Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3G1_LEIIN

TriTrypDb:

LINF_280014000

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3G1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.574
CLV_C14_Caspase3-7	792	796	PF00656	0.626
CLV_NRD_NRD_1	203	205	PF00675	0.629
CLV_NRD_NRD_1	283	285	PF00675	0.452
CLV_NRD_NRD_1	291	293	PF00675	0.545
CLV_NRD_NRD_1	576	578	PF00675	0.401
CLV_NRD_NRD_1	594	596	PF00675	0.552
CLV_NRD_NRD_1	680	682	PF00675	0.414
CLV_NRD_NRD_1	719	721	PF00675	0.597
CLV_NRD_NRD_1	83	85	PF00675	0.432
CLV_NRD_NRD_1	94	96	PF00675	0.293
CLV_PCSK_KEX2_1	283	285	PF00082	0.512
CLV_PCSK_KEX2_1	291	293	PF00082	0.674
CLV_PCSK_KEX2_1	576	578	PF00082	0.401
CLV_PCSK_KEX2_1	594	596	PF00082	0.552
CLV_PCSK_KEX2_1	680	682	PF00082	0.414
CLV_PCSK_KEX2_1	83	85	PF00082	0.432
CLV_PCSK_SKI1_1	148	152	PF00082	0.386
CLV_PCSK_SKI1_1	506	510	PF00082	0.468
CLV_PCSK_SKI1_1	513	517	PF00082	0.413
CLV_PCSK_SKI1_1	63	67	PF00082	0.326
CLV_PCSK_SKI1_1	733	737	PF00082	0.629
CLV_PCSK_SKI1_1	95	99	PF00082	0.432
DEG_APCC_DBOX_1	575	583	PF00400	0.371
DEG_Nend_UBRbox_1	1	4	PF02207	0.693
DEG_SCF_FBW7_1	32	37	PF00400	0.702
DEG_SPOP_SBC_1	602	606	PF00917	0.545
DOC_CDC14_PxL_1	419	427	PF14671	0.500
DOC_CYCLIN_RxL_1	503	511	PF00134	0.478
DOC_MAPK_gen_1	465	473	PF00069	0.521
DOC_MAPK_gen_1	694	702	PF00069	0.391
DOC_MAPK_gen_1	83	93	PF00069	0.330
DOC_MAPK_HePTP_8	338	350	PF00069	0.494
DOC_MAPK_MEF2A_6	341	350	PF00069	0.483
DOC_PP1_RVXF_1	455	462	PF00149	0.441
DOC_PP1_RVXF_1	504	511	PF00149	0.477
DOC_PP1_RVXF_1	538	545	PF00149	0.583
DOC_PP2B_LxvP_1	162	165	PF13499	0.658
DOC_PP4_FxxP_1	248	251	PF00568	0.439
DOC_PP4_FxxP_1	476	479	PF00568	0.474
DOC_PP4_FxxP_1	725	728	PF00568	0.636
DOC_SPAK_OSR1_1	806	810	PF12202	0.535
DOC_USP7_MATH_1	22	26	PF00917	0.686
DOC_USP7_MATH_1	227	231	PF00917	0.697
DOC_USP7_MATH_1	393	397	PF00917	0.407
DOC_USP7_MATH_1	601	605	PF00917	0.565
DOC_USP7_MATH_1	608	612	PF00917	0.663
DOC_USP7_MATH_1	667	671	PF00917	0.421
DOC_USP7_MATH_1	773	777	PF00917	0.513
DOC_WW_Pin1_4	118	123	PF00397	0.287
DOC_WW_Pin1_4	160	165	PF00397	0.546
DOC_WW_Pin1_4	218	223	PF00397	0.675
DOC_WW_Pin1_4	30	35	PF00397	0.702
DOC_WW_Pin1_4	44	49	PF00397	0.544
DOC_WW_Pin1_4	604	609	PF00397	0.669
DOC_WW_Pin1_4	680	685	PF00397	0.394
DOC_WW_Pin1_4	723	728	PF00397	0.566
LIG_14-3-3_CanoR_1	291	296	PF00244	0.563
LIG_14-3-3_CanoR_1	345	351	PF00244	0.477
LIG_14-3-3_CanoR_1	576	580	PF00244	0.553
LIG_14-3-3_CanoR_1	615	624	PF00244	0.594
LIG_14-3-3_CanoR_1	697	703	PF00244	0.377
LIG_14-3-3_CanoR_1	822	826	PF00244	0.609
LIG_Actin_WH2_2	620	638	PF00022	0.406
LIG_BRCT_BRCA1_1	207	211	PF00533	0.725
LIG_BRCT_BRCA1_1	229	233	PF00533	0.562
LIG_BRCT_BRCA1_1	395	399	PF00533	0.392
LIG_CaM_IQ_9	459	474	PF13499	0.519
LIG_CaMK_CASK_1	90	95	PF00069	0.432
LIG_CSL_BTD_1	91	94	PF09270	0.326
LIG_deltaCOP1_diTrp_1	239	248	PF00928	0.521
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.432
LIG_EVH1_2	569	573	PF00568	0.505
LIG_FHA_1	128	134	PF00498	0.326
LIG_FHA_1	219	225	PF00498	0.697
LIG_FHA_1	263	269	PF00498	0.554
LIG_FHA_1	31	37	PF00498	0.702
LIG_FHA_1	319	325	PF00498	0.458
LIG_FHA_1	327	333	PF00498	0.427
LIG_FHA_1	357	363	PF00498	0.538
LIG_FHA_1	607	613	PF00498	0.645
LIG_FHA_1	64	70	PF00498	0.326
LIG_FHA_2	112	118	PF00498	0.419
LIG_FHA_2	161	167	PF00498	0.666
LIG_FHA_2	399	405	PF00498	0.407
LIG_FHA_2	449	455	PF00498	0.505
LIG_FHA_2	681	687	PF00498	0.506
LIG_FHA_2	71	77	PF00498	0.296
LIG_FHA_2	857	863	PF00498	0.691
LIG_IBAR_NPY_1	308	310	PF08397	0.422
LIG_LIR_Apic_2	503	507	PF02991	0.459
LIG_LIR_Gen_1	152	162	PF02991	0.569
LIG_LIR_Gen_1	239	248	PF02991	0.521
LIG_LIR_Gen_1	319	328	PF02991	0.492
LIG_LIR_Gen_1	344	353	PF02991	0.474
LIG_LIR_Nem_3	152	157	PF02991	0.433
LIG_LIR_Nem_3	230	236	PF02991	0.577
LIG_LIR_Nem_3	239	245	PF02991	0.551
LIG_LIR_Nem_3	275	281	PF02991	0.465
LIG_LIR_Nem_3	294	298	PF02991	0.324
LIG_LIR_Nem_3	319	323	PF02991	0.464
LIG_LIR_Nem_3	344	350	PF02991	0.393
LIG_LIR_Nem_3	548	553	PF02991	0.351
LIG_LIR_Nem_3	688	693	PF02991	0.528
LIG_LYPXL_yS_3	422	425	PF13949	0.489
LIG_LYPXL_yS_3	690	693	PF13949	0.400
LIG_MLH1_MIPbox_1	207	211	PF16413	0.725
LIG_MYND_1	234	238	PF01753	0.586
LIG_NRBOX	424	430	PF00104	0.506
LIG_NRBOX	862	868	PF00104	0.651
LIG_Pex14_1	622	626	PF04695	0.469
LIG_Pex14_1	678	682	PF04695	0.514
LIG_Pex14_2	618	622	PF04695	0.500
LIG_PTB_Apo_2	305	312	PF02174	0.458
LIG_PTB_Apo_2	319	326	PF02174	0.371
LIG_PTB_Apo_2	760	767	PF02174	0.529
LIG_REV1ctd_RIR_1	459	469	PF16727	0.522
LIG_REV1ctd_RIR_1	507	517	PF16727	0.479
LIG_SH2_CRK	320	324	PF00017	0.481
LIG_SH2_GRB2like	320	323	PF00017	0.468
LIG_SH2_NCK_1	682	686	PF00017	0.378
LIG_SH2_PTP2	108	111	PF00017	0.432
LIG_SH2_PTP2	644	647	PF00017	0.586
LIG_SH2_SRC	315	318	PF00017	0.378
LIG_SH2_SRC	432	435	PF00017	0.598
LIG_SH2_STAP1	320	324	PF00017	0.442
LIG_SH2_STAT5	108	111	PF00017	0.432
LIG_SH2_STAT5	210	213	PF00017	0.724
LIG_SH2_STAT5	310	313	PF00017	0.511
LIG_SH2_STAT5	315	318	PF00017	0.529
LIG_SH2_STAT5	320	323	PF00017	0.360
LIG_SH2_STAT5	342	345	PF00017	0.380
LIG_SH2_STAT5	373	376	PF00017	0.423
LIG_SH2_STAT5	387	390	PF00017	0.427
LIG_SH2_STAT5	485	488	PF00017	0.455
LIG_SH2_STAT5	626	629	PF00017	0.557
LIG_SH2_STAT5	644	647	PF00017	0.356
LIG_SH2_STAT5	682	685	PF00017	0.374
LIG_SH3_3	231	237	PF00018	0.599
LIG_SH3_3	29	35	PF00018	0.701
LIG_SH3_3	409	415	PF00018	0.422
LIG_SH3_3	640	646	PF00018	0.430
LIG_SH3_3	751	757	PF00018	0.472
LIG_SH3_3	791	797	PF00018	0.517
LIG_SH3_3	88	94	PF00018	0.326
LIG_TYR_ITIM	642	647	PF00017	0.565
LIG_UBA3_1	729	737	PF00899	0.583
LIG_WRC_WIRS_1	151	156	PF05994	0.392
MOD_CK1_1	160	166	PF00069	0.549
MOD_CK1_1	212	218	PF00069	0.692
MOD_CK1_1	294	300	PF00069	0.544
MOD_CK1_1	44	50	PF00069	0.686
MOD_CK1_1	604	610	PF00069	0.697
MOD_CK1_1	611	617	PF00069	0.600
MOD_CK1_1	816	822	PF00069	0.599
MOD_CK2_1	160	166	PF00069	0.638
MOD_CK2_1	212	218	PF00069	0.639
MOD_CK2_1	398	404	PF00069	0.370
MOD_CK2_1	786	792	PF00069	0.791
MOD_CK2_1	821	827	PF00069	0.642
MOD_GlcNHglycan	197	200	PF01048	0.714
MOD_GlcNHglycan	211	214	PF01048	0.534
MOD_GlcNHglycan	229	232	PF01048	0.593
MOD_GlcNHglycan	415	418	PF01048	0.441
MOD_GlcNHglycan	441	444	PF01048	0.593
MOD_GlcNHglycan	618	621	PF01048	0.533
MOD_GlcNHglycan	741	744	PF01048	0.654
MOD_GlcNHglycan	750	753	PF01048	0.454
MOD_GlcNHglycan	788	791	PF01048	0.793
MOD_GlcNHglycan	802	805	PF01048	0.479
MOD_GlcNHglycan	810	813	PF01048	0.437
MOD_GlcNHglycan	815	818	PF01048	0.407
MOD_GlcNHglycan	859	862	PF01048	0.707
MOD_GSK3_1	195	202	PF00069	0.700
MOD_GSK3_1	205	212	PF00069	0.617
MOD_GSK3_1	294	301	PF00069	0.542
MOD_GSK3_1	30	37	PF00069	0.703
MOD_GSK3_1	394	401	PF00069	0.599
MOD_GSK3_1	435	442	PF00069	0.600
MOD_GSK3_1	602	609	PF00069	0.561
MOD_GSK3_1	821	828	PF00069	0.636
MOD_GSK3_1	857	864	PF00069	0.706
MOD_N-GLC_1	205	210	PF02516	0.722
MOD_N-GLC_1	254	259	PF02516	0.436
MOD_N-GLC_1	551	556	PF02516	0.461
MOD_N-GLC_1	616	621	PF02516	0.592
MOD_N-GLC_2	586	588	PF02516	0.465
MOD_NEK2_1	150	155	PF00069	0.426
MOD_NEK2_1	157	162	PF00069	0.476
MOD_NEK2_1	254	259	PF00069	0.436
MOD_NEK2_1	346	351	PF00069	0.427
MOD_NEK2_1	356	361	PF00069	0.364
MOD_NEK2_1	36	41	PF00069	0.802
MOD_NEK2_1	381	386	PF00069	0.552
MOD_NEK2_1	486	491	PF00069	0.455
MOD_NEK2_1	508	513	PF00069	0.467
MOD_NEK2_1	551	556	PF00069	0.461
MOD_NEK2_1	628	633	PF00069	0.518
MOD_NEK2_1	741	746	PF00069	0.640
MOD_NEK2_1	747	752	PF00069	0.521
MOD_NEK2_1	799	804	PF00069	0.581
MOD_NEK2_1	821	826	PF00069	0.555
MOD_NEK2_1	834	839	PF00069	0.662
MOD_NEK2_2	394	399	PF00069	0.493
MOD_NEK2_2	667	672	PF00069	0.505
MOD_NEK2_2	728	733	PF00069	0.486
MOD_PIKK_1	182	188	PF00454	0.704
MOD_PIKK_1	199	205	PF00454	0.689
MOD_PIKK_1	22	28	PF00454	0.691
MOD_PIKK_1	551	557	PF00454	0.471
MOD_PIKK_1	741	747	PF00454	0.542
MOD_PKA_1	291	297	PF00069	0.576
MOD_PKA_2	12	18	PF00069	0.688
MOD_PKA_2	199	205	PF00069	0.689
MOD_PKA_2	291	297	PF00069	0.547
MOD_PKA_2	575	581	PF00069	0.548
MOD_PKA_2	821	827	PF00069	0.659
MOD_Plk_1	116	122	PF00069	0.326
MOD_Plk_1	381	387	PF00069	0.496
MOD_Plk_1	448	454	PF00069	0.519
MOD_Plk_1	551	557	PF00069	0.471
MOD_Plk_1	667	673	PF00069	0.511
MOD_Plk_1	861	867	PF00069	0.652
MOD_Plk_2-3	836	842	PF00069	0.705
MOD_Plk_2-3	849	855	PF00069	0.538
MOD_Plk_4	241	247	PF00069	0.579
MOD_Plk_4	254	260	PF00069	0.411
MOD_Plk_4	291	297	PF00069	0.576
MOD_Plk_4	357	363	PF00069	0.500
MOD_Plk_4	394	400	PF00069	0.486
MOD_Plk_4	448	454	PF00069	0.503
MOD_Plk_4	816	822	PF00069	0.599
MOD_Plk_4	862	868	PF00069	0.554
MOD_ProDKin_1	118	124	PF00069	0.287
MOD_ProDKin_1	160	166	PF00069	0.553
MOD_ProDKin_1	218	224	PF00069	0.675
MOD_ProDKin_1	30	36	PF00069	0.704
MOD_ProDKin_1	44	50	PF00069	0.543
MOD_ProDKin_1	604	610	PF00069	0.672
MOD_ProDKin_1	680	686	PF00069	0.393
MOD_ProDKin_1	723	729	PF00069	0.570
MOD_SUMO_rev_2	430	438	PF00179	0.619
TRG_DiLeu_BaEn_2	687	693	PF01217	0.535
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.665
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.392
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.631
TRG_DiLeu_BaLyEn_6	743	748	PF01217	0.394
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.589
TRG_ENDOCYTIC_2	310	313	PF00928	0.444
TRG_ENDOCYTIC_2	320	323	PF00928	0.396
TRG_ENDOCYTIC_2	422	425	PF00928	0.489
TRG_ENDOCYTIC_2	644	647	PF00928	0.586
TRG_ENDOCYTIC_2	682	685	PF00928	0.374
TRG_ENDOCYTIC_2	690	693	PF00928	0.400
TRG_ER_diArg_1	282	284	PF00400	0.428
TRG_ER_diArg_1	290	292	PF00400	0.563
TRG_ER_diArg_1	333	336	PF00400	0.401
TRG_ER_diArg_1	57	60	PF00400	0.495
TRG_ER_diArg_1	633	636	PF00400	0.496
TRG_ER_diArg_1	679	681	PF00400	0.415
TRG_ER_FFAT_2	208	215	PF00635	0.604
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T3	Leptomonas seymouri	44%	100%
A0A3S7X1B1	Leishmania donovani	100%	100%
E9AZQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8I3	Leishmania major	90%	100%