Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3G3_LEIIN

TriTrypDb:

LINF_280014200

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	366	368	PF00082	0.756
CLV_PCSK_KEX2_1	395	397	PF00082	0.730
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.756
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.730
CLV_PCSK_SKI1_1	104	108	PF00082	0.710
CLV_PCSK_SKI1_1	12	16	PF00082	0.585
CLV_PCSK_SKI1_1	154	158	PF00082	0.754
CLV_PCSK_SKI1_1	269	273	PF00082	0.633
CLV_PCSK_SKI1_1	343	347	PF00082	0.787
DEG_Nend_UBRbox_3	1	3	PF02207	0.567
DEG_SCF_FBW7_2	311	318	PF00400	0.652
DEG_SPOP_SBC_1	231	235	PF00917	0.737
DEG_SPOP_SBC_1	288	292	PF00917	0.824
DEG_SPOP_SBC_1	96	100	PF00917	0.671
DOC_CKS1_1	312	317	PF01111	0.689
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.842
DOC_PP1_RVXF_1	65	72	PF00149	0.576
DOC_PP2B_LxvP_1	195	198	PF13499	0.830
DOC_PP2B_LxvP_1	346	349	PF13499	0.844
DOC_USP7_MATH_1	225	229	PF00917	0.736
DOC_USP7_MATH_1	231	235	PF00917	0.827
DOC_USP7_MATH_1	245	249	PF00917	0.830
DOC_USP7_MATH_1	276	280	PF00917	0.642
DOC_USP7_MATH_1	288	292	PF00917	0.655
DOC_USP7_MATH_1	357	361	PF00917	0.723
DOC_USP7_MATH_1	394	398	PF00917	0.652
DOC_USP7_MATH_1	438	442	PF00917	0.721
DOC_USP7_MATH_1	96	100	PF00917	0.650
DOC_WW_Pin1_4	123	128	PF00397	0.754
DOC_WW_Pin1_4	177	182	PF00397	0.725
DOC_WW_Pin1_4	2	7	PF00397	0.761
DOC_WW_Pin1_4	26	31	PF00397	0.693
DOC_WW_Pin1_4	284	289	PF00397	0.816
DOC_WW_Pin1_4	306	311	PF00397	0.670
DOC_WW_Pin1_4	406	411	PF00397	0.710
DOC_WW_Pin1_4	490	495	PF00397	0.546
DOC_WW_Pin1_4	78	83	PF00397	0.701
LIG_14-3-3_CanoR_1	123	127	PF00244	0.637
LIG_14-3-3_CanoR_1	162	170	PF00244	0.626
LIG_14-3-3_CanoR_1	219	224	PF00244	0.661
LIG_14-3-3_CanoR_1	246	251	PF00244	0.804
LIG_14-3-3_CanoR_1	269	274	PF00244	0.685
LIG_14-3-3_CanoR_1	389	393	PF00244	0.664
LIG_14-3-3_CanoR_1	406	410	PF00244	0.686
LIG_14-3-3_CanoR_1	416	425	PF00244	0.681
LIG_14-3-3_CanoR_1	67	72	PF00244	0.643
LIG_Clathr_ClatBox_1	106	110	PF01394	0.707
LIG_DLG_GKlike_1	219	227	PF00625	0.666
LIG_FHA_1	165	171	PF00498	0.764
LIG_FHA_1	190	196	PF00498	0.834
LIG_FHA_1	325	331	PF00498	0.761
LIG_FHA_1	335	341	PF00498	0.656
LIG_FHA_1	388	394	PF00498	0.761
LIG_FHA_1	418	424	PF00498	0.635
LIG_FHA_1	463	469	PF00498	0.509
LIG_FHA_1	50	56	PF00498	0.801
LIG_FHA_1	96	102	PF00498	0.665
LIG_FHA_2	270	276	PF00498	0.722
LIG_Integrin_RGD_1	116	118	PF01839	0.808
LIG_LIR_Apic_2	424	428	PF02991	0.721
LIG_LIR_Nem_3	498	504	PF02991	0.587
LIG_LIR_Nem_3	58	64	PF02991	0.768
LIG_Pex14_1	497	501	PF04695	0.628
LIG_SH2_GRB2like	61	64	PF00017	0.688
LIG_SH2_STAT5	203	206	PF00017	0.851
LIG_SH2_STAT5	425	428	PF00017	0.795
LIG_SH3_2	312	317	PF14604	0.650
LIG_SH3_3	194	200	PF00018	0.753
LIG_SH3_3	224	230	PF00018	0.642
LIG_SH3_3	239	245	PF00018	0.660
LIG_SH3_3	250	256	PF00018	0.661
LIG_SH3_3	309	315	PF00018	0.694
LIG_SH3_3	66	72	PF00018	0.691
LIG_SH3_3	79	85	PF00018	0.633
LIG_SUMO_SIM_par_1	441	450	PF11976	0.639
LIG_SUMO_SIM_par_1	456	462	PF11976	0.581
LIG_SxIP_EBH_1	392	401	PF03271	0.625
LIG_TRAF2_1	272	275	PF00917	0.719
LIG_TRAF2_1	316	319	PF00917	0.832
LIG_WW_3	126	130	PF00397	0.717
LIG_WW_3	243	247	PF00397	0.724
MOD_CDC14_SPxK_1	126	129	PF00782	0.758
MOD_CDK_SPxK_1	123	129	PF00069	0.757
MOD_CDK_SPxK_1	311	317	PF00069	0.657
MOD_CDK_SPxxK_3	289	296	PF00069	0.641
MOD_CDK_SPxxK_3	306	313	PF00069	0.677
MOD_CK1_1	158	164	PF00069	0.665
MOD_CK1_1	191	197	PF00069	0.716
MOD_CK1_1	202	208	PF00069	0.784
MOD_CK1_1	279	285	PF00069	0.815
MOD_CK1_1	287	293	PF00069	0.703
MOD_CK1_1	29	35	PF00069	0.688
MOD_CK1_1	299	305	PF00069	0.518
MOD_CK1_1	306	312	PF00069	0.536
MOD_CK1_1	362	368	PF00069	0.812
MOD_CK1_1	370	376	PF00069	0.700
MOD_CK1_1	421	427	PF00069	0.767
MOD_CK1_1	433	439	PF00069	0.580
MOD_CK1_1	493	499	PF00069	0.557
MOD_CK1_1	5	11	PF00069	0.593
MOD_CK1_1	78	84	PF00069	0.837
MOD_CK1_1	99	105	PF00069	0.654
MOD_CK2_1	162	168	PF00069	0.841
MOD_CK2_1	269	275	PF00069	0.671
MOD_GlcNHglycan	138	141	PF01048	0.783
MOD_GlcNHglycan	164	167	PF01048	0.761
MOD_GlcNHglycan	207	210	PF01048	0.671
MOD_GlcNHglycan	216	219	PF01048	0.697
MOD_GlcNHglycan	223	226	PF01048	0.624
MOD_GlcNHglycan	227	230	PF01048	0.592
MOD_GlcNHglycan	259	262	PF01048	0.611
MOD_GlcNHglycan	278	281	PF01048	0.613
MOD_GlcNHglycan	297	301	PF01048	0.761
MOD_GlcNHglycan	305	308	PF01048	0.747
MOD_GlcNHglycan	31	34	PF01048	0.713
MOD_GlcNHglycan	369	372	PF01048	0.692
MOD_GlcNHglycan	37	40	PF01048	0.649
MOD_GSK3_1	118	125	PF00069	0.789
MOD_GSK3_1	127	134	PF00069	0.713
MOD_GSK3_1	158	165	PF00069	0.815
MOD_GSK3_1	199	206	PF00069	0.820
MOD_GSK3_1	207	214	PF00069	0.732
MOD_GSK3_1	221	228	PF00069	0.642
MOD_GSK3_1	284	291	PF00069	0.806
MOD_GSK3_1	299	306	PF00069	0.602
MOD_GSK3_1	324	331	PF00069	0.645
MOD_GSK3_1	365	372	PF00069	0.739
MOD_GSK3_1	414	421	PF00069	0.751
MOD_GSK3_1	423	430	PF00069	0.641
MOD_GSK3_1	462	469	PF00069	0.606
MOD_GSK3_1	49	56	PF00069	0.734
MOD_GSK3_1	63	70	PF00069	0.573
MOD_GSK3_1	71	78	PF00069	0.738
MOD_GSK3_1	95	102	PF00069	0.794
MOD_N-GLC_1	158	163	PF02516	0.756
MOD_N-GLC_1	352	357	PF02516	0.839
MOD_N-GLC_1	454	459	PF02516	0.491
MOD_N-GLC_2	183	185	PF02516	0.673
MOD_NEK2_1	15	20	PF00069	0.525
MOD_NEK2_1	263	268	PF00069	0.691
MOD_NEK2_1	369	374	PF00069	0.712
MOD_NEK2_1	454	459	PF00069	0.491
MOD_NEK2_1	75	80	PF00069	0.750
MOD_NEK2_2	131	136	PF00069	0.648
MOD_OFUCOSY	124	131	PF10250	0.656
MOD_PKA_2	122	128	PF00069	0.680
MOD_PKA_2	170	176	PF00069	0.688
MOD_PKA_2	245	251	PF00069	0.725
MOD_PKA_2	328	334	PF00069	0.659
MOD_PKA_2	388	394	PF00069	0.680
MOD_PKA_2	405	411	PF00069	0.664
MOD_PKA_2	421	427	PF00069	0.601
MOD_PKA_2	53	59	PF00069	0.647
MOD_Plk_1	158	164	PF00069	0.620
MOD_Plk_1	171	177	PF00069	0.545
MOD_Plk_1	454	460	PF00069	0.485
MOD_Plk_1	96	102	PF00069	0.707
MOD_Plk_4	110	116	PF00069	0.793
MOD_Plk_4	16	22	PF00069	0.488
MOD_Plk_4	199	205	PF00069	0.843
MOD_Plk_4	388	394	PF00069	0.841
MOD_Plk_4	454	460	PF00069	0.498
MOD_Plk_4	5	11	PF00069	0.563
MOD_ProDKin_1	123	129	PF00069	0.757
MOD_ProDKin_1	177	183	PF00069	0.726
MOD_ProDKin_1	2	8	PF00069	0.760
MOD_ProDKin_1	26	32	PF00069	0.690
MOD_ProDKin_1	284	290	PF00069	0.815
MOD_ProDKin_1	306	312	PF00069	0.777
MOD_ProDKin_1	406	412	PF00069	0.706
MOD_ProDKin_1	490	496	PF00069	0.552
MOD_ProDKin_1	78	84	PF00069	0.701
MOD_SUMO_for_1	400	403	PF00179	0.695
MOD_SUMO_rev_2	421	431	PF00179	0.725
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.792
TRG_ER_diArg_1	256	259	PF00400	0.729
TRG_ER_diArg_1	340	343	PF00400	0.840
TRG_NES_CRM1_1	467	481	PF08389	0.618
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.784
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.802

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IER7	Leishmania donovani	99%	100%
A4HGD0	Leishmania braziliensis	57%	98%
E9AZQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8I1	Leishmania major	86%	100%