Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sas10/Utp3/C1D family/Sas10 C-terminal domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I3E7_LEIIN

TriTrypDb:

LINF_280012400

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I3E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3E7

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.471
CLV_C14_Caspase3-7	15	19	PF00656	0.626
CLV_C14_Caspase3-7	27	31	PF00656	0.606
CLV_C14_Caspase3-7	447	451	PF00656	0.614
CLV_NRD_NRD_1	118	120	PF00675	0.530
CLV_NRD_NRD_1	12	14	PF00675	0.539
CLV_NRD_NRD_1	190	192	PF00675	0.177
CLV_NRD_NRD_1	228	230	PF00675	0.277
CLV_NRD_NRD_1	303	305	PF00675	0.415
CLV_NRD_NRD_1	389	391	PF00675	0.450
CLV_NRD_NRD_1	46	48	PF00675	0.517
CLV_NRD_NRD_1	469	471	PF00675	0.496
CLV_NRD_NRD_1	481	483	PF00675	0.427
CLV_NRD_NRD_1	490	492	PF00675	0.172
CLV_NRD_NRD_1	510	512	PF00675	0.125
CLV_NRD_NRD_1	519	521	PF00675	0.277
CLV_NRD_NRD_1	96	98	PF00675	0.408
CLV_PCSK_FUR_1	301	305	PF00082	0.562
CLV_PCSK_KEX2_1	10	12	PF00082	0.540
CLV_PCSK_KEX2_1	118	120	PF00082	0.532
CLV_PCSK_KEX2_1	303	305	PF00082	0.522
CLV_PCSK_KEX2_1	388	390	PF00082	0.433
CLV_PCSK_KEX2_1	481	483	PF00082	0.496
CLV_PCSK_KEX2_1	490	492	PF00082	0.178
CLV_PCSK_KEX2_1	519	521	PF00082	0.256
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.540
CLV_PCSK_PC7_1	515	521	PF00082	0.256
CLV_PCSK_SKI1_1	165	169	PF00082	0.468
CLV_PCSK_SKI1_1	3	7	PF00082	0.634
CLV_PCSK_SKI1_1	308	312	PF00082	0.504
CLV_PCSK_SKI1_1	47	51	PF00082	0.565
CLV_PCSK_SKI1_1	501	505	PF00082	0.223
CLV_Separin_Metazoa	162	166	PF03568	0.186
CLV_Separin_Metazoa	385	389	PF03568	0.546
DEG_APCC_DBOX_1	243	251	PF00400	0.374
DEG_APCC_DBOX_1	303	311	PF00400	0.423
DOC_CYCLIN_RxL_1	162	172	PF00134	0.307
DOC_CYCLIN_yClb5_NLxxxL_5	198	204	PF00134	0.398
DOC_MAPK_gen_1	519	528	PF00069	0.256
DOC_MAPK_RevD_3	105	119	PF00069	0.525
DOC_USP7_MATH_1	108	112	PF00917	0.502
DOC_USP7_MATH_1	123	127	PF00917	0.418
DOC_USP7_MATH_1	280	284	PF00917	0.598
DOC_USP7_MATH_1	288	292	PF00917	0.571
DOC_USP7_MATH_1	412	416	PF00917	0.693
DOC_USP7_MATH_1	465	469	PF00917	0.445
DOC_USP7_MATH_1	476	480	PF00917	0.424
DOC_USP7_UBL2_3	405	409	PF12436	0.647
DOC_USP7_UBL2_3	492	496	PF12436	0.223
DOC_USP7_UBL2_3	6	10	PF12436	0.519
DOC_USP7_UBL2_3	94	98	PF12436	0.474
DOC_WW_Pin1_4	157	162	PF00397	0.340
DOC_WW_Pin1_4	191	196	PF00397	0.389
LIG_14-3-3_CanoR_1	400	407	PF00244	0.617
LIG_14-3-3_CanoR_1	97	107	PF00244	0.453
LIG_APCC_ABBA_1	243	248	PF00400	0.374
LIG_BIR_III_2	132	136	PF00653	0.505
LIG_BRCT_BRCA1_1	532	536	PF00533	0.354
LIG_eIF4E_1	259	265	PF01652	0.327
LIG_FHA_1	217	223	PF00498	0.374
LIG_FHA_2	146	152	PF00498	0.412
LIG_FHA_2	48	54	PF00498	0.651
LIG_FHA_2	98	104	PF00498	0.484
LIG_LIR_Gen_1	141	150	PF02991	0.393
LIG_LIR_Gen_1	219	227	PF02991	0.374
LIG_LIR_Gen_1	355	365	PF02991	0.481
LIG_LIR_Gen_1	450	460	PF02991	0.453
LIG_LIR_Gen_1	58	68	PF02991	0.531
LIG_LIR_Nem_3	141	147	PF02991	0.402
LIG_LIR_Nem_3	219	224	PF02991	0.374
LIG_LIR_Nem_3	355	361	PF02991	0.470
LIG_LIR_Nem_3	450	456	PF02991	0.452
LIG_LIR_Nem_3	541	547	PF02991	0.223
LIG_LIR_Nem_3	58	64	PF02991	0.544
LIG_NRBOX	162	168	PF00104	0.435
LIG_PCNA_yPIPBox_3	256	265	PF02747	0.318
LIG_PDZ_Class_1	555	560	PF00595	0.354
LIG_REV1ctd_RIR_1	355	364	PF16727	0.573
LIG_RPA_C_Fungi	465	477	PF08784	0.420
LIG_SH2_GRB2like	34	37	PF00017	0.462
LIG_SH2_STAP1	189	193	PF00017	0.375
LIG_SH2_STAP1	453	457	PF00017	0.453
LIG_SH2_STAT5	214	217	PF00017	0.208
LIG_SH2_STAT5	221	224	PF00017	0.208
LIG_SH2_STAT5	246	249	PF00017	0.208
LIG_SH2_STAT5	34	37	PF00017	0.544
LIG_SH3_3	404	410	PF00018	0.542
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.420
LIG_SUMO_SIM_anti_2	378	385	PF11976	0.526
LIG_SUMO_SIM_anti_2	84	93	PF11976	0.452
LIG_SUMO_SIM_par_1	166	172	PF11976	0.229
LIG_TRAF2_1	100	103	PF00917	0.522
LIG_TRAF2_1	252	255	PF00917	0.318
LIG_TRAF2_1	349	352	PF00917	0.634
LIG_TRAF2_1	483	486	PF00917	0.606
LIG_UBA3_1	163	171	PF00899	0.315
LIG_UBA3_1	383	392	PF00899	0.507
LIG_WRC_WIRS_1	200	205	PF05994	0.354
MOD_CDK_SPxxK_3	191	198	PF00069	0.229
MOD_CK1_1	266	272	PF00069	0.457
MOD_CK2_1	145	151	PF00069	0.371
MOD_CK2_1	199	205	PF00069	0.403
MOD_CK2_1	346	352	PF00069	0.639
MOD_CK2_1	379	385	PF00069	0.449
MOD_CK2_1	9	15	PF00069	0.546
MOD_CK2_1	97	103	PF00069	0.526
MOD_Cter_Amidation	227	230	PF01082	0.223
MOD_Cter_Amidation	493	496	PF01082	0.363
MOD_Cter_Amidation	7	10	PF01082	0.641
MOD_GlcNHglycan	265	268	PF01048	0.393
MOD_GlcNHglycan	282	285	PF01048	0.539
MOD_GlcNHglycan	332	335	PF01048	0.457
MOD_GlcNHglycan	342	345	PF01048	0.511
MOD_GlcNHglycan	478	481	PF01048	0.533
MOD_GSK3_1	199	206	PF00069	0.385
MOD_GSK3_1	263	270	PF00069	0.403
MOD_GSK3_1	322	329	PF00069	0.480
MOD_GSK3_1	335	342	PF00069	0.441
MOD_GSK3_1	396	403	PF00069	0.633
MOD_GSK3_1	43	50	PF00069	0.708
MOD_GSK3_1	528	535	PF00069	0.354
MOD_N-GLC_1	335	340	PF02516	0.554
MOD_N-GLC_2	43	45	PF02516	0.512
MOD_NEK2_1	203	208	PF00069	0.230
MOD_NEK2_1	210	215	PF00069	0.213
MOD_NEK2_1	216	221	PF00069	0.208
MOD_NEK2_1	257	262	PF00069	0.327
MOD_NEK2_1	289	294	PF00069	0.592
MOD_NEK2_1	335	340	PF00069	0.556
MOD_PIKK_1	528	534	PF00454	0.302
MOD_PKA_1	124	130	PF00069	0.662
MOD_PKA_1	330	336	PF00069	0.572
MOD_PKA_1	47	53	PF00069	0.653
MOD_PKA_1	9	15	PF00069	0.637
MOD_PKA_1	97	103	PF00069	0.483
MOD_PKA_2	401	407	PF00069	0.703
MOD_PKA_2	43	49	PF00069	0.530
MOD_Plk_2-3	379	385	PF00069	0.571
MOD_Plk_2-3	446	452	PF00069	0.600
MOD_Plk_4	169	175	PF00069	0.362
MOD_Plk_4	199	205	PF00069	0.313
MOD_Plk_4	216	222	PF00069	0.117
MOD_Plk_4	379	385	PF00069	0.481
MOD_ProDKin_1	157	163	PF00069	0.331
MOD_ProDKin_1	191	197	PF00069	0.229
MOD_SUMO_for_1	156	159	PF00179	0.392
MOD_SUMO_for_1	224	227	PF00179	0.208
MOD_SUMO_for_1	538	541	PF00179	0.273
MOD_SUMO_rev_2	186	194	PF00179	0.341
MOD_SUMO_rev_2	202	208	PF00179	0.315
MOD_SUMO_rev_2	248	257	PF00179	0.304
TRG_DiLeu_BaEn_1	159	164	PF01217	0.340
TRG_DiLeu_BaEn_1	379	384	PF01217	0.538
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.324
TRG_DiLeu_LyEn_5	162	167	PF01217	0.186
TRG_ENDOCYTIC_2	221	224	PF00928	0.208
TRG_ENDOCYTIC_2	453	456	PF00928	0.487
TRG_ER_diArg_1	387	390	PF00400	0.469
TRG_ER_diArg_1	481	483	PF00400	0.646
TRG_ER_diArg_1	505	508	PF00400	0.290
TRG_NLS_MonoExtC_3	8	13	PF00514	0.543
TRG_NLS_MonoExtC_3	96	102	PF00514	0.532
TRG_NLS_MonoExtN_4	6	13	PF00514	0.533
TRG_NLS_MonoExtN_4	94	101	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.192
TRG_PTS1	557	560	PF00515	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH2	Leptomonas seymouri	74%	100%
A0A0S4JBP1	Bodo saltans	40%	100%
A0A1X0NYI2	Trypanosomatidae	49%	100%
A0A3S7X1D4	Leishmania donovani	100%	100%
A0A422P1Q1	Trypanosoma rangeli	50%	100%
A4HGB3	Leishmania braziliensis	85%	98%
D0A800	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AZN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q8J7	Leishmania major	96%	100%
V5BG83	Trypanosoma cruzi	48%	100%