LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Cilia- and flagella-associated protein 52

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cilia- and flagella-associated protein 52
Gene product:
WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4I3I7_LEIIN
TriTrypDb:
LINF_280016800
Length:
629

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 11
GO:0005840 ribosome 5 12
GO:0005929 cilium 4 12
GO:0031514 motile cilium 5 12
GO:0032991 protein-containing complex 1 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12
GO:1990904 ribonucleoprotein complex 2 12
GO:0005815 microtubule organizing center 2 1
GO:0005930 axoneme 2 1
GO:0036064 ciliary basal body 3 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I3I7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3I7

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044782 cilium organization 5 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.473
CLV_C14_Caspase3-7 47 51 PF00656 0.414
CLV_NRD_NRD_1 185 187 PF00675 0.386
CLV_NRD_NRD_1 199 201 PF00675 0.327
CLV_NRD_NRD_1 500 502 PF00675 0.326
CLV_NRD_NRD_1 98 100 PF00675 0.317
CLV_PCSK_KEX2_1 199 201 PF00082 0.355
CLV_PCSK_KEX2_1 500 502 PF00082 0.328
CLV_PCSK_KEX2_1 98 100 PF00082 0.334
CLV_PCSK_SKI1_1 103 107 PF00082 0.306
CLV_PCSK_SKI1_1 167 171 PF00082 0.304
CLV_PCSK_SKI1_1 399 403 PF00082 0.355
CLV_PCSK_SKI1_1 436 440 PF00082 0.268
CLV_PCSK_SKI1_1 452 456 PF00082 0.334
CLV_PCSK_SKI1_1 572 576 PF00082 0.208
CLV_Separin_Metazoa 358 362 PF03568 0.316
DEG_APCC_DBOX_1 102 110 PF00400 0.312
DOC_ANK_TNKS_1 598 605 PF00023 0.451
DOC_MAPK_gen_1 108 116 PF00069 0.256
DOC_MAPK_gen_1 186 193 PF00069 0.450
DOC_MAPK_gen_1 199 207 PF00069 0.246
DOC_MAPK_gen_1 415 425 PF00069 0.372
DOC_MAPK_gen_1 98 106 PF00069 0.314
DOC_MAPK_HePTP_8 183 195 PF00069 0.502
DOC_MAPK_MEF2A_6 186 195 PF00069 0.492
DOC_MAPK_MEF2A_6 581 589 PF00069 0.386
DOC_MAPK_MEF2A_6 63 71 PF00069 0.434
DOC_PP1_RVXF_1 154 161 PF00149 0.331
DOC_PP1_RVXF_1 397 403 PF00149 0.353
DOC_SPAK_OSR1_1 563 567 PF12202 0.419
DOC_USP7_MATH_1 51 55 PF00917 0.485
DOC_USP7_UBL2_3 418 422 PF12436 0.496
DOC_WW_Pin1_4 4 9 PF00397 0.461
DOC_WW_Pin1_4 556 561 PF00397 0.502
DOC_WW_Pin1_4 598 603 PF00397 0.419
LIG_14-3-3_CanoR_1 177 182 PF00244 0.372
LIG_14-3-3_CanoR_1 199 203 PF00244 0.372
LIG_14-3-3_CanoR_1 317 327 PF00244 0.328
LIG_14-3-3_CanoR_1 506 510 PF00244 0.440
LIG_APCC_ABBAyCdc20_2 529 535 PF00400 0.345
LIG_BH_BH3_1 244 260 PF00452 0.449
LIG_BRCT_BRCA1_1 336 340 PF00533 0.296
LIG_BRCT_BRCA1_1 52 56 PF00533 0.439
LIG_CaM_IQ_9 264 280 PF13499 0.451
LIG_Clathr_ClatBox_1 359 363 PF01394 0.412
LIG_FHA_1 131 137 PF00498 0.473
LIG_FHA_1 153 159 PF00498 0.411
LIG_FHA_1 168 174 PF00498 0.208
LIG_FHA_1 178 184 PF00498 0.320
LIG_FHA_1 202 208 PF00498 0.314
LIG_FHA_1 253 259 PF00498 0.403
LIG_FHA_1 301 307 PF00498 0.433
LIG_FHA_1 355 361 PF00498 0.462
LIG_FHA_1 453 459 PF00498 0.379
LIG_FHA_1 477 483 PF00498 0.427
LIG_FHA_1 494 500 PF00498 0.397
LIG_FHA_1 5 11 PF00498 0.407
LIG_FHA_1 548 554 PF00498 0.321
LIG_FHA_1 66 72 PF00498 0.475
LIG_FHA_2 217 223 PF00498 0.324
LIG_FHA_2 340 346 PF00498 0.414
LIG_FHA_2 481 487 PF00498 0.502
LIG_GBD_Chelix_1 491 499 PF00786 0.307
LIG_KLC1_Yacidic_2 514 518 PF13176 0.445
LIG_LIR_Nem_3 508 513 PF02991 0.298
LIG_MLH1_MIPbox_1 53 57 PF16413 0.462
LIG_PCNA_yPIPBox_3 563 577 PF02747 0.451
LIG_PDZ_Class_3 624 629 PF00595 0.566
LIG_Pex14_2 332 336 PF04695 0.354
LIG_SH2_STAT5 122 125 PF00017 0.419
LIG_SH2_STAT5 213 216 PF00017 0.292
LIG_SH2_STAT5 298 301 PF00017 0.298
LIG_SH2_STAT5 307 310 PF00017 0.266
LIG_SH2_STAT5 498 501 PF00017 0.419
LIG_SH2_STAT5 509 512 PF00017 0.250
LIG_SH2_STAT5 516 519 PF00017 0.190
LIG_SH2_STAT5 75 78 PF00017 0.334
LIG_SH3_3 123 129 PF00018 0.502
LIG_SH3_3 24 30 PF00018 0.454
LIG_SH3_3 327 333 PF00018 0.298
LIG_SH3_3 78 84 PF00018 0.450
LIG_SUMO_SIM_anti_2 288 295 PF11976 0.338
LIG_SUMO_SIM_par_1 130 138 PF11976 0.473
LIG_SUMO_SIM_par_1 179 184 PF11976 0.462
LIG_SUMO_SIM_par_1 203 208 PF11976 0.330
LIG_SUMO_SIM_par_1 606 613 PF11976 0.408
LIG_SUMO_SIM_par_1 67 72 PF11976 0.446
LIG_UBA3_1 100 108 PF00899 0.369
MOD_CDK_SPK_2 4 9 PF00069 0.461
MOD_CDK_SPxxK_3 556 563 PF00069 0.386
MOD_CDK_SPxxK_3 598 605 PF00069 0.270
MOD_CK1_1 201 207 PF00069 0.446
MOD_CK1_1 365 371 PF00069 0.492
MOD_CK1_1 383 389 PF00069 0.225
MOD_CK1_1 65 71 PF00069 0.377
MOD_CK2_1 114 120 PF00069 0.254
MOD_CK2_1 352 358 PF00069 0.371
MOD_CK2_1 458 464 PF00069 0.254
MOD_Cter_Amidation 603 606 PF01082 0.289
MOD_GlcNHglycan 18 21 PF01048 0.413
MOD_GlcNHglycan 219 222 PF01048 0.344
MOD_GlcNHglycan 243 246 PF01048 0.375
MOD_GlcNHglycan 261 264 PF01048 0.259
MOD_GlcNHglycan 382 385 PF01048 0.268
MOD_GlcNHglycan 396 399 PF01048 0.354
MOD_GlcNHglycan 71 74 PF01048 0.334
MOD_GlcNHglycan 77 80 PF01048 0.292
MOD_GSK3_1 203 210 PF00069 0.394
MOD_GSK3_1 246 253 PF00069 0.345
MOD_GSK3_1 273 280 PF00069 0.374
MOD_GSK3_1 335 342 PF00069 0.401
MOD_GSK3_1 372 379 PF00069 0.260
MOD_GSK3_1 454 461 PF00069 0.390
MOD_GSK3_1 472 479 PF00069 0.157
MOD_GSK3_1 482 489 PF00069 0.241
MOD_GSK3_1 517 524 PF00069 0.291
MOD_GSK3_1 552 559 PF00069 0.263
MOD_GSK3_1 589 596 PF00069 0.314
MOD_GSK3_1 65 72 PF00069 0.333
MOD_GSK3_1 75 82 PF00069 0.307
MOD_N-GLC_1 162 167 PF02516 0.359
MOD_N-GLC_1 273 278 PF02516 0.378
MOD_N-GLC_1 365 370 PF02516 0.457
MOD_N-GLC_2 354 356 PF02516 0.466
MOD_NEK2_1 16 21 PF00069 0.451
MOD_NEK2_1 198 203 PF00069 0.478
MOD_NEK2_1 259 264 PF00069 0.311
MOD_NEK2_1 318 323 PF00069 0.378
MOD_NEK2_1 380 385 PF00069 0.270
MOD_NEK2_1 400 405 PF00069 0.173
MOD_NEK2_1 458 463 PF00069 0.325
MOD_NEK2_1 564 569 PF00069 0.260
MOD_NEK2_1 589 594 PF00069 0.254
MOD_NEK2_1 67 72 PF00069 0.321
MOD_NEK2_2 172 177 PF00069 0.281
MOD_NEK2_2 335 340 PF00069 0.442
MOD_PIKK_1 517 523 PF00454 0.355
MOD_PK_1 606 612 PF00069 0.254
MOD_PKA_1 241 247 PF00069 0.424
MOD_PKA_2 198 204 PF00069 0.470
MOD_PKA_2 318 324 PF00069 0.319
MOD_PKA_2 45 51 PF00069 0.417
MOD_PKA_2 505 511 PF00069 0.442
MOD_Plk_1 130 136 PF00069 0.345
MOD_Plk_1 273 279 PF00069 0.361
MOD_Plk_1 458 464 PF00069 0.285
MOD_Plk_1 493 499 PF00069 0.448
MOD_Plk_1 517 523 PF00069 0.309
MOD_Plk_4 130 136 PF00069 0.345
MOD_Plk_4 22 28 PF00069 0.384
MOD_Plk_4 247 253 PF00069 0.330
MOD_Plk_4 335 341 PF00069 0.436
MOD_Plk_4 376 382 PF00069 0.260
MOD_Plk_4 505 511 PF00069 0.401
MOD_ProDKin_1 4 10 PF00069 0.449
MOD_ProDKin_1 556 562 PF00069 0.386
MOD_ProDKin_1 598 604 PF00069 0.270
MOD_SUMO_rev_2 459 468 PF00179 0.257
MOD_SUMO_rev_2 601 607 PF00179 0.270
TRG_DiLeu_BaLyEn_6 96 101 PF01217 0.441
TRG_ER_diArg_1 198 200 PF00400 0.379
TRG_ER_diArg_1 317 320 PF00400 0.473
TRG_ER_diArg_1 499 501 PF00400 0.336
TRG_ER_diArg_1 98 100 PF00400 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB29 Leptomonas seymouri 88% 100%
A0A0S4JJ02 Bodo saltans 59% 100%
A0A0S4JL38 Bodo saltans 23% 100%
A0A0S4JL93 Bodo saltans 25% 87%
A0A0S4KEW0 Bodo saltans 23% 98%
A0A1X0NYB9 Trypanosomatidae 67% 100%
A0A3Q8IGC4 Leishmania donovani 23% 100%
A0A3R7N3I7 Trypanosoma rangeli 67% 99%
A0A3S7X1E5 Leishmania donovani 100% 100%
A4HDT7 Leishmania braziliensis 23% 100%
A4HGF6 Leishmania braziliensis 95% 100%
A4I135 Leishmania infantum 23% 100%
A8ILK1 Chlamydomonas reinhardtii 46% 100%
D0A7V6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E1BKF9 Bos taurus 42% 100%
E9AX72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AZS9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
F1SS88 Sus scrofa 43% 100%
Q06078 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 67%
Q26613 Strongylocentrotus purpuratus 21% 92%
Q4Q8F5 Leishmania major 98% 100%
Q4QAA4 Leishmania major 23% 100%
Q5F201 Mus musculus 42% 100%
Q8N1V2 Homo sapiens 41% 100%
Q95JL5 Macaca fascicularis 35% 100%
Q9LFE2 Arabidopsis thaliana 21% 72%
Q9UKB1 Homo sapiens 24% 100%
Q9VPR4 Drosophila melanogaster 22% 100%
Q9Y1C1 Lytechinus variegatus 21% 95%
V5BIZ5 Trypanosoma cruzi 67% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS