Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4I3I9_LEIIN

TriTrypDb:

LINF_280017000

Length:

519

Annotations

Annotations by Jardim et al.

Plasma membrane, Amastin surface glyco

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A4I3I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	357	359	PF00675	0.533
CLV_NRD_NRD_1	4	6	PF00675	0.443
CLV_PCSK_KEX2_1	356	358	PF00082	0.522
CLV_PCSK_KEX2_1	398	400	PF00082	0.480
CLV_PCSK_KEX2_1	4	6	PF00082	0.451
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.522
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.505
CLV_PCSK_SKI1_1	148	152	PF00082	0.329
CLV_PCSK_SKI1_1	398	402	PF00082	0.492
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.293
DOC_MAPK_gen_1	398	406	PF00069	0.340
DOC_MAPK_gen_1	428	437	PF00069	0.498
DOC_MAPK_MEF2A_6	148	155	PF00069	0.453
DOC_MAPK_RevD_3	344	358	PF00069	0.313
DOC_PP2B_LxvP_1	376	379	PF13499	0.261
DOC_PP2B_LxvP_1	420	423	PF13499	0.293
DOC_PP2B_LxvP_1	514	517	PF13499	0.374
DOC_PP2B_PxIxI_1	202	208	PF00149	0.234
DOC_USP7_MATH_1	17	21	PF00917	0.744
DOC_USP7_MATH_1	402	406	PF00917	0.311
DOC_WW_Pin1_4	13	18	PF00397	0.669
DOC_WW_Pin1_4	5	10	PF00397	0.703
LIG_14-3-3_CanoR_1	190	195	PF00244	0.311
LIG_14-3-3_CanoR_1	248	252	PF00244	0.452
LIG_14-3-3_CanoR_1	368	372	PF00244	0.317
LIG_14-3-3_CanoR_1	392	400	PF00244	0.361
LIG_14-3-3_CanoR_1	456	465	PF00244	0.318
LIG_14-3-3_CanoR_1	67	72	PF00244	0.619
LIG_BIR_II_1	1	5	PF00653	0.783
LIG_BRCT_BRCA1_1	341	345	PF00533	0.467
LIG_BRCT_BRCA1_1	402	406	PF00533	0.325
LIG_BRCT_BRCA1_1	433	437	PF00533	0.384
LIG_CaM_NSCaTE_8	503	510	PF13499	0.293
LIG_EH1_1	436	444	PF00400	0.293
LIG_eIF4E_1	251	257	PF01652	0.378
LIG_eIF4E_1	371	377	PF01652	0.322
LIG_FHA_1	119	125	PF00498	0.708
LIG_FHA_1	147	153	PF00498	0.509
LIG_FHA_1	220	226	PF00498	0.245
LIG_FHA_1	287	293	PF00498	0.377
LIG_FHA_1	359	365	PF00498	0.302
LIG_FHA_1	372	378	PF00498	0.260
LIG_FHA_1	460	466	PF00498	0.319
LIG_FHA_2	109	115	PF00498	0.675
LIG_FHA_2	38	44	PF00498	0.712
LIG_GBD_Chelix_1	311	319	PF00786	0.290
LIG_IRF3_LxIS_1	442	448	PF10401	0.359
LIG_LIR_Apic_2	119	125	PF02991	0.659
LIG_LIR_Gen_1	234	243	PF02991	0.360
LIG_LIR_Gen_1	250	261	PF02991	0.485
LIG_LIR_Gen_1	332	343	PF02991	0.378
LIG_LIR_Gen_1	403	414	PF02991	0.371
LIG_LIR_Gen_1	434	445	PF02991	0.468
LIG_LIR_Nem_3	234	238	PF02991	0.494
LIG_LIR_Nem_3	250	256	PF02991	0.476
LIG_LIR_Nem_3	258	262	PF02991	0.361
LIG_LIR_Nem_3	332	338	PF02991	0.392
LIG_LIR_Nem_3	342	348	PF02991	0.359
LIG_LIR_Nem_3	382	388	PF02991	0.301
LIG_LIR_Nem_3	403	409	PF02991	0.399
LIG_LIR_Nem_3	434	440	PF02991	0.373
LIG_LIR_Nem_3	441	447	PF02991	0.360
LIG_LIR_Nem_3	468	473	PF02991	0.313
LIG_LIR_Nem_3	478	484	PF02991	0.301
LIG_LIR_Nem_3	485	490	PF02991	0.288
LIG_LYPXL_yS_3	202	205	PF13949	0.234
LIG_LYPXL_yS_3	473	476	PF13949	0.305
LIG_MYND_1	137	141	PF01753	0.561
LIG_NRBOX	306	312	PF00104	0.354
LIG_PAM2_1	255	267	PF00658	0.378
LIG_PAM2_1	296	308	PF00658	0.293
LIG_PDZ_Wminus1_1	517	519	PF00595	0.579
LIG_Pex14_1	253	257	PF04695	0.378
LIG_Pex14_1	355	359	PF04695	0.318
LIG_Pex14_2	158	162	PF04695	0.422
LIG_SH2_CRK	122	126	PF00017	0.682
LIG_SH2_CRK	220	224	PF00017	0.261
LIG_SH2_CRK	335	339	PF00017	0.390
LIG_SH2_CRK	481	485	PF00017	0.379
LIG_SH2_SRC	131	134	PF00017	0.576
LIG_SH2_STAP1	396	400	PF00017	0.243
LIG_SH2_STAT3	490	493	PF00017	0.322
LIG_SH2_STAT5	122	125	PF00017	0.627
LIG_SH3_3	135	141	PF00018	0.642
LIG_SH3_3	471	477	PF00018	0.326
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.261
LIG_SUMO_SIM_anti_2	438	444	PF11976	0.329
LIG_SUMO_SIM_par_1	221	227	PF11976	0.273
LIG_TRAF2_1	112	115	PF00917	0.783
LIG_WRC_WIRS_1	232	237	PF05994	0.354
LIG_WRC_WIRS_1	256	261	PF05994	0.342
MOD_CDC14_SPxK_1	16	19	PF00782	0.523
MOD_CDK_SPxK_1	13	19	PF00069	0.537
MOD_CDK_SPxxK_3	5	12	PF00069	0.548
MOD_CK1_1	20	26	PF00069	0.502
MOD_CK1_1	234	240	PF00069	0.461
MOD_CK1_1	30	36	PF00069	0.545
MOD_CK1_1	394	400	PF00069	0.486
MOD_CK1_1	438	444	PF00069	0.374
MOD_CK1_1	448	454	PF00069	0.343
MOD_CK1_1	8	14	PF00069	0.741
MOD_CK2_1	108	114	PF00069	0.591
MOD_CK2_1	67	73	PF00069	0.609
MOD_GlcNHglycan	240	243	PF01048	0.383
MOD_GlcNHglycan	245	248	PF01048	0.356
MOD_GlcNHglycan	393	396	PF01048	0.289
MOD_GlcNHglycan	477	480	PF01048	0.469
MOD_GlcNHglycan	56	59	PF01048	0.772
MOD_GlcNHglycan	63	66	PF01048	0.563
MOD_GlcNHglycan	87	90	PF01048	0.546
MOD_GSK3_1	13	20	PF00069	0.543
MOD_GSK3_1	219	226	PF00069	0.363
MOD_GSK3_1	234	241	PF00069	0.388
MOD_GSK3_1	243	250	PF00069	0.391
MOD_GSK3_1	271	278	PF00069	0.357
MOD_GSK3_1	35	42	PF00069	0.701
MOD_GSK3_1	367	374	PF00069	0.464
MOD_GSK3_1	431	438	PF00069	0.398
MOD_GSK3_1	61	68	PF00069	0.697
MOD_GSK3_1	81	88	PF00069	0.474
MOD_N-GLC_1	379	384	PF02516	0.409
MOD_N-GLC_1	465	470	PF02516	0.254
MOD_N-GLC_1	5	10	PF02516	0.605
MOD_N-GLC_2	459	461	PF02516	0.267
MOD_NEK2_1	108	113	PF00069	0.656
MOD_NEK2_1	162	167	PF00069	0.374
MOD_NEK2_1	219	224	PF00069	0.345
MOD_NEK2_1	238	243	PF00069	0.305
MOD_NEK2_1	255	260	PF00069	0.309
MOD_NEK2_1	262	267	PF00069	0.355
MOD_NEK2_1	271	276	PF00069	0.304
MOD_NEK2_1	286	291	PF00069	0.321
MOD_NEK2_1	296	301	PF00069	0.277
MOD_NEK2_1	339	344	PF00069	0.453
MOD_NEK2_1	400	405	PF00069	0.405
MOD_NEK2_1	407	412	PF00069	0.411
MOD_NEK2_1	415	420	PF00069	0.363
MOD_NEK2_1	445	450	PF00069	0.485
MOD_NEK2_1	496	501	PF00069	0.431
MOD_NEK2_1	507	512	PF00069	0.453
MOD_NEK2_1	52	57	PF00069	0.571
MOD_PIKK_1	17	23	PF00454	0.646
MOD_PIKK_1	35	41	PF00454	0.843
MOD_PIKK_1	65	71	PF00454	0.723
MOD_PK_1	431	437	PF00069	0.293
MOD_PKA_2	243	249	PF00069	0.362
MOD_PKA_2	284	290	PF00069	0.307
MOD_PKA_2	367	373	PF00069	0.471
MOD_PKA_2	391	397	PF00069	0.469
MOD_PKA_2	457	463	PF00069	0.385
MOD_PKB_1	5	13	PF00069	0.580
MOD_Plk_1	118	124	PF00069	0.587
MOD_Plk_4	224	230	PF00069	0.395
MOD_Plk_4	231	237	PF00069	0.419
MOD_Plk_4	296	302	PF00069	0.332
MOD_Plk_4	330	336	PF00069	0.436
MOD_Plk_4	339	345	PF00069	0.435
MOD_Plk_4	350	356	PF00069	0.348
MOD_Plk_4	367	373	PF00069	0.280
MOD_Plk_4	402	408	PF00069	0.369
MOD_Plk_4	415	421	PF00069	0.385
MOD_Plk_4	431	437	PF00069	0.350
MOD_Plk_4	465	471	PF00069	0.315
MOD_Plk_4	496	502	PF00069	0.358
MOD_Plk_4	507	513	PF00069	0.392
MOD_Plk_4	81	87	PF00069	0.598
MOD_ProDKin_1	13	19	PF00069	0.582
MOD_ProDKin_1	5	11	PF00069	0.630
MOD_SUMO_for_1	112	115	PF00179	0.582
MOD_SUMO_rev_2	42	49	PF00179	0.540
TRG_DiLeu_BaEn_1	48	53	PF01217	0.535
TRG_ENDOCYTIC_2	202	205	PF00928	0.293
TRG_ENDOCYTIC_2	220	223	PF00928	0.293
TRG_ENDOCYTIC_2	251	254	PF00928	0.357
TRG_ENDOCYTIC_2	335	338	PF00928	0.437
TRG_ENDOCYTIC_2	385	388	PF00928	0.343
TRG_ENDOCYTIC_2	473	476	PF00928	0.378
TRG_ENDOCYTIC_2	481	484	PF00928	0.378
TRG_ER_diArg_1	175	178	PF00400	0.267
TRG_ER_diArg_1	357	359	PF00400	0.261
TRG_ER_diArg_1	4	7	PF00400	0.602
TRG_ER_diArg_1	455	458	PF00400	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	32%	100%
A0A0N1PC74	Leptomonas seymouri	60%	100%
A0A0N1PCA2	Leptomonas seymouri	27%	100%
A0A3Q8I8Q6	Leishmania donovani	27%	100%
A0A3S7WR28	Leishmania donovani	26%	100%
A0A3S7X1E1	Leishmania donovani	99%	100%
A4H605	Leishmania braziliensis	29%	100%
A4H606	Leishmania braziliensis	28%	100%
A4HGF8	Leishmania braziliensis	71%	100%
A4HUD2	Leishmania infantum	28%	100%
A4HUD3	Leishmania infantum	26%	100%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8F3	Leishmania major	89%	100%
Q4QHJ3	Leishmania major	25%	100%
Q4QHJ4	Leishmania major	28%	100%