Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3D3_LEIIN

TriTrypDb:

LINF_280011000

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	451	457	PF00089	0.637
CLV_NRD_NRD_1	380	382	PF00675	0.652
CLV_NRD_NRD_1	396	398	PF00675	0.543
CLV_NRD_NRD_1	446	448	PF00675	0.654
CLV_NRD_NRD_1	45	47	PF00675	0.712
CLV_NRD_NRD_1	490	492	PF00675	0.750
CLV_PCSK_KEX2_1	395	397	PF00082	0.597
CLV_PCSK_KEX2_1	446	448	PF00082	0.654
CLV_PCSK_KEX2_1	45	47	PF00082	0.679
CLV_PCSK_KEX2_1	490	492	PF00082	0.750
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.597
CLV_PCSK_SKI1_1	252	256	PF00082	0.590
CLV_PCSK_SKI1_1	267	271	PF00082	0.452
CLV_PCSK_SKI1_1	301	305	PF00082	0.616
CLV_PCSK_SKI1_1	397	401	PF00082	0.585
CLV_PCSK_SKI1_1	447	451	PF00082	0.690
CLV_Separin_Metazoa	75	79	PF03568	0.587
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_SPOP_SBC_1	50	54	PF00917	0.610
DOC_CDC14_PxL_1	126	134	PF14671	0.543
DOC_CKS1_1	440	445	PF01111	0.636
DOC_CYCLIN_RxL_1	113	123	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.596
DOC_PP2B_LxvP_1	70	73	PF13499	0.681
DOC_PP4_MxPP_1	404	407	PF00568	0.674
DOC_USP7_MATH_1	44	48	PF00917	0.639
DOC_USP7_MATH_1	494	498	PF00917	0.742
DOC_USP7_MATH_1	66	70	PF00917	0.705
DOC_USP7_MATH_2	136	142	PF00917	0.669
DOC_WW_Pin1_4	142	147	PF00397	0.655
DOC_WW_Pin1_4	160	165	PF00397	0.610
DOC_WW_Pin1_4	189	194	PF00397	0.760
DOC_WW_Pin1_4	228	233	PF00397	0.636
DOC_WW_Pin1_4	245	250	PF00397	0.637
DOC_WW_Pin1_4	252	257	PF00397	0.636
DOC_WW_Pin1_4	439	444	PF00397	0.657
DOC_WW_Pin1_4	471	476	PF00397	0.648
DOC_WW_Pin1_4	5	10	PF00397	0.629
DOC_WW_Pin1_4	64	69	PF00397	0.753
LIG_14-3-3_CanoR_1	216	224	PF00244	0.585
LIG_14-3-3_CanoR_1	243	248	PF00244	0.704
LIG_14-3-3_CanoR_1	396	402	PF00244	0.610
LIG_14-3-3_CanoR_1	446	450	PF00244	0.636
LIG_14-3-3_CanoR_1	45	49	PF00244	0.628
LIG_14-3-3_CanoR_1	490	498	PF00244	0.624
LIG_Actin_WH2_2	197	214	PF00022	0.516
LIG_CtBP_PxDLS_1	73	77	PF00389	0.623
LIG_EVH1_2	406	410	PF00568	0.702
LIG_FHA_1	103	109	PF00498	0.660
LIG_FHA_1	257	263	PF00498	0.551
LIG_FHA_1	302	308	PF00498	0.639
LIG_FHA_1	446	452	PF00498	0.650
LIG_FHA_1	50	56	PF00498	0.720
LIG_FHA_2	15	21	PF00498	0.547
LIG_FHA_2	313	319	PF00498	0.721
LIG_GBD_Chelix_1	118	126	PF00786	0.622
LIG_LIR_Gen_1	178	185	PF02991	0.555
LIG_LIR_Gen_1	497	501	PF02991	0.738
LIG_LIR_Gen_1	79	88	PF02991	0.637
LIG_LIR_Nem_3	17	21	PF02991	0.594
LIG_LIR_Nem_3	178	183	PF02991	0.547
LIG_LIR_Nem_3	497	501	PF02991	0.721
LIG_MYND_3	129	133	PF01753	0.553
LIG_SH2_CRK	180	184	PF00017	0.650
LIG_SH2_STAT3	353	356	PF00017	0.732
LIG_SH2_STAT5	114	117	PF00017	0.490
LIG_SH2_STAT5	25	28	PF00017	0.541
LIG_SH3_3	430	436	PF00018	0.735
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.485
LIG_SUMO_SIM_par_1	96	101	PF11976	0.550
LIG_TRAF2_1	104	107	PF00917	0.560
LIG_TRAF2_1	309	312	PF00917	0.544
LIG_TRAF2_1	376	379	PF00917	0.538
MOD_CDK_SPK_2	142	147	PF00069	0.713
MOD_CDK_SPxxK_3	245	252	PF00069	0.591
MOD_CDK_SPxxK_3	439	446	PF00069	0.637
MOD_CK1_1	101	107	PF00069	0.587
MOD_CK1_1	131	137	PF00069	0.748
MOD_CK1_1	155	161	PF00069	0.804
MOD_CK1_1	189	195	PF00069	0.752
MOD_CK1_1	412	418	PF00069	0.796
MOD_CK1_1	456	462	PF00069	0.602
MOD_CK1_1	474	480	PF00069	0.651
MOD_CK1_1	483	489	PF00069	0.699
MOD_CK1_1	5	11	PF00069	0.732
MOD_CK2_1	101	107	PF00069	0.528
MOD_CK2_1	14	20	PF00069	0.551
MOD_CK2_1	184	190	PF00069	0.669
MOD_CK2_1	21	27	PF00069	0.562
MOD_CK2_1	312	318	PF00069	0.766
MOD_CK2_1	328	334	PF00069	0.564
MOD_GlcNHglycan	164	167	PF01048	0.758
MOD_GlcNHglycan	186	189	PF01048	0.737
MOD_GlcNHglycan	339	342	PF01048	0.571
MOD_GlcNHglycan	437	440	PF01048	0.660
MOD_GlcNHglycan	456	459	PF01048	0.619
MOD_GlcNHglycan	492	495	PF01048	0.663
MOD_GlcNHglycan	99	103	PF01048	0.618
MOD_GSK3_1	138	145	PF00069	0.676
MOD_GSK3_1	216	223	PF00069	0.531
MOD_GSK3_1	228	235	PF00069	0.635
MOD_GSK3_1	252	259	PF00069	0.612
MOD_GSK3_1	3	10	PF00069	0.734
MOD_GSK3_1	328	335	PF00069	0.642
MOD_GSK3_1	337	344	PF00069	0.706
MOD_GSK3_1	435	442	PF00069	0.660
MOD_GSK3_1	456	463	PF00069	0.611
MOD_GSK3_1	485	492	PF00069	0.639
MOD_GSK3_1	64	71	PF00069	0.636
MOD_GSK3_1	98	105	PF00069	0.599
MOD_LATS_1	452	458	PF00433	0.623
MOD_N-GLC_1	14	19	PF02516	0.544
MOD_N-GLC_1	412	417	PF02516	0.668
MOD_NEK2_1	184	189	PF00069	0.758
MOD_NEK2_1	2	7	PF00069	0.708
MOD_NEK2_1	21	26	PF00069	0.468
MOD_NEK2_1	323	328	PF00069	0.618
MOD_NEK2_2	238	243	PF00069	0.625
MOD_OFUCOSY	253	258	PF10250	0.606
MOD_PIKK_1	131	137	PF00454	0.627
MOD_PIKK_1	216	222	PF00454	0.524
MOD_PIKK_1	295	301	PF00454	0.517
MOD_PIKK_1	474	480	PF00454	0.753
MOD_PKA_1	490	496	PF00069	0.748
MOD_PKA_2	102	108	PF00069	0.670
MOD_PKA_2	220	226	PF00069	0.696
MOD_PKA_2	329	335	PF00069	0.609
MOD_PKA_2	337	343	PF00069	0.605
MOD_PKA_2	44	50	PF00069	0.647
MOD_PKA_2	445	451	PF00069	0.633
MOD_PKA_2	453	459	PF00069	0.621
MOD_PKA_2	489	495	PF00069	0.694
MOD_Plk_1	14	20	PF00069	0.585
MOD_Plk_1	26	32	PF00069	0.549
MOD_Plk_1	412	418	PF00069	0.669
MOD_Plk_1	460	466	PF00069	0.633
MOD_Plk_2-3	312	318	PF00069	0.651
MOD_Plk_4	179	185	PF00069	0.680
MOD_Plk_4	21	27	PF00069	0.682
MOD_Plk_4	461	467	PF00069	0.692
MOD_ProDKin_1	142	148	PF00069	0.653
MOD_ProDKin_1	160	166	PF00069	0.611
MOD_ProDKin_1	189	195	PF00069	0.783
MOD_ProDKin_1	228	234	PF00069	0.634
MOD_ProDKin_1	245	251	PF00069	0.636
MOD_ProDKin_1	252	258	PF00069	0.629
MOD_ProDKin_1	439	445	PF00069	0.655
MOD_ProDKin_1	471	477	PF00069	0.647
MOD_ProDKin_1	5	11	PF00069	0.625
MOD_ProDKin_1	64	70	PF00069	0.747
MOD_SUMO_for_1	83	86	PF00179	0.643
TRG_DiLeu_BaEn_1	206	211	PF01217	0.483
TRG_ENDOCYTIC_2	180	183	PF00928	0.678
TRG_ENDOCYTIC_2	80	83	PF00928	0.628
TRG_ER_diArg_1	445	447	PF00400	0.812
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S4	Leptomonas seymouri	43%	95%
A0A3Q8IHY9	Leishmania donovani	99%	100%
A4HG99	Leishmania braziliensis	71%	100%
E9AZM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8L1	Leishmania major	91%	100%