Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3K0_LEIIN

TriTrypDb:

LINF_280017900

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3K0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.723
CLV_C14_Caspase3-7	479	483	PF00656	0.712
CLV_C14_Caspase3-7	491	495	PF00656	0.727
CLV_NRD_NRD_1	162	164	PF00675	0.559
CLV_NRD_NRD_1	220	222	PF00675	0.737
CLV_NRD_NRD_1	259	261	PF00675	0.734
CLV_NRD_NRD_1	293	295	PF00675	0.515
CLV_NRD_NRD_1	385	387	PF00675	0.801
CLV_NRD_NRD_1	518	520	PF00675	0.634
CLV_NRD_NRD_1	568	570	PF00675	0.728
CLV_NRD_NRD_1	595	597	PF00675	0.588
CLV_NRD_NRD_1	72	74	PF00675	0.665
CLV_PCSK_FUR_1	291	295	PF00082	0.634
CLV_PCSK_FUR_1	568	572	PF00082	0.713
CLV_PCSK_FUR_1	593	597	PF00082	0.607
CLV_PCSK_KEX2_1	162	164	PF00082	0.563
CLV_PCSK_KEX2_1	220	222	PF00082	0.737
CLV_PCSK_KEX2_1	259	261	PF00082	0.713
CLV_PCSK_KEX2_1	293	295	PF00082	0.515
CLV_PCSK_KEX2_1	384	386	PF00082	0.751
CLV_PCSK_KEX2_1	568	570	PF00082	0.830
CLV_PCSK_KEX2_1	595	597	PF00082	0.556
CLV_PCSK_KEX2_1	72	74	PF00082	0.665
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.751
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.812
CLV_PCSK_SKI1_1	174	178	PF00082	0.789
CLV_PCSK_SKI1_1	230	234	PF00082	0.651
CLV_PCSK_SKI1_1	286	290	PF00082	0.528
CLV_PCSK_SKI1_1	322	326	PF00082	0.783
DEG_Nend_UBRbox_3	1	3	PF02207	0.679
DEG_SPOP_SBC_1	185	189	PF00917	0.688
DEG_SPOP_SBC_1	231	235	PF00917	0.815
DEG_SPOP_SBC_1	37	41	PF00917	0.812
DEG_SPOP_SBC_1	548	552	PF00917	0.663
DEG_SPOP_SBC_1	558	562	PF00917	0.656
DEG_SPOP_SBC_1	582	586	PF00917	0.749
DEG_SPOP_SBC_1	81	85	PF00917	0.699
DOC_ANK_TNKS_1	629	636	PF00023	0.751
DOC_CYCLIN_yCln2_LP_2	689	695	PF00134	0.718
DOC_MAPK_gen_1	593	602	PF00069	0.583
DOC_MAPK_gen_1	72	78	PF00069	0.676
DOC_MAPK_RevD_3	60	73	PF00069	0.719
DOC_PP2B_LxvP_1	689	692	PF13499	0.756
DOC_PP2B_LxvP_1	695	698	PF13499	0.680
DOC_PP2B_LxvP_1	78	81	PF13499	0.586
DOC_USP7_MATH_1	123	127	PF00917	0.739
DOC_USP7_MATH_1	186	190	PF00917	0.720
DOC_USP7_MATH_1	215	219	PF00917	0.831
DOC_USP7_MATH_1	232	236	PF00917	0.672
DOC_USP7_MATH_1	251	255	PF00917	0.566
DOC_USP7_MATH_1	331	335	PF00917	0.674
DOC_USP7_MATH_1	346	350	PF00917	0.752
DOC_USP7_MATH_1	35	39	PF00917	0.808
DOC_USP7_MATH_1	430	434	PF00917	0.726
DOC_USP7_MATH_1	533	537	PF00917	0.695
DOC_USP7_MATH_1	548	552	PF00917	0.726
DOC_USP7_MATH_1	55	59	PF00917	0.498
DOC_USP7_MATH_1	581	585	PF00917	0.710
DOC_USP7_MATH_1	698	702	PF00917	0.747
DOC_USP7_MATH_1	719	723	PF00917	0.675
DOC_USP7_MATH_1	724	728	PF00917	0.790
DOC_USP7_MATH_1	739	743	PF00917	0.599
DOC_USP7_MATH_1	81	85	PF00917	0.720
DOC_WW_Pin1_4	224	229	PF00397	0.648
DOC_WW_Pin1_4	27	32	PF00397	0.811
DOC_WW_Pin1_4	33	38	PF00397	0.724
DOC_WW_Pin1_4	388	393	PF00397	0.769
DOC_WW_Pin1_4	44	49	PF00397	0.843
DOC_WW_Pin1_4	503	508	PF00397	0.739
DOC_WW_Pin1_4	551	556	PF00397	0.748
DOC_WW_Pin1_4	563	568	PF00397	0.793
DOC_WW_Pin1_4	84	89	PF00397	0.730
LIG_14-3-3_CanoR_1	144	149	PF00244	0.728
LIG_14-3-3_CanoR_1	163	173	PF00244	0.605
LIG_14-3-3_CanoR_1	174	179	PF00244	0.703
LIG_14-3-3_CanoR_1	230	238	PF00244	0.675
LIG_14-3-3_CanoR_1	245	251	PF00244	0.622
LIG_14-3-3_CanoR_1	269	276	PF00244	0.714
LIG_14-3-3_CanoR_1	370	379	PF00244	0.724
LIG_14-3-3_CanoR_1	385	394	PF00244	0.824
LIG_14-3-3_CanoR_1	519	525	PF00244	0.839
LIG_14-3-3_CanoR_1	557	567	PF00244	0.768
LIG_14-3-3_CanoR_1	732	740	PF00244	0.718
LIG_BIR_III_4	195	199	PF00653	0.620
LIG_FHA_1	140	146	PF00498	0.713
LIG_FHA_1	399	405	PF00498	0.717
LIG_FHA_1	472	478	PF00498	0.816
LIG_FHA_1	762	768	PF00498	0.664
LIG_FHA_1	85	91	PF00498	0.579
LIG_FHA_2	165	171	PF00498	0.605
LIG_FHA_2	413	419	PF00498	0.617
LIG_FHA_2	484	490	PF00498	0.748
LIG_FHA_2	771	777	PF00498	0.717
LIG_LIR_Apic_2	606	611	PF02991	0.552
LIG_LIR_Nem_3	147	151	PF02991	0.504
LIG_LIR_Nem_3	284	288	PF02991	0.523
LIG_LIR_Nem_3	410	416	PF02991	0.586
LIG_SH2_CRK	597	601	PF00017	0.600
LIG_SH2_STAP1	208	212	PF00017	0.612
LIG_SH2_STAT3	3	6	PF00017	0.662
LIG_SH2_STAT3	615	618	PF00017	0.666
LIG_SH2_STAT5	537	540	PF00017	0.697
LIG_SH3_3	31	37	PF00018	0.791
LIG_SH3_3	321	327	PF00018	0.569
LIG_SH3_3	455	461	PF00018	0.740
LIG_SH3_3	552	558	PF00018	0.726
LIG_SH3_3	655	661	PF00018	0.706
LIG_SH3_3	680	686	PF00018	0.576
LIG_SH3_3	694	700	PF00018	0.759
LIG_SH3_3	87	93	PF00018	0.648
LIG_SUMO_SIM_par_1	474	483	PF11976	0.662
LIG_SxIP_EBH_1	126	137	PF03271	0.606
LIG_TRAF2_1	773	776	PF00917	0.674
LIG_WRC_WIRS_1	145	150	PF05994	0.509
MOD_CDC14_SPxK_1	227	230	PF00782	0.665
MOD_CDC14_SPxK_1	554	557	PF00782	0.784
MOD_CDC14_SPxK_1	566	569	PF00782	0.672
MOD_CDK_SPK_2	563	568	PF00069	0.838
MOD_CDK_SPxK_1	224	230	PF00069	0.667
MOD_CDK_SPxK_1	551	557	PF00069	0.784
MOD_CDK_SPxK_1	563	569	PF00069	0.673
MOD_CDK_SPxxK_3	563	570	PF00069	0.800
MOD_CK1_1	109	115	PF00069	0.753
MOD_CK1_1	136	142	PF00069	0.816
MOD_CK1_1	168	174	PF00069	0.608
MOD_CK1_1	237	243	PF00069	0.757
MOD_CK1_1	249	255	PF00069	0.605
MOD_CK1_1	265	271	PF00069	0.634
MOD_CK1_1	29	35	PF00069	0.727
MOD_CK1_1	334	340	PF00069	0.738
MOD_CK1_1	36	42	PF00069	0.780
MOD_CK1_1	407	413	PF00069	0.485
MOD_CK1_1	483	489	PF00069	0.681
MOD_CK1_1	495	501	PF00069	0.751
MOD_CK1_1	503	509	PF00069	0.695
MOD_CK1_1	536	542	PF00069	0.697
MOD_CK1_1	543	549	PF00069	0.711
MOD_CK1_1	550	556	PF00069	0.730
MOD_CK1_1	560	566	PF00069	0.739
MOD_CK1_1	584	590	PF00069	0.648
MOD_CK1_1	702	708	PF00069	0.668
MOD_CK1_1	709	715	PF00069	0.680
MOD_CK1_1	84	90	PF00069	0.676
MOD_CK2_1	164	170	PF00069	0.595
MOD_CK2_1	370	376	PF00069	0.812
MOD_CK2_1	412	418	PF00069	0.613
MOD_CK2_1	430	436	PF00069	0.498
MOD_CK2_1	770	776	PF00069	0.666
MOD_Cter_Amidation	291	294	PF01082	0.551
MOD_Cter_Amidation	70	73	PF01082	0.658
MOD_GlcNHglycan	108	111	PF01048	0.586
MOD_GlcNHglycan	114	117	PF01048	0.481
MOD_GlcNHglycan	170	173	PF01048	0.670
MOD_GlcNHglycan	209	213	PF01048	0.798
MOD_GlcNHglycan	234	237	PF01048	0.744
MOD_GlcNHglycan	24	27	PF01048	0.809
MOD_GlcNHglycan	253	256	PF01048	0.770
MOD_GlcNHglycan	264	267	PF01048	0.613
MOD_GlcNHglycan	270	273	PF01048	0.493
MOD_GlcNHglycan	306	309	PF01048	0.633
MOD_GlcNHglycan	367	370	PF01048	0.796
MOD_GlcNHglycan	372	375	PF01048	0.733
MOD_GlcNHglycan	40	43	PF01048	0.830
MOD_GlcNHglycan	409	412	PF01048	0.469
MOD_GlcNHglycan	432	435	PF01048	0.681
MOD_GlcNHglycan	467	470	PF01048	0.721
MOD_GlcNHglycan	53	56	PF01048	0.824
MOD_GlcNHglycan	546	549	PF01048	0.626
MOD_GlcNHglycan	57	60	PF01048	0.672
MOD_GlcNHglycan	653	656	PF01048	0.761
MOD_GlcNHglycan	689	692	PF01048	0.675
MOD_GlcNHglycan	69	72	PF01048	0.529
MOD_GlcNHglycan	704	707	PF01048	0.597
MOD_GlcNHglycan	711	714	PF01048	0.583
MOD_GlcNHglycan	721	724	PF01048	0.547
MOD_GlcNHglycan	726	729	PF01048	0.632
MOD_GlcNHglycan	749	752	PF01048	0.662
MOD_GlcNHglycan	84	87	PF01048	0.676
MOD_GlcNHglycan	94	97	PF01048	0.809
MOD_GSK3_1	102	109	PF00069	0.718
MOD_GSK3_1	133	140	PF00069	0.771
MOD_GSK3_1	164	171	PF00069	0.600
MOD_GSK3_1	180	187	PF00069	0.693
MOD_GSK3_1	215	222	PF00069	0.767
MOD_GSK3_1	22	29	PF00069	0.648
MOD_GSK3_1	226	233	PF00069	0.647
MOD_GSK3_1	234	241	PF00069	0.643
MOD_GSK3_1	246	253	PF00069	0.509
MOD_GSK3_1	261	268	PF00069	0.584
MOD_GSK3_1	299	306	PF00069	0.489
MOD_GSK3_1	33	40	PF00069	0.770
MOD_GSK3_1	346	353	PF00069	0.794
MOD_GSK3_1	380	387	PF00069	0.825
MOD_GSK3_1	403	410	PF00069	0.511
MOD_GSK3_1	467	474	PF00069	0.741
MOD_GSK3_1	478	485	PF00069	0.792
MOD_GSK3_1	490	497	PF00069	0.636
MOD_GSK3_1	499	506	PF00069	0.496
MOD_GSK3_1	51	58	PF00069	0.690
MOD_GSK3_1	532	539	PF00069	0.694
MOD_GSK3_1	540	547	PF00069	0.703
MOD_GSK3_1	557	564	PF00069	0.737
MOD_GSK3_1	581	588	PF00069	0.705
MOD_GSK3_1	635	642	PF00069	0.772
MOD_GSK3_1	698	705	PF00069	0.783
MOD_GSK3_1	719	726	PF00069	0.661
MOD_GSK3_1	80	87	PF00069	0.677
MOD_N-GLC_1	44	49	PF02516	0.779
MOD_N-GLC_1	465	470	PF02516	0.643
MOD_N-GLC_1	483	488	PF02516	0.692
MOD_N-GLC_1	648	653	PF02516	0.746
MOD_NEK2_1	121	126	PF00069	0.687
MOD_NEK2_1	404	409	PF00069	0.615
MOD_NEK2_1	467	472	PF00069	0.712
MOD_NEK2_1	501	506	PF00069	0.749
MOD_NEK2_1	733	738	PF00069	0.749
MOD_NEK2_1	82	87	PF00069	0.709
MOD_NEK2_2	272	277	PF00069	0.540
MOD_NEK2_2	451	456	PF00069	0.661
MOD_PIKK_1	215	221	PF00454	0.758
MOD_PIKK_1	404	410	PF00454	0.638
MOD_PIKK_1	443	449	PF00454	0.734
MOD_PIKK_1	614	620	PF00454	0.579
MOD_PIKK_1	676	682	PF00454	0.642
MOD_PKA_1	384	390	PF00069	0.751
MOD_PKA_2	156	162	PF00069	0.603
MOD_PKA_2	219	225	PF00069	0.695
MOD_PKA_2	261	267	PF00069	0.786
MOD_PKA_2	268	274	PF00069	0.685
MOD_PKA_2	334	340	PF00069	0.746
MOD_PKA_2	384	390	PF00069	0.824
MOD_PKA_2	51	57	PF00069	0.623
MOD_PKA_2	575	581	PF00069	0.717
MOD_PKA_2	629	635	PF00069	0.775
MOD_PKA_2	656	662	PF00069	0.595
MOD_PKB_1	260	268	PF00069	0.821
MOD_Plk_1	346	352	PF00069	0.787
MOD_Plk_1	539	545	PF00069	0.639
MOD_Plk_2-3	412	418	PF00069	0.613
MOD_Plk_4	29	35	PF00069	0.737
MOD_Plk_4	533	539	PF00069	0.658
MOD_Plk_4	540	546	PF00069	0.611
MOD_Plk_4	706	712	PF00069	0.784
MOD_ProDKin_1	224	230	PF00069	0.649
MOD_ProDKin_1	27	33	PF00069	0.812
MOD_ProDKin_1	388	394	PF00069	0.769
MOD_ProDKin_1	44	50	PF00069	0.844
MOD_ProDKin_1	503	509	PF00069	0.738
MOD_ProDKin_1	551	557	PF00069	0.750
MOD_ProDKin_1	563	569	PF00069	0.792
MOD_ProDKin_1	84	90	PF00069	0.729
TRG_DiLeu_BaEn_1	412	417	PF01217	0.585
TRG_DiLeu_BaEn_4	775	781	PF01217	0.719
TRG_DiLeu_BaLyEn_6	729	734	PF01217	0.655
TRG_ENDOCYTIC_2	285	288	PF00928	0.541
TRG_ENDOCYTIC_2	597	600	PF00928	0.607
TRG_ER_diArg_1	161	163	PF00400	0.603
TRG_ER_diArg_1	220	223	PF00400	0.739
TRG_ER_diArg_1	242	245	PF00400	0.760
TRG_ER_diArg_1	259	262	PF00400	0.720
TRG_ER_diArg_1	291	294	PF00400	0.653
TRG_ER_diArg_1	340	343	PF00400	0.788
TRG_ER_diArg_1	567	569	PF00400	0.790
TRG_ER_diArg_1	593	596	PF00400	0.539
TRG_ER_diArg_1	72	74	PF00400	0.665
TRG_NLS_MonoExtC_3	568	573	PF00514	0.729
TRG_NLS_MonoExtN_4	567	574	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I844	Leptomonas seymouri	35%	100%
A0A3S7X1G0	Leishmania donovani	99%	100%
A4HGG8	Leishmania braziliensis	59%	98%
E9AZU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8E5	Leishmania major	87%	100%