Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Modifier of rudimentary (Mod(r)) protein - putative

Species:

Leishmania infantum

UniProt:

A4I3D0_LEIIN

TriTrypDb:

LINF_280010600

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000813	ESCRT I complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0036452	ESCRT complex	2	12
GO:0098796	membrane protein complex	2	12

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Expansion

Sequence features

A4I3D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3D0

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0044237	cellular metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0045184	establishment of protein localization	3	12

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.608
CLV_NRD_NRD_1	231	233	PF00675	0.546
CLV_NRD_NRD_1	242	244	PF00675	0.436
CLV_PCSK_KEX2_1	13	15	PF00082	0.607
CLV_PCSK_KEX2_1	231	233	PF00082	0.544
CLV_PCSK_KEX2_1	242	244	PF00082	0.454
CLV_PCSK_KEX2_1	275	277	PF00082	0.506
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.521
CLV_PCSK_SKI1_1	102	106	PF00082	0.575
CLV_PCSK_SKI1_1	121	125	PF00082	0.683

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q4	Leptomonas seymouri	77%	100%
A0A0S4JBQ7	Bodo saltans	31%	100%
A0A1X0NYI9	Trypanosomatidae	42%	100%
A0A3S7X186	Leishmania donovani	100%	100%
A0A422P1P4	Trypanosoma rangeli	41%	100%
A4HG97	Leishmania braziliensis	86%	100%
D0A814	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AZL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q8L4	Leishmania major	95%	100%
V5DH66	Trypanosoma cruzi	42%	93%

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