ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies)/Ankyrin repeats (3 copies)/Ankyrin repeat - putative

Species:

Leishmania infantum

UniProt:

A4I3E2_LEIIN

TriTrypDb:

LINF_280011900

Length:

233

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.471
CLV_C14_Caspase3-7	45	49	PF00656	0.393
CLV_NRD_NRD_1	187	189	PF00675	0.675
CLV_PCSK_SKI1_1	121	125	PF00082	0.433
DEG_APCC_DBOX_1	11	19	PF00400	0.575
DEG_Nend_UBRbox_2	1	3	PF02207	0.590
DEG_SPOP_SBC_1	217	221	PF00917	0.634
DOC_MAPK_MEF2A_6	207	215	PF00069	0.532
DOC_PP4_FxxP_1	11	14	PF00568	0.599
DOC_USP7_MATH_1	203	207	PF00917	0.678
DOC_USP7_MATH_1	217	221	PF00917	0.522
DOC_USP7_UBL2_3	164	168	PF12436	0.476
LIG_APCC_ABBA_1	1	6	PF00400	0.638
LIG_FHA_1	219	225	PF00498	0.550
LIG_FHA_2	14	20	PF00498	0.534
LIG_Integrin_isoDGR_2	172	174	PF01839	0.444
LIG_LIR_Apic_2	147	152	PF02991	0.635
LIG_LIR_Apic_2	2	7	PF02991	0.639
LIG_LIR_Apic_2	8	14	PF02991	0.637
LIG_LIR_Gen_1	129	140	PF02991	0.512
LIG_MYND_3	67	71	PF01753	0.375
LIG_RPA_C_Fungi	94	106	PF08784	0.393
LIG_SH2_NCK_1	27	31	PF00017	0.531
LIG_SH2_PTP2	149	152	PF00017	0.628
LIG_SH2_SRC	149	152	PF00017	0.629
LIG_SH2_STAP1	128	132	PF00017	0.518
LIG_SH2_STAT3	128	131	PF00017	0.469
LIG_SH2_STAT5	149	152	PF00017	0.577
LIG_SH2_STAT5	39	42	PF00017	0.341
LIG_SH3_1	188	194	PF00018	0.655
LIG_SH3_2	194	199	PF14604	0.619
LIG_SH3_3	188	194	PF00018	0.668
LIG_SH3_3	208	214	PF00018	0.642
LIG_SH3_3	77	83	PF00018	0.264
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.393
LIG_TRAF2_1	178	181	PF00917	0.589
MOD_CK2_1	138	144	PF00069	0.533
MOD_GlcNHglycan	203	206	PF01048	0.666
MOD_GlcNHglycan	225	228	PF01048	0.562
MOD_GlcNHglycan	23	26	PF01048	0.457
MOD_GSK3_1	134	141	PF00069	0.501
MOD_NEK2_1	119	124	PF00069	0.487
MOD_NEK2_1	21	26	PF00069	0.484
MOD_NEK2_1	223	228	PF00069	0.615
MOD_PIKK_1	218	224	PF00454	0.564
MOD_Plk_1	142	148	PF00069	0.641
MOD_Plk_1	153	159	PF00069	0.602
MOD_Plk_2-3	13	19	PF00069	0.507
MOD_Plk_2-3	176	182	PF00069	0.601
MOD_Plk_4	134	140	PF00069	0.392
MOD_Plk_4	145	151	PF00069	0.541
MOD_Plk_4	153	159	PF00069	0.657
MOD_SUMO_rev_2	169	179	PF00179	0.728
MOD_SUMO_rev_2	180	185	PF00179	0.602
TRG_DiLeu_BaEn_1	134	139	PF01217	0.409
TRG_ENDOCYTIC_2	132	135	PF00928	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F3	Leptomonas seymouri	74%	100%
A0A1X0NYH9	Trypanosomatidae	40%	95%
A0A3R7KXF5	Trypanosoma rangeli	45%	100%
A0A3S7X195	Leishmania donovani	98%	100%
A4HGA8	Leishmania braziliensis	85%	100%
D0A806	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AZM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8K2	Leishmania major	94%	100%
Q6NSI1	Homo sapiens	24%	73%
V5BQC3	Trypanosoma cruzi	45%	98%