LeishMANIAdb
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Electron transfer flavoprotein subunit alpha

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Electron transfer flavoprotein subunit alpha
Gene product:
electron-transfer-flavoprotein - alpha polypeptide - putative
Species:
Leishmania infantum
UniProt:
A4I3J0_LEIIN
TriTrypDb:
LINF_280017100
Length:
325

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), electron-transfer-flavo, alpha polypeptide

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005759 mitochondrial matrix 5 11
GO:0031974 membrane-enclosed lumen 2 11
GO:0043233 organelle lumen 3 11
GO:0070013 intracellular organelle lumen 4 11
GO:0110165 cellular anatomical entity 1 11
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I3J0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3J0

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006635 fatty acid beta-oxidation 6 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009062 fatty acid catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0016042 lipid catabolic process 4 1
GO:0016054 organic acid catabolic process 4 1
GO:0019395 fatty acid oxidation 5 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0030258 lipid modification 4 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 7 1
GO:0034440 lipid oxidation 5 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044242 cellular lipid catabolic process 4 1
GO:0044248 cellular catabolic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044282 small molecule catabolic process 3 1
GO:0046395 carboxylic acid catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0072329 monocarboxylic acid catabolic process 6 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0009055 electron transfer activity 3 11
GO:0016491 oxidoreductase activity 2 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0050660 flavin adenine dinucleotide binding 4 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 212 216 PF00082 0.241
DEG_Nend_Nbox_1 1 3 PF02207 0.532
DOC_CDC14_PxL_1 309 317 PF14671 0.361
DOC_CYCLIN_yCln2_LP_2 226 232 PF00134 0.461
DOC_MAPK_gen_1 58 67 PF00069 0.486
DOC_MAPK_MEF2A_6 36 44 PF00069 0.551
DOC_MAPK_MEF2A_6 60 69 PF00069 0.495
DOC_PIKK_1 218 226 PF02985 0.499
DOC_PP2B_PxIxI_1 82 88 PF00149 0.398
DOC_USP7_MATH_1 114 118 PF00917 0.509
DOC_USP7_MATH_1 45 49 PF00917 0.551
DOC_USP7_MATH_1 99 103 PF00917 0.455
DOC_USP7_UBL2_3 147 151 PF12436 0.499
DOC_WW_Pin1_4 177 182 PF00397 0.527
DOC_WW_Pin1_4 21 26 PF00397 0.527
DOC_WW_Pin1_4 225 230 PF00397 0.453
LIG_14-3-3_CanoR_1 115 122 PF00244 0.495
LIG_14-3-3_CanoR_1 135 139 PF00244 0.436
LIG_14-3-3_CanoR_1 3 9 PF00244 0.473
LIG_FHA_1 123 129 PF00498 0.495
LIG_FHA_1 178 184 PF00498 0.604
LIG_FHA_1 235 241 PF00498 0.461
LIG_FHA_1 314 320 PF00498 0.382
LIG_FHA_2 158 164 PF00498 0.439
LIG_FHA_2 288 294 PF00498 0.448
LIG_FHA_2 66 72 PF00498 0.512
LIG_LIR_Nem_3 218 223 PF02991 0.447
LIG_LIR_Nem_3 293 299 PF02991 0.375
LIG_LIR_Nem_3 301 305 PF02991 0.381
LIG_LIR_Nem_3 306 312 PF02991 0.159
LIG_LIR_Nem_3 79 84 PF02991 0.457
LIG_SH2_CRK 154 158 PF00017 0.499
LIG_SH2_CRK 81 85 PF00017 0.461
LIG_SH2_NCK_1 94 98 PF00017 0.462
LIG_SH2_STAP1 94 98 PF00017 0.461
LIG_SH2_STAT5 154 157 PF00017 0.551
LIG_SH2_STAT5 245 248 PF00017 0.447
LIG_SH2_STAT5 264 267 PF00017 0.361
LIG_SH2_STAT5 94 97 PF00017 0.478
LIG_SUMO_SIM_par_1 64 71 PF11976 0.551
LIG_TRAF2_1 290 293 PF00917 0.502
LIG_TYR_ITIM 152 157 PF00017 0.499
MOD_CK1_1 24 30 PF00069 0.506
MOD_CK1_1 61 67 PF00069 0.480
MOD_CK2_1 157 163 PF00069 0.439
MOD_CK2_1 287 293 PF00069 0.489
MOD_CK2_1 65 71 PF00069 0.495
MOD_GlcNHglycan 101 104 PF01048 0.240
MOD_GlcNHglycan 170 173 PF01048 0.249
MOD_GlcNHglycan 208 211 PF01048 0.286
MOD_GlcNHglycan 269 272 PF01048 0.247
MOD_GlcNHglycan 28 31 PF01048 0.274
MOD_GlcNHglycan 47 50 PF01048 0.318
MOD_GSK3_1 141 148 PF00069 0.448
MOD_GSK3_1 153 160 PF00069 0.440
MOD_GSK3_1 61 68 PF00069 0.524
MOD_NEK2_1 157 162 PF00069 0.545
MOD_NEK2_1 2 7 PF00069 0.509
MOD_NEK2_1 279 284 PF00069 0.515
MOD_NEK2_1 98 103 PF00069 0.481
MOD_NEK2_2 142 147 PF00069 0.499
MOD_PK_1 58 64 PF00069 0.523
MOD_PKA_2 114 120 PF00069 0.495
MOD_PKA_2 134 140 PF00069 0.436
MOD_PKA_2 157 163 PF00069 0.455
MOD_PKA_2 2 8 PF00069 0.503
MOD_Plk_1 129 135 PF00069 0.453
MOD_Plk_4 129 135 PF00069 0.422
MOD_Plk_4 203 209 PF00069 0.499
MOD_Plk_4 61 67 PF00069 0.553
MOD_ProDKin_1 177 183 PF00069 0.527
MOD_ProDKin_1 21 27 PF00069 0.527
MOD_ProDKin_1 225 231 PF00069 0.453
MOD_SUMO_for_1 49 52 PF00179 0.551
TRG_DiLeu_LyEn_5 80 85 PF01217 0.499
TRG_ENDOCYTIC_2 154 157 PF00928 0.499
TRG_ENDOCYTIC_2 302 305 PF00928 0.349
TRG_ENDOCYTIC_2 81 84 PF00928 0.461
TRG_ENDOCYTIC_2 94 97 PF00928 0.461
TRG_Pf-PMV_PEXEL_1 221 225 PF00026 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVZ5 Leptomonas seymouri 78% 100%
A0A0S4II76 Bodo saltans 65% 100%
A0A1X0NYC9 Trypanosomatidae 66% 100%
A0A3S5H7J1 Leishmania donovani 100% 100%
A0A422N351 Trypanosoma rangeli 64% 100%
A2XNR6 Oryza sativa subsp. indica 43% 91%
A4HGF9 Leishmania braziliensis 86% 100%
D0A7V3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AZT2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
G3KIM6 Anaerotignum propionicum 34% 89%
H6LBB1 Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) 29% 78%
H6LGM8 Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) 38% 82%
O33096 Mycobacterium leprae (strain TN) 37% 100%
O85692 Megasphaera elsdenii 34% 96%
P0CN60 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 44% 94%
P0CN61 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 44% 94%
P13803 Rattus norvegicus 52% 98%
P13804 Homo sapiens 52% 98%
P38974 Paracoccus denitrificans 53% 100%
P52039 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) 35% 97%
P53573 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 49% 100%
P53578 Clostridium saccharobutylicum 37% 97%
P71153 Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) 39% 98%
P78790 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 95%
P94551 Bacillus subtilis (strain 168) 35% 100%
P9WNG8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 37% 100%
P9WNG9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 37% 100%
Q12480 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 94%
Q2KJE4 Bos taurus 52% 98%
Q46907 Escherichia coli (strain K12) 32% 100%
Q4Q8F2 Leishmania major 97% 100%
Q54FD7 Dictyostelium discoideum 48% 92%
Q5RC31 Pongo abelii 52% 98%
Q5Y223 Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071) 45% 94%
Q75LJ3 Oryza sativa subsp. japonica 43% 91%
Q8HXY0 Macaca fascicularis 51% 98%
Q8J112 Cryptococcus neoformans var. grubii 43% 94%
Q93615 Caenorhabditis elegans 52% 98%
Q99LC5 Mus musculus 52% 98%
Q9C6I6 Arabidopsis thaliana 43% 90%
Q9HZP7 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS