Leucine-rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeat - putative

Species:

Leishmania infantum

UniProt:

A4I3J5_LEIIN

TriTrypDb:

LINF_280017400

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4I3J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.369
CLV_C14_Caspase3-7	359	363	PF00656	0.454
CLV_C14_Caspase3-7	889	893	PF00656	0.583
CLV_C14_Caspase3-7	922	926	PF00656	0.488
CLV_NRD_NRD_1	316	318	PF00675	0.446
CLV_NRD_NRD_1	347	349	PF00675	0.476
CLV_NRD_NRD_1	693	695	PF00675	0.429
CLV_NRD_NRD_1	88	90	PF00675	0.582
CLV_PCSK_KEX2_1	247	249	PF00082	0.482
CLV_PCSK_KEX2_1	316	318	PF00082	0.420
CLV_PCSK_KEX2_1	347	349	PF00082	0.476
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.482
CLV_PCSK_SKI1_1	248	252	PF00082	0.423
CLV_PCSK_SKI1_1	317	321	PF00082	0.421
CLV_PCSK_SKI1_1	396	400	PF00082	0.536
CLV_PCSK_SKI1_1	424	428	PF00082	0.357
CLV_PCSK_SKI1_1	513	517	PF00082	0.515
CLV_PCSK_SKI1_1	694	698	PF00082	0.462
CLV_PCSK_SKI1_1	906	910	PF00082	0.525
DEG_APCC_DBOX_1	193	201	PF00400	0.439
DEG_APCC_DBOX_1	247	255	PF00400	0.421
DEG_APCC_DBOX_1	257	265	PF00400	0.335
DEG_APCC_DBOX_1	316	324	PF00400	0.413
DEG_APCC_DBOX_1	423	431	PF00400	0.346
DEG_SPOP_SBC_1	701	705	PF00917	0.430
DOC_CDC14_PxL_1	954	962	PF14671	0.530
DOC_CYCLIN_RxL_1	245	255	PF00134	0.400
DOC_CYCLIN_RxL_1	510	518	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	399	402	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.383
DOC_MAPK_DCC_7	396	405	PF00069	0.510
DOC_MAPK_DCC_7	544	553	PF00069	0.387
DOC_MAPK_gen_1	316	323	PF00069	0.418
DOC_MAPK_gen_1	347	353	PF00069	0.454
DOC_MAPK_gen_1	66	75	PF00069	0.391
DOC_MAPK_gen_1	810	819	PF00069	0.531
DOC_MAPK_gen_1	936	944	PF00069	0.489
DOC_MAPK_MEF2A_6	316	323	PF00069	0.418
DOC_MAPK_MEF2A_6	396	405	PF00069	0.510
DOC_MAPK_MEF2A_6	544	553	PF00069	0.387
DOC_MAPK_MEF2A_6	702	710	PF00069	0.458
DOC_MAPK_MEF2A_6	936	944	PF00069	0.489
DOC_PP1_RVXF_1	61	68	PF00149	0.389
DOC_PP1_RVXF_1	791	797	PF00149	0.533
DOC_PP2B_LxvP_1	23	26	PF13499	0.436
DOC_PP2B_LxvP_1	399	402	PF13499	0.513
DOC_PP2B_LxvP_1	633	636	PF13499	0.381
DOC_PP2B_LxvP_1	860	863	PF13499	0.601
DOC_PP2B_LxvP_1	960	963	PF13499	0.534
DOC_PP4_FxxP_1	658	661	PF00568	0.529
DOC_PP4_FxxP_1	789	792	PF00568	0.542
DOC_USP7_MATH_1	106	110	PF00917	0.384
DOC_USP7_MATH_1	33	37	PF00917	0.499
DOC_USP7_MATH_1	337	341	PF00917	0.542
DOC_USP7_MATH_1	346	350	PF00917	0.459
DOC_USP7_MATH_1	446	450	PF00917	0.500
DOC_USP7_MATH_1	585	589	PF00917	0.554
DOC_USP7_MATH_1	772	776	PF00917	0.577
DOC_USP7_MATH_1	792	796	PF00917	0.436
DOC_USP7_MATH_1	820	824	PF00917	0.574
DOC_USP7_MATH_1	840	844	PF00917	0.516
DOC_WW_Pin1_4	176	181	PF00397	0.496
DOC_WW_Pin1_4	241	246	PF00397	0.484
DOC_WW_Pin1_4	341	346	PF00397	0.708
DOC_WW_Pin1_4	390	395	PF00397	0.577
DOC_WW_Pin1_4	911	916	PF00397	0.543
DOC_WW_Pin1_4	936	941	PF00397	0.511
DOC_WW_Pin1_4	958	963	PF00397	0.567
LIG_14-3-3_CanoR_1	186	192	PF00244	0.545
LIG_14-3-3_CanoR_1	258	262	PF00244	0.443
LIG_14-3-3_CanoR_1	329	337	PF00244	0.545
LIG_14-3-3_CanoR_1	347	352	PF00244	0.385
LIG_14-3-3_CanoR_1	364	373	PF00244	0.397
LIG_14-3-3_CanoR_1	424	433	PF00244	0.415
LIG_14-3-3_CanoR_1	52	59	PF00244	0.387
LIG_14-3-3_CanoR_1	544	548	PF00244	0.414
LIG_14-3-3_CanoR_1	577	581	PF00244	0.462
LIG_14-3-3_CanoR_1	584	590	PF00244	0.537
LIG_14-3-3_CanoR_1	675	679	PF00244	0.597
LIG_14-3-3_CanoR_1	702	707	PF00244	0.489
LIG_14-3-3_CanoR_1	709	714	PF00244	0.369
LIG_14-3-3_CanoR_1	793	797	PF00244	0.551
LIG_14-3-3_CanoR_1	89	96	PF00244	0.498
LIG_14-3-3_CanoR_1	946	954	PF00244	0.504
LIG_Actin_WH2_2	450	465	PF00022	0.374
LIG_Actin_WH2_2	563	579	PF00022	0.399
LIG_Actin_WH2_2	628	645	PF00022	0.402
LIG_BIR_III_2	231	235	PF00653	0.536
LIG_BIR_III_4	746	750	PF00653	0.513
LIG_BRCT_BRCA1_1	654	658	PF00533	0.516
LIG_Clathr_ClatBox_1	430	434	PF01394	0.371
LIG_CSL_BTD_1	443	446	PF09270	0.529
LIG_deltaCOP1_diTrp_1	894	902	PF00928	0.562
LIG_eIF4E_1	367	373	PF01652	0.364
LIG_FHA_1	135	141	PF00498	0.518
LIG_FHA_1	217	223	PF00498	0.500
LIG_FHA_1	251	257	PF00498	0.508
LIG_FHA_1	329	335	PF00498	0.601
LIG_FHA_1	366	372	PF00498	0.366
LIG_FHA_1	434	440	PF00498	0.443
LIG_FHA_1	466	472	PF00498	0.376
LIG_FHA_1	675	681	PF00498	0.384
LIG_FHA_1	695	701	PF00498	0.324
LIG_FHA_1	918	924	PF00498	0.515
LIG_FHA_2	122	128	PF00498	0.398
LIG_FHA_2	406	412	PF00498	0.275
LIG_FHA_2	512	518	PF00498	0.502
LIG_FHA_2	610	616	PF00498	0.493
LIG_FHA_2	726	732	PF00498	0.611
LIG_FHA_2	859	865	PF00498	0.672
LIG_FHA_2	887	893	PF00498	0.670
LIG_FHA_2	89	95	PF00498	0.513
LIG_IRF3_LxIS_1	750	756	PF10401	0.506
LIG_LIR_Apic_2	655	661	PF02991	0.526
LIG_LIR_Apic_2	788	792	PF02991	0.551
LIG_LIR_Gen_1	292	302	PF02991	0.460
LIG_LIR_Gen_1	795	803	PF02991	0.572
LIG_LIR_Gen_1	893	902	PF02991	0.530
LIG_LIR_Gen_1	907	918	PF02991	0.513
LIG_LIR_Gen_1	939	949	PF02991	0.492
LIG_LIR_LC3C_4	109	114	PF02991	0.344
LIG_LIR_Nem_3	292	298	PF02991	0.434
LIG_LIR_Nem_3	442	447	PF02991	0.530
LIG_LIR_Nem_3	453	457	PF02991	0.391
LIG_LIR_Nem_3	751	755	PF02991	0.556
LIG_LIR_Nem_3	795	799	PF02991	0.568
LIG_LIR_Nem_3	907	913	PF02991	0.528
LIG_LIR_Nem_3	939	944	PF02991	0.494
LIG_LIR_Nem_3	964	969	PF02991	0.559
LIG_MYND_1	27	31	PF01753	0.498
LIG_MYND_1	958	962	PF01753	0.537
LIG_MYND_3	197	201	PF01753	0.413
LIG_NRBOX	426	432	PF00104	0.402
LIG_Pex14_1	217	221	PF04695	0.374
LIG_Pex14_2	375	379	PF04695	0.415
LIG_Pex14_2	654	658	PF04695	0.516
LIG_Rb_LxCxE_1	428	442	PF01857	0.400
LIG_SH2_NCK_1	803	807	PF00017	0.539
LIG_SH2_SRC	547	550	PF00017	0.441
LIG_SH2_SRC	580	583	PF00017	0.519
LIG_SH2_SRC	649	652	PF00017	0.496
LIG_SH2_STAP1	562	566	PF00017	0.378
LIG_SH2_STAT5	221	224	PF00017	0.378
LIG_SH2_STAT5	28	31	PF00017	0.576
LIG_SH2_STAT5	367	370	PF00017	0.443
LIG_SH2_STAT5	547	550	PF00017	0.409
LIG_SH2_STAT5	679	682	PF00017	0.383
LIG_SH2_STAT5	716	719	PF00017	0.492
LIG_SH3_2	391	396	PF14604	0.522
LIG_SH3_3	141	147	PF00018	0.499
LIG_SH3_3	186	192	PF00018	0.581
LIG_SH3_3	27	33	PF00018	0.563
LIG_SH3_3	388	394	PF00018	0.508
LIG_SH3_3	395	401	PF00018	0.534
LIG_SH3_3	659	665	PF00018	0.587
LIG_SH3_3	956	962	PF00018	0.534
LIG_SUMO_SIM_par_1	552	558	PF11976	0.332
LIG_UBA3_1	690	695	PF00899	0.459
LIG_WW_1	25	28	PF00397	0.468
LIG_WW_3	344	348	PF00397	0.490
MOD_CDC14_SPxK_1	244	247	PF00782	0.476
MOD_CDC14_SPxK_1	344	347	PF00782	0.515
MOD_CDC14_SPxK_1	393	396	PF00782	0.587
MOD_CDK_SPxK_1	241	247	PF00069	0.493
MOD_CDK_SPxK_1	341	347	PF00069	0.539
MOD_CDK_SPxK_1	390	396	PF00069	0.580
MOD_CDK_SPxxK_3	241	248	PF00069	0.489
MOD_CDK_SPxxK_3	341	348	PF00069	0.512
MOD_CK1_1	105	111	PF00069	0.396
MOD_CK1_1	121	127	PF00069	0.317
MOD_CK1_1	157	163	PF00069	0.465
MOD_CK1_1	176	182	PF00069	0.427
MOD_CK1_1	279	285	PF00069	0.515
MOD_CK1_1	294	300	PF00069	0.588
MOD_CK1_1	533	539	PF00069	0.552
MOD_CK1_1	557	563	PF00069	0.350
MOD_CK1_1	583	589	PF00069	0.574
MOD_CK1_1	748	754	PF00069	0.534
MOD_CK1_1	818	824	PF00069	0.581
MOD_CK1_1	875	881	PF00069	0.641
MOD_CK1_1	914	920	PF00069	0.553
MOD_CK2_1	327	333	PF00069	0.476
MOD_CK2_1	498	504	PF00069	0.553
MOD_CK2_1	609	615	PF00069	0.478
MOD_CK2_1	725	731	PF00069	0.608
MOD_CK2_1	753	759	PF00069	0.597
MOD_CK2_1	763	769	PF00069	0.556
MOD_CK2_1	770	776	PF00069	0.475
MOD_CK2_1	858	864	PF00069	0.674
MOD_CK2_1	964	970	PF00069	0.785
MOD_CMANNOS	131	134	PF00535	0.404
MOD_Cter_Amidation	87	90	PF01082	0.573
MOD_GlcNHglycan	104	107	PF01048	0.393
MOD_GlcNHglycan	175	178	PF01048	0.432
MOD_GlcNHglycan	189	192	PF01048	0.644
MOD_GlcNHglycan	239	244	PF01048	0.518
MOD_GlcNHglycan	278	281	PF01048	0.541
MOD_GlcNHglycan	312	315	PF01048	0.567
MOD_GlcNHglycan	339	342	PF01048	0.601
MOD_GlcNHglycan	35	38	PF01048	0.494
MOD_GlcNHglycan	39	44	PF01048	0.419
MOD_GlcNHglycan	427	430	PF01048	0.421
MOD_GlcNHglycan	448	451	PF01048	0.449
MOD_GlcNHglycan	494	497	PF01048	0.519
MOD_GlcNHglycan	535	538	PF01048	0.592
MOD_GlcNHglycan	54	57	PF01048	0.393
MOD_GlcNHglycan	562	565	PF01048	0.418
MOD_GlcNHglycan	587	590	PF01048	0.560
MOD_GlcNHglycan	609	612	PF01048	0.495
MOD_GlcNHglycan	687	690	PF01048	0.545
MOD_GlcNHglycan	738	742	PF01048	0.585
MOD_GlcNHglycan	746	750	PF01048	0.492
MOD_GlcNHglycan	75	78	PF01048	0.417
MOD_GlcNHglycan	755	758	PF01048	0.523
MOD_GlcNHglycan	772	775	PF01048	0.509
MOD_GlcNHglycan	846	849	PF01048	0.643
MOD_GlcNHglycan	866	869	PF01048	0.558
MOD_GlcNHglycan	878	881	PF01048	0.579
MOD_GlcNHglycan	904	909	PF01048	0.529
MOD_GlcNHglycan	949	952	PF01048	0.546
MOD_GlcNHglycan	954	957	PF01048	0.595
MOD_GlcNHglycan	966	969	PF01048	0.509
MOD_GSK3_1	102	109	PF00069	0.402
MOD_GSK3_1	130	137	PF00069	0.458
MOD_GSK3_1	178	185	PF00069	0.569
MOD_GSK3_1	287	294	PF00069	0.566
MOD_GSK3_1	337	344	PF00069	0.782
MOD_GSK3_1	433	440	PF00069	0.437
MOD_GSK3_1	446	453	PF00069	0.401
MOD_GSK3_1	543	550	PF00069	0.474
MOD_GSK3_1	576	583	PF00069	0.454
MOD_GSK3_1	588	595	PF00069	0.520
MOD_GSK3_1	670	677	PF00069	0.478
MOD_GSK3_1	69	76	PF00069	0.421
MOD_GSK3_1	696	703	PF00069	0.439
MOD_GSK3_1	725	732	PF00069	0.572
MOD_GSK3_1	831	838	PF00069	0.591
MOD_GSK3_1	840	847	PF00069	0.545
MOD_GSK3_1	872	879	PF00069	0.598
MOD_GSK3_1	882	889	PF00069	0.726
MOD_GSK3_1	958	965	PF00069	0.582
MOD_N-GLC_1	154	159	PF02516	0.356
MOD_N-GLC_1	310	315	PF02516	0.619
MOD_N-GLC_1	831	836	PF02516	0.555
MOD_NEK2_1	199	204	PF00069	0.463
MOD_NEK2_1	250	255	PF00069	0.395
MOD_NEK2_1	270	275	PF00069	0.424
MOD_NEK2_1	327	332	PF00069	0.443
MOD_NEK2_1	405	410	PF00069	0.415
MOD_NEK2_1	478	483	PF00069	0.414
MOD_NEK2_1	576	581	PF00069	0.438
MOD_NEK2_1	609	614	PF00069	0.526
MOD_NEK2_1	685	690	PF00069	0.365
MOD_NEK2_1	696	701	PF00069	0.403
MOD_NEK2_1	737	742	PF00069	0.567
MOD_NEK2_1	753	758	PF00069	0.529
MOD_NEK2_1	846	851	PF00069	0.551
MOD_NEK2_1	909	914	PF00069	0.584
MOD_NEK2_1	916	921	PF00069	0.535
MOD_NEK2_2	725	730	PF00069	0.546
MOD_NEK2_2	840	845	PF00069	0.554
MOD_PK_1	702	708	PF00069	0.447
MOD_PK_1	709	715	PF00069	0.360
MOD_PK_1	763	769	PF00069	0.562
MOD_PKA_1	347	353	PF00069	0.430
MOD_PKA_1	694	700	PF00069	0.420
MOD_PKA_2	257	263	PF00069	0.385
MOD_PKA_2	328	334	PF00069	0.436
MOD_PKA_2	346	352	PF00069	0.379
MOD_PKA_2	543	549	PF00069	0.430
MOD_PKA_2	576	582	PF00069	0.466
MOD_PKA_2	583	589	PF00069	0.738
MOD_PKA_2	674	680	PF00069	0.428
MOD_PKA_2	701	707	PF00069	0.447
MOD_PKA_2	792	798	PF00069	0.554
MOD_PKA_2	844	850	PF00069	0.586
MOD_PKA_2	875	881	PF00069	0.629
MOD_PKA_2	88	94	PF00069	0.540
MOD_PKB_1	605	613	PF00069	0.494
MOD_PKB_1	692	700	PF00069	0.421
MOD_Plk_1	157	163	PF00069	0.324
MOD_Plk_1	557	563	PF00069	0.324
MOD_Plk_1	614	620	PF00069	0.395
MOD_Plk_1	904	910	PF00069	0.510
MOD_Plk_2-3	890	896	PF00069	0.569
MOD_Plk_4	130	136	PF00069	0.466
MOD_Plk_4	168	174	PF00069	0.371
MOD_Plk_4	199	205	PF00069	0.376
MOD_Plk_4	217	223	PF00069	0.306
MOD_Plk_4	347	353	PF00069	0.466
MOD_Plk_4	450	456	PF00069	0.428
MOD_Plk_4	543	549	PF00069	0.542
MOD_Plk_4	557	563	PF00069	0.303
MOD_Plk_4	674	680	PF00069	0.428
MOD_Plk_4	748	754	PF00069	0.547
MOD_Plk_4	798	804	PF00069	0.576
MOD_ProDKin_1	176	182	PF00069	0.506
MOD_ProDKin_1	241	247	PF00069	0.483
MOD_ProDKin_1	341	347	PF00069	0.697
MOD_ProDKin_1	390	396	PF00069	0.580
MOD_ProDKin_1	911	917	PF00069	0.540
MOD_ProDKin_1	936	942	PF00069	0.511
MOD_ProDKin_1	958	964	PF00069	0.570
MOD_SUMO_for_1	647	650	PF00179	0.482
TRG_DiLeu_BaEn_2	936	942	PF01217	0.511
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.409
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.386
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.367
TRG_ENDOCYTIC_2	966	969	PF00928	0.562
TRG_ER_diArg_1	227	230	PF00400	0.422
TRG_ER_diArg_1	346	348	PF00400	0.512
TRG_ER_diArg_1	604	607	PF00400	0.547
TRG_ER_diArg_1	691	694	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV9	Leptomonas seymouri	30%	100%
A0A3Q8IDR9	Leishmania donovani	100%	100%
A4HGG3	Leishmania braziliensis	61%	100%
E9AZT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%