Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3I0_LEIIN

TriTrypDb:

LINF_280016100

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3I0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.608
CLV_NRD_NRD_1	249	251	PF00675	0.469
CLV_NRD_NRD_1	82	84	PF00675	0.528
CLV_PCSK_KEX2_1	195	197	PF00082	0.608
CLV_PCSK_KEX2_1	249	251	PF00082	0.469
DEG_APCC_DBOX_1	180	188	PF00400	0.452
DEG_APCC_DBOX_1	82	90	PF00400	0.455
DEG_SPOP_SBC_1	134	138	PF00917	0.685
DOC_CDC14_PxL_1	377	385	PF14671	0.296
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.291
DOC_MAPK_DCC_7	376	385	PF00069	0.298
DOC_MAPK_HePTP_8	373	385	PF00069	0.294
DOC_MAPK_MEF2A_6	376	385	PF00069	0.298
DOC_MAPK_RevD_3	182	196	PF00069	0.455
DOC_PP1_RVXF_1	285	291	PF00149	0.382
DOC_PP2B_LxvP_1	378	381	PF13499	0.404
DOC_USP7_MATH_1	15	19	PF00917	0.787
DOC_USP7_MATH_1	233	237	PF00917	0.601
DOC_USP7_MATH_1	312	316	PF00917	0.602
DOC_USP7_MATH_2	128	134	PF00917	0.628
DOC_WW_Pin1_4	10	15	PF00397	0.625
DOC_WW_Pin1_4	114	119	PF00397	0.598
DOC_WW_Pin1_4	19	24	PF00397	0.685
DOC_WW_Pin1_4	225	230	PF00397	0.669
DOC_WW_Pin1_4	293	298	PF00397	0.520
DOC_WW_Pin1_4	345	350	PF00397	0.438
DOC_WW_Pin1_4	54	59	PF00397	0.582
LIG_14-3-3_CanoR_1	216	225	PF00244	0.564
LIG_14-3-3_CanoR_1	249	259	PF00244	0.520
LIG_14-3-3_CanoR_1	331	336	PF00244	0.560
LIG_14-3-3_CanoR_1	9	16	PF00244	0.691
LIG_BIR_II_1	1	5	PF00653	0.750
LIG_BIR_III_2	205	209	PF00653	0.637
LIG_BRCT_BRCA1_1	218	222	PF00533	0.600
LIG_DLG_GKlike_1	331	338	PF00625	0.552
LIG_FHA_2	166	172	PF00498	0.532
LIG_LIR_Apic_2	265	271	PF02991	0.525
LIG_LIR_Gen_1	219	229	PF02991	0.598
LIG_LIR_Nem_3	219	225	PF02991	0.599
LIG_LIR_Nem_3	334	338	PF02991	0.508
LIG_NRBOX	222	228	PF00104	0.555
LIG_RPA_C_Fungi	326	338	PF08784	0.496
LIG_SH2_PTP2	268	271	PF00017	0.524
LIG_SH2_SRC	150	153	PF00017	0.434
LIG_SH2_SRC	51	54	PF00017	0.505
LIG_SH2_STAT5	102	105	PF00017	0.398
LIG_SH2_STAT5	150	153	PF00017	0.434
LIG_SH2_STAT5	268	271	PF00017	0.524
LIG_SH2_STAT5	358	361	PF00017	0.411
LIG_SH2_STAT5	51	54	PF00017	0.562
LIG_SH3_2	101	106	PF14604	0.549
LIG_SH3_3	150	156	PF00018	0.371
LIG_SH3_3	98	104	PF00018	0.559
LIG_WRC_WIRS_1	244	249	PF05994	0.348
MOD_CDK_SPxxK_3	54	61	PF00069	0.603
MOD_CK1_1	133	139	PF00069	0.656
MOD_CK1_1	228	234	PF00069	0.601
MOD_GlcNHglycan	132	135	PF01048	0.649
MOD_GlcNHglycan	17	20	PF01048	0.771
MOD_GlcNHglycan	314	317	PF01048	0.409
MOD_GlcNHglycan	343	346	PF01048	0.397
MOD_GlcNHglycan	92	95	PF01048	0.569
MOD_GSK3_1	128	135	PF00069	0.699
MOD_GSK3_1	15	22	PF00069	0.650
MOD_GSK3_1	228	235	PF00069	0.643
MOD_GSK3_1	239	246	PF00069	0.389
MOD_GSK3_1	258	265	PF00069	0.367
MOD_GSK3_1	327	334	PF00069	0.590
MOD_GSK3_1	341	348	PF00069	0.295
MOD_GSK3_1	90	97	PF00069	0.456
MOD_N-GLC_1	113	118	PF02516	0.565
MOD_NEK2_1	113	118	PF00069	0.627
MOD_NEK2_1	262	267	PF00069	0.514
MOD_NEK2_1	327	332	PF00069	0.569
MOD_NEK2_1	341	346	PF00069	0.342
MOD_NEK2_1	79	84	PF00069	0.584
MOD_PIKK_1	239	245	PF00454	0.530
MOD_PKA_2	8	14	PF00069	0.745
MOD_Plk_4	243	249	PF00069	0.351
MOD_ProDKin_1	10	16	PF00069	0.629
MOD_ProDKin_1	114	120	PF00069	0.606
MOD_ProDKin_1	19	25	PF00069	0.684
MOD_ProDKin_1	225	231	PF00069	0.668
MOD_ProDKin_1	293	299	PF00069	0.517
MOD_ProDKin_1	345	351	PF00069	0.433
MOD_ProDKin_1	54	60	PF00069	0.576
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.538
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.536
TRG_ENDOCYTIC_2	102	105	PF00928	0.398
TRG_ENDOCYTIC_2	150	153	PF00928	0.434
TRG_ER_diArg_1	194	196	PF00400	0.574
TRG_ER_diArg_1	248	250	PF00400	0.468
TRG_ER_diArg_1	287	290	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYD6	Trypanosomatidae	34%	78%
A0A3S7X1C6	Leishmania donovani	98%	95%
A4HGE9	Leishmania braziliensis	70%	100%
E9AZS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8G2	Leishmania major	88%	100%