LeishMANIAdb
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Cilia- and flagella-associated protein 52

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cilia- and flagella-associated protein 52
Gene product:
WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4I3I7_LEIIN
TriTrypDb:
LINF_280016800
Length:
629

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 11
GO:0005815 microtubule organizing center 2 1
GO:0005840 ribosome 5 12
GO:0005929 cilium 4 12
GO:0005930 axoneme 2 1
GO:0031514 motile cilium 5 12
GO:0032991 protein-containing complex 1 12
GO:0036064 ciliary basal body 3 1
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I3I7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3I7

Function

Biological processes
TermNameLevelCount
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044782 cilium organization 5 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 403 407 PF00656 0.473
CLV_C14_Caspase3-7 47 51 PF00656 0.414
CLV_NRD_NRD_1 185 187 PF00675 0.386
CLV_NRD_NRD_1 199 201 PF00675 0.327
CLV_NRD_NRD_1 500 502 PF00675 0.326
CLV_NRD_NRD_1 98 100 PF00675 0.317
CLV_PCSK_KEX2_1 199 201 PF00082 0.355
CLV_PCSK_KEX2_1 500 502 PF00082 0.328
CLV_PCSK_KEX2_1 98 100 PF00082 0.334
CLV_PCSK_SKI1_1 103 107 PF00082 0.306
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PB29 Leptomonas seymouri 88% 100%
A0A0S4JJ02 Bodo saltans 59% 100%
A0A0S4JL38 Bodo saltans 23% 100%
A0A0S4JL93 Bodo saltans 25% 87%
A0A0S4KEW0 Bodo saltans 23% 98%
A0A1X0NYB9 Trypanosomatidae 67% 100%
A0A3Q8IGC4 Leishmania donovani 23% 100%
A0A3R7N3I7 Trypanosoma rangeli 67% 99%
A0A3S7X1E5 Leishmania donovani 100% 100%
A4HDT7 Leishmania braziliensis 23% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS