Electron transfer flavoprotein subunit alpha

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electron-transfer-flavoprotein - alpha polypeptide - putative

Species:

Leishmania infantum

UniProt:

A4I3J0_LEIIN

TriTrypDb:

LINF_280017100

Length:

325

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), electron-transfer-flavo, alpha polypeptide

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11

Previous1Next

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I3J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3J0

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009055	electron transfer activity	3	11
GO:0016491	oxidoreductase activity	2	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	212	216	PF00082	0.241
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DOC_CDC14_PxL_1	309	317	PF14671	0.361
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.461
DOC_MAPK_gen_1	58	67	PF00069	0.486
DOC_MAPK_MEF2A_6	36	44	PF00069	0.551
DOC_MAPK_MEF2A_6	60	69	PF00069	0.495
DOC_PIKK_1	218	226	PF02985	0.499
DOC_PP2B_PxIxI_1	82	88	PF00149	0.398
DOC_USP7_MATH_1	114	118	PF00917	0.509

Previous1 2 3 4 5…8Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVZ5	Leptomonas seymouri	78%	100%
A0A0S4II76	Bodo saltans	65%	100%
A0A1X0NYC9	Trypanosomatidae	66%	100%
A0A3S5H7J1	Leishmania donovani	100%	100%
A0A422N351	Trypanosoma rangeli	64%	100%
A2XNR6	Oryza sativa subsp. indica	43%	91%
A4HGF9	Leishmania braziliensis	86%	100%
D0A7V3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AZT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
G3KIM6	Anaerotignum propionicum	34%	89%

Previous1 2 3 4 5Next