LeishMANIAdb
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Putative long-chain-fatty-acid-CoA ligase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative long-chain-fatty-acid-CoA ligase
Gene product:
long-chain-fatty-acid-CoA ligase - putative
Species:
Leishmania infantum
UniProt:
A4I3J3_LEIIN
TriTrypDb:
LINF_280017200 *
Length:
736

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, long-chain-fatty-acid-CoA ligase (Fragment)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I3J3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3J3

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006633 fatty acid biosynthetic process 5 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0016053 organic acid biosynthetic process 4 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046394 carboxylic acid biosynthetic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0072330 monocarboxylic acid biosynthetic process 6 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 17
GO:0004467 long-chain fatty acid-CoA ligase activity 3 5
GO:0015645 fatty acid ligase activity 2 5
GO:0016405 CoA-ligase activity 4 10
GO:0016874 ligase activity 2 17
GO:0016877 ligase activity, forming carbon-sulfur bonds 3 10
GO:0016878 acid-thiol ligase activity 4 10
GO:0140657 ATP-dependent activity 1 5
GO:0031957 very long-chain fatty acid-CoA ligase activity 3 1
GO:0016207 4-coumarate-CoA ligase activity 5 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 192 194 PF00675 0.613
CLV_NRD_NRD_1 288 290 PF00675 0.605
CLV_NRD_NRD_1 449 451 PF00675 0.404
CLV_NRD_NRD_1 460 462 PF00675 0.346
CLV_NRD_NRD_1 63 65 PF00675 0.367
CLV_PCSK_KEX2_1 192 194 PF00082 0.661
CLV_PCSK_KEX2_1 229 231 PF00082 0.400
CLV_PCSK_KEX2_1 261 263 PF00082 0.572
CLV_PCSK_KEX2_1 288 290 PF00082 0.721
CLV_PCSK_KEX2_1 63 65 PF00082 0.353
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.428
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.554
CLV_PCSK_SKI1_1 166 170 PF00082 0.436
CLV_PCSK_SKI1_1 21 25 PF00082 0.469
CLV_PCSK_SKI1_1 224 228 PF00082 0.456
CLV_PCSK_SKI1_1 230 234 PF00082 0.487
CLV_PCSK_SKI1_1 30 34 PF00082 0.437
CLV_PCSK_SKI1_1 673 677 PF00082 0.322
CLV_PCSK_SKI1_1 695 699 PF00082 0.362
CLV_PCSK_SKI1_1 718 722 PF00082 0.256
CLV_PCSK_SKI1_1 727 731 PF00082 0.369
CLV_PCSK_SKI1_1 89 93 PF00082 0.436
CLV_Separin_Metazoa 715 719 PF03568 0.353
DEG_APCC_DBOX_1 33 41 PF00400 0.321
DEG_ODPH_VHL_1 701 713 PF01847 0.288
DOC_CKS1_1 135 140 PF01111 0.330
DOC_CYCLIN_yCln2_LP_2 135 141 PF00134 0.358
DOC_CYCLIN_yCln2_LP_2 507 513 PF00134 0.289
DOC_MAPK_gen_1 144 152 PF00069 0.370
DOC_MAPK_gen_1 337 347 PF00069 0.289
DOC_MAPK_gen_1 622 631 PF00069 0.374
DOC_MAPK_gen_1 694 700 PF00069 0.431
DOC_MAPK_gen_1 726 735 PF00069 0.472
DOC_PP1_RVXF_1 671 678 PF00149 0.288
DOC_PP2B_LxvP_1 478 481 PF13499 0.289
DOC_PP2B_LxvP_1 700 703 PF13499 0.288
DOC_USP7_MATH_1 245 249 PF00917 0.727
DOC_USP7_MATH_1 26 30 PF00917 0.337
DOC_USP7_MATH_1 332 336 PF00917 0.314
DOC_USP7_MATH_1 404 408 PF00917 0.406
DOC_USP7_MATH_1 561 565 PF00917 0.275
DOC_USP7_MATH_1 602 606 PF00917 0.289
DOC_USP7_UBL2_3 229 233 PF12436 0.645
DOC_USP7_UBL2_3 267 271 PF12436 0.426
DOC_USP7_UBL2_3 723 727 PF12436 0.398
DOC_WW_Pin1_4 134 139 PF00397 0.323
DOC_WW_Pin1_4 248 253 PF00397 0.439
DOC_WW_Pin1_4 450 455 PF00397 0.256
DOC_WW_Pin1_4 521 526 PF00397 0.387
DOC_WW_Pin1_4 95 100 PF00397 0.595
LIG_14-3-3_CanoR_1 497 507 PF00244 0.270
LIG_14-3-3_CanoR_1 613 617 PF00244 0.289
LIG_14-3-3_CanoR_1 673 678 PF00244 0.395
LIG_APCC_ABBAyCdc20_2 638 644 PF00400 0.313
LIG_BRCT_BRCA1_1 207 211 PF00533 0.469
LIG_Clathr_ClatBox_1 312 316 PF01394 0.288
LIG_deltaCOP1_diTrp_1 375 379 PF00928 0.335
LIG_EH1_1 391 399 PF00400 0.289
LIG_eIF4E_1 217 223 PF01652 0.418
LIG_FHA_1 109 115 PF00498 0.378
LIG_FHA_1 119 125 PF00498 0.320
LIG_FHA_1 163 169 PF00498 0.543
LIG_FHA_1 208 214 PF00498 0.426
LIG_FHA_1 233 239 PF00498 0.558
LIG_FHA_1 380 386 PF00498 0.358
LIG_FHA_1 437 443 PF00498 0.325
LIG_FHA_1 593 599 PF00498 0.334
LIG_FHA_1 684 690 PF00498 0.364
LIG_FHA_1 719 725 PF00498 0.289
LIG_FHA_2 10 16 PF00498 0.451
LIG_FHA_2 213 219 PF00498 0.322
LIG_FHA_2 337 343 PF00498 0.463
LIG_FHA_2 412 418 PF00498 0.289
LIG_FHA_2 491 497 PF00498 0.274
LIG_FHA_2 574 580 PF00498 0.289
LIG_FHA_2 674 680 PF00498 0.400
LIG_GBD_Chelix_1 397 405 PF00786 0.200
LIG_LIR_Apic_2 241 245 PF02991 0.530
LIG_LIR_Apic_2 76 82 PF02991 0.492
LIG_LIR_Gen_1 15 24 PF02991 0.365
LIG_LIR_Gen_1 175 183 PF02991 0.451
LIG_LIR_Gen_1 432 442 PF02991 0.295
LIG_LIR_Gen_1 549 560 PF02991 0.295
LIG_LIR_Gen_1 605 616 PF02991 0.246
LIG_LIR_Gen_1 708 717 PF02991 0.304
LIG_LIR_Nem_3 15 19 PF02991 0.368
LIG_LIR_Nem_3 175 179 PF02991 0.474
LIG_LIR_Nem_3 432 437 PF02991 0.303
LIG_LIR_Nem_3 439 444 PF02991 0.257
LIG_LIR_Nem_3 46 50 PF02991 0.318
LIG_LIR_Nem_3 549 555 PF02991 0.294
LIG_LIR_Nem_3 563 569 PF02991 0.221
LIG_LIR_Nem_3 605 611 PF02991 0.218
LIG_LIR_Nem_3 708 713 PF02991 0.333
LIG_PCNA_yPIPBox_3 17 30 PF02747 0.338
LIG_Pex14_2 566 570 PF04695 0.270
LIG_SH2_CRK 10 14 PF00017 0.337
LIG_SH2_CRK 120 124 PF00017 0.286
LIG_SH2_CRK 331 335 PF00017 0.397
LIG_SH2_CRK 47 51 PF00017 0.352
LIG_SH2_CRK 608 612 PF00017 0.401
LIG_SH2_CRK 704 708 PF00017 0.295
LIG_SH2_GRB2like 569 572 PF00017 0.401
LIG_SH2_NCK_1 331 335 PF00017 0.236
LIG_SH2_NCK_1 552 556 PF00017 0.266
LIG_SH2_PTP2 441 444 PF00017 0.236
LIG_SH2_PTP2 710 713 PF00017 0.348
LIG_SH2_SRC 552 555 PF00017 0.290
LIG_SH2_STAP1 10 14 PF00017 0.325
LIG_SH2_STAP1 110 114 PF00017 0.358
LIG_SH2_STAP1 120 124 PF00017 0.244
LIG_SH2_STAP1 176 180 PF00017 0.411
LIG_SH2_STAP1 217 221 PF00017 0.328
LIG_SH2_STAP1 341 345 PF00017 0.288
LIG_SH2_STAP1 643 647 PF00017 0.401
LIG_SH2_STAT3 532 535 PF00017 0.288
LIG_SH2_STAT5 103 106 PF00017 0.557
LIG_SH2_STAT5 110 113 PF00017 0.424
LIG_SH2_STAT5 120 123 PF00017 0.305
LIG_SH2_STAT5 151 154 PF00017 0.383
LIG_SH2_STAT5 180 183 PF00017 0.511
LIG_SH2_STAT5 348 351 PF00017 0.270
LIG_SH2_STAT5 441 444 PF00017 0.265
LIG_SH2_STAT5 532 535 PF00017 0.401
LIG_SH2_STAT5 608 611 PF00017 0.401
LIG_SH2_STAT5 710 713 PF00017 0.348
LIG_SH3_1 192 198 PF00018 0.454
LIG_SH3_3 192 198 PF00018 0.469
LIG_SH3_3 35 41 PF00018 0.398
LIG_SH3_3 507 513 PF00018 0.324
LIG_SH3_3 519 525 PF00018 0.283
LIG_SH3_3 530 536 PF00018 0.253
LIG_SH3_3 595 601 PF00018 0.278
LIG_SH3_3 711 717 PF00018 0.270
LIG_SH3_3 79 85 PF00018 0.439
LIG_SH3_5 99 103 PF00018 0.377
LIG_SUMO_SIM_anti_2 614 621 PF11976 0.313
LIG_SUMO_SIM_anti_2 657 664 PF11976 0.330
LIG_TRAF2_1 282 285 PF00917 0.506
LIG_TYR_ITIM 8 13 PF00017 0.336
LIG_WRC_WIRS_1 413 418 PF05994 0.423
MOD_CDK_SPxxK_3 450 457 PF00069 0.348
MOD_CK1_1 204 210 PF00069 0.487
MOD_CK1_1 248 254 PF00069 0.644
MOD_CK1_1 350 356 PF00069 0.330
MOD_CK1_1 490 496 PF00069 0.267
MOD_CK2_1 450 456 PF00069 0.265
MOD_CK2_1 490 496 PF00069 0.289
MOD_CK2_1 543 549 PF00069 0.421
MOD_CK2_1 573 579 PF00069 0.289
MOD_CK2_1 624 630 PF00069 0.357
MOD_CK2_1 673 679 PF00069 0.400
MOD_CK2_1 9 15 PF00069 0.431
MOD_GlcNHglycan 154 158 PF01048 0.448
MOD_GlcNHglycan 247 250 PF01048 0.692
MOD_GlcNHglycan 254 257 PF01048 0.564
MOD_GlcNHglycan 316 319 PF01048 0.416
MOD_GlcNHglycan 334 337 PF01048 0.391
MOD_GlcNHglycan 349 352 PF01048 0.334
MOD_GlcNHglycan 474 477 PF01048 0.320
MOD_GlcNHglycan 488 492 PF01048 0.354
MOD_GlcNHglycan 545 548 PF01048 0.485
MOD_GlcNHglycan 571 574 PF01048 0.328
MOD_GlcNHglycan 604 607 PF01048 0.261
MOD_GlcNHglycan 626 629 PF01048 0.345
MOD_GSK3_1 104 111 PF00069 0.481
MOD_GSK3_1 118 125 PF00069 0.261
MOD_GSK3_1 153 160 PF00069 0.460
MOD_GSK3_1 201 208 PF00069 0.620
MOD_GSK3_1 248 255 PF00069 0.423
MOD_GSK3_1 332 339 PF00069 0.316
MOD_GSK3_1 346 353 PF00069 0.309
MOD_GSK3_1 521 528 PF00069 0.346
MOD_GSK3_1 569 576 PF00069 0.161
MOD_GSK3_1 602 609 PF00069 0.236
MOD_GSK3_1 683 690 PF00069 0.399
MOD_N-GLC_1 201 206 PF02516 0.537
MOD_N-GLC_1 718 723 PF02516 0.319
MOD_NEK2_1 109 114 PF00069 0.368
MOD_NEK2_1 126 131 PF00069 0.388
MOD_NEK2_1 139 144 PF00069 0.421
MOD_NEK2_1 153 158 PF00069 0.299
MOD_NEK2_1 212 217 PF00069 0.449
MOD_NEK2_1 346 351 PF00069 0.334
MOD_NEK2_1 43 48 PF00069 0.323
MOD_NEK2_1 505 510 PF00069 0.274
MOD_NEK2_1 611 616 PF00069 0.270
MOD_NEK2_2 429 434 PF00069 0.401
MOD_NEK2_2 464 469 PF00069 0.288
MOD_NEK2_2 561 566 PF00069 0.326
MOD_NEK2_2 9 14 PF00069 0.330
MOD_PIKK_1 139 145 PF00454 0.414
MOD_PIKK_1 505 511 PF00454 0.344
MOD_PKA_2 336 342 PF00069 0.311
MOD_PKA_2 379 385 PF00069 0.353
MOD_PKA_2 612 618 PF00069 0.289
MOD_PKB_1 289 297 PF00069 0.520
MOD_PKB_1 671 679 PF00069 0.227
MOD_Plk_1 429 435 PF00069 0.293
MOD_Plk_1 631 637 PF00069 0.253
MOD_Plk_1 73 79 PF00069 0.368
MOD_Plk_4 110 116 PF00069 0.385
MOD_Plk_4 118 124 PF00069 0.293
MOD_Plk_4 207 213 PF00069 0.530
MOD_Plk_4 308 314 PF00069 0.355
MOD_Plk_4 381 387 PF00069 0.324
MOD_Plk_4 436 442 PF00069 0.268
MOD_Plk_4 490 496 PF00069 0.274
MOD_Plk_4 528 534 PF00069 0.321
MOD_Plk_4 561 567 PF00069 0.272
MOD_Plk_4 606 612 PF00069 0.415
MOD_Plk_4 631 637 PF00069 0.431
MOD_Plk_4 655 661 PF00069 0.347
MOD_Plk_4 9 15 PF00069 0.327
MOD_ProDKin_1 134 140 PF00069 0.327
MOD_ProDKin_1 248 254 PF00069 0.434
MOD_ProDKin_1 450 456 PF00069 0.256
MOD_ProDKin_1 521 527 PF00069 0.387
MOD_ProDKin_1 95 101 PF00069 0.586
MOD_SUMO_rev_2 158 168 PF00179 0.454
MOD_SUMO_rev_2 225 235 PF00179 0.577
MOD_SUMO_rev_2 264 269 PF00179 0.481
MOD_SUMO_rev_2 691 696 PF00179 0.304
TRG_DiLeu_BaEn_1 466 471 PF01217 0.416
TRG_ENDOCYTIC_2 10 13 PF00928 0.341
TRG_ENDOCYTIC_2 120 123 PF00928 0.253
TRG_ENDOCYTIC_2 16 19 PF00928 0.272
TRG_ENDOCYTIC_2 176 179 PF00928 0.410
TRG_ENDOCYTIC_2 441 444 PF00928 0.270
TRG_ENDOCYTIC_2 47 50 PF00928 0.311
TRG_ENDOCYTIC_2 552 555 PF00928 0.256
TRG_ENDOCYTIC_2 608 611 PF00928 0.421
TRG_ENDOCYTIC_2 710 713 PF00928 0.318
TRG_ER_diArg_1 191 193 PF00400 0.379
TRG_ER_diArg_1 287 289 PF00400 0.659
TRG_ER_diArg_1 62 64 PF00400 0.519
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 273 278 PF00026 0.661

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IL67 Bodo saltans 42% 95%
A0A0S4J3H6 Bodo saltans 24% 100%
A0A1X0NYK4 Trypanosomatidae 51% 100%
A0A3Q8ID29 Leishmania donovani 99% 99%
A0A3R7KRF3 Trypanosoma rangeli 51% 100%
A0A3S7WVG2 Leishmania donovani 24% 100%
A0A3S7WVH9 Leishmania donovani 20% 100%
A0A3S7WVL1 Leishmania donovani 24% 100%
A4HA52 Leishmania braziliensis 21% 100%
A4HGG0 Leishmania braziliensis 82% 100%
A4HYA8 Leishmania infantum 24% 100%
A4HYB7 Leishmania infantum 20% 100%
D0A7V2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AGS6 Leishmania infantum 24% 100%
E9AZT3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P14912 Petroselinum crispum 22% 100%
Q4Q8F1 Leishmania major 92% 100%
Q4QDB5 Leishmania major 21% 100%
Q4QDB6 Leishmania major 23% 100%
V5AUI9 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS