Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3H7_LEIIN

TriTrypDb:

LINF_280015600

Length:

939

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	859	863	PF00656	0.679
CLV_NRD_NRD_1	193	195	PF00675	0.713
CLV_NRD_NRD_1	197	199	PF00675	0.625
CLV_NRD_NRD_1	362	364	PF00675	0.459
CLV_NRD_NRD_1	496	498	PF00675	0.499
CLV_NRD_NRD_1	749	751	PF00675	0.674
CLV_NRD_NRD_1	769	771	PF00675	0.263
CLV_NRD_NRD_1	788	790	PF00675	0.314
CLV_NRD_NRD_1	797	799	PF00675	0.247
CLV_PCSK_FUR_1	494	498	PF00082	0.611
CLV_PCSK_KEX2_1	193	195	PF00082	0.681
CLV_PCSK_KEX2_1	197	199	PF00082	0.629
CLV_PCSK_KEX2_1	362	364	PF00082	0.425
CLV_PCSK_KEX2_1	496	498	PF00082	0.490
CLV_PCSK_KEX2_1	646	648	PF00082	0.499
CLV_PCSK_KEX2_1	719	721	PF00082	0.569
CLV_PCSK_KEX2_1	749	751	PF00082	0.674
CLV_PCSK_KEX2_1	769	771	PF00082	0.263
CLV_PCSK_KEX2_1	788	790	PF00082	0.314
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.536
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.544
CLV_PCSK_PC7_1	193	199	PF00082	0.727
CLV_PCSK_PC7_1	358	364	PF00082	0.368
CLV_PCSK_PC7_1	745	751	PF00082	0.663
CLV_PCSK_PC7_1	765	771	PF00082	0.290
CLV_PCSK_SKI1_1	189	193	PF00082	0.790
CLV_PCSK_SKI1_1	213	217	PF00082	0.692
CLV_PCSK_SKI1_1	231	235	PF00082	0.529
CLV_PCSK_SKI1_1	303	307	PF00082	0.678
CLV_PCSK_SKI1_1	481	485	PF00082	0.405
CLV_PCSK_SKI1_1	533	537	PF00082	0.485
CLV_PCSK_SKI1_1	724	728	PF00082	0.466
CLV_PCSK_SKI1_1	789	793	PF00082	0.418
CLV_PCSK_SKI1_1	794	798	PF00082	0.440
CLV_PCSK_SKI1_1	920	924	PF00082	0.554
DEG_APCC_DBOX_1	212	220	PF00400	0.692
DEG_APCC_DBOX_1	517	525	PF00400	0.413
DEG_APCC_DBOX_1	630	638	PF00400	0.462
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DEG_SCF_FBW7_1	589	596	PF00400	0.455
DEG_SCF_FBW7_1	816	823	PF00400	0.563
DOC_CDC14_PxL_1	677	685	PF14671	0.475
DOC_CDC14_PxL_1	705	713	PF14671	0.517
DOC_CKS1_1	442	447	PF01111	0.582
DOC_CYCLIN_RxL_1	186	195	PF00134	0.565
DOC_CYCLIN_RxL_1	228	238	PF00134	0.660
DOC_CYCLIN_RxL_1	297	310	PF00134	0.616
DOC_CYCLIN_yClb5_NLxxxL_5	474	483	PF00134	0.552
DOC_MAPK_gen_1	394	403	PF00069	0.504
DOC_MAPK_gen_1	57	65	PF00069	0.595
DOC_MAPK_HePTP_8	393	405	PF00069	0.553
DOC_MAPK_MEF2A_6	396	405	PF00069	0.480
DOC_MAPK_MEF2A_6	518	526	PF00069	0.412
DOC_MAPK_MEF2A_6	570	577	PF00069	0.392
DOC_MAPK_MEF2A_6	631	638	PF00069	0.551
DOC_MAPK_MEF2A_6	85	94	PF00069	0.429
DOC_MAPK_NFAT4_5	631	639	PF00069	0.544
DOC_MAPK_RevD_3	634	647	PF00069	0.431
DOC_PP2B_LxvP_1	403	406	PF13499	0.547
DOC_PP2B_LxvP_1	575	578	PF13499	0.422
DOC_PP2B_LxvP_1	636	639	PF13499	0.407
DOC_PP2B_LxvP_1	660	663	PF13499	0.670
DOC_PP2B_LxvP_1	90	93	PF13499	0.435
DOC_PP4_FxxP_1	46	49	PF00568	0.519
DOC_PP4_FxxP_1	884	887	PF00568	0.688
DOC_USP7_MATH_1	138	142	PF00917	0.648
DOC_USP7_MATH_1	275	279	PF00917	0.705
DOC_USP7_MATH_1	354	358	PF00917	0.570
DOC_USP7_MATH_1	495	499	PF00917	0.621
DOC_USP7_MATH_1	553	557	PF00917	0.409
DOC_USP7_MATH_1	593	597	PF00917	0.450
DOC_USP7_MATH_1	898	902	PF00917	0.751
DOC_USP7_MATH_1	907	911	PF00917	0.777
DOC_USP7_MATH_1	927	931	PF00917	0.535
DOC_USP7_MATH_2	122	128	PF00917	0.610
DOC_USP7_UBL2_3	390	394	PF12436	0.586
DOC_WW_Pin1_4	172	177	PF00397	0.620
DOC_WW_Pin1_4	338	343	PF00397	0.606
DOC_WW_Pin1_4	441	446	PF00397	0.532
DOC_WW_Pin1_4	589	594	PF00397	0.405
DOC_WW_Pin1_4	670	675	PF00397	0.441
DOC_WW_Pin1_4	816	821	PF00397	0.568
DOC_WW_Pin1_4	900	905	PF00397	0.795
DOC_WW_Pin1_4	921	926	PF00397	0.521
LIG_14-3-3_CanoR_1	193	201	PF00244	0.540
LIG_14-3-3_CanoR_1	494	503	PF00244	0.558
LIG_14-3-3_CanoR_1	570	574	PF00244	0.522
LIG_14-3-3_CanoR_1	60	66	PF00244	0.516
LIG_14-3-3_CanoR_1	650	660	PF00244	0.669
LIG_APCC_ABBA_1	688	693	PF00400	0.448
LIG_BRCT_BRCA1_1	555	559	PF00533	0.495
LIG_Clathr_ClatBox_1	521	525	PF01394	0.395
LIG_CtBP_PxDLS_1	122	126	PF00389	0.617
LIG_FHA_1	398	404	PF00498	0.396
LIG_FHA_1	469	475	PF00498	0.563
LIG_FHA_1	570	576	PF00498	0.462
LIG_FHA_1	821	827	PF00498	0.512
LIG_FHA_2	112	118	PF00498	0.592
LIG_FHA_2	138	144	PF00498	0.656
LIG_FHA_2	362	368	PF00498	0.552
LIG_FHA_2	415	421	PF00498	0.582
LIG_FHA_2	442	448	PF00498	0.575
LIG_FHA_2	652	658	PF00498	0.538
LIG_FHA_2	698	704	PF00498	0.574
LIG_FHA_2	817	823	PF00498	0.566
LIG_FHA_2	852	858	PF00498	0.538
LIG_LIR_Apic_2	44	49	PF02991	0.510
LIG_LIR_Apic_2	883	887	PF02991	0.690
LIG_LIR_Gen_1	209	219	PF02991	0.704
LIG_LIR_Gen_1	400	410	PF02991	0.554
LIG_LIR_Gen_1	556	563	PF02991	0.454
LIG_LIR_Gen_1	693	702	PF02991	0.440
LIG_LIR_Gen_1	819	829	PF02991	0.571
LIG_LIR_Nem_3	151	157	PF02991	0.786
LIG_LIR_Nem_3	209	214	PF02991	0.717
LIG_LIR_Nem_3	400	405	PF02991	0.506
LIG_LIR_Nem_3	485	490	PF02991	0.604
LIG_LIR_Nem_3	529	535	PF02991	0.468
LIG_LIR_Nem_3	556	562	PF02991	0.419
LIG_LIR_Nem_3	571	577	PF02991	0.412
LIG_LIR_Nem_3	735	740	PF02991	0.428
LIG_LIR_Nem_3	819	824	PF02991	0.545
LIG_Pex14_1	42	46	PF04695	0.495
LIG_PTB_Apo_2	278	285	PF02174	0.792
LIG_PTB_Phospho_1	278	284	PF10480	0.790
LIG_SH2_CRK	442	446	PF00017	0.584
LIG_SH2_CRK	758	762	PF00017	0.462
LIG_SH2_NCK_1	587	591	PF00017	0.491
LIG_SH2_SRC	29	32	PF00017	0.441
LIG_SH2_SRC	691	694	PF00017	0.488
LIG_SH2_SRC	806	809	PF00017	0.474
LIG_SH2_STAP1	29	33	PF00017	0.579
LIG_SH2_STAP1	301	305	PF00017	0.715
LIG_SH2_STAP1	399	403	PF00017	0.381
LIG_SH2_STAP1	452	456	PF00017	0.434
LIG_SH2_STAP1	554	558	PF00017	0.394
LIG_SH2_STAT5	359	362	PF00017	0.539
LIG_SH2_STAT5	399	402	PF00017	0.390
LIG_SH2_STAT5	561	564	PF00017	0.421
LIG_SH2_STAT5	574	577	PF00017	0.384
LIG_SH2_STAT5	642	645	PF00017	0.510
LIG_SH2_STAT5	754	757	PF00017	0.534
LIG_SH2_STAT5	806	809	PF00017	0.474
LIG_SH3_3	125	131	PF00018	0.496
LIG_SH3_3	290	296	PF00018	0.757
LIG_SH3_3	403	409	PF00018	0.450
LIG_SH3_3	463	469	PF00018	0.612
LIG_SH3_3	570	576	PF00018	0.531
LIG_SH3_3	659	665	PF00018	0.631
LIG_SH3_3	919	925	PF00018	0.671
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.553
LIG_SUMO_SIM_par_1	121	127	PF11976	0.616
LIG_SUMO_SIM_par_1	470	476	PF11976	0.534
LIG_SUMO_SIM_par_1	520	525	PF11976	0.448
LIG_TRAF2_1	376	379	PF00917	0.582
LIG_TRAF2_1	417	420	PF00917	0.606
LIG_TRAF2_1	690	693	PF00917	0.499
LIG_TYR_ITIM	530	535	PF00017	0.330
LIG_UBA3_1	304	311	PF00899	0.530
LIG_UBA3_1	526	533	PF00899	0.334
LIG_WRC_WIRS_1	43	48	PF05994	0.499
LIG_WRC_WIRS_1	514	519	PF05994	0.477
LIG_WRC_WIRS_1	543	548	PF05994	0.475
LIG_WW_1	674	677	PF00397	0.415
MOD_CDK_SPK_2	441	446	PF00069	0.511
MOD_CDK_SPxxK_3	338	345	PF00069	0.588
MOD_CK1_1	161	167	PF00069	0.784
MOD_CK1_1	307	313	PF00069	0.642
MOD_CK1_1	371	377	PF00069	0.596
MOD_CK1_1	5	11	PF00069	0.666
MOD_CK1_1	588	594	PF00069	0.418
MOD_CK1_1	903	909	PF00069	0.760
MOD_CK2_1	111	117	PF00069	0.598
MOD_CK2_1	137	143	PF00069	0.583
MOD_CK2_1	248	254	PF00069	0.672
MOD_CK2_1	414	420	PF00069	0.582
MOD_CK2_1	441	447	PF00069	0.573
MOD_CK2_1	588	594	PF00069	0.488
MOD_CK2_1	649	655	PF00069	0.625
MOD_Cter_Amidation	786	789	PF01082	0.421
MOD_GlcNHglycan	140	143	PF01048	0.614
MOD_GlcNHglycan	160	163	PF01048	0.473
MOD_GlcNHglycan	183	186	PF01048	0.720
MOD_GlcNHglycan	194	197	PF01048	0.616
MOD_GlcNHglycan	250	253	PF01048	0.616
MOD_GlcNHglycan	268	271	PF01048	0.754
MOD_GlcNHglycan	311	314	PF01048	0.667
MOD_GlcNHglycan	4	7	PF01048	0.629
MOD_GlcNHglycan	555	558	PF01048	0.442
MOD_GlcNHglycan	683	686	PF01048	0.522
MOD_GlcNHglycan	900	903	PF01048	0.747
MOD_GlcNHglycan	905	908	PF01048	0.760
MOD_GSK3_1	157	164	PF00069	0.818
MOD_GSK3_1	177	184	PF00069	0.707
MOD_GSK3_1	218	225	PF00069	0.686
MOD_GSK3_1	244	251	PF00069	0.551
MOD_GSK3_1	367	374	PF00069	0.550
MOD_GSK3_1	564	571	PF00069	0.515
MOD_GSK3_1	585	592	PF00069	0.446
MOD_GSK3_1	651	658	PF00069	0.554
MOD_GSK3_1	666	673	PF00069	0.511
MOD_GSK3_1	816	823	PF00069	0.539
MOD_GSK3_1	894	901	PF00069	0.783
MOD_GSK3_1	903	910	PF00069	0.752
MOD_NEK2_1	123	128	PF00069	0.608
MOD_NEK2_1	157	162	PF00069	0.804
MOD_NEK2_1	192	197	PF00069	0.551
MOD_NEK2_1	2	7	PF00069	0.728
MOD_NEK2_1	222	227	PF00069	0.683
MOD_NEK2_1	304	309	PF00069	0.610
MOD_NEK2_1	368	373	PF00069	0.513
MOD_NEK2_1	389	394	PF00069	0.637
MOD_NEK2_1	683	688	PF00069	0.527
MOD_NEK2_1	727	732	PF00069	0.393
MOD_NEK2_1	856	861	PF00069	0.604
MOD_NEK2_2	569	574	PF00069	0.436
MOD_PIKK_1	177	183	PF00454	0.776
MOD_PIKK_1	415	421	PF00454	0.541
MOD_PIKK_1	564	570	PF00454	0.523
MOD_PIKK_1	727	733	PF00454	0.416
MOD_PKA_2	181	187	PF00069	0.631
MOD_PKA_2	192	198	PF00069	0.620
MOD_PKA_2	354	360	PF00069	0.542
MOD_PKA_2	361	367	PF00069	0.531
MOD_PKA_2	495	501	PF00069	0.590
MOD_PKA_2	569	575	PF00069	0.381
MOD_PKA_2	630	636	PF00069	0.428
MOD_PKA_2	649	655	PF00069	0.343
MOD_Plk_1	123	129	PF00069	0.529
MOD_Plk_1	368	374	PF00069	0.531
MOD_Plk_1	593	599	PF00069	0.447
MOD_Plk_1	727	733	PF00069	0.416
MOD_Plk_1	856	862	PF00069	0.595
MOD_Plk_2-3	468	474	PF00069	0.621
MOD_Plk_4	222	228	PF00069	0.691
MOD_Plk_4	244	250	PF00069	0.639
MOD_Plk_4	331	337	PF00069	0.496
MOD_Plk_4	394	400	PF00069	0.551
MOD_Plk_4	569	575	PF00069	0.369
MOD_Plk_4	593	599	PF00069	0.531
MOD_Plk_4	638	644	PF00069	0.491
MOD_Plk_4	851	857	PF00069	0.551
MOD_ProDKin_1	172	178	PF00069	0.621
MOD_ProDKin_1	338	344	PF00069	0.600
MOD_ProDKin_1	441	447	PF00069	0.532
MOD_ProDKin_1	589	595	PF00069	0.402
MOD_ProDKin_1	670	676	PF00069	0.432
MOD_ProDKin_1	816	822	PF00069	0.574
MOD_ProDKin_1	900	906	PF00069	0.797
MOD_ProDKin_1	921	927	PF00069	0.509
MOD_SUMO_rev_2	468	477	PF00179	0.626
MOD_SUMO_rev_2	51	59	PF00179	0.520
MOD_SUMO_rev_2	525	535	PF00179	0.464
MOD_SUMO_rev_2	716	721	PF00179	0.534
TRG_DiLeu_BaEn_1	531	536	PF01217	0.453
TRG_DiLeu_BaEn_1	632	637	PF01217	0.557
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.617
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.651
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.564
TRG_ENDOCYTIC_2	301	304	PF00928	0.637
TRG_ENDOCYTIC_2	532	535	PF00928	0.393
TRG_ENDOCYTIC_2	574	577	PF00928	0.425
TRG_ENDOCYTIC_2	677	680	PF00928	0.482
TRG_ENDOCYTIC_2	691	694	PF00928	0.487
TRG_ER_diArg_1	192	194	PF00400	0.680
TRG_ER_diArg_1	197	199	PF00400	0.619
TRG_ER_diArg_1	493	496	PF00400	0.626
TRG_ER_diArg_1	749	751	PF00400	0.652
TRG_ER_diArg_1	769	771	PF00400	0.330
TRG_ER_diArg_1	788	790	PF00400	0.314
TRG_NES_CRM1_1	240	254	PF08389	0.629
TRG_NES_CRM1_1	31	47	PF08389	0.522
TRG_NES_CRM1_1	424	435	PF08389	0.429
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.741
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W5	Leptomonas seymouri	48%	89%
A0A1X0NZW9	Trypanosomatidae	35%	95%
A0A3Q8IDR2	Leishmania donovani	100%	100%
A0A3R7M3D8	Trypanosoma rangeli	35%	100%
A4HGE4	Leishmania braziliensis	77%	100%
E9AZR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8G7	Leishmania major	94%	100%
V5D1P8	Trypanosoma cruzi	36%	100%