Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3C5_LEIIN

TriTrypDb:

LINF_280010100

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3C5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	206	208	PF00675	0.484
CLV_NRD_NRD_1	226	228	PF00675	0.376
CLV_NRD_NRD_1	272	274	PF00675	0.499
CLV_PCSK_FUR_1	355	359	PF00082	0.503
CLV_PCSK_KEX2_1	226	228	PF00082	0.376
CLV_PCSK_KEX2_1	272	274	PF00082	0.409
CLV_PCSK_KEX2_1	357	359	PF00082	0.482
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.482
CLV_PCSK_SKI1_1	237	241	PF00082	0.325
CLV_PCSK_SKI1_1	281	285	PF00082	0.465
CLV_PCSK_SKI1_1	289	293	PF00082	0.368
CLV_PCSK_SKI1_1	357	361	PF00082	0.460
CLV_PCSK_SKI1_1	60	64	PF00082	0.360
DEG_COP1_1	247	256	PF00400	0.301
DEG_Nend_UBRbox_2	1	3	PF02207	0.508
DEG_SPOP_SBC_1	28	32	PF00917	0.526
DOC_CDC14_PxL_1	297	305	PF14671	0.499
DOC_CDC14_PxL_1	332	340	PF14671	0.528
DOC_CYCLIN_RxL_1	286	295	PF00134	0.486
DOC_CYCLIN_RxL_1	354	364	PF00134	0.521
DOC_MAPK_gen_1	176	186	PF00069	0.401
DOC_MAPK_gen_1	207	213	PF00069	0.492
DOC_MAPK_gen_1	281	288	PF00069	0.355
DOC_MAPK_gen_1	325	332	PF00069	0.507
DOC_PP1_SILK_1	203	208	PF00149	0.454
DOC_PP4_FxxP_1	315	318	PF00568	0.455
DOC_PP4_MxPP_1	316	319	PF00568	0.491
DOC_USP7_MATH_1	201	205	PF00917	0.395
DOC_WW_Pin1_4	160	165	PF00397	0.540
DOC_WW_Pin1_4	6	11	PF00397	0.468
LIG_14-3-3_CanoR_1	145	152	PF00244	0.489
LIG_14-3-3_CanoR_1	18	24	PF00244	0.497
LIG_14-3-3_CanoR_1	226	232	PF00244	0.480
LIG_14-3-3_CanoR_1	287	292	PF00244	0.398
LIG_14-3-3_CanoR_1	327	331	PF00244	0.585
LIG_14-3-3_CanoR_1	337	345	PF00244	0.361
LIG_14-3-3_CanoR_1	358	367	PF00244	0.467
LIG_14-3-3_CanoR_1	372	380	PF00244	0.488
LIG_Actin_WH2_2	211	228	PF00022	0.321
LIG_APCC_ABBA_1	144	149	PF00400	0.284
LIG_BRCT_BRCA1_1	373	377	PF00533	0.445
LIG_Clathr_ClatBox_1	76	80	PF01394	0.310
LIG_deltaCOP1_diTrp_1	137	147	PF00928	0.360
LIG_EH1_1	259	267	PF00400	0.259
LIG_FHA_1	189	195	PF00498	0.458
LIG_FHA_1	327	333	PF00498	0.516
LIG_FHA_2	293	299	PF00498	0.374
LIG_FHA_2	318	324	PF00498	0.580
LIG_LIR_Apic_2	312	318	PF02991	0.437
LIG_LIR_Gen_1	106	115	PF02991	0.340
LIG_LIR_Gen_1	374	382	PF02991	0.432
LIG_LIR_Nem_3	101	107	PF02991	0.369
LIG_LIR_Nem_3	137	143	PF02991	0.372
LIG_NRBOX	110	116	PF00104	0.439
LIG_NRBOX	72	78	PF00104	0.315
LIG_Pex14_2	377	381	PF04695	0.399
LIG_Pex14_2	58	62	PF04695	0.430
LIG_Rb_pABgroove_1	371	379	PF01858	0.505
LIG_SH2_SRC	121	124	PF00017	0.471
LIG_SH2_STAP1	107	111	PF00017	0.312
LIG_SH2_STAP1	121	125	PF00017	0.339
LIG_SH2_STAT3	167	170	PF00017	0.532
LIG_SH2_STAT5	104	107	PF00017	0.355
LIG_SH2_STAT5	138	141	PF00017	0.333
LIG_SH2_STAT5	167	170	PF00017	0.532
LIG_SH2_STAT5	277	280	PF00017	0.397
LIG_SH3_3	238	244	PF00018	0.462
LIG_SH3_3	248	254	PF00018	0.365
LIG_SUMO_SIM_anti_2	130	137	PF11976	0.322
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.375
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.316
LIG_SUMO_SIM_par_1	130	137	PF11976	0.340
LIG_SUMO_SIM_par_1	328	333	PF11976	0.508
LIG_TRAF2_1	24	27	PF00917	0.484
LIG_TRAF2_1	309	312	PF00917	0.386
LIG_WRC_WIRS_1	20	25	PF05994	0.507
LIG_WRC_WIRS_1	59	64	PF05994	0.462
MOD_CK1_1	106	112	PF00069	0.247
MOD_CK1_1	148	154	PF00069	0.418
MOD_CK1_1	361	367	PF00069	0.535
MOD_CK2_1	148	154	PF00069	0.383
MOD_CK2_1	21	27	PF00069	0.519
MOD_CK2_1	311	317	PF00069	0.447
MOD_GlcNHglycan	199	202	PF01048	0.475
MOD_GlcNHglycan	227	230	PF01048	0.531
MOD_GlcNHglycan	339	342	PF01048	0.481
MOD_GlcNHglycan	345	348	PF01048	0.427
MOD_GSK3_1	197	204	PF00069	0.376
MOD_GSK3_1	361	368	PF00069	0.486
MOD_GSK3_1	92	99	PF00069	0.484
MOD_N-GLC_1	245	250	PF02516	0.541
MOD_N-GLC_1	292	297	PF02516	0.369
MOD_N-GLC_2	44	46	PF02516	0.353
MOD_NEK2_1	225	230	PF00069	0.526
MOD_NEK2_1	292	297	PF00069	0.368
MOD_NEK2_1	326	331	PF00069	0.499
MOD_NEK2_1	58	63	PF00069	0.449
MOD_NEK2_2	13	18	PF00069	0.485
MOD_PIKK_1	275	281	PF00454	0.401
MOD_PIKK_1	371	377	PF00454	0.448
MOD_PKA_1	281	287	PF00069	0.423
MOD_PKA_2	225	231	PF00069	0.465
MOD_PKA_2	326	332	PF00069	0.621
MOD_PKA_2	371	377	PF00069	0.414
MOD_Plk_1	13	19	PF00069	0.456
MOD_Plk_1	148	154	PF00069	0.434
MOD_Plk_1	292	298	PF00069	0.375
MOD_Plk_1	311	317	PF00069	0.311
MOD_Plk_2-3	311	317	PF00069	0.509
MOD_Plk_4	106	112	PF00069	0.389
MOD_Plk_4	201	207	PF00069	0.443
MOD_Plk_4	281	287	PF00069	0.420
MOD_Plk_4	292	298	PF00069	0.375
MOD_Plk_4	311	317	PF00069	0.311
MOD_Plk_4	326	332	PF00069	0.489
MOD_Plk_4	58	64	PF00069	0.500
MOD_Plk_4	98	104	PF00069	0.437
MOD_ProDKin_1	160	166	PF00069	0.531
MOD_ProDKin_1	6	12	PF00069	0.466
MOD_SUMO_rev_2	317	326	PF00179	0.491
TRG_DiLeu_BaEn_2	310	316	PF01217	0.422
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.497
TRG_ENDOCYTIC_2	107	110	PF00928	0.328
TRG_ENDOCYTIC_2	121	124	PF00928	0.404
TRG_ER_diArg_1	225	227	PF00400	0.358
TRG_ER_diArg_1	286	289	PF00400	0.354
TRG_ER_diArg_1	82	85	PF00400	0.343
TRG_NES_CRM1_1	210	222	PF08389	0.363
TRG_NES_CRM1_1	67	80	PF08389	0.323
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB59	Leptomonas seymouri	79%	97%
A0A0S4JB68	Bodo saltans	51%	93%
A0A1X0NYX9	Trypanosomatidae	55%	94%
A0A3Q8IEP5	Leishmania donovani	100%	100%
A0A422P1Q9	Trypanosoma rangeli	54%	99%
A4HG91	Leishmania braziliensis	86%	100%
D0A821	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
E9AZL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F1QN74	Danio rerio	27%	86%
O75800	Homo sapiens	31%	88%
Q4Q8L9	Leishmania major	95%	100%
Q5FWU8	Xenopus laevis	33%	88%
Q6AXZ5	Rattus norvegicus	31%	88%
Q99ML0	Mus musculus	32%	88%
Q9VU41	Drosophila melanogaster	29%	85%
V5B0T6	Trypanosoma cruzi	54%	98%