Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3E1_LEIIN

TriTrypDb:

LINF_280011800

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.564
CLV_NRD_NRD_1	208	210	PF00675	0.705
CLV_NRD_NRD_1	343	345	PF00675	0.458
CLV_PCSK_KEX2_1	142	144	PF00082	0.531
CLV_PCSK_KEX2_1	208	210	PF00082	0.605
CLV_PCSK_KEX2_1	343	345	PF00082	0.399
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.531
CLV_PCSK_SKI1_1	200	204	PF00082	0.722
CLV_PCSK_SKI1_1	256	260	PF00082	0.378
DEG_SCF_FBW7_1	290	296	PF00400	0.628
DOC_CKS1_1	290	295	PF01111	0.637
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.472
DOC_MAPK_MEF2A_6	327	335	PF00069	0.420
DOC_MAPK_RevD_3	329	344	PF00069	0.434
DOC_PP1_RVXF_1	336	343	PF00149	0.564
DOC_PP2B_LxvP_1	235	238	PF13499	0.488
DOC_PP2B_LxvP_1	331	334	PF13499	0.486
DOC_PP4_FxxP_1	295	298	PF00568	0.500
DOC_USP7_MATH_1	103	107	PF00917	0.598
DOC_USP7_MATH_1	285	289	PF00917	0.593
DOC_WW_Pin1_4	24	29	PF00397	0.503
DOC_WW_Pin1_4	241	246	PF00397	0.551
DOC_WW_Pin1_4	286	291	PF00397	0.699
LIG_14-3-3_CanoR_1	102	111	PF00244	0.346
LIG_14-3-3_CanoR_1	143	149	PF00244	0.505
LIG_14-3-3_CanoR_1	280	285	PF00244	0.627
LIG_14-3-3_CanoR_1	82	92	PF00244	0.444
LIG_Actin_WH2_2	159	177	PF00022	0.455
LIG_Actin_WH2_2	247	262	PF00022	0.423
LIG_CaM_IQ_9	268	283	PF13499	0.485
LIG_eIF4E_1	263	269	PF01652	0.380
LIG_FHA_1	181	187	PF00498	0.508
LIG_FHA_1	264	270	PF00498	0.494
LIG_FHA_1	66	72	PF00498	0.447
LIG_FHA_2	242	248	PF00498	0.500
LIG_FHA_2	272	278	PF00498	0.576
LIG_GBD_Chelix_1	170	178	PF00786	0.475
LIG_LIR_Apic_2	292	298	PF02991	0.530
LIG_LIR_Gen_1	14	21	PF02991	0.543
LIG_LIR_Nem_3	129	134	PF02991	0.433
LIG_LIR_Nem_3	14	19	PF02991	0.490
LIG_LIR_Nem_3	247	251	PF02991	0.552
LIG_LIR_Nem_3	346	352	PF02991	0.420
LIG_LIR_Nem_3	355	359	PF02991	0.463
LIG_LIR_Nem_3	53	58	PF02991	0.453
LIG_PTB_Apo_2	133	140	PF02174	0.557
LIG_REV1ctd_RIR_1	129	139	PF16727	0.453
LIG_SH2_STAP1	111	115	PF00017	0.499
LIG_SH2_STAP1	263	267	PF00017	0.434
LIG_SH2_STAT3	38	41	PF00017	0.550
LIG_SH2_STAT5	138	141	PF00017	0.391
LIG_SH2_STAT5	352	355	PF00017	0.497
LIG_SH2_STAT5	58	61	PF00017	0.465
LIG_SH2_STAT5	99	102	PF00017	0.456
LIG_SH3_1	351	357	PF00018	0.543
LIG_SH3_3	121	127	PF00018	0.466
LIG_SH3_3	181	187	PF00018	0.461
LIG_SH3_3	287	293	PF00018	0.655
LIG_SH3_3	351	357	PF00018	0.605
LIG_TRFH_1	295	299	PF08558	0.492
LIG_TRFH_1	58	62	PF08558	0.466
MOD_CK1_1	233	239	PF00069	0.556
MOD_CK1_1	24	30	PF00069	0.555
MOD_CK1_1	289	295	PF00069	0.640
MOD_CK2_1	19	25	PF00069	0.584
MOD_CK2_1	241	247	PF00069	0.511
MOD_GlcNHglycan	105	108	PF01048	0.622
MOD_GlcNHglycan	121	124	PF01048	0.424
MOD_GlcNHglycan	232	235	PF01048	0.471
MOD_GlcNHglycan	318	321	PF01048	0.464
MOD_GlcNHglycan	322	325	PF01048	0.438
MOD_GSK3_1	115	122	PF00069	0.569
MOD_GSK3_1	20	27	PF00069	0.485
MOD_GSK3_1	259	266	PF00069	0.376
MOD_GSK3_1	285	292	PF00069	0.553
MOD_GSK3_1	316	323	PF00069	0.492
MOD_GSK3_1	98	105	PF00069	0.500
MOD_NEK2_1	19	24	PF00069	0.577
MOD_NEK2_1	50	55	PF00069	0.466
MOD_PIKK_1	11	17	PF00454	0.435
MOD_PIKK_1	225	231	PF00454	0.468
MOD_PIKK_1	37	43	PF00454	0.499
MOD_PKA_2	103	109	PF00069	0.664
MOD_PKA_2	259	265	PF00069	0.434
MOD_Plk_1	107	113	PF00069	0.605
MOD_Plk_1	180	186	PF00069	0.479
MOD_Plk_1	263	269	PF00069	0.444
MOD_Plk_2-3	159	165	PF00069	0.607
MOD_Plk_4	263	269	PF00069	0.439
MOD_Plk_4	50	56	PF00069	0.484
MOD_ProDKin_1	24	30	PF00069	0.510
MOD_ProDKin_1	241	247	PF00069	0.542
MOD_ProDKin_1	286	292	PF00069	0.695
TRG_DiLeu_BaEn_1	264	269	PF01217	0.383
TRG_ENDOCYTIC_2	138	141	PF00928	0.352
TRG_ER_diArg_1	173	176	PF00400	0.451
TRG_ER_diArg_1	194	197	PF00400	0.632
TRG_ER_diArg_1	208	210	PF00400	0.627
TRG_ER_diArg_1	342	344	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA55	Leptomonas seymouri	51%	75%
A0A3Q8IQE0	Leishmania donovani	99%	71%
A4HGA7	Leishmania braziliensis	77%	100%
E9AZM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8K3	Leishmania major	89%	100%