Gluconokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gluconokinase

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3I5_LEIIN

TriTrypDb:

LINF_280016600

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3I5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0006082	organic acid metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009987	cellular process	1	7
GO:0016052	carbohydrate catabolic process	4	7
GO:0016054	organic acid catabolic process	4	7
GO:0016310	phosphorylation	5	7
GO:0019520	aldonic acid metabolic process	4	7
GO:0019521	D-gluconate metabolic process	5	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0032787	monocarboxylic acid metabolic process	6	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044262	obsolete cellular carbohydrate metabolic process	3	7
GO:0044275	obsolete cellular carbohydrate catabolic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	7
GO:0046176	aldonic acid catabolic process	5	7
GO:0046177	D-gluconate catabolic process	6	7
GO:0046395	carboxylic acid catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:0072329	monocarboxylic acid catabolic process	6	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0046316	gluconokinase activity	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.579
CLV_NRD_NRD_1	43	45	PF00675	0.286
CLV_PCSK_KEX2_1	17	19	PF00082	0.436
CLV_PCSK_KEX2_1	43	45	PF00082	0.286
CLV_PCSK_SKI1_1	137	141	PF00082	0.374
CLV_PCSK_SKI1_1	21	25	PF00082	0.382
CLV_PCSK_SKI1_1	47	51	PF00082	0.302
DEG_APCC_DBOX_1	46	54	PF00400	0.345
DEG_Nend_UBRbox_1	1	4	PF02207	0.439
DEG_SPOP_SBC_1	139	143	PF00917	0.371
DOC_CKS1_1	23	28	PF01111	0.279
DOC_USP7_MATH_1	139	143	PF00917	0.453
DOC_USP7_MATH_2	112	118	PF00917	0.391
DOC_WW_Pin1_4	144	149	PF00397	0.520
DOC_WW_Pin1_4	22	27	PF00397	0.275
LIG_14-3-3_CanoR_1	137	146	PF00244	0.516
LIG_Actin_WH2_2	131	147	PF00022	0.348
LIG_FHA_1	116	122	PF00498	0.426
LIG_FHA_1	139	145	PF00498	0.436
LIG_FHA_2	6	12	PF00498	0.363
LIG_IRF3_LxIS_1	140	147	PF10401	0.364
LIG_LIR_Gen_1	70	80	PF02991	0.451
LIG_LIR_Nem_3	69	75	PF02991	0.447
LIG_MYND_2	124	128	PF01753	0.394
LIG_PDZ_Class_1	150	155	PF00595	0.518
LIG_SH2_STAT5	55	58	PF00017	0.376
LIG_SH3_1	145	151	PF00018	0.446
LIG_SH3_3	145	151	PF00018	0.510
LIG_SH3_3	20	26	PF00018	0.348
LIG_SUMO_SIM_par_1	117	123	PF11976	0.390
MOD_GlcNHglycan	2	5	PF01048	0.450
MOD_GlcNHglycan	39	42	PF01048	0.336
MOD_GlcNHglycan	76	79	PF01048	0.372
MOD_GSK3_1	110	117	PF00069	0.446
MOD_GSK3_1	123	130	PF00069	0.358
MOD_GSK3_1	140	147	PF00069	0.545
MOD_GSK3_1	62	69	PF00069	0.467
MOD_GSK3_1	95	102	PF00069	0.444
MOD_NEK2_1	140	145	PF00069	0.492
MOD_NEK2_1	94	99	PF00069	0.407
MOD_PIKK_1	99	105	PF00454	0.379
MOD_Plk_4	123	129	PF00069	0.323
MOD_Plk_4	31	37	PF00069	0.441
MOD_ProDKin_1	144	150	PF00069	0.522
MOD_ProDKin_1	22	28	PF00069	0.280
MOD_SUMO_rev_2	77	83	PF00179	0.369
TRG_DiLeu_BaEn_1	131	136	PF01217	0.293
TRG_ER_diArg_1	16	18	PF00400	0.412
TRG_ER_diArg_1	42	44	PF00400	0.286
TRG_NES_CRM1_1	134	149	PF08389	0.334
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIM9	Leptomonas seymouri	52%	81%
A0A1X0NYC5	Trypanosomatidae	33%	71%
A0A3Q8IES5	Leishmania donovani	97%	75%
A0A3R7MBD0	Trypanosoma rangeli	45%	75%
A4HGF4	Leishmania braziliensis	71%	100%
B0BML1	Xenopus tropicalis	36%	82%
E9AZS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P39208	Escherichia coli (strain K12)	39%	83%
P46859	Escherichia coli (strain K12)	35%	89%
Q32PY9	Rattus norvegicus	40%	84%
Q54PI5	Dictyostelium discoideum	31%	78%
Q5FQ97	Gluconobacter oxydans (strain 621H)	38%	87%
Q5T6J7	Homo sapiens	38%	83%
Q8R0J8	Mus musculus	40%	84%
Q9SLE0	Arabidopsis thaliana	38%	82%