CKS1_1 208 213 PF01111 0.481
DOC_MAPK_gen_1 12 22 PF00069 0.381
DOC_MAPK_gen_1 397 407 PF00069 0.563
DOC_MAPK_MEF2A_6 12 20 PF00069 0.365
DOC_PP2B_LxvP_1 110 113 PF13499 0.564
DOC_PP4_FxxP_1 119 122 PF00568 0.560
DOC_PP4_FxxP_1 128 131 PF00568 0.687
DOC_PP4_FxxP_1 22 25 PF00568 0.450
DOC_USP7_MATH_1 113 117 PF00917 0.488
DOC_USP7_MATH_1 131 135 PF00917 0.541
DOC_USP7_MATH_1 157 161 PF00917 0.603
DOC_USP7_MATH_1 162 166 PF00917 0.638
DOC_USP7_MATH_1 176 180 PF00917 0.649
DOC_USP7_MATH_1 213 217 PF00917 0.601
DOC_USP7_MATH_1 283 287 PF00917 0.345
DOC_USP7_MATH_1 31 35 PF00917 0.448
DOC_USP7_UBL2_3 380 384 PF12436 0.403
DOC_USP7_UBL2_3 97 101 PF12436 0.504
DOC_WW_Pin1_4 127 132 PF00397 0.670
DOC_WW_Pin1_4 155 160 PF00397 0.680
DOC_WW_Pin1_4 166 171 PF00397 0.538
DOC_WW_Pin1_4 186 191 PF00397 0.602
DOC_WW_Pin1_4 207 212 PF00397 0.615
DOC_WW_Pin1_4 221 226 PF00397 0.514
DOC_WW_Pin1_4 421 426 PF00397 0.659
LIG_14-3-3_CanoR_1 114 122 PF00244 0.487
LIG_14-3-3_CanoR_1 254 259 PF00244 0.494
LIG_14-3-3_CanoR_1 33 37 PF00244 0.496
LIG_14-3-3_CanoR_1 96 104 PF00244 0.587
LIG_BIR_II_1 1 5 PF00653 0.394
LIG_BRCT_BRCA1_1 115 119 PF00533 0.437
LIG_BRCT_BRCA1_1 213 217 PF00533 0.511
LIG_BRCT_BRCA1_1 256 260 PF00533 0.326
LIG_eIF4E_1 89 95 PF01652 0.253
LIG_EVH1_1 208 212 PF00568 0.480
LIG_FHA_2 221 227 PF00498 0.462
LIG_FHA_2 272 278 PF00498 0.528
LIG_FHA_2 79 85 PF00498 0.435
LIG_FHA_2 98 104 PF00498 0.321
LIG_Integrin_RGD_1 275 277 PF01839 0.608
LIG_LIR_Apic_2 116 122 PF02991 0.556
LIG_LIR_Apic_2 19 25 PF02991 0.435
LIG_LIR_Gen_1 2 11 PF02991 0.442
LIG_LIR_Gen_1 246 256 PF02991 0.433
LIG_LIR_Gen_1 267 273 PF02991 0.435
LIG_LIR_Gen_1 399 407 PF02991 0.453
LIG_LIR_Gen_1 50 61 PF02991 0.574
LIG_LIR_Gen_1 74 85 PF02991 0.417
LIG_LIR_Gen_1 88 95 PF02991 0.339
LIG_LIR_Nem_3 246 252 PF02991 0.410
LIG_LIR_Nem_3 267 272 PF02991 0.484
LIG_LIR_Nem_3 292 296 PF02991 0.381
LIG_LIR_Nem_3 399 405 PF02991 0.435
LIG_LIR_Nem_3 74 80 PF02991 0.418
LIG_LIR_Nem_3 88 92 PF02991 0.340
LIG_MLH1_MIPbox_1 115 119 PF16413 0.457
LIG_Pex14_2 249 253 PF04695 0.366
LIG_Pex14_2 293 297 PF04695 0.403
LIG_PTB_Apo_2 299 306 PF02174 0.480
LIG_PTB_Phospho_1 299 305 PF10480 0.478
LIG_Rb_pABgroove_1 263 271 PF01858 0.280
LIG_SH2_CRK 305 309 PF00017 0.450
LIG_SH2_CRK 89 93 PF00017 0.357
LIG_SH2_NCK_1 120 124 PF00017 0.390
LIG_SH2_SRC 120 123 PF00017 0.392
LIG_SH2_SRC 364 367 PF00017 0.369
LIG_SH2_STAP1 364 368 PF00017 0.550
LIG_SH2_STAP1 402 406 PF00017 0.459
LIG_SH2_STAP1 89 93 PF00017 0.376
LIG_SH2_STAT5 230 233 PF00017 0.488
LIG_SH2_STAT5 296 299 PF00017 0.443
LIG_SH2_STAT5 374 377 PF00017 0.554
LIG_SH2_STAT5 53 56 PF00017 0.611
LIG_SH2_STAT5 93 96 PF00017 0.383
LIG_SH3_3 119 125 PF00018 0.501
LIG_SH3_3 15 21 PF00018 0.386
LIG_SH3_3 206 212 PF00018 0.632
LIG_SH3_3 255 261 PF00018 0.505
LIG_SUMO_SIM_anti_2 81 88 PF11976 0.363
LIG_TRAF2_1 396 399 PF00917 0.495
LIG_TYR_ITIM 303 308 PF00017 0.443
LIG_WW_3 111 115 PF00397 0.380
MOD_CDC14_SPxK_1 169 172 PF00782 0.696
MOD_CDK_SPxK_1 166 172 PF00069 0.716
MOD_CDK_SPxK_1 221 227 PF00069 0.544
MOD_CK1_1 165 171 PF00069 0.623
MOD_CK1_1 233 239 PF00069 0.457
MOD_CK2_1 103 109 PF00069 0.457
MOD_CK2_1 185 191 PF00069 0.494
MOD_CK2_1 220 226 PF00069 0.461
MOD_CK2_1 24 30 PF00069 0.472
MOD_CK2_1 31 37 PF00069 0.438
MOD_CK2_1 393 399 PF00069 0.507
MOD_DYRK1A_RPxSP_1 421 425 PF00069 0.693
MOD_GlcNHglycan 149 152 PF01048 0.597
MOD_GlcNHglycan 164 167 PF01048 0.641
MOD_GlcNHglycan 176 179 PF01048 0.573
MOD_GlcNHglycan 197 200 PF01048 0.655
MOD_GlcNHglycan 416 419 PF01048 0.447
MOD_GSK3_1 127 134 PF00069 0.601
MOD_GSK3_1 153 160 PF00069 0.605
MOD_GSK3_1 162 169 PF00069 0.614
MOD_GSK3_1 174 181 PF00069 0.614
MOD_GSK3_1 207 214 PF00069 0.546
MOD_GSK3_1 238 245 PF00069 0.357
MOD_GSK3_1 279 286 PF00069 0.461
MOD_GSK3_1 47 54 PF00069 0.546
MOD_N-GLC_1 238 243 PF02516 0.609
MOD_N-GLC_1 97 102 PF02516 0.495
MOD_NEK2_1 1 6 PF00069 0.449
MOD_NEK2_2 213 218 PF00069 0.506
MOD_PIKK_1 103 109 PF00454 0.481
MOD_PIKK_1 157 163 PF00454 0.638
MOD_PIKK_1 233 239 PF00454 0.407
MOD_PIKK_1 283 289 PF00454 0.522
MOD_PIKK_1 71 77 PF00454 0.497
MOD_PK_1 254 260 PF00069 0.313
MOD_PK_1 384 390 PF00069 0.458
MOD_PKA_1 96 102 PF00069 0.564
MOD_PKA_2 113 119 PF00069 0.475
MOD_PKA_2 162 168 PF00069 0.690
MOD_PKA_2 306 312 PF00069 0.436
MOD_PKA_2 32 38 PF00069 0.445
MOD_PKA_2 393 399 PF00069 0.480
MOD_Plk_1 238 244 PF00069 0.597
MOD_Plk_1 364 370 PF00069 0.372
MOD_Plk_1 384 390 PF00069 0.343
MOD_Plk_1 78 84 PF00069 0.368
MOD_Plk_2-3 73 79 PF00069 0.437
MOD_Plk_4 213 219 PF00069 0.664
MOD_Plk_4 292 298 PF00069 0.435
MOD_Plk_4 384 390 PF00069 0.458
MOD_ProDKin_1 127 133 PF00069 0.670
MOD_ProDKin_1 155 161 PF00069 0.682
MOD_ProDKin_1 166 172 PF00069 0.539
MOD_ProDKin_1 186 192 PF00069 0.601
MOD_ProDKin_1 207 213 PF00069 0.615
MOD_ProDKin_1 221 227 PF00069 0.505
MOD_ProDKin_1 421 427 PF00069 0.661
MOD_SUMO_rev_2 373 382 PF00179 0.535
TRG_ENDOCYTIC_2 296 299 PF00928 0.389
TRG_ENDOCYTIC_2 305 308 PF00928 0.334
TRG_ENDOCYTIC_2 402 405 PF00928 0.460
TRG_ENDOCYTIC_2 53 56 PF00928 0.594
TRG_ENDOCYTIC_2 89 92 PF00928 0.365
TRG_ER_diArg_1 40 42 PF00400 0.412
TRG_ER_diArg_1 409 412 PF00400 0.466
TRG_ER_diArg_1 431 434 PF00400 0.655
TRG_NLS_MonoExtN_4 409 414 PF00514 0.586
TRG_Pf-PMV_PEXEL_1 333 337 PF00026 0.473

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7J6 Leptomonas seymouri 63% 94%
A0A0N1II86 Leptomonas seymouri 24% 74%
A0A0S4JFD7 Bodo saltans 25% 71%
A0A0S4KKB5 Bodo saltans 27% 100%
A0A1X0NMV7 Trypanosomatidae 26% 74%
A0A1X0NYM5 Trypanosomatidae 35% 99%
A0A3R7KQJ5 Trypanosoma rangeli 36% 100%
A0A3S5H6A9 Leishmania donovani 23% 75%
A0A3S7X1F4 Leishmania donovani 99% 100%
A0A422NE50 Trypanosoma rangeli 25% 75%
A4H5I7 Leishmania braziliensis 24% 100%
A4HGH2 Leishmania braziliensis 78% 100%
A4HTS8 Leishmania infantum 23% 100%
D0A836 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A989 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 75%
E9AML1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AZU4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q8E1 Leishmania major 92% 100%
Q4QI25 Leishmania major 23% 100%
V5DJB6 Trypanosoma cruzi 25% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS