LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Saccharopine dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
A4I3C3_LEIIN
TriTrypDb:
LINF_280009700
Length:
392

Annotations

Annotations by Jardim et al.

Oxidoreductase, saccharopine dehydrogenase, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005811 lipid droplet 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I3C3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3C3

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006664 glycolipid metabolic process 5 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009247 glycolipid biosynthetic process 5 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901137 carbohydrate derivative biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1903509 liposaccharide metabolic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0016491 oxidoreductase activity 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 114 116 PF00675 0.388
CLV_NRD_NRD_1 235 237 PF00675 0.310
CLV_NRD_NRD_1 25 27 PF00675 0.332
CLV_NRD_NRD_1 278 280 PF00675 0.330
CLV_NRD_NRD_1 346 348 PF00675 0.465
CLV_PCSK_KEX2_1 114 116 PF00082 0.327
CLV_PCSK_KEX2_1 235 237 PF00082 0.351
CLV_PCSK_KEX2_1 278 280 PF00082 0.330
CLV_PCSK_KEX2_1 315 317 PF00082 0.339
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.408
CLV_PCSK_SKI1_1 279 283 PF00082 0.429
CLV_PCSK_SKI1_1 284 288 PF00082 0.429
CLV_PCSK_SKI1_1 64 68 PF00082 0.179
DEG_COP1_1 50 58 PF00400 0.273
DOC_CKS1_1 355 360 PF01111 0.292
DOC_MAPK_gen_1 369 377 PF00069 0.343
DOC_MAPK_MEF2A_6 48 55 PF00069 0.385
DOC_USP7_MATH_1 153 157 PF00917 0.425
DOC_USP7_MATH_1 169 173 PF00917 0.418
DOC_USP7_MATH_1 195 199 PF00917 0.470
DOC_USP7_MATH_1 299 303 PF00917 0.402
DOC_USP7_MATH_1 37 41 PF00917 0.385
DOC_USP7_UBL2_3 27 31 PF12436 0.316
DOC_USP7_UBL2_3 344 348 PF12436 0.466
DOC_WW_Pin1_4 107 112 PF00397 0.293
DOC_WW_Pin1_4 164 169 PF00397 0.481
DOC_WW_Pin1_4 189 194 PF00397 0.441
DOC_WW_Pin1_4 204 209 PF00397 0.455
DOC_WW_Pin1_4 354 359 PF00397 0.287
LIG_14-3-3_CanoR_1 18 24 PF00244 0.373
LIG_14-3-3_CanoR_1 235 241 PF00244 0.431
LIG_14-3-3_CanoR_1 260 270 PF00244 0.520
LIG_14-3-3_CanoR_1 347 352 PF00244 0.467
LIG_Actin_WH2_2 336 354 PF00022 0.385
LIG_BIR_II_1 1 5 PF00653 0.442
LIG_BRCT_BRCA1_1 282 286 PF00533 0.268
LIG_DLG_GKlike_1 347 355 PF00625 0.366
LIG_eIF4E_1 328 334 PF01652 0.355
LIG_FHA_1 108 114 PF00498 0.249
LIG_FHA_1 14 20 PF00498 0.310
LIG_FHA_1 235 241 PF00498 0.288
LIG_FHA_1 377 383 PF00498 0.522
LIG_FHA_1 55 61 PF00498 0.399
LIG_FHA_1 73 79 PF00498 0.134
LIG_FHA_1 99 105 PF00498 0.249
LIG_FHA_2 185 191 PF00498 0.492
LIG_Integrin_isoDGR_2 217 219 PF01839 0.404
LIG_LIR_Gen_1 254 263 PF02991 0.373
LIG_LIR_Gen_1 264 274 PF02991 0.317
LIG_LIR_Nem_3 254 258 PF02991 0.474
LIG_LIR_Nem_3 264 269 PF02991 0.442
LIG_MLH1_MIPbox_1 282 286 PF16413 0.268
LIG_NRP_CendR_1 389 392 PF00754 0.506
LIG_Pex14_2 220 224 PF04695 0.409
LIG_Pex14_2 303 307 PF04695 0.389
LIG_PTB_Apo_2 214 221 PF02174 0.396
LIG_SH2_GRB2like 215 218 PF00017 0.469
LIG_SH2_PTP2 266 269 PF00017 0.333
LIG_SH2_SRC 215 218 PF00017 0.410
LIG_SH2_SRC 247 250 PF00017 0.254
LIG_SH2_STAP1 328 332 PF00017 0.420
LIG_SH2_STAT5 103 106 PF00017 0.274
LIG_SH2_STAT5 147 150 PF00017 0.286
LIG_SH2_STAT5 163 166 PF00017 0.222
LIG_SH2_STAT5 23 26 PF00017 0.334
LIG_SH2_STAT5 247 250 PF00017 0.255
LIG_SH2_STAT5 266 269 PF00017 0.467
LIG_SH2_STAT5 285 288 PF00017 0.393
LIG_SH2_STAT5 328 331 PF00017 0.304
LIG_SH3_3 352 358 PF00018 0.317
LIG_SH3_3 85 91 PF00018 0.285
LIG_SUMO_SIM_anti_2 155 161 PF11976 0.339
LIG_SUMO_SIM_anti_2 192 198 PF11976 0.461
LIG_SUMO_SIM_anti_2 264 271 PF11976 0.365
LIG_SUMO_SIM_anti_2 3 9 PF11976 0.361
LIG_SUMO_SIM_par_1 192 198 PF11976 0.403
LIG_SUMO_SIM_par_1 378 383 PF11976 0.496
LIG_WRC_WIRS_1 55 60 PF05994 0.385
MOD_CDK_SPxK_1 204 210 PF00069 0.357
MOD_CDK_SPxxK_3 107 114 PF00069 0.273
MOD_CK1_1 172 178 PF00069 0.299
MOD_CK1_1 376 382 PF00069 0.440
MOD_CK2_1 225 231 PF00069 0.472
MOD_CK2_1 319 325 PF00069 0.326
MOD_Cter_Amidation 313 316 PF01082 0.468
MOD_GlcNHglycan 243 246 PF01048 0.419
MOD_GlcNHglycan 312 315 PF01048 0.374
MOD_GlcNHglycan 321 324 PF01048 0.368
MOD_GlcNHglycan 69 72 PF01048 0.332
MOD_GSK3_1 13 20 PF00069 0.362
MOD_GSK3_1 236 243 PF00069 0.429
MOD_GSK3_1 280 287 PF00069 0.479
MOD_GSK3_1 73 80 PF00069 0.312
MOD_N-GLC_1 172 177 PF02516 0.446
MOD_N-GLC_1 184 189 PF02516 0.483
MOD_N-GLC_1 98 103 PF02516 0.341
MOD_NEK2_1 10 15 PF00069 0.285
MOD_NEK2_1 223 228 PF00069 0.415
MOD_NEK2_1 240 245 PF00069 0.284
MOD_NEK2_1 251 256 PF00069 0.451
MOD_NEK2_1 259 264 PF00069 0.292
MOD_NEK2_1 286 291 PF00069 0.489
MOD_NEK2_1 298 303 PF00069 0.371
MOD_NEK2_2 17 22 PF00069 0.385
MOD_NEK2_2 299 304 PF00069 0.360
MOD_OFUCOSY 72 77 PF10250 0.273
MOD_PIKK_1 37 43 PF00454 0.360
MOD_PKA_1 347 353 PF00069 0.380
MOD_PKA_2 17 23 PF00069 0.385
MOD_PKA_2 218 224 PF00069 0.319
MOD_PKA_2 234 240 PF00069 0.204
MOD_PKA_2 259 265 PF00069 0.512
MOD_Plk_1 317 323 PF00069 0.428
MOD_Plk_4 155 161 PF00069 0.449
MOD_Plk_4 236 242 PF00069 0.322
MOD_Plk_4 262 268 PF00069 0.450
MOD_Plk_4 338 344 PF00069 0.357
MOD_Plk_4 376 382 PF00069 0.468
MOD_Plk_4 54 60 PF00069 0.378
MOD_ProDKin_1 107 113 PF00069 0.293
MOD_ProDKin_1 164 170 PF00069 0.482
MOD_ProDKin_1 189 195 PF00069 0.438
MOD_ProDKin_1 204 210 PF00069 0.452
MOD_ProDKin_1 354 360 PF00069 0.291
MOD_SUMO_for_1 47 50 PF00179 0.341
MOD_SUMO_rev_2 228 234 PF00179 0.317
MOD_SUMO_rev_2 383 391 PF00179 0.490
TRG_ENDOCYTIC_2 266 269 PF00928 0.333
TRG_ER_diArg_1 113 115 PF00400 0.420
TRG_ER_diArg_1 234 236 PF00400 0.305
TRG_ER_diArg_1 277 279 PF00400 0.325
TRG_ER_diLys_1 389 392 PF00400 0.598

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYN7 Leptomonas seymouri 62% 100%
A0A0S4IJU8 Bodo saltans 41% 99%
A0A1X0NQA2 Trypanosomatidae 43% 99%
A0A3R7KXD1 Trypanosoma rangeli 46% 100%
A0A3S7X166 Leishmania donovani 99% 100%
A0A422NEM4 Trypanosoma rangeli 41% 100%
A0PQ21 Mycobacterium ulcerans (strain Agy99) 29% 94%
A1KMU7 Mycobacterium bovis (strain BCG / Pasteur 1173P2) 30% 94%
A4HG79 Leishmania braziliensis 84% 100%
A5U6W1 Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) 30% 94%
E9AZJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O53176 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 34% 94%
P9WGV4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 30% 94%
P9WGV5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 30% 94%
Q3T067 Bos taurus 29% 91%
Q4Q8N2 Leishmania major 96% 100%
Q5R5C9 Pongo abelii 29% 91%
Q6AY30 Rattus norvegicus 29% 91%
Q7D745 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 34% 94%
Q7TXK2 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 30% 94%
Q8LGI2 Arabidopsis thaliana 27% 86%
Q8NBX0 Homo sapiens 29% 91%
Q8R127 Mus musculus 29% 91%
Q9CD87 Mycobacterium leprae (strain TN) 30% 94%
Q9GZE9 Caenorhabditis elegans 26% 92%
V5AMR3 Trypanosoma cruzi 40% 100%
V5CHW2 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS