Putative p450 reductase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p450 reductase - putative

Species:

Leishmania infantum

UniProt:

A4I3K3_LEIIN

TriTrypDb:

LINF_280018200

Length:

645

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic CYP450 reductases.. For some reason, these proteins duplicated in Kinetoplastids. Localization: ER (by homology)

Annotations by Jardim et al.

Membrane associated proteins, p450 reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I3K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3K3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003958	NADPH-hemoprotein reductase activity	5	4
GO:0005488	binding	1	11
GO:0010181	FMN binding	4	11
GO:0016491	oxidoreductase activity	2	11
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	4
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	4
GO:0032553	ribonucleotide binding	3	11
GO:0036094	small molecule binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	341	347	PF00089	0.265
CLV_NRD_NRD_1	174	176	PF00675	0.176
CLV_NRD_NRD_1	410	412	PF00675	0.248
CLV_NRD_NRD_1	477	479	PF00675	0.242
CLV_NRD_NRD_1	511	513	PF00675	0.193
CLV_NRD_NRD_1	532	534	PF00675	0.208
CLV_NRD_NRD_1	598	600	PF00675	0.307
CLV_PCSK_KEX2_1	174	176	PF00082	0.176
CLV_PCSK_KEX2_1	511	513	PF00082	0.192
CLV_PCSK_KEX2_1	532	534	PF00082	0.206

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X2	Leptomonas seymouri	76%	100%
A0A0N1I491	Leptomonas seymouri	26%	100%
A0A0N1IBR8	Leptomonas seymouri	30%	82%
A0A0S4KLI2	Bodo saltans	24%	100%
A0A1X0NZ83	Trypanosomatidae	59%	100%
A0A1X0P5U2	Trypanosomatidae	33%	93%
A0A1X0P9S6	Trypanosomatidae	26%	100%
A0A2U1KZS6	Artemisia annua	36%	91%
A0A2U1LIM9	Artemisia annua	35%	92%
A0A3Q8II21	Leishmania donovani	30%	100%

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