LeishMANIAdb
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P27 protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
P27 protein
Gene product:
P27 protein - putative
Species:
Leishmania infantum
UniProt:
A4I3H5_LEIIN
TriTrypDb:
LINF_280015400
Length:
240

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), P27

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I3H5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3H5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 200 204 PF00082 0.655
DEG_APCC_DBOX_1 93 101 PF00400 0.536
DOC_CYCLIN_RxL_1 194 208 PF00134 0.374
DOC_PP1_RVXF_1 120 126 PF00149 0.373
DOC_PP1_RVXF_1 78 85 PF00149 0.595
DOC_PP4_FxxP_1 125 128 PF00568 0.388
DOC_USP7_MATH_1 233 237 PF00917 0.541
LIG_14-3-3_CanoR_1 122 126 PF00244 0.412
LIG_BIR_II_1 1 5 PF00653 0.688
LIG_BRCT_BRCA1_1 115 119 PF00533 0.274
LIG_BRCT_BRCA1_1 68 72 PF00533 0.694
LIG_EH_1 29 33 PF12763 0.640
LIG_FHA_1 108 114 PF00498 0.281
LIG_FHA_1 170 176 PF00498 0.426
LIG_FHA_1 3 9 PF00498 0.700
LIG_IBAR_NPY_1 76 78 PF08397 0.623
LIG_LIR_Apic_2 124 128 PF02991 0.424
LIG_LIR_LC3C_4 110 113 PF02991 0.221
LIG_LIR_Nem_3 116 121 PF02991 0.308
LIG_Pex14_1 55 59 PF04695 0.605
LIG_REV1ctd_RIR_1 70 76 PF16727 0.595
LIG_SH2_CRK 61 65 PF00017 0.631
LIG_SH2_GRB2like 205 208 PF00017 0.375
LIG_SH2_PTP2 23 26 PF00017 0.580
LIG_SH2_SRC 189 192 PF00017 0.349
LIG_SH2_STAP1 115 119 PF00017 0.323
LIG_SH2_STAT5 189 192 PF00017 0.378
LIG_SH2_STAT5 23 26 PF00017 0.586
LIG_SH2_STAT5 44 47 PF00017 0.589
LIG_SH2_STAT5 81 84 PF00017 0.612
LIG_SH3_4 141 148 PF00018 0.445
LIG_SUMO_SIM_anti_2 110 116 PF11976 0.394
LIG_SUMO_SIM_par_1 110 116 PF11976 0.316
MOD_CK1_1 2 8 PF00069 0.684
MOD_CK1_1 9 15 PF00069 0.654
MOD_CK1_1 99 105 PF00069 0.562
MOD_CK2_1 85 91 PF00069 0.579
MOD_GlcNHglycan 224 229 PF01048 0.671
MOD_GlcNHglycan 235 238 PF01048 0.732
MOD_GlcNHglycan 48 51 PF01048 0.383
MOD_GlcNHglycan 8 11 PF01048 0.501
MOD_GSK3_1 113 120 PF00069 0.306
MOD_GSK3_1 2 9 PF00069 0.742
MOD_GSK3_1 99 106 PF00069 0.522
MOD_NEK2_1 117 122 PF00069 0.480
MOD_NEK2_1 137 142 PF00069 0.314
MOD_NEK2_1 85 90 PF00069 0.579
MOD_NEK2_2 128 133 PF00069 0.370
MOD_NEK2_2 212 217 PF00069 0.349
MOD_PKA_2 121 127 PF00069 0.421
MOD_PKA_2 2 8 PF00069 0.666
MOD_Plk_1 128 134 PF00069 0.365
MOD_Plk_1 167 173 PF00069 0.465
MOD_Plk_1 200 206 PF00069 0.435
MOD_Plk_1 85 91 PF00069 0.579
MOD_Plk_2-3 86 92 PF00069 0.581
MOD_Plk_4 103 109 PF00069 0.321
MOD_Plk_4 113 119 PF00069 0.290
MOD_Plk_4 121 127 PF00069 0.325
MOD_Plk_4 200 206 PF00069 0.361
TRG_ENDOCYTIC_2 160 163 PF00928 0.413
TRG_ENDOCYTIC_2 61 64 PF00928 0.628
TRG_NES_CRM1_1 173 187 PF08389 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYK0 Leptomonas seymouri 63% 99%
A0A0S4IVH5 Bodo saltans 48% 99%
A0A0S4IXX7 Bodo saltans 48% 91%
A0A1X0NYZ9 Trypanosomatidae 63% 100%
A0A3Q8IGT4 Leishmania donovani 61% 99%
A0A422MZK8 Trypanosoma rangeli 62% 100%
A4HGE2 Leishmania braziliensis 83% 100%
A4HLG1 Leishmania braziliensis 60% 100%
A4I8X2 Leishmania infantum 61% 99%
E9AZR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B3U1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 100%
I1ZAQ0 Leishmania donovani 100% 100%
Q4Q483 Leishmania major 62% 100%
Q4Q8G9 Leishmania major 94% 100%
V5AL49 Trypanosoma cruzi 63% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS