PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3J2_LEIIN

TriTrypDb:

LINF_280015800

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3J2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.716
CLV_C14_Caspase3-7	368	372	PF00656	0.580
CLV_NRD_NRD_1	163	165	PF00675	0.545
CLV_NRD_NRD_1	198	200	PF00675	0.684
CLV_NRD_NRD_1	258	260	PF00675	0.434
CLV_NRD_NRD_1	264	266	PF00675	0.406
CLV_NRD_NRD_1	28	30	PF00675	0.469
CLV_NRD_NRD_1	426	428	PF00675	0.444
CLV_NRD_NRD_1	455	457	PF00675	0.465
CLV_NRD_NRD_1	541	543	PF00675	0.499
CLV_NRD_NRD_1	92	94	PF00675	0.520
CLV_PCSK_KEX2_1	163	165	PF00082	0.545
CLV_PCSK_KEX2_1	198	200	PF00082	0.684
CLV_PCSK_KEX2_1	258	260	PF00082	0.438
CLV_PCSK_KEX2_1	28	30	PF00082	0.469
CLV_PCSK_KEX2_1	426	428	PF00082	0.444
CLV_PCSK_KEX2_1	455	457	PF00082	0.465
CLV_PCSK_KEX2_1	540	542	PF00082	0.489
CLV_PCSK_KEX2_1	547	549	PF00082	0.521
CLV_PCSK_KEX2_1	92	94	PF00082	0.511
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.583
CLV_PCSK_SKI1_1	154	158	PF00082	0.386
CLV_PCSK_SKI1_1	171	175	PF00082	0.553
CLV_PCSK_SKI1_1	248	252	PF00082	0.430
CLV_PCSK_SKI1_1	28	32	PF00082	0.497
CLV_PCSK_SKI1_1	346	350	PF00082	0.445
CLV_PCSK_SKI1_1	4	8	PF00082	0.457
CLV_PCSK_SKI1_1	416	420	PF00082	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.587
DOC_CYCLIN_yCln2_LP_2	304	307	PF00134	0.388
DOC_MAPK_DCC_7	265	275	PF00069	0.435
DOC_MAPK_gen_1	375	384	PF00069	0.406
DOC_MAPK_MEF2A_6	286	294	PF00069	0.544
DOC_MAPK_MEF2A_6	378	386	PF00069	0.444
DOC_PP1_SILK_1	292	297	PF00149	0.451
DOC_PP2B_LxvP_1	304	307	PF13499	0.388
DOC_PP4_FxxP_1	556	559	PF00568	0.386
DOC_USP7_MATH_1	194	198	PF00917	0.722
DOC_USP7_MATH_1	440	444	PF00917	0.448
DOC_USP7_MATH_2	211	217	PF00917	0.577
DOC_WW_Pin1_4	197	202	PF00397	0.684
DOC_WW_Pin1_4	242	247	PF00397	0.554
DOC_WW_Pin1_4	268	273	PF00397	0.417
DOC_WW_Pin1_4	620	625	PF00397	0.636
LIG_14-3-3_CanoR_1	171	180	PF00244	0.514
LIG_14-3-3_CanoR_1	360	366	PF00244	0.613
LIG_14-3-3_CanoR_1	378	383	PF00244	0.508
LIG_14-3-3_CanoR_1	430	435	PF00244	0.499
LIG_14-3-3_CanoR_1	459	464	PF00244	0.509
LIG_14-3-3_CanoR_1	98	107	PF00244	0.469
LIG_Actin_WH2_2	141	156	PF00022	0.458
LIG_APCC_ABBA_1	549	554	PF00400	0.438
LIG_APCC_ABBAyCdc20_2	548	554	PF00400	0.468
LIG_BRCT_BRCA1_1	191	195	PF00533	0.646
LIG_BRCT_BRCA1_1	622	626	PF00533	0.635
LIG_deltaCOP1_diTrp_1	486	490	PF00928	0.393
LIG_eIF4E_1	506	512	PF01652	0.478
LIG_FHA_1	148	154	PF00498	0.384
LIG_FHA_1	269	275	PF00498	0.405
LIG_FHA_1	322	328	PF00498	0.345
LIG_FHA_2	232	238	PF00498	0.635
LIG_FHA_2	448	454	PF00498	0.334
LIG_FHA_2	534	540	PF00498	0.433
LIG_FHA_2	604	610	PF00498	0.616
LIG_FHA_2	620	626	PF00498	0.520
LIG_LIR_Apic_2	401	405	PF02991	0.327
LIG_LIR_Apic_2	553	559	PF02991	0.423
LIG_LIR_Gen_1	252	261	PF02991	0.423
LIG_LIR_Gen_1	385	395	PF02991	0.431
LIG_LIR_Gen_1	417	425	PF02991	0.405
LIG_LIR_Gen_1	449	458	PF02991	0.484
LIG_LIR_Gen_1	504	513	PF02991	0.370
LIG_LIR_Gen_1	520	530	PF02991	0.353
LIG_LIR_Nem_3	252	257	PF02991	0.370
LIG_LIR_Nem_3	385	390	PF02991	0.465
LIG_LIR_Nem_3	417	422	PF02991	0.444
LIG_LIR_Nem_3	449	454	PF02991	0.479
LIG_LIR_Nem_3	486	490	PF02991	0.458
LIG_LIR_Nem_3	520	525	PF02991	0.571
LIG_LIR_Nem_3	89	94	PF02991	0.486
LIG_Pex14_1	415	419	PF04695	0.445
LIG_SH2_CRK	522	526	PF00017	0.431
LIG_SH2_CRK	91	95	PF00017	0.436
LIG_SH2_PTP2	87	90	PF00017	0.445
LIG_SH2_STAP1	310	314	PF00017	0.374
LIG_SH2_STAP1	437	441	PF00017	0.429
LIG_SH2_STAP1	552	556	PF00017	0.528
LIG_SH2_STAP1	613	617	PF00017	0.608
LIG_SH2_STAT3	318	321	PF00017	0.411
LIG_SH2_STAT5	152	155	PF00017	0.343
LIG_SH2_STAT5	474	477	PF00017	0.411
LIG_SH2_STAT5	517	520	PF00017	0.390
LIG_SH2_STAT5	87	90	PF00017	0.404
LIG_SH3_3	429	435	PF00018	0.511
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.456
LIG_SUMO_SIM_par_1	271	277	PF11976	0.413
LIG_TRAF2_1	167	170	PF00917	0.669
LIG_TRAF2_1	204	207	PF00917	0.665
LIG_TRAF2_1	250	253	PF00917	0.440
LIG_TRAF2_1	351	354	PF00917	0.367
LIG_TRAF2_1	356	359	PF00917	0.386
LIG_TRFH_1	556	560	PF08558	0.458
MOD_CDC14_SPxK_1	245	248	PF00782	0.350
MOD_CDK_SPxK_1	242	248	PF00069	0.393
MOD_CK1_1	189	195	PF00069	0.701
MOD_CK1_1	197	203	PF00069	0.708
MOD_CK2_1	164	170	PF00069	0.693
MOD_CK2_1	187	193	PF00069	0.816
MOD_CK2_1	353	359	PF00069	0.401
MOD_CK2_1	440	446	PF00069	0.347
MOD_CK2_1	447	453	PF00069	0.357
MOD_CK2_1	459	465	PF00069	0.365
MOD_CK2_1	533	539	PF00069	0.424
MOD_CK2_1	619	625	PF00069	0.671
MOD_Cter_Amidation	161	164	PF01082	0.514
MOD_GlcNHglycan	100	103	PF01048	0.360
MOD_GlcNHglycan	166	169	PF01048	0.674
MOD_GlcNHglycan	189	192	PF01048	0.752
MOD_GlcNHglycan	353	358	PF01048	0.417
MOD_GlcNHglycan	367	370	PF01048	0.660
MOD_GlcNHglycan	432	435	PF01048	0.480
MOD_GlcNHglycan	595	598	PF01048	0.593
MOD_GSK3_1	183	190	PF00069	0.768
MOD_GSK3_1	349	356	PF00069	0.483
MOD_GSK3_1	361	368	PF00069	0.525
MOD_GSK3_1	378	385	PF00069	0.522
MOD_GSK3_1	40	47	PF00069	0.438
MOD_GSK3_1	593	600	PF00069	0.568
MOD_LATS_1	134	140	PF00433	0.531
MOD_N-GLC_1	136	141	PF02516	0.567
MOD_N-GLC_1	533	538	PF02516	0.484
MOD_NEK2_1	10	15	PF00069	0.452
MOD_NEK2_1	157	162	PF00069	0.440
MOD_NEK2_1	274	279	PF00069	0.425
MOD_NEK2_1	290	295	PF00069	0.387
MOD_NEK2_1	333	338	PF00069	0.463
MOD_NEK2_1	365	370	PF00069	0.664
MOD_NEK2_1	382	387	PF00069	0.412
MOD_NEK2_1	458	463	PF00069	0.530
MOD_NEK2_2	310	315	PF00069	0.369
MOD_PIKK_1	183	189	PF00454	0.766
MOD_PIKK_1	276	282	PF00454	0.439
MOD_PIKK_1	321	327	PF00454	0.346
MOD_PIKK_1	40	46	PF00454	0.436
MOD_PIKK_1	533	539	PF00454	0.466
MOD_PIKK_1	611	617	PF00454	0.635
MOD_PKA_2	10	16	PF00069	0.512
MOD_PKA_2	213	219	PF00069	0.702
MOD_PKA_2	458	464	PF00069	0.495
MOD_PKA_2	593	599	PF00069	0.557
MOD_PKB_1	96	104	PF00069	0.413
MOD_Plk_1	310	316	PF00069	0.368
MOD_Plk_1	341	347	PF00069	0.386
MOD_Plk_1	533	539	PF00069	0.461
MOD_Plk_4	290	296	PF00069	0.442
MOD_Plk_4	382	388	PF00069	0.378
MOD_Plk_4	466	472	PF00069	0.476
MOD_Plk_4	521	527	PF00069	0.460
MOD_ProDKin_1	197	203	PF00069	0.687
MOD_ProDKin_1	242	248	PF00069	0.548
MOD_ProDKin_1	268	274	PF00069	0.409
MOD_ProDKin_1	620	626	PF00069	0.641
MOD_SUMO_for_1	204	207	PF00179	0.629
MOD_SUMO_rev_2	539	549	PF00179	0.540
TRG_AP2beta_CARGO_1	417	426	PF09066	0.457
TRG_DiLeu_BaEn_1	453	458	PF01217	0.454
TRG_DiLeu_BaEn_4	252	258	PF01217	0.445
TRG_DiLeu_BaEn_4	553	559	PF01217	0.483
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.375
TRG_DiLeu_LyEn_5	269	274	PF01217	0.493
TRG_ENDOCYTIC_2	506	509	PF00928	0.395
TRG_ENDOCYTIC_2	522	525	PF00928	0.414
TRG_ENDOCYTIC_2	87	90	PF00928	0.375
TRG_ENDOCYTIC_2	91	94	PF00928	0.386
TRG_ER_diArg_1	163	165	PF00400	0.545
TRG_ER_diArg_1	257	259	PF00400	0.413
TRG_ER_diArg_1	425	427	PF00400	0.434
TRG_ER_diArg_1	454	456	PF00400	0.457
TRG_ER_diArg_1	482	485	PF00400	0.471
TRG_ER_diArg_1	540	542	PF00400	0.507
TRG_ER_diArg_1	548	551	PF00400	0.529
TRG_ER_diArg_1	91	93	PF00400	0.462
TRG_ER_diArg_1	96	99	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P278	Leptomonas seymouri	66%	100%
A0A0S4IQ65	Bodo saltans	31%	88%
A0A1X0NYR6	Trypanosomatidae	46%	100%
A0A3Q8IDU9	Leishmania donovani	99%	100%
A4HGE6	Leishmania braziliensis	85%	100%
E9AZR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8G5	Leishmania major	95%	100%